US6136311A
(en)
|
1996-05-06 |
2000-10-24 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of cancer
|
US6870034B2
(en)
*
|
2002-02-05 |
2005-03-22 |
Genentech, Inc. |
Protein purification
|
US20160279239A1
(en)
|
2011-05-02 |
2016-09-29 |
Immunomedics, Inc. |
Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
|
CN1802388B
(zh)
*
|
2003-05-09 |
2011-01-05 |
杜克大学 |
Cd20特异抗体及使用它们的方法
|
AU2004265253B2
(en)
*
|
2003-07-28 |
2011-09-01 |
Genentech, Inc. |
Reducing protein A leaching during protein A affinity chromatography
|
SE0400501D0
(sv)
*
|
2004-02-27 |
2004-02-27 |
Amersham Biosciences Ab |
Antibody purification
|
AU2005241431A1
(en)
*
|
2004-04-16 |
2005-11-17 |
Genentech, Inc. |
Assay for antibodies
|
US20160355591A1
(en)
|
2011-05-02 |
2016-12-08 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
AU2006259298B2
(en)
*
|
2005-06-17 |
2012-06-14 |
Wyeth Llc |
Methods of purifying Fc region containing proteins
|
CN101511858A
(zh)
*
|
2005-07-25 |
2009-08-19 |
特鲁比昂药品公司 |
用于蛋白质解聚的组合物和方法
|
CA2636109A1
(en)
*
|
2006-01-06 |
2007-07-19 |
Amgen Inc. |
Methods and systems for isolating target molecules from complex solutions by column-chromatography using eluants containing organic solvents
|
WO2007109163A2
(en)
*
|
2006-03-16 |
2007-09-27 |
Amgen Inc |
Wash buffer and method of using
|
AU2007227700A1
(en)
*
|
2006-03-20 |
2007-09-27 |
Medarex, Inc. |
Protein purification
|
JP2009531324A
(ja)
|
2006-03-20 |
2009-09-03 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
癌標的化のための操作された抗前立腺幹細胞抗原(psca)抗体
|
JP2009532474A
(ja)
|
2006-04-05 |
2009-09-10 |
アボツト・バイオテクノロジー・リミテツド |
抗体精製
|
JP5386354B2
(ja)
*
|
2006-09-08 |
2014-01-15 |
ワイス・エルエルシー |
アフィニティークロマトグラフィーを使用するタンパク質精製におけるアルギニン洗浄
|
US8911964B2
(en)
|
2006-09-13 |
2014-12-16 |
Abbvie Inc. |
Fed-batch method of making human anti-TNF-alpha antibody
|
WO2008033517A2
(en)
|
2006-09-13 |
2008-03-20 |
Abbott Laboratories |
Cell culture improvements
|
DK2089429T3
(en)
*
|
2006-10-19 |
2015-01-12 |
Janssen Biotech Inc |
PROCEDURE FOR MANUFACTURING NON-AGGREGATED ANTIBODY-FC DOMAINS
|
WO2008127305A2
(en)
*
|
2006-11-01 |
2008-10-23 |
Biogen Idec Ma Inc. |
Method of isolating biomacromolecules using low ph and divalent cations
|
US7691980B2
(en)
*
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
US7999085B2
(en)
*
|
2007-01-09 |
2011-08-16 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
NZ577933A
(en)
|
2007-01-22 |
2011-12-22 |
Genentech Inc |
Polyelectrolyte precipitation and purification of antibodies
|
AU2008208837A1
(en)
*
|
2007-01-26 |
2008-07-31 |
Merck Serono S.A. |
Purification of Fc-TACT fusion proteins using the oilbody technology
|
JP6126773B2
(ja)
|
2007-09-04 |
2017-05-10 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原(psca)抗体
|
EP2209498A2
(de)
*
|
2007-10-03 |
2010-07-28 |
Cornell University |
Behandlung von proliferativen erkrankungen mit psma-antikörpern
|
CA2722466A1
(en)
*
|
2008-04-29 |
2009-11-05 |
Tariq Ghayur |
Dual variable domain immunoglobulins and uses thereof
|
AU2009256246B2
(en)
|
2008-06-03 |
2013-07-18 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
SG191639A1
(en)
|
2008-06-03 |
2013-07-31 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
EP2321422A4
(de)
|
2008-07-08 |
2013-06-19 |
Abbvie Inc |
Prostaglandin-e2-immunglobuline mit doppelter variabler domäne und verwendungen davon
|
US20100069616A1
(en)
*
|
2008-08-06 |
2010-03-18 |
The Regents Of The University Of California |
Engineered antibody-nanoparticle conjugates
|
CN104974251A
(zh)
|
2008-10-20 |
2015-10-14 |
Abbvie公司 |
在抗体纯化过程中的病毒灭活
|
CA2911256A1
(en)
|
2008-10-20 |
2010-12-09 |
Robert K. Hickman |
Isolation and purification of antibodies using protein a affinity chromatography
|
KR101093717B1
(ko)
*
|
2008-11-26 |
2011-12-19 |
한국생명공학연구원 |
Vegf―특이적인 인간항체
|
CA2752510C
(en)
*
|
2009-02-17 |
2024-01-23 |
Neil Bander |
Methods and kits for diagnosis of cancer and prediction of therapeutic value
|
EP2473524A4
(de)
*
|
2009-09-01 |
2013-05-22 |
Abbott Lab |
Immunglobuline mit zweifacher variabler domäne und ihre verwendung
|
WO2011038894A1
(en)
*
|
2009-10-01 |
2011-04-07 |
F. Hoffmann-La Roche Ag |
Protein a chromatography
|
ES2604103T3
(es)
|
2009-10-01 |
2017-03-03 |
F. Hoffmann-La Roche Ag |
Filtración final de una preparación de inmunoglobulina en múltiples pasos
|
PE20121531A1
(es)
|
2009-10-15 |
2012-12-22 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
US8772459B2
(en)
|
2009-12-02 |
2014-07-08 |
Imaginab, Inc. |
J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use
|
US8937159B2
(en)
|
2009-12-16 |
2015-01-20 |
Abbvie Biotherapeutics Inc. |
Anti-HER2 antibodies and their uses
|
PL2513134T3
(pl)
|
2009-12-18 |
2018-02-28 |
Novartis Ag |
Roztwór do przemywania i sposób chromatografii powinowactwa
|
DK2526114T3
(da)
*
|
2010-01-22 |
2014-09-29 |
Boehringer Ingelheim Int |
Kromatografisk fremgangsmåde til oprensning af FC-indeholdende proteiner
|
US20120034207A1
(en)
*
|
2010-06-16 |
2012-02-09 |
Mclean Michael D |
Production of her receptor antibodies in plant
|
NZ607480A
(en)
|
2010-08-03 |
2014-10-31 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
EP2600901B1
(de)
|
2010-08-06 |
2019-03-27 |
ModernaTX, Inc. |
Pharmazeutische zusammensetzungen enthaltenbearbeitete nukleinsäuren und ihre medizinische verwendung
|
BR112013004581A2
(pt)
|
2010-08-26 |
2017-06-27 |
Abbvie Inc |
imunoglobulinas de domínio variável dual e seus usos
|
US20120237975A1
(en)
|
2010-10-01 |
2012-09-20 |
Jason Schrum |
Engineered nucleic acids and methods of use thereof
|
US8962804B2
(en)
|
2010-10-08 |
2015-02-24 |
City Of Hope |
Meditopes and meditope-binding antibodies and uses thereof
|
CA2820095C
(en)
|
2010-12-21 |
2019-02-26 |
F. Hoffmann-La Roche Ag |
Isoform enriched antibody preparation and method for obtaining it
|
BR112013024933A2
(pt)
*
|
2011-03-29 |
2016-09-06 |
Glaxosmithkline Llc |
sistema tampão para purificação de proteínas
|
AU2012236099A1
(en)
|
2011-03-31 |
2013-10-03 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
US9062106B2
(en)
|
2011-04-27 |
2015-06-23 |
Abbvie Inc. |
Methods for controlling the galactosylation profile of recombinantly-expressed proteins
|
CN107115526A
(zh)
|
2011-05-02 |
2017-09-01 |
免疫医疗公司 |
用于小体积施用的同种异型选择的抗体的超滤浓缩
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
RS62993B1
(sr)
|
2011-10-03 |
2022-03-31 |
Modernatx Inc |
Modifikovani nukleozidi, nukleotidi, i nukleinske kiseline, i njihove upotrebe
|
CN107840888B
(zh)
|
2011-10-10 |
2022-03-29 |
希望之城公司 |
中间位和中间位结合抗体及其用途
|
AU2012340766B2
(en)
|
2011-11-23 |
2018-05-10 |
Medimmune, Llc |
Binding molecules specific for HER3 and uses thereof
|
WO2013090648A1
(en)
|
2011-12-16 |
2013-06-20 |
modeRNA Therapeutics |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
EP2797955A2
(de)
|
2011-12-30 |
2014-11-05 |
AbbVie Inc. |
Immunglobuline mit zweifacher variabler domäne gegen il-13 und/oder il-17
|
EP3501550A1
(de)
|
2012-04-02 |
2019-06-26 |
Moderna Therapeutics, Inc. |
Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
|
US9878056B2
(en)
|
2012-04-02 |
2018-01-30 |
Modernatx, Inc. |
Modified polynucleotides for the production of cosmetic proteins and peptides
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
EP2836518B1
(de)
*
|
2012-04-11 |
2019-01-02 |
Bioverativ Therapeutics Inc. |
Verfahren zum nachweis von glykosaminoglykanen
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
WO2013158279A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Protein purification methods to reduce acidic species
|
US9249182B2
(en)
|
2012-05-24 |
2016-02-02 |
Abbvie, Inc. |
Purification of antibodies using hydrophobic interaction chromatography
|
EP2682168A1
(de)
|
2012-07-02 |
2014-01-08 |
Millipore Corporation |
Reinigung biologischer Moleküle
|
US20150218208A1
(en)
|
2012-08-27 |
2015-08-06 |
Asahi Kasei Medical Co., Ltd. |
Method for purifying antibody by temperature-responsive chromatography
|
US9206390B2
(en)
|
2012-09-02 |
2015-12-08 |
Abbvie, Inc. |
Methods to control protein heterogeneity
|
US9512214B2
(en)
|
2012-09-02 |
2016-12-06 |
Abbvie, Inc. |
Methods to control protein heterogeneity
|
AR093311A1
(es)
|
2012-11-01 |
2015-05-27 |
Abbvie Inc |
Inmunoglobulinas de dominio variable dual contra el factor de crecimiento endotelial vascular (vegf) y el ligando involucrado en la señalizacion celula a celula a traves del receptor notch (dll4)
|
SI2922554T1
(sl)
|
2012-11-26 |
2022-06-30 |
Modernatx, Inc. |
Terminalno modificirana RNA
|
EP2931301B2
(de)
*
|
2012-12-17 |
2021-09-15 |
Merck Sharp & Dohme Corp. |
Verfahren zum reinigen von insulin und analoga davon
|
CA2902854C
(en)
|
2013-03-08 |
2024-01-23 |
Genzyme Corporation |
Integrated continuous manufacturing of therapeutic protein drug substances
|
SG11201507230PA
(en)
|
2013-03-12 |
2015-10-29 |
Abbvie Inc |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
US10023608B1
(en)
|
2013-03-13 |
2018-07-17 |
Amgen Inc. |
Protein purification methods to remove impurities
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
WO2014159579A1
(en)
|
2013-03-14 |
2014-10-02 |
Abbvie Inc. |
MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
|
US9499614B2
(en)
|
2013-03-14 |
2016-11-22 |
Abbvie Inc. |
Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
MX2015013166A
(es)
|
2013-03-15 |
2015-12-11 |
Abbvie Inc |
Proteinas de union especificas duales dirigidas contra il-1 beta y/o il-17.
|
WO2014170867A1
(en)
|
2013-04-18 |
2014-10-23 |
Institut National De La Sante Et De La Recherche Medicale |
Composition with reduced immunogenicity
|
TW201509432A
(zh)
|
2013-07-05 |
2015-03-16 |
Lab Francais Du Fractionnement |
親和層析基質
|
MY193481A
(en)
|
2013-09-13 |
2022-10-17 |
Genentech Inc |
Method and compositions comprising purified recombinant polypeptides
|
CN105722992B
(zh)
|
2013-09-13 |
2021-04-20 |
豪夫迈·罗氏有限公司 |
用于检测和定量细胞系和重组多肽产物中的宿主细胞蛋白的组合物和方法
|
US11305012B2
(en)
|
2013-09-24 |
2022-04-19 |
Medimmune, Llc |
Binding molecules specific for HER3 and uses thereof
|
US10323076B2
(en)
|
2013-10-03 |
2019-06-18 |
Modernatx, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
US9598667B2
(en)
|
2013-10-04 |
2017-03-21 |
Abbvie Inc. |
Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
|
US8946395B1
(en)
|
2013-10-18 |
2015-02-03 |
Abbvie Inc. |
Purification of proteins using hydrophobic interaction chromatography
|
US9181337B2
(en)
|
2013-10-18 |
2015-11-10 |
Abbvie, Inc. |
Modulated lysine variant species compositions and methods for producing and using the same
|
US9085618B2
(en)
|
2013-10-18 |
2015-07-21 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same
|
US20150139988A1
(en)
|
2013-11-15 |
2015-05-21 |
Abbvie, Inc. |
Glycoengineered binding protein compositions
|
WO2015103545A1
(en)
|
2014-01-03 |
2015-07-09 |
Bio-Rad Laboratories, Inc. |
Removal of impurities from protein a eluates
|
TWI671312B
(zh)
|
2014-01-17 |
2019-09-11 |
美商健臻公司 |
無菌層析法及製法
|
TWI709569B
(zh)
|
2014-01-17 |
2020-11-11 |
美商健臻公司 |
無菌層析樹脂及其用於製造方法的用途
|
WO2015157634A1
(en)
|
2014-04-11 |
2015-10-15 |
Kolltan Pharmaceuticals, Inc. |
Anti-erbb antibodies and methods of use thereof
|
TWI535784B
(zh)
|
2014-08-26 |
2016-06-01 |
財團法人工業技術研究院 |
剪切增稠配方、及包含其之複合材料
|
EA201790558A1
(ru)
|
2014-10-15 |
2017-08-31 |
Ксенотера |
Композиция с пониженной иммуногенностью
|
US11566082B2
(en)
|
2014-11-17 |
2023-01-31 |
Cytiva Bioprocess R&D Ab |
Mutated immunoglobulin-binding polypeptides
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|
NZ732628A
(en)
*
|
2014-12-22 |
2019-01-25 |
Systimmune Inc |
Bispecific tetravalent antibodies with binding specificity for first and second egfr family members and methods of making and using thereof
|
EP3252158A4
(de)
|
2015-01-26 |
2018-07-18 |
Kaneka Corporation |
Mutantes immunglobulin-kappa-ketten-bindendes protein mit variabler region
|
WO2016121701A1
(ja)
|
2015-01-26 |
2016-08-04 |
株式会社カネカ |
免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス
|
MX2017011121A
(es)
|
2015-03-13 |
2017-11-28 |
Bristol Myers Squibb Co |
Uso de lavados alcalinos durante la cromatografia para remover impurezas.
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
MX2018001566A
(es)
|
2015-08-07 |
2019-04-25 |
Imaginab Inc |
Construcciones de union a antigeno para moleculas diana.
|
WO2017195638A1
(ja)
|
2016-05-09 |
2017-11-16 |
株式会社カネカ |
抗体またはκ鎖可変領域含有抗体断片の精製方法
|
US10730908B2
(en)
|
2016-05-11 |
2020-08-04 |
Ge Healthcare Bioprocess R&D Ab |
Separation method
|
US10654887B2
(en)
|
2016-05-11 |
2020-05-19 |
Ge Healthcare Bio-Process R&D Ab |
Separation matrix
|
US10513537B2
(en)
|
2016-05-11 |
2019-12-24 |
Ge Healthcare Bioprocess R&D Ab |
Separation matrix
|
US11753438B2
(en)
|
2016-05-11 |
2023-09-12 |
Cytiva Bioprocess R&D Ab |
Method of cleaning and/or sanitizing a separation matrix
|
US11708390B2
(en)
|
2016-05-11 |
2023-07-25 |
Cytiva Bioprocess R&D Ab |
Method of storing a separation matrix
|
US10703774B2
(en)
|
2016-09-30 |
2020-07-07 |
Ge Healthcare Bioprocess R&D Ab |
Separation method
|
US10889615B2
(en)
|
2016-05-11 |
2021-01-12 |
Cytiva Bioprocess R&D Ab |
Mutated immunoglobulin-binding polypeptides
|
KR102578256B1
(ko)
*
|
2016-08-11 |
2023-09-15 |
리플리겐 코포레이션 |
친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질
|
CN107964044B
(zh)
*
|
2016-10-19 |
2021-11-19 |
无锡科捷诺生物科技有限责任公司 |
从乳样中纯化抗cd20单克隆抗体的方法
|
WO2018147960A1
(en)
|
2017-02-08 |
2018-08-16 |
Imaginab, Inc. |
Extension sequences for diabodies
|
EP3606964A4
(de)
|
2017-04-03 |
2020-12-09 |
Immunomedics, Inc. |
Subkutane verabreichung von antikörper-arzneimittelkonjugaten zur krebstherapie
|
WO2018237159A1
(en)
|
2017-06-21 |
2018-12-27 |
Cephalon, Inc. |
WASH PAD FOR CATIONIC EXCHANGE CHROMATOGRAPHY
|
US11779860B2
(en)
|
2017-08-07 |
2023-10-10 |
Repligen Corporation |
Fc binding proteins with cysteine in the C-terminal helical region
|
WO2019036626A1
(en)
|
2017-08-17 |
2019-02-21 |
Just Biotherapeutics, Inc. |
PROCESS FOR PURIFYING GLYCOSYLATED PROTEIN FROM GALECTINES AND OTHER HOST CELL CONTAMINANTS
|
EP3560945A1
(de)
*
|
2018-04-27 |
2019-10-30 |
F. Hoffmann-La Roche AG |
Verfahren zur reinigung von polypeptiden mit polysorbaten
|
CA3110666A1
(en)
|
2018-08-31 |
2020-03-05 |
Genzyme Corporation |
Sterile chromatography resin and use thereof in manufacturing processes
|
US11034774B2
(en)
|
2018-10-30 |
2021-06-15 |
The Regents Of The University Of California |
Engineered antibodies for the detection of phosphorylated tyrosine
|
CN113166200B
(zh)
*
|
2018-12-21 |
2024-03-01 |
上海药明生物技术有限公司 |
一种提高蛋白a层析法去除聚集体的方法
|
JP7412440B2
(ja)
|
2019-03-29 |
2024-01-12 |
エフ. ホフマン-ラ ロシュ アーゲー |
アビド結合多重特異性抗体を作製する方法
|
AU2020266993A1
(en)
|
2019-04-30 |
2022-01-06 |
Xenothera |
Association of polyclonal antibodies and anti-PD1 or anti-PDL1 antibodies for the treatment of cancer
|
AR122270A1
(es)
|
2019-05-20 |
2022-08-31 |
Novartis Ag |
Conjugados de anticuerpo-fármaco inhibidores de mcl-1 y sus métodos de uso
|
EP4251209A1
(de)
|
2020-11-24 |
2023-10-04 |
Novartis AG |
Bcl-xl-inhibitor-antikörper-wirkstoff-konjugate und verfahren zur verwendung davon
|
WO2023225359A1
(en)
|
2022-05-20 |
2023-11-23 |
Novartis Ag |
Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
|
WO2023223097A1
(en)
|
2022-05-20 |
2023-11-23 |
Novartis Ag |
Antibody drug conjugates
|