CY1125068T1 - Ενωσεις τετραϋποκατεστημενου αλκενιου και χρηση αυτων - Google Patents
Ενωσεις τετραϋποκατεστημενου αλκενιου και χρηση αυτωνInfo
- Publication number
- CY1125068T1 CY1125068T1 CY20211100961T CY211100961T CY1125068T1 CY 1125068 T1 CY1125068 T1 CY 1125068T1 CY 20211100961 T CY20211100961 T CY 20211100961T CY 211100961 T CY211100961 T CY 211100961T CY 1125068 T1 CY1125068 T1 CY 1125068T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- quatern
- breast cancer
- alkene compounds
- subject
- Prior art date
Links
- -1 ALKENE COMPOUNDS Chemical class 0.000 title 1
- 206010006187 Breast cancer Diseases 0.000 abstract 3
- 208000026310 Breast neoplasm Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 102100038595 Estrogen receptor Human genes 0.000 abstract 1
- 101710196141 Estrogen receptor Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
- C07D317/06—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Στο παρόν έγγραφο γνωστοποιούνται ενώσεις ή φαρμακευτικώς αποδεκτά άλατα αυτών και μέθοδοι χρήσης των ενώσεων για τη θεραπευτική αντιμετώπιση του καρκίνου του μαστού με τη χορήγηση σε ένα υποκείμενο που χρήζει αυτής, μιας θεραπευτικώς δραστικής ποσότητας των ενώσεων ή των φαρμακευτικώς αποδεκτών αλάτων αυτών. Ο καρκίνος του μαστού δύναται να είναι καρκίνος του μαστού θετικός σε ER και/ή το υποκείμενο που χρήζει θεραπευτικής αντιμετώπισης δύναται να εκφράζει μια μεταλλακτή πρωτεΐνη ER-α.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562168581P | 2015-05-29 | 2015-05-29 | |
US201562168529P | 2015-05-29 | 2015-05-29 | |
US201562269745P | 2015-12-18 | 2015-12-18 | |
PCT/US2016/034782 WO2016196346A1 (en) | 2015-05-29 | 2016-05-27 | Tetrasubstituted alkene compounds and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1125068T1 true CY1125068T1 (el) | 2023-03-24 |
Family
ID=57398096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100961T CY1125068T1 (el) | 2015-05-29 | 2021-11-08 | Ενωσεις τετραϋποκατεστημενου αλκενιου και χρηση αυτων |
Country Status (33)
Country | Link |
---|---|
US (2) | US9796683B2 (el) |
EP (2) | EP3981766A1 (el) |
JP (1) | JP6325760B1 (el) |
KR (1) | KR102664618B1 (el) |
CN (2) | CN107847498B (el) |
AU (1) | AU2016271126B2 (el) |
BR (1) | BR112017025546B1 (el) |
CA (1) | CA2987321C (el) |
CL (1) | CL2017002996A1 (el) |
CO (1) | CO2017013432A2 (el) |
CY (1) | CY1125068T1 (el) |
DK (1) | DK3302471T3 (el) |
ES (1) | ES2895511T3 (el) |
HR (1) | HRP20211542T1 (el) |
HU (1) | HUE056199T2 (el) |
IL (1) | IL255765B2 (el) |
JO (1) | JO3735B1 (el) |
LT (1) | LT3302471T (el) |
MA (1) | MA43364B1 (el) |
MD (1) | MD3302471T2 (el) |
MX (1) | MX2017015226A (el) |
MY (1) | MY186977A (el) |
PE (1) | PE20181083A1 (el) |
PH (1) | PH12017502142A1 (el) |
PL (1) | PL3302471T3 (el) |
PT (1) | PT3302471T (el) |
RS (1) | RS62481B1 (el) |
RU (1) | RU2733741C2 (el) |
SI (1) | SI3302471T1 (el) |
TW (1) | TWI704137B (el) |
UA (1) | UA120882C2 (el) |
WO (2) | WO2016196337A1 (el) |
ZA (1) | ZA201707912B (el) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI704137B (zh) | 2015-05-29 | 2020-09-11 | 日商衛材R&D企管股份有限公司 | 四取代烯化合物及其等之用途 |
JP2019535778A (ja) * | 2016-11-24 | 2019-12-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 四置換アルケン化合物及び乳がんを治療するためのその使用 |
MA46896A (fr) * | 2016-11-24 | 2019-10-02 | Eisai R&D Man Co Ltd | Composés d'alcène tétrasubstitués et leur utilisation |
EP3544967B1 (en) * | 2016-11-28 | 2023-06-28 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
KR102517650B1 (ko) * | 2017-03-16 | 2023-04-05 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 유방암의 치료를 위한 조합물 요법 |
WO2019225552A1 (en) * | 2018-05-22 | 2019-11-28 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
KR20210105384A (ko) * | 2018-12-17 | 2021-08-26 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 에스트로겐 수용체 길항제 |
AU2020274113A1 (en) | 2019-05-14 | 2021-11-11 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
KR20220012891A (ko) | 2019-05-24 | 2022-02-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 에스트로겐 수용체-알파 억제제의 경구 투여 형태로 암을 치료하는 방법 |
MX2021015486A (es) | 2019-06-19 | 2022-01-24 | Jiangsu Hengrui Medicine Co | Derivado de indazol, metodo de preparacion y aplicacion farmaceutica del mismo. |
CN110452177A (zh) * | 2019-09-02 | 2019-11-15 | 南通大学 | 一种5-溴-4-氟-1h-吲唑的合成方法 |
WO2021097046A1 (en) | 2019-11-13 | 2021-05-20 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
WO2022001971A1 (zh) | 2020-06-28 | 2022-01-06 | 南京明德新药研发有限公司 | 并环吲唑类化合物 |
WO2022098953A1 (en) | 2020-11-06 | 2022-05-12 | Eisai R&D Management Co., Ltd. | Method of treating breast cancer |
CN114644616B (zh) * | 2020-12-18 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 一种吲唑类衍生物的药学上可接受的盐、结晶形式及其制备方法 |
CN114644615B (zh) * | 2020-12-18 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 一种吲唑类衍生物的结晶形式及其制备方法 |
TW202241879A (zh) * | 2020-12-18 | 2022-11-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種吲唑類衍生物的藥學上可接受鹽、結晶形式及其製備方法 |
CA3214408A1 (en) | 2021-03-23 | 2022-09-29 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
WO2023272410A1 (zh) * | 2021-06-27 | 2023-01-05 | 北京盛诺基医药科技股份有限公司 | 一种ERα受体共价结合拮抗剂 |
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DE3907290A1 (de) | 1989-03-07 | 1990-09-13 | Gerhard Prof Dr Eisenbrand | Steroidhormonrezeptoraffine antitumorwirkstoffe |
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US8785501B2 (en) | 2009-10-13 | 2014-07-22 | Duquesne University Of The Holy Spirit | Anti-cancer tamoxifen-melatonin hybrid ligand |
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GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
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NZ630124A (en) | 2012-03-20 | 2016-01-29 | Seragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
US9365510B2 (en) | 2012-04-16 | 2016-06-14 | British Columbia Cancer Agency Branch | Aziridine bisphenol ethers and related compounds and methods for their use |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
MX2015017655A (es) | 2013-06-19 | 2016-04-15 | Seragon Pharmaceuticals Inc | Modulador de receptores de estrogeno y uso del mismo. |
CA2915534A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Azetidine estrogen receptor modulators and uses thereof |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
EP3116497A2 (en) | 2014-03-13 | 2017-01-18 | F. Hoffmann-La Roche AG | Therapeutic combinations with estrogen receptor modulators |
WO2016055982A1 (en) | 2014-10-10 | 2016-04-14 | Acerta Pharma B.V. | Quinoline and quinazoline compounds |
JP6807841B2 (ja) | 2014-12-18 | 2021-01-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | エストロゲン受容体モジュレーター及びその使用 |
TWI704137B (zh) | 2015-05-29 | 2020-09-11 | 日商衛材R&D企管股份有限公司 | 四取代烯化合物及其等之用途 |
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2016
- 2016-05-27 TW TW105116750A patent/TWI704137B/zh active
- 2016-05-27 DK DK16804153.1T patent/DK3302471T3/da active
- 2016-05-27 IL IL255765A patent/IL255765B2/en unknown
- 2016-05-27 ES ES16804153T patent/ES2895511T3/es active Active
- 2016-05-27 HR HRP20211542TT patent/HRP20211542T1/hr unknown
- 2016-05-27 UA UAA201712962A patent/UA120882C2/uk unknown
- 2016-05-27 KR KR1020177037820A patent/KR102664618B1/ko active IP Right Grant
- 2016-05-27 LT LTEPPCT/US2016/034782T patent/LT3302471T/lt unknown
- 2016-05-27 MD MDE20180368T patent/MD3302471T2/ro unknown
- 2016-05-27 EP EP21191181.3A patent/EP3981766A1/en not_active Withdrawn
- 2016-05-27 PE PE2017002481A patent/PE20181083A1/es unknown
- 2016-05-27 PT PT168041531T patent/PT3302471T/pt unknown
- 2016-05-27 PL PL16804153T patent/PL3302471T3/pl unknown
- 2016-05-27 BR BR112017025546-4A patent/BR112017025546B1/pt active IP Right Grant
- 2016-05-27 CN CN201680043755.7A patent/CN107847498B/zh active Active
- 2016-05-27 WO PCT/US2016/034764 patent/WO2016196337A1/en active Application Filing
- 2016-05-27 SI SI201631340T patent/SI3302471T1/sl unknown
- 2016-05-27 AU AU2016271126A patent/AU2016271126B2/en active Active
- 2016-05-27 MY MYPI2017001740A patent/MY186977A/en unknown
- 2016-05-27 WO PCT/US2016/034782 patent/WO2016196346A1/en active Application Filing
- 2016-05-27 CA CA2987321A patent/CA2987321C/en active Active
- 2016-05-27 RS RS20211306A patent/RS62481B1/sr unknown
- 2016-05-27 HU HUE16804153A patent/HUE056199T2/hu unknown
- 2016-05-27 JP JP2017560920A patent/JP6325760B1/ja active Active
- 2016-05-27 RU RU2017146408A patent/RU2733741C2/ru active
- 2016-05-27 MA MA43364A patent/MA43364B1/fr unknown
- 2016-05-27 CN CN202110301494.7A patent/CN113024466A/zh active Pending
- 2016-05-27 US US15/167,373 patent/US9796683B2/en active Active
- 2016-05-27 EP EP16804153.1A patent/EP3302471B1/en active Active
- 2016-05-27 MX MX2017015226A patent/MX2017015226A/es unknown
- 2016-05-29 JO JOP/2016/0102A patent/JO3735B1/ar active
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2017
- 2017-09-22 US US15/713,107 patent/US10851065B2/en active Active
- 2017-11-21 ZA ZA2017/07912A patent/ZA201707912B/en unknown
- 2017-11-24 PH PH12017502142A patent/PH12017502142A1/en unknown
- 2017-11-27 CL CL2017002996A patent/CL2017002996A1/es unknown
- 2017-12-27 CO CONC2017/0013432A patent/CO2017013432A2/es unknown
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2021
- 2021-11-08 CY CY20211100961T patent/CY1125068T1/el unknown
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