CY1119410T1 - Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi) - Google Patents

Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi)

Info

Publication number
CY1119410T1
CY1119410T1 CY20171101040T CY171101040T CY1119410T1 CY 1119410 T1 CY1119410 T1 CY 1119410T1 CY 20171101040 T CY20171101040 T CY 20171101040T CY 171101040 T CY171101040 T CY 171101040T CY 1119410 T1 CY1119410 T1 CY 1119410T1
Authority
CY
Cyprus
Prior art keywords
tfpi
monoclonal antibodies
antibodies against
inhibitor
antibodies
Prior art date
Application number
CY20171101040T
Other languages
English (en)
Inventor
Peter Scholz
Zhuozhi Wang
Junliang Pan
Joanna Grudzinska
Christian Votsmeier
Jan Tebbe
Jörg BIRKENFELD
Nina Wobst
Simone BRÜCKNER
Susanne Steinig
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44542552&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119410(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of CY1119410T1 publication Critical patent/CY1119410T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Abstract

Απομονωμένα μονόκλωνα αντισώματα που δεσμεύουν τον αναστολέα της οδού του ιστικού παράγοντα ανθρώπου (TFPI). Απομονωμένα, επίσης, μόρια νουκλεϊκού οξέος που κωδικοποιούν μονοκλωνικά αντισώματα που δεσμεύουν τον TFPI. Παρέχονται, επίσης, φαρμακευτικές συνθέσεις που περιλαμβάνουν τα αντι-TFPI μονοκλωνικά αντισώματα και μέθοδοι θεραπείας ελλείψεων ή ελαττωμάτων στην πήξη με χορήγηση των αντισωμάτων. Παρέχονται, επίσης, μέθοδοι παραγωγής των αντισωμάτων.
CY20171101040T 2010-03-01 2017-10-05 Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi) CY1119410T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01
PCT/US2011/026766 WO2011109452A1 (en) 2010-03-01 2011-03-01 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Publications (1)

Publication Number Publication Date
CY1119410T1 true CY1119410T1 (el) 2018-03-07

Family

ID=44542552

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20171101040T CY1119410T1 (el) 2010-03-01 2017-10-05 Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi)
CY20201100019T CY1122476T1 (el) 2010-03-01 2020-01-09 Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (τfρι)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20201100019T CY1122476T1 (el) 2010-03-01 2020-01-09 Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (τfρι)

Country Status (36)

Country Link
US (3) US9309324B2 (el)
EP (2) EP2542257B1 (el)
JP (4) JP6025570B2 (el)
KR (4) KR101807894B1 (el)
CN (5) CN102939098B (el)
AU (1) AU2011223710B2 (el)
BR (1) BR112012022258A2 (el)
CA (3) CA2976671C (el)
CL (2) CL2012002415A1 (el)
CO (1) CO6620068A2 (el)
CR (1) CR20120453A (el)
CU (1) CU23982B1 (el)
CY (2) CY1119410T1 (el)
DK (2) DK3345615T3 (el)
DO (1) DOP2012000239A (el)
EA (2) EA032189B9 (el)
EC (2) ECSP12012134A (el)
ES (2) ES2642512T3 (el)
GT (1) GT201200252A (el)
HK (2) HK1232232A1 (el)
HR (2) HRP20171472T1 (el)
HU (2) HUE047173T2 (el)
IL (3) IL221551B (el)
LT (2) LT2542257T (el)
ME (2) ME03578B (el)
MX (2) MX2012010198A (el)
MY (1) MY174760A (el)
NZ (2) NZ702494A (el)
PE (1) PE20160538A1 (el)
PH (3) PH12018500639A1 (el)
PL (2) PL3345615T3 (el)
PT (2) PT2542257T (el)
RS (2) RS56409B1 (el)
SG (3) SG10201502587SA (el)
SI (2) SI2542257T1 (el)
WO (1) WO2011109452A1 (el)

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WO2010072691A1 (en) 2008-12-22 2010-07-01 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor
CN102939098B (zh) * 2010-03-01 2016-08-03 拜耳医药保健有限公司 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
WO2012001087A1 (en) * 2010-06-30 2012-01-05 Novo Nordisk A/S Antibodies that are capable of specifically binding tissue factor pathway inhibitor
WO2012135671A2 (en) * 2011-04-01 2012-10-04 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
CN107266574A (zh) * 2012-03-30 2017-10-20 拜尔健康护理有限责任公司 蛋白酶调节的抗体
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
AR095502A1 (es) * 2013-03-15 2015-10-21 Bayer Healthcare Llc Anticuerpos profármaco contra el inhibidor de la vía del factor tisular
JP6454678B2 (ja) * 2013-03-15 2019-01-16 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ ｐＨ範囲で結合性が異なる薬物動態改善のための抗ＴＦＰＩ抗体変異体
CN112225812A (zh) * 2015-02-25 2021-01-15 财团法人牧岩生命科学研究所 结合tfpi的新型抗体以及包含所述抗体的组合物
CN114163531A (zh) * 2015-08-19 2022-03-11 辉瑞公司 组织因子途径抑制剂抗体及其用途
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
KR20210074335A (ko) * 2018-10-11 2021-06-21 화이자 인코포레이티드 Tfpi 길항제의 투여량 섭생법
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
CN117285632A (zh) * 2022-06-17 2023-12-26 安源医药科技（上海）有限公司 针对tfpi的单克隆抗体及其用途

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