CY1118846T1 - Τριαζολοπυριδαζινες ως ρυθμιστες της κινασης τυροσινης - Google Patents
Τριαζολοπυριδαζινες ως ρυθμιστες της κινασης τυροσινηςInfo
- Publication number
- CY1118846T1 CY1118846T1 CY20171100145T CY171100145T CY1118846T1 CY 1118846 T1 CY1118846 T1 CY 1118846T1 CY 20171100145 T CY20171100145 T CY 20171100145T CY 171100145 T CY171100145 T CY 171100145T CY 1118846 T1 CY1118846 T1 CY 1118846T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- met
- subject
- tyrosine kinase
- triazolopyridasins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η εφεύρεση αφορά σε ενώσεις τριαζολοπυριδαζίνης του Τύπου (I): όπου τα R1, R5, R6, R7, R8, και Α είναι όπως ορίζονται στην παρούσα, η χρήση τέτοιων ενώσεων ως ρυθμιστών της πρωτεϊνικής κινάσης τυροσίνης, συγκεκριμένα αναστολείς του c-Met, και η χρήση τέτοιων ενώσεων για να μειωθεί ή ν' ανασταλεί η ενεργότητα της κινάσης του c-Met σ' ένα κύτταρο ή ένα υποκείμενο, και ρυθμίζουν την έκφραση του c-Met σ’ ένα κύτταρο ή υποκείμενο, και η χρήση τέτοιων ενώσεων για την πρόληψη ή τη θεραπευτική αντιμετώπιση σ ένα υποκείμενο μίας κυτταρικής πολλαπλασιαστικής διαταραχής και/ή διαταραχές που σχετίζονται με c-Met. Η παρούσα εφεύρεση αναφέρεται περαιτέρω σε φαρμακευτικές συνθέσεις που περιλαμβάνουν ενώσεις της παρούσας εφεύρεσης και σε μεθόδους για τη θεραπευτική αντιμετώπιση καταστάσεων, όπως καρκίνοι και άλλες κυτταρικές πολλαπλασιαστικές διαταραχές.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75263405P | 2005-12-21 | 2005-12-21 | |
PCT/US2006/048241 WO2007075567A1 (en) | 2005-12-21 | 2006-12-18 | Triazolopyridazines as tyrosine kinase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118846T1 true CY1118846T1 (el) | 2018-01-10 |
Family
ID=37964498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100145T CY1118846T1 (el) | 2005-12-21 | 2017-02-01 | Τριαζολοπυριδαζινες ως ρυθμιστες της κινασης τυροσινης |
Country Status (40)
Country | Link |
---|---|
US (2) | US8030305B2 (el) |
EP (1) | EP1966214B9 (el) |
JP (1) | JP5292102B2 (el) |
KR (1) | KR101412675B1 (el) |
CN (1) | CN101374843B (el) |
AP (1) | AP3433A (el) |
AR (1) | AR058703A1 (el) |
AU (1) | AU2006331912B2 (el) |
BR (1) | BRPI0620292B1 (el) |
CA (1) | CA2634721C (el) |
CR (1) | CR10170A (el) |
CY (1) | CY1118846T1 (el) |
DK (1) | DK1966214T3 (el) |
EA (1) | EA015754B1 (el) |
EC (1) | ECSP088573A (el) |
ES (1) | ES2612377T3 (el) |
GT (1) | GT200800105A (el) |
HN (1) | HN2008000931A (el) |
HR (1) | HRP20170103T1 (el) |
HU (1) | HUE030390T2 (el) |
IL (1) | IL192108A (el) |
LT (1) | LT1966214T (el) |
MA (1) | MA30084B1 (el) |
ME (1) | ME02736B (el) |
MX (1) | MX2008008277A (el) |
MY (1) | MY159523A (el) |
NI (1) | NI200800179A (el) |
NO (1) | NO340958B1 (el) |
NZ (1) | NZ568807A (el) |
PE (2) | PE20070752A1 (el) |
PL (1) | PL1966214T3 (el) |
PT (1) | PT1966214T (el) |
RS (1) | RS55630B1 (el) |
SV (1) | SV2008002963A (el) |
TN (1) | TNSN08278A1 (el) |
TW (1) | TWI399378B (el) |
UA (1) | UA98297C2 (el) |
UY (1) | UY30041A1 (el) |
WO (1) | WO2007075567A1 (el) |
ZA (1) | ZA200806277B (el) |
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- 2008-07-03 NO NO20083013A patent/NO340958B1/no unknown
- 2008-07-18 ZA ZA200806277A patent/ZA200806277B/xx unknown
- 2008-07-21 CR CR10170A patent/CR10170A/es not_active Application Discontinuation
- 2008-08-07 US US12/187,524 patent/US8173654B2/en active Active
-
2017
- 2017-01-23 HR HRP20170103TT patent/HRP20170103T1/hr unknown
- 2017-02-01 CY CY20171100145T patent/CY1118846T1/el unknown
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