DE60333371D1 - 3-(sulfonamidoethyl)-indol-derivate zur verwendung als glucocorticoid-mimetika bei der behandlung von entzündlichen, allergischen und proliferativen erkrankungen - Google Patents
3-(sulfonamidoethyl)-indol-derivate zur verwendung als glucocorticoid-mimetika bei der behandlung von entzündlichen, allergischen und proliferativen erkrankungenInfo
- Publication number
- DE60333371D1 DE60333371D1 DE60333371T DE60333371T DE60333371D1 DE 60333371 D1 DE60333371 D1 DE 60333371D1 DE 60333371 T DE60333371 T DE 60333371T DE 60333371 T DE60333371 T DE 60333371T DE 60333371 D1 DE60333371 D1 DE 60333371D1
- Authority
- DE
- Germany
- Prior art keywords
- allergic
- inflammatory
- sulfonamidoethyl
- treatment
- proliferative diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40743802P | 2002-08-29 | 2002-08-29 | |
PCT/US2003/025062 WO2004019935A1 (en) | 2002-08-29 | 2003-08-12 | -3 (sulfonamidoethyl) -indole derivaties for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60333371D1 true DE60333371D1 (de) | 2010-08-26 |
Family
ID=31978485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60333371T Expired - Lifetime DE60333371D1 (de) | 2002-08-29 | 2003-08-12 | 3-(sulfonamidoethyl)-indol-derivate zur verwendung als glucocorticoid-mimetika bei der behandlung von entzündlichen, allergischen und proliferativen erkrankungen |
Country Status (23)
Country | Link |
---|---|
US (1) | US20040097574A1 (de) |
EP (1) | EP1539141B1 (de) |
JP (1) | JP4619786B2 (de) |
KR (1) | KR20050036982A (de) |
CN (1) | CN1678306A (de) |
AT (1) | ATE473740T1 (de) |
AU (1) | AU2003255259A1 (de) |
BR (1) | BR0313923A (de) |
CA (1) | CA2496580A1 (de) |
CO (1) | CO5550451A2 (de) |
DE (1) | DE60333371D1 (de) |
EA (1) | EA011095B1 (de) |
EC (1) | ECSP055611A (de) |
ES (1) | ES2349164T3 (de) |
HR (1) | HRP20050185A2 (de) |
MX (1) | MXPA05002297A (de) |
NO (1) | NO20051527L (de) |
NZ (1) | NZ538932A (de) |
PL (1) | PL375513A1 (de) |
RS (1) | RS20050174A (de) |
UA (1) | UA82675C2 (de) |
WO (1) | WO2004019935A1 (de) |
ZA (1) | ZA200500153B (de) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2472746A1 (en) * | 2002-01-14 | 2003-07-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof |
CA2477764A1 (en) * | 2002-03-26 | 2003-10-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
ES2298508T3 (es) * | 2002-03-26 | 2008-05-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para prepararlos, composiciones farmaceuticas y sus usos. |
US7186864B2 (en) * | 2002-05-29 | 2007-03-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
US7074806B2 (en) * | 2002-06-06 | 2006-07-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
GB0215293D0 (en) * | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
CA2496175A1 (en) | 2002-08-21 | 2004-03-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
EP1583745A1 (de) * | 2003-01-03 | 2005-10-12 | Boehringer Ingelheim Pharmaceuticals Inc. | 1-propanol- und 1-propylaminderivate undderen verwendung als glucocorticoidliganden |
US20040224992A1 (en) * | 2003-02-27 | 2004-11-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
US7507843B2 (en) * | 2003-10-16 | 2009-03-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols |
ATE544765T1 (de) | 2003-12-22 | 2012-02-15 | Leuven K U Res & Dev | Imidazoä4,5-cüpyridinverbindungen und verfahren zur antiviralen behandlung |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
EP1723102A2 (de) * | 2004-03-11 | 2006-11-22 | Elan Pharmaceuticals, Inc. | N-substituierte benzolsulfonamide |
US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
FR2870846B1 (fr) * | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
PE20060748A1 (es) | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
CA2584413A1 (en) * | 2004-10-29 | 2006-05-04 | Astrazeneca Ab | Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
CA2592388C (en) * | 2004-12-21 | 2013-04-02 | Steven S. Bondy | Imidazo[4,5-c]pyridine compound and method of antiviral treatment |
JP2008525525A (ja) * | 2004-12-27 | 2008-07-17 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメティクス、その製法、医薬組成物及び使用 |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
TW200815361A (en) * | 2005-10-20 | 2008-04-01 | Astrazeneca Ab | Chemical compounds |
EP2532678A1 (de) | 2005-10-21 | 2012-12-12 | Novartis AG | Menschliche Antikörper gegen IL13 und therapeutische Verwendungen |
TW200800150A (en) | 2005-12-21 | 2008-01-01 | Organon Nv | Compounds with medicinal effects due to interaction with the glucocorticoid receptor |
GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
AU2007208109B2 (en) | 2006-01-24 | 2012-08-23 | Eli Lilly And Company | Indole sulfonamide modulators of progesterone receptors |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
PT2013211E (pt) | 2006-04-21 | 2012-06-21 | Novartis Ag | Derivados de purina para utilização como agonistas de receptores a2a de adenosina |
ES2339298T3 (es) * | 2006-07-07 | 2010-05-18 | Gilead Sciences, Inc. | Compuesto de piridazina novedoso y uso del mismo. |
EP2099767A1 (de) | 2006-11-01 | 2009-09-16 | Brystol-Myers Squibb Company | Modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-b-aktivität und deren verwendung |
TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
KR20090097908A (ko) | 2006-12-06 | 2009-09-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 모사물, 이의 제조 방법, 이의 약제학적 조성물 및 용도 |
JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
WO2008079073A1 (en) * | 2006-12-22 | 2008-07-03 | Astrazeneca Ab | Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders |
WO2008085608A1 (en) | 2007-01-10 | 2008-07-17 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
AR065804A1 (es) | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
PL2155721T3 (pl) | 2007-05-07 | 2011-07-29 | Novartis Ag | Związki organiczne |
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2003
- 2003-08-12 BR BR0313923-9A patent/BR0313923A/pt not_active Expired - Fee Related
- 2003-08-12 PL PL03375513A patent/PL375513A1/xx not_active Application Discontinuation
- 2003-08-12 US US10/639,080 patent/US20040097574A1/en not_active Abandoned
- 2003-08-12 WO PCT/US2003/025062 patent/WO2004019935A1/en active Application Filing
- 2003-08-12 DE DE60333371T patent/DE60333371D1/de not_active Expired - Lifetime
- 2003-08-12 ES ES03791670T patent/ES2349164T3/es not_active Expired - Lifetime
- 2003-08-12 CA CA002496580A patent/CA2496580A1/en not_active Abandoned
- 2003-08-12 RS YUP-2005/0174A patent/RS20050174A/sr unknown
- 2003-08-12 CN CNA038205971A patent/CN1678306A/zh active Pending
- 2003-08-12 AT AT03791670T patent/ATE473740T1/de active
- 2003-08-12 EP EP03791670A patent/EP1539141B1/de not_active Expired - Lifetime
- 2003-08-12 JP JP2004532889A patent/JP4619786B2/ja not_active Expired - Fee Related
- 2003-08-12 KR KR1020057003328A patent/KR20050036982A/ko not_active Application Discontinuation
- 2003-08-12 EA EA200500304A patent/EA011095B1/ru not_active IP Right Cessation
- 2003-08-12 AU AU2003255259A patent/AU2003255259A1/en not_active Abandoned
- 2003-08-12 MX MXPA05002297A patent/MXPA05002297A/es unknown
- 2003-08-12 NZ NZ538932A patent/NZ538932A/en not_active IP Right Cessation
- 2003-12-08 UA UAA200502726A patent/UA82675C2/uk unknown
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2005
- 2005-01-07 ZA ZA200500153A patent/ZA200500153B/en unknown
- 2005-02-17 EC EC2005005611A patent/ECSP055611A/es unknown
- 2005-02-25 HR HR20050185A patent/HRP20050185A2/hr not_active Application Discontinuation
- 2005-03-22 NO NO20051527A patent/NO20051527L/no not_active Application Discontinuation
- 2005-03-28 CO CO05026977A patent/CO5550451A2/es not_active Application Discontinuation
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ECSP055611A (es) | 2005-05-30 |
EA200500304A1 (ru) | 2005-10-27 |
MXPA05002297A (es) | 2005-06-08 |
RS20050174A (en) | 2007-06-04 |
JP4619786B2 (ja) | 2011-01-26 |
NZ538932A (en) | 2007-04-27 |
CA2496580A1 (en) | 2004-03-11 |
ZA200500153B (en) | 2006-07-26 |
EP1539141A1 (de) | 2005-06-15 |
ATE473740T1 (de) | 2010-07-15 |
CO5550451A2 (es) | 2005-08-31 |
EA011095B1 (ru) | 2008-12-30 |
CN1678306A (zh) | 2005-10-05 |
WO2004019935A1 (en) | 2004-03-11 |
PL375513A1 (en) | 2005-11-28 |
HRP20050185A2 (en) | 2006-05-31 |
JP2006504681A (ja) | 2006-02-09 |
EP1539141B1 (de) | 2010-07-14 |
ES2349164T3 (es) | 2010-12-28 |
KR20050036982A (ko) | 2005-04-20 |
NO20051527D0 (no) | 2005-03-22 |
UA82675C2 (uk) | 2008-05-12 |
NO20051527L (no) | 2005-03-22 |
US20040097574A1 (en) | 2004-05-20 |
BR0313923A (pt) | 2005-07-12 |
AU2003255259A1 (en) | 2004-03-19 |
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