PE20121531A1 - Inmunoglobulinas con dominio variable dual - Google Patents
Inmunoglobulinas con dominio variable dualInfo
- Publication number
- PE20121531A1 PE20121531A1 PE2012000467A PE2012000467A PE20121531A1 PE 20121531 A1 PE20121531 A1 PE 20121531A1 PE 2012000467 A PE2012000467 A PE 2012000467A PE 2012000467 A PE2012000467 A PE 2012000467A PE 20121531 A1 PE20121531 A1 PE 20121531A1
- Authority
- PE
- Peru
- Prior art keywords
- ngf
- variable domain
- seq
- nos
- sequence
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
SE REFIERE A UNA PROTEINA DE UNION QUE COMPRENDE A) UNA PRIMERA CADENA POLIPEPTIDICA: VD1-(X1)n-VD2-C-(X2)n, DONDE VD1 Y VD2 RESPECTIVAMENTE SON UN PRIMER Y SEGUNDO DOMINIO VARIABLE DE LA CADENA PESADA, CON UNA SECUENCIA DE AMINOACIDOS DE SEQ ID NOs: 28, 30, 32 Y 34; C ES UN DOMINIO CONSTANTE DE LA CADENA PESADA, X1 ES UN CONECTOR CON LA CONDICION DE QUE NO SEA CH1; X2 ES UNA REGION Fc SELECCIONADA DE IgG1, IgG2, IgG3, IgG4, IgA, IgM, IgE Y IgD Y B) UNA SEGUNDA CADENA POLIPEPTIDICA: VD1-(X1)n-VD2-C-(X2)n, DONDE VD1 Y VD2 RESPECTIVAMENTE SON UN PRIMER Y SEGUNDO DOMINIO VARIABLE DE LA CADENA LIVIANA, CON UNA SECUENCIA DE AMINOACIDOS DE SEQ ID NOs: 29, 31, 33 Y 35; C ES UN DOMINIO CONSTANTE DE LA CADENA LIVIANA; X1 ES UN CONECTOR CON LA CONDICION DE QUE NO SEA CH1; X2 NO COMPRENDE UNA REGION Fc; n ES 0 O 1; X1 O X2 SE SELECCIONA DE UNA SECUENCIA DE AMINOACIDOS DE SEQ ID NOs: 1-26; DONDE DICHA PROTEINA DE UNION ES CAPAZ DE UNIR UN PAR DE ANTIGENOS DEL GRUPO FORMADO POR NGF Y PGE2, NGF Y TNF-ALFA, NGF Y IL-1BETA, NGF Y IL-6R. SE REFIERE TAMBIEN A UN CONJUGADO DE PROTEINA, UN ACIDO NUCLEICO, UN VECTOR, UNA CELULA HUESPED, UN METODO DE PRODUCCION Y UNA COMPOSICION FARMACEUTICA. DICHA PROTEINA DE UNION ES UTIL PARA EL TRATAMIENTO DE ARTRITIS REUMATOIDE, HEPATITIS CRONICA ACTIVA, PSORIASIS, DERMATITIS
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PE2012000467A PE20121531A1 (es) | 2009-10-15 | 2010-10-15 | Inmunoglobulinas con dominio variable dual |
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US (1) | US8716450B2 (es) |
EP (1) | EP2488658A4 (es) |
JP (1) | JP2013507928A (es) |
KR (1) | KR20140015139A (es) |
CN (1) | CN102666875A (es) |
AR (1) | AR078651A1 (es) |
AU (1) | AU2010306677B2 (es) |
BR (1) | BR112012008833A2 (es) |
CA (1) | CA2775959A1 (es) |
CL (1) | CL2012000957A1 (es) |
CO (1) | CO6541597A2 (es) |
CR (1) | CR20120248A (es) |
DO (1) | DOP2012000104A (es) |
EC (1) | ECSP12011885A (es) |
GT (1) | GT201200109A (es) |
IL (1) | IL219119A0 (es) |
MX (1) | MX2012004415A (es) |
PE (1) | PE20121531A1 (es) |
RU (1) | RU2012119756A (es) |
TW (1) | TW201119676A (es) |
UY (1) | UY32948A (es) |
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- 2010-10-15 US US12/905,474 patent/US8716450B2/en active Active
- 2010-10-15 TW TW099135370A patent/TW201119676A/zh unknown
- 2010-10-15 WO PCT/US2010/052843 patent/WO2011047262A2/en active Application Filing
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- 2010-10-15 RU RU2012119756/10A patent/RU2012119756A/ru not_active Application Discontinuation
- 2010-10-15 BR BR112012008833A patent/BR112012008833A2/pt not_active IP Right Cessation
- 2010-10-15 KR KR1020127012401A patent/KR20140015139A/ko not_active Application Discontinuation
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CN102666875A (zh) | 2012-09-12 |
ECSP12011885A (es) | 2012-07-31 |
DOP2012000104A (es) | 2013-01-31 |
JP2013507928A (ja) | 2013-03-07 |
ZA201203462B (en) | 2014-10-29 |
WO2011047262A4 (en) | 2011-11-10 |
CO6541597A2 (es) | 2012-10-16 |
TW201119676A (en) | 2011-06-16 |
IL219119A0 (en) | 2012-06-28 |
EP2488658A2 (en) | 2012-08-22 |
CA2775959A1 (en) | 2011-04-21 |
MX2012004415A (es) | 2012-05-08 |
US8716450B2 (en) | 2014-05-06 |
CL2012000957A1 (es) | 2013-09-06 |
AU2010306677B2 (en) | 2013-05-23 |
WO2011047262A3 (en) | 2011-09-09 |
AU2010306677A1 (en) | 2012-05-31 |
KR20140015139A (ko) | 2014-02-06 |
US20110091463A1 (en) | 2011-04-21 |
WO2011047262A2 (en) | 2011-04-21 |
CR20120248A (es) | 2012-08-14 |
GT201200109A (es) | 2013-09-11 |
BR112012008833A2 (pt) | 2015-09-08 |
EP2488658A4 (en) | 2013-06-19 |
RU2012119756A (ru) | 2013-11-20 |
AR078651A1 (es) | 2011-11-23 |
UY32948A (es) | 2011-02-28 |
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