CY1123688T1 - Μεθοδοι για τη θεραπευτικη αντιμετωπιση ογκων χρησιμοποιωντας αμφιειδικο αντισωμα cd3xcd20 - Google Patents
Μεθοδοι για τη θεραπευτικη αντιμετωπιση ογκων χρησιμοποιωντας αμφιειδικο αντισωμα cd3xcd20Info
- Publication number
- CY1123688T1 CY1123688T1 CY20201100782T CY201100782T CY1123688T1 CY 1123688 T1 CY1123688 T1 CY 1123688T1 CY 20201100782 T CY20201100782 T CY 20201100782T CY 201100782 T CY201100782 T CY 201100782T CY 1123688 T1 CY1123688 T1 CY 1123688T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibody
- dose
- cd3xcd20
- methods
- administering
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Η παρούσα εφεύρεση σχετίζεται με μια μέθοδο (δοσολογικό σχήμα) για τη χορήγηση ενός CD3XCD20 αμφιειδικού αντισώματος σε ασθενή που είναι άνθρωπος, που περιλαμβάνει: (α) χορήγηση μιας πρώτης δόσης του εν λόγω αντισώματος σε συγκεκριμένη δοσολογία• και διαδοχικά (β) χορήγηση μιας δεύτερης δόσης του εν λόγω αντισώματος μετά από μια χρονική περίοδο, όπου η εν λόγω δεύτερη δόση υπερβαίνει την εν λόγω πρώτη δόση. Οι μέθοδοι της εφεύρεσης (και παρομοίως το δοσολογικό σχήμα της εφεύρεσης) είναι επίσης κατάλληλες για τη θεραπευτική αντιμετώπιση καρκίνου Β κυττάρων (θετικών σε CD20) σε ασθενή που είναι άνθρωπος, ή για τη βελτίωση και/ή πρόληψη μιας ιατρικής πάθησης που μεσολαβείται από την περιοδική ή συνεχή χορήγηση ενός CD3XCD20 αμφιειδικού αντισώματος σε ασθενή που είναι άνθρωπος. Η παρούσα εφεύρεση σχετίζεται επίσης με τη χρήση ενός CD3XCD20 αμφιειδικού αντισώματος για την παρασκευή μιας φαρμακευτικής σύνθεσης που θα χρησιμοποιηθεί σε μια μέθοδο ή σχήμα θεραπευτικής αγωγής όπως ορίζεται από οποιαδήποτε από τις παραπάνω αξιώσεις. Μια φαρμακευτική συσκευασία ή κιτ που περιλαμβάνει την πρώτη δόση, τη δεύτερη δόση και οποιαδήποτε επακόλουθη δόση, είναι επίσης τμήμα της παρούσας εφεύρεσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201462080716P | 2014-11-17 | 2014-11-17 | |
US201562160788P | 2015-05-13 | 2015-05-13 | |
PCT/US2015/061139 WO2016081490A1 (en) | 2014-11-17 | 2015-11-17 | Methods for tumor treatment using cd3xcd20 bispecific antibody |
Publications (1)
Publication Number | Publication Date |
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CY1123688T1 true CY1123688T1 (el) | 2022-03-24 |
Family
ID=54705901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100782T CY1123688T1 (el) | 2014-11-17 | 2020-08-21 | Μεθοδοι για τη θεραπευτικη αντιμετωπιση ογκων χρησιμοποιωντας αμφιειδικο αντισωμα cd3xcd20 |
Country Status (21)
Country | Link |
---|---|
US (1) | US10662244B2 (el) |
EP (2) | EP3699198A1 (el) |
JP (1) | JP6681396B2 (el) |
KR (1) | KR102614189B1 (el) |
AU (1) | AU2015350075B2 (el) |
CA (1) | CA2967820A1 (el) |
CY (1) | CY1123688T1 (el) |
DK (1) | DK3221359T3 (el) |
ES (1) | ES2809455T3 (el) |
HK (1) | HK1244293A1 (el) |
HR (1) | HRP20201001T1 (el) |
HU (1) | HUE050831T2 (el) |
IL (1) | IL252232B (el) |
LT (1) | LT3221359T (el) |
MX (1) | MX2017006312A (el) |
PL (1) | PL3221359T3 (el) |
PT (1) | PT3221359T (el) |
RS (1) | RS60739B1 (el) |
SI (1) | SI3221359T1 (el) |
WO (1) | WO2016081490A1 (el) |
ZA (1) | ZA201703290B (el) |
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PT3221359T (pt) | 2020-06-23 |
DK3221359T3 (da) | 2020-06-22 |
KR102614189B1 (ko) | 2023-12-18 |
SI3221359T1 (sl) | 2020-08-31 |
IL252232A0 (en) | 2017-07-31 |
HUE050831T2 (hu) | 2021-01-28 |
HK1244293A1 (zh) | 2018-08-03 |
JP6681396B2 (ja) | 2020-04-15 |
EP3221359A1 (en) | 2017-09-27 |
WO2016081490A1 (en) | 2016-05-26 |
CA2967820A1 (en) | 2016-05-26 |
JP2018505129A (ja) | 2018-02-22 |
PL3221359T3 (pl) | 2020-11-16 |
MX2017006312A (es) | 2017-08-21 |
ES2809455T3 (es) | 2021-03-04 |
US10662244B2 (en) | 2020-05-26 |
KR20170089881A (ko) | 2017-08-04 |
AU2015350075A1 (en) | 2017-06-29 |
AU2015350075B2 (en) | 2021-06-03 |
LT3221359T (lt) | 2020-07-27 |
IL252232B (en) | 2021-03-25 |
EP3221359B1 (en) | 2020-05-27 |
US20180194841A1 (en) | 2018-07-12 |
RS60739B1 (sr) | 2020-09-30 |
ZA201703290B (en) | 2021-06-30 |
HRP20201001T1 (hr) | 2020-10-16 |
EP3699198A1 (en) | 2020-08-26 |
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