EA200870373A1 - Пиридил- и пиримидинилзамещённые производные пиррола, тиофена и фурана в качестве ингибиторов киназ - Google Patents

Пиридил- и пиримидинилзамещённые производные пиррола, тиофена и фурана в качестве ингибиторов киназ

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Publication number
EA200870373A1
EA200870373A1 EA200870373A EA200870373A EA200870373A1 EA 200870373 A1 EA200870373 A1 EA 200870373A1 EA 200870373 A EA200870373 A EA 200870373A EA 200870373 A EA200870373 A EA 200870373A EA 200870373 A1 EA200870373 A1 EA 200870373A1
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EA
Eurasian Patent Office
Prior art keywords
pyrimidynyl
thiophen
pyrrol
furan
pyridyl
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EA200870373A
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English (en)
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EA015126B1 (ru
Inventor
Эрмес Ванотти
Марина Кальдарелли
Алессандра Чирла
Барбара Форте
Антонелла Эрмоли
Мария Меничинчери
Антонио Пиллан
Алессандра Сколаро
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НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.
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Publication of EA200870373A1 publication Critical patent/EA200870373A1/ru
Publication of EA015126B1 publication Critical patent/EA015126B1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Настоящее изобретение относится к соединениям формулы (I)или их фармацевтически приемлемым солям, где G, W, R, R, R, Rи Rимеют значения, указанные в описании. Следующими объектами настоящего изобретения являются способы получения соединений формулы (I) и промежуточные соединения таких способов, фармацевтические композиции, содержащие их, и способы лечения клеточных пролиферативных нарушений. Фактически соединения формулы (I) являются пригодными в терапии, при лечении заболеваний, связанных с нарушением регуляции активности протеинкиназы, подобных раку.
EA200870373A 2006-03-27 2007-03-19 Пиридил- и пиримидинилзамещённые производные пиррола, тиофена и фурана в качестве ингибиторов киназ EA015126B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06111766 2006-03-27
PCT/EP2007/052587 WO2007110344A1 (en) 2006-03-27 2007-03-19 Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors

Publications (2)

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EA200870373A1 true EA200870373A1 (ru) 2009-04-28
EA015126B1 EA015126B1 (ru) 2011-06-30

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EA200870373A EA015126B1 (ru) 2006-03-27 2007-03-19 Пиридил- и пиримидинилзамещённые производные пиррола, тиофена и фурана в качестве ингибиторов киназ

Country Status (22)

Country Link
US (4) US8263604B2 (ru)
EP (1) EP2004623B1 (ru)
JP (1) JP5261370B2 (ru)
KR (2) KR20090008286A (ru)
CN (1) CN101410387B (ru)
AR (1) AR060150A1 (ru)
AU (1) AU2007229559B2 (ru)
BR (1) BRPI0709680B8 (ru)
CA (1) CA2646952C (ru)
CL (1) CL2007000806A1 (ru)
EA (1) EA015126B1 (ru)
ES (1) ES2436532T3 (ru)
HK (1) HK1129101A1 (ru)
IL (1) IL194157A (ru)
MX (1) MX2008012422A (ru)
NO (1) NO342798B1 (ru)
NZ (1) NZ572202A (ru)
SG (1) SG173320A1 (ru)
TW (1) TWI394749B (ru)
UA (1) UA94097C2 (ru)
WO (1) WO2007110344A1 (ru)
ZA (1) ZA200808966B (ru)

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