MX2017006312A - Metodos para el tratamiento tumoral utilizando el anticuerpo biespecifico cd3xcd20. - Google Patents
Metodos para el tratamiento tumoral utilizando el anticuerpo biespecifico cd3xcd20.Info
- Publication number
- MX2017006312A MX2017006312A MX2017006312A MX2017006312A MX2017006312A MX 2017006312 A MX2017006312 A MX 2017006312A MX 2017006312 A MX2017006312 A MX 2017006312A MX 2017006312 A MX2017006312 A MX 2017006312A MX 2017006312 A MX2017006312 A MX 2017006312A
- Authority
- MX
- Mexico
- Prior art keywords
- dose
- bispecific antibody
- methods
- administering
- antibody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un método (régimen de dosificación) para administrar un anticuerpo biespecífico CD3 x CD20 a un paciente humano, que comprende (a) administrar una primera dosis de dicho anticuerpo en una dosificación específica; y consecutivamente (b) administrar una segunda dosis de dicho anticuerpo después de un período de tiempo, en el que dicha segunda dosis excede dicha primera dosis. Los métodos de la invención (y también el régimen de dosificación de la invención) también son adecuados para tratar el cáncer de células B (CD20-positivo) en un paciente humano, o para mejorar y/o prevenir un estado medico mediado por la administración periódica o continuada de un anticuerpo biespecífico CD3 x CD20 a un paciente humano. La presente invención también se refiere al uso de un anticuerpo biespecífico CD3 x CD20 para la preparación de una composición farmacéutica para ser utilizada en un método o régimen de tratamiento como se define en una cualquiera de las reivindicaciones anteriores. También son parte de la presente invención un paquete farmacéutico o kit que comprende la primera dosis, la segunda dosis y cualquier dosis posterior.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462080716P | 2014-11-17 | 2014-11-17 | |
US201562160788P | 2015-05-13 | 2015-05-13 | |
PCT/US2015/061139 WO2016081490A1 (en) | 2014-11-17 | 2015-11-17 | Methods for tumor treatment using cd3xcd20 bispecific antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017006312A true MX2017006312A (es) | 2017-08-21 |
Family
ID=54705901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017006312A MX2017006312A (es) | 2014-11-17 | 2015-11-17 | Metodos para el tratamiento tumoral utilizando el anticuerpo biespecifico cd3xcd20. |
Country Status (21)
Country | Link |
---|---|
US (1) | US10662244B2 (es) |
EP (2) | EP3699198A1 (es) |
JP (1) | JP6681396B2 (es) |
KR (1) | KR102614189B1 (es) |
AU (1) | AU2015350075B2 (es) |
CA (1) | CA2967820A1 (es) |
CY (1) | CY1123688T1 (es) |
DK (1) | DK3221359T3 (es) |
ES (1) | ES2809455T3 (es) |
HK (1) | HK1244293A1 (es) |
HR (1) | HRP20201001T1 (es) |
HU (1) | HUE050831T2 (es) |
IL (1) | IL252232B (es) |
LT (1) | LT3221359T (es) |
MX (1) | MX2017006312A (es) |
PL (1) | PL3221359T3 (es) |
PT (1) | PT3221359T (es) |
RS (1) | RS60739B1 (es) |
SI (1) | SI3221359T1 (es) |
WO (1) | WO2016081490A1 (es) |
ZA (1) | ZA201703290B (es) |
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CA2958479A1 (en) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anti-cll-1 antibodies and immunoconjugates |
HUE050831T2 (hu) | 2014-11-17 | 2021-01-28 | Regeneron Pharma | Daganatkezelési módszerek a CD3XCD20 bispecifikus antitest használatával |
KR102663073B1 (ko) | 2015-01-08 | 2024-05-07 | 젠맵 에이/에스 | Cd3 및 cd20에 대항한 이중특이적 항체 |
JP6871874B2 (ja) | 2015-06-16 | 2021-05-19 | ジェネンテック, インコーポレイテッド | FcRH5に対するヒト化親和性成熟抗体及び使用方法 |
JP2018526972A (ja) | 2015-06-16 | 2018-09-20 | ジェネンテック, インコーポレイテッド | 抗cd3抗体及び使用方法 |
TW201718647A (zh) | 2015-06-16 | 2017-06-01 | 建南德克公司 | 抗-cll-1抗體及使用方法 |
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-
2015
- 2015-11-17 HU HUE15801637A patent/HUE050831T2/hu unknown
- 2015-11-17 PT PT158016378T patent/PT3221359T/pt unknown
- 2015-11-17 MX MX2017006312A patent/MX2017006312A/es unknown
- 2015-11-17 EP EP20167215.1A patent/EP3699198A1/en active Pending
- 2015-11-17 DK DK15801637.8T patent/DK3221359T3/da active
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- 2015-11-17 EP EP15801637.8A patent/EP3221359B1/en active Active
- 2015-11-17 SI SI201531249T patent/SI3221359T1/sl unknown
- 2015-11-17 LT LTEP15801637.8T patent/LT3221359T/lt unknown
- 2015-11-17 WO PCT/US2015/061139 patent/WO2016081490A1/en active Application Filing
- 2015-11-17 US US15/527,002 patent/US10662244B2/en active Active
- 2015-11-17 JP JP2017526515A patent/JP6681396B2/ja active Active
- 2015-11-17 AU AU2015350075A patent/AU2015350075B2/en active Active
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Also Published As
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WO2016081490A1 (en) | 2016-05-26 |
IL252232A0 (en) | 2017-07-31 |
EP3221359A1 (en) | 2017-09-27 |
PL3221359T3 (pl) | 2020-11-16 |
DK3221359T3 (da) | 2020-06-22 |
ZA201703290B (en) | 2021-06-30 |
HRP20201001T1 (hr) | 2020-10-16 |
EP3699198A1 (en) | 2020-08-26 |
RS60739B1 (sr) | 2020-09-30 |
JP6681396B2 (ja) | 2020-04-15 |
EP3221359B1 (en) | 2020-05-27 |
ES2809455T3 (es) | 2021-03-04 |
KR102614189B1 (ko) | 2023-12-18 |
LT3221359T (lt) | 2020-07-27 |
US10662244B2 (en) | 2020-05-26 |
IL252232B (en) | 2021-03-25 |
SI3221359T1 (sl) | 2020-08-31 |
HK1244293A1 (zh) | 2018-08-03 |
CY1123688T1 (el) | 2022-03-24 |
AU2015350075A1 (en) | 2017-06-29 |
PT3221359T (pt) | 2020-06-23 |
KR20170089881A (ko) | 2017-08-04 |
AU2015350075B2 (en) | 2021-06-03 |
CA2967820A1 (en) | 2016-05-26 |
JP2018505129A (ja) | 2018-02-22 |
HUE050831T2 (hu) | 2021-01-28 |
US20180194841A1 (en) | 2018-07-12 |
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