ATE293106T1 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number: ATE293106T1
Authority: AT; Austria
Prior art keywords: citalopram; producing citalopram; cyanophthalide; cyclized; bromine
Prior art date: 2003-10-28

Application number

AT03425693T

Other languages

English (en)

Inventor

Giovanni Cotticelli

Lernia Gianluca Di

Milanesi Silvia

Original Assignee

Adorkem Technology Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-28

Filing date

2003-10-28

Publication date

2005-04-15

2003-10-28 Application filed by Adorkem Technology Spa filed Critical Adorkem Technology Spa

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE293106T1 publication Critical patent/ATE293106T1/de

Links

229960001653 citalopram Drugs 0.000 title abstract 2
WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 abstract 1
XEEGWTLAFIZLSF-UHFFFAOYSA-N 1-oxo-3h-2-benzofuran-5-carbonitrile Chemical compound N#CC1=CC=C2C(=O)OCC2=C1 XEEGWTLAFIZLSF-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
BRKADVNLTRCLOW-UHFFFAOYSA-M magnesium;fluorobenzene;bromide Chemical compound [Mg+2].[Br-].FC1=CC=[C-]C=C1 BRKADVNLTRCLOW-UHFFFAOYSA-M 0.000 abstract 1
NGPAITITALWALP-UHFFFAOYSA-M magnesium;n,n-dimethylpropan-1-amine;chloride Chemical compound [Mg+2].[Cl-].CN(C)CC[CH2-] NGPAITITALWALP-UHFFFAOYSA-M 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT03425693T 2003-10-28 2003-10-28 Verfahren zur herstellung von citalopram ATE293106T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03425693A EP1506963B1 (de)	2003-10-28	2003-10-28	Verfahren zur Herstellung von Citalopram

Publications (1)

Publication Number	Publication Date
ATE293106T1 true ATE293106T1 (de)	2005-04-15

Family

ID=33560918

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03425693T ATE293106T1 (de)	2003-10-28	2003-10-28	Verfahren zur herstellung von citalopram
AT04791287T ATE420870T1 (de)	2003-10-28	2004-10-22	Verfahren zur herstellung von citalopram

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT04791287T ATE420870T1 (de)	2003-10-28	2004-10-22	Verfahren zur herstellung von citalopram

Country Status (15)

Country	Link
US (1)	US20070060759A1 (de)
EP (2)	EP1506963B1 (de)
JP (1)	JP2007511477A (de)
CN (1)	CN1875013A (de)
AT (2)	ATE293106T1 (de)
BR (1)	BRPI0415778A (de)
CA (1)	CA2543155A1 (de)
DE (2)	DE60300502T2 (de)
DK (2)	DK1506963T3 (de)
ES (1)	ES2240931T3 (de)
HK (1)	HK1075041A1 (de)
PL (1)	PL379659A1 (de)
PT (1)	PT1506963E (de)
SI (1)	SI1506963T1 (de)
WO (1)	WO2005049595A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9314444B2 (en)	2009-01-12	2016-04-19	Biokier, Inc.	Composition and method for treatment of NASH
PL2376077T3 (pl)	2009-01-12	2017-10-31	Biokier Inc	Kompozycja i sposób leczenia cukrzycy
US9006288B2 (en)	2009-01-12	2015-04-14	Biokier, Inc.	Composition and method for treatment of diabetes
EP2480246A4 (de)	2009-09-23	2013-02-27	Biokier Inc	Zusammensetzung und verfahren zur behandlung von diabetes
KR20190015609A (ko)	2011-05-02	2019-02-13	바이오키어 인코포레이티드	당뇨병 치료를 위한 조성물 및 치료법
US20150073057A1 (en)	2013-09-06	2015-03-12	Biokier, Inc.	Composition and method for treatment of diabetes
CN111302971B (zh) *	2018-12-12	2023-08-22	上海奥博生物医药股份有限公司	一种连续制备5-氰二醇的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
HU228744B1 (en) *	1997-07-08	2013-05-28	Lundbeck & Co As H	Method for preparation of citalopram and intermediates used for them
UA62985C2 (en) *	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
EP1042310B1 (de) *	1997-11-11	2002-07-31	H. Lundbeck A/S	Verfahren zur Herstellung von Citalopram
EP1355897A1 (de) *	2001-01-30	2003-10-29	Orion Corporation Fermion	Verfahren zur herstellung von 1-(3-dimethylaminopropyl)-1-(4-fluorphenyl)-1,3-dihydrobenzofuran-5-carbonitrile
US6967259B2 (en) *	2001-09-24	2005-11-22	Pharmachem Technologies Limited	Process for the preparation of Citalopram intermediate

2003
- 2003-10-28 DE DE60300502T patent/DE60300502T2/de not_active Expired - Fee Related
- 2003-10-28 ES ES03425693T patent/ES2240931T3/es not_active Expired - Lifetime
- 2003-10-28 EP EP03425693A patent/EP1506963B1/de not_active Expired - Lifetime
- 2003-10-28 DK DK03425693T patent/DK1506963T3/da active
- 2003-10-28 PT PT03425693T patent/PT1506963E/pt unknown
- 2003-10-28 AT AT03425693T patent/ATE293106T1/de not_active IP Right Cessation
- 2003-10-28 SI SI200330042T patent/SI1506963T1/xx unknown
2004
- 2004-10-22 DK DK04791287T patent/DK1682526T3/da active
- 2004-10-22 AT AT04791287T patent/ATE420870T1/de not_active IP Right Cessation
- 2004-10-22 PL PL379659A patent/PL379659A1/pl not_active Application Discontinuation
- 2004-10-22 WO PCT/EP2004/052626 patent/WO2005049595A1/en active Application Filing
- 2004-10-22 CA CA002543155A patent/CA2543155A1/en not_active Abandoned
- 2004-10-22 DE DE602004019127T patent/DE602004019127D1/de not_active Expired - Fee Related
- 2004-10-22 JP JP2006537287A patent/JP2007511477A/ja active Pending
- 2004-10-22 CN CNA200480031662XA patent/CN1875013A/zh active Pending
- 2004-10-22 US US10/577,869 patent/US20070060759A1/en not_active Abandoned
- 2004-10-22 EP EP04791287A patent/EP1682526B1/de active Active
- 2004-10-22 BR BRPI0415778-8A patent/BRPI0415778A/pt not_active IP Right Cessation
2005
- 2005-08-16 HK HK05107094A patent/HK1075041A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1506963E (pt)	2005-08-31
ES2240931T3 (es)	2005-10-16
SI1506963T1 (en)	2005-10-31
CA2543155A1 (en)	2005-06-02
DE60300502T2 (de)	2006-02-23
JP2007511477A (ja)	2007-05-10
ATE420870T1 (de)	2009-01-15
EP1506963A1 (de)	2005-02-16
BRPI0415778A (pt)	2006-12-26
CN1875013A (zh)	2006-12-06
WO2005049595A1 (en)	2005-06-02
EP1682526B1 (de)	2009-01-14
DE602004019127D1 (de)	2009-03-05
PL379659A1 (pl)	2006-10-30
DE60300502D1 (de)	2005-05-19
EP1506963B1 (de)	2005-04-13
DK1506963T3 (da)	2005-08-01
HK1075041A1 (en)	2005-12-02
EP1682526A1 (de)	2006-07-26
US20070060759A1 (en)	2007-03-15
DK1682526T3 (da)	2009-03-23

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Legal Events

Date

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Title

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2005-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1506963

Country of ref document: EP

2010-07-15

REN

Ceased due to non-payment of the annual fee