ATE244889T1 - Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen - Google Patents

Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen

Info

Publication number
ATE244889T1
ATE244889T1 AT99906769T AT99906769T ATE244889T1 AT E244889 T1 ATE244889 T1 AT E244889T1 AT 99906769 T AT99906769 T AT 99906769T AT 99906769 T AT99906769 T AT 99906769T AT E244889 T1 ATE244889 T1 AT E244889T1
Authority
AT
Austria
Prior art keywords
protein
amount
determining
sample
disease
Prior art date
Application number
AT99906769T
Other languages
English (en)
Inventor
Stanley B Prusiner
Jiri G Safar
Fred E Cohen
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE244889T1 publication Critical patent/ATE244889T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99906769T 1998-02-20 1999-02-05 Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen ATE244889T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2695798A 1998-02-20 1998-02-20
US15105798A 1998-09-10 1998-09-10
PCT/US1999/002580 WO1999042829A1 (en) 1998-02-20 1999-02-05 Assay for specific strains of multiple disease related conformations of a protein

Publications (1)

Publication Number Publication Date
ATE244889T1 true ATE244889T1 (de) 2003-07-15

Family

ID=26701861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99906769T ATE244889T1 (de) 1998-02-20 1999-02-05 Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen

Country Status (10)

Country Link
EP (1) EP1057022B1 (de)
JP (1) JP2003519357A (de)
KR (1) KR20010041135A (de)
AT (1) ATE244889T1 (de)
AU (1) AU753331B2 (de)
BR (1) BR9908059A (de)
CA (1) CA2318477A1 (de)
DE (2) DE69909442T2 (de)
ES (1) ES2203073T3 (de)
WO (1) WO1999042829A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620629B1 (en) 1997-02-21 2003-09-16 The Regents Of The University Of California Method for detecting prions
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
US6221614B1 (en) 1997-02-21 2001-04-24 The Regents Of The University Of California Removal of prions from blood, plasma and other liquids
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
KR20010112840A (ko) * 2000-06-15 2001-12-22 김유삼 기능성 단백질의 패턴분석을 이용한 진단 시스템
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US6716589B2 (en) * 2000-11-20 2004-04-06 Alphabeta Ab Discordant helix stabilization for prevention of amyloid formation
AUPR293801A0 (en) * 2001-02-07 2001-03-01 Novapharm Research (Australia) Pty Ltd Prion disinfection
GB2376071A (en) * 2001-05-31 2002-12-04 Mini Agriculture & Fisheries Method for typing a TSE strain
JP2005504289A (ja) 2001-09-20 2005-02-10 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア プリオンアッセイ用に調製された筋肉試料
US7052849B2 (en) 2001-11-23 2006-05-30 Syn X Pharma, Inc. Protein biopolymer markers predictive of insulin resistance
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
MX2007008497A (es) * 2005-01-13 2007-09-14 Novartis Vaccines & Diagnostic Ensayos inmunosorbentes enlazados a enzimas usando reactivos de peptidos especificos de prion.
US8293174B2 (en) 2007-10-17 2012-10-23 American Sterilizer Company Prion deactivating composition and methods of using same
JP5747444B2 (ja) * 2010-04-27 2015-07-15 パナソニックヘルスケア株式会社 βアミロイドに関連する病的状態の診断補助方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806627A (en) * 1987-05-29 1989-02-21 Research Foundation Of Mental Hygiene Inc. Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins
AU4376093A (en) * 1992-05-15 1993-12-13 Instituto Nazionale Neurologico C. Besta Soluble prion polypeptides, and methods for detecting and purifying thereof
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5757361A (en) * 1996-03-20 1998-05-26 International Business Machines Corporation Method and apparatus in computer systems to selectively map tablet input devices using a virtual boundary
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US5977324A (en) * 1998-02-20 1999-11-02 The Regents Of The University Of California Process for concentrating protein with disease-related conformation

Also Published As

Publication number Publication date
DE1057022T1 (de) 2001-10-25
EP1057022B1 (de) 2003-07-09
DE69909442D1 (de) 2003-08-14
EP1057022A1 (de) 2000-12-06
KR20010041135A (ko) 2001-05-15
ES2203073T3 (es) 2004-04-01
CA2318477A1 (en) 1999-08-26
JP2003519357A (ja) 2003-06-17
EP1057022A4 (de) 2001-05-30
AU753331B2 (en) 2002-10-17
AU2660299A (en) 1999-09-06
DE69909442T2 (de) 2004-04-22
WO1999042829A1 (en) 1999-08-26
BR9908059A (pt) 2002-01-08

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