EA200870415A1 - Хиназолины для ингибирования pdk 1 - Google Patents
Хиназолины для ингибирования pdk 1Info
- Publication number
- EA200870415A1 EA200870415A1 EA200870415A EA200870415A EA200870415A1 EA 200870415 A1 EA200870415 A1 EA 200870415A1 EA 200870415 A EA200870415 A EA 200870415A EA 200870415 A EA200870415 A EA 200870415A EA 200870415 A1 EA200870415 A1 EA 200870415A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- quinazolins
- compounds
- inhibit pdk
- pdk
- inhibit
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Abstract
Данное изобретение предлагает хиназолиновые соединения, которые являются ингибиторами PDK1. Также предложены фармацевтические композиции, содержащие указанные соединения, а также способы лечения пролиферативных заболеваний, таких как рак, с помощью данных соединений или композиций.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79030406P | 2006-04-06 | 2006-04-06 | |
PCT/US2007/008592 WO2007117607A2 (en) | 2006-04-06 | 2007-04-05 | Quinazolines for pdk1 inhibition |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200870415A1 true EA200870415A1 (ru) | 2009-02-27 |
Family
ID=38476139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870415A EA200870415A1 (ru) | 2006-04-06 | 2007-04-05 | Хиназолины для ингибирования pdk 1 |
Country Status (22)
Country | Link |
---|---|
US (1) | US7932262B2 (ru) |
EP (1) | EP2004615A2 (ru) |
JP (1) | JP2009532486A (ru) |
KR (1) | KR20080111114A (ru) |
CN (1) | CN101454294A (ru) |
AR (1) | AR060358A1 (ru) |
AU (1) | AU2007235339A1 (ru) |
BR (1) | BRPI0710521A2 (ru) |
CA (1) | CA2648529A1 (ru) |
CR (1) | CR10427A (ru) |
EA (1) | EA200870415A1 (ru) |
EC (1) | ECSP088823A (ru) |
GT (1) | GT200800202A (ru) |
MA (1) | MA30358B1 (ru) |
MX (1) | MX2008012852A (ru) |
NO (1) | NO20084665L (ru) |
PE (1) | PE20080059A1 (ru) |
SM (1) | SMP200800059B (ru) |
TN (1) | TNSN08375A1 (ru) |
TW (1) | TW200808739A (ru) |
WO (1) | WO2007117607A2 (ru) |
ZA (1) | ZA200808307B (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2718876C2 (ru) * | 2013-08-23 | 2020-04-15 | Ньюфарма, Инк. | Некоторые химические соединения, композиции и способы |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
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EA200900819A1 (ru) * | 2006-12-22 | 2010-02-26 | Новартис Аг | Хиназолины для ингибирования pdk1 |
UY31137A1 (es) * | 2007-06-14 | 2009-01-05 | Smithkline Beecham Corp | Derivados de quinazolina como inhibidores de la pi3 quinasa |
US8389531B2 (en) | 2007-07-11 | 2013-03-05 | Hetero Drugs Limited | Process for erlotinib hydrochloride |
US20100311965A1 (en) | 2007-12-28 | 2010-12-09 | Carna Biosciences Inc. | 2-aminoquinazoline derivative |
BRPI0906799A2 (pt) * | 2008-01-11 | 2015-07-14 | Hoffmann La Roche | Moduladores para amiloide beta |
WO2009131173A1 (ja) | 2008-04-23 | 2009-10-29 | 協和発酵キリン株式会社 | 2-アミノキナゾリン誘導体 |
MX2010012699A (es) | 2008-05-23 | 2010-12-07 | Novartis Ag | Derivados de quinolinas y quinoxalinas como inhibidores de cinasa de proteina tirosina. |
US8415376B2 (en) | 2008-05-30 | 2013-04-09 | Amgen Inc. | Inhibitors of PI3 kinase |
US20100121052A1 (en) * | 2008-06-20 | 2010-05-13 | Rama Jain | Novel compounds for treating proliferative diseases |
JP2012514020A (ja) * | 2008-12-29 | 2012-06-21 | フォーヴィア・ファーマシューティカルズ | 置換キナゾリン化合物 |
WO2012044090A2 (ko) * | 2010-09-29 | 2012-04-05 | 크리스탈지노믹스(주) | 단백질 키나제 억제 활성을 갖는 신규한 아미노퀴나졸린 화합물 |
WO2013050527A1 (en) | 2011-10-05 | 2013-04-11 | H. Lundbeck A/S | Quinazoline derivatives as pde10a enzyme inhibitors |
KR101360948B1 (ko) * | 2012-01-17 | 2014-02-12 | 한국과학기술연구원 | 신규한 2-아미노퀴나졸린 유도체 및 이를 유효성분으로 포함하는 항암제 |
GB201216017D0 (en) * | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
ES2924480T3 (es) * | 2013-12-06 | 2022-10-07 | Mychunter Therapeutics Inc | Derivado novedoso de quinazolina |
RU2685234C1 (ru) * | 2013-12-09 | 2019-04-17 | Юсб Байофарма Спрл | Конденсированные бициклические гетероароматические производные в качестве модуляторов активности tnf |
GB201403536D0 (en) | 2014-02-28 | 2014-04-16 | Cancer Rec Tech Ltd | Inhibitor compounds |
LT3122358T (lt) | 2014-03-26 | 2021-04-12 | Astex Therapeutics Ltd. | Egfr ir cmet inhibitorių deriniai, skirti vėžio gydymui |
US10047037B2 (en) | 2014-09-01 | 2018-08-14 | Nippon Soda Co., Ltd. | Method for producing 2-amino-substituted benzaldehyde compound |
TW202237569A (zh) | 2014-12-24 | 2022-10-01 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
KR101960624B1 (ko) | 2014-12-24 | 2019-03-20 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 이소퀴놀린 화합물 |
SG11201705192PA (en) | 2014-12-24 | 2017-07-28 | Gilead Sciences Inc | Fused pyrimidine compounds for the treatment of hiv |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
CN107613769A (zh) * | 2015-02-17 | 2018-01-19 | 润新生物公司 | 某些化学实体、组合物和方法 |
CN106316965B (zh) * | 2015-07-03 | 2021-08-27 | 上海医药集团股份有限公司 | 喹唑啉类化合物、其中间体、制备方法、药物组合物和应用 |
US10494378B2 (en) * | 2015-07-21 | 2019-12-03 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Fused ring pyrimidine compound, intermediate, and preparation method, composition and use thereof |
EP3868751B1 (en) | 2015-10-02 | 2023-10-25 | Sentinel Oncology Limited | 2-aminoquinazoline derivatives as p70s6 kinase inhibitors |
CN105753793B (zh) * | 2016-01-19 | 2018-09-04 | 河北医科大学 | 芳甲酰脲偶联喹唑啉类化合物及其制备方法、药物组合物及药物用途 |
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-
2007
- 2007-04-04 TW TW096112158A patent/TW200808739A/zh unknown
- 2007-04-04 AR ARP070101448A patent/AR060358A1/es unknown
- 2007-04-05 EA EA200870415A patent/EA200870415A1/ru unknown
- 2007-04-05 JP JP2009504315A patent/JP2009532486A/ja not_active Withdrawn
- 2007-04-05 KR KR1020087026508A patent/KR20080111114A/ko not_active Application Discontinuation
- 2007-04-05 BR BRPI0710521-5A patent/BRPI0710521A2/pt not_active IP Right Cessation
- 2007-04-05 EP EP07755008A patent/EP2004615A2/en not_active Withdrawn
- 2007-04-05 MX MX2008012852A patent/MX2008012852A/es not_active Application Discontinuation
- 2007-04-05 CA CA002648529A patent/CA2648529A1/en not_active Abandoned
- 2007-04-05 US US12/295,967 patent/US7932262B2/en not_active Expired - Fee Related
- 2007-04-05 SM SM200800059T patent/SMP200800059B/it unknown
- 2007-04-05 WO PCT/US2007/008592 patent/WO2007117607A2/en active Application Filing
- 2007-04-05 AU AU2007235339A patent/AU2007235339A1/en not_active Abandoned
- 2007-04-05 CN CNA2007800195027A patent/CN101454294A/zh active Pending
- 2007-04-09 PE PE2007000418A patent/PE20080059A1/es not_active Application Discontinuation
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2008
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- 2008-10-15 EC EC2008008823A patent/ECSP088823A/es unknown
- 2008-10-27 MA MA31336A patent/MA30358B1/fr unknown
- 2008-11-05 NO NO20084665A patent/NO20084665L/no not_active Application Discontinuation
- 2008-11-05 CR CR10427A patent/CR10427A/es not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2718876C2 (ru) * | 2013-08-23 | 2020-04-15 | Ньюфарма, Инк. | Некоторые химические соединения, композиции и способы |
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ZA200808307B (en) | 2010-01-27 |
EP2004615A2 (en) | 2008-12-24 |
TNSN08375A1 (en) | 2009-12-29 |
JP2009532486A (ja) | 2009-09-10 |
ECSP088823A (es) | 2008-12-30 |
US20100048561A1 (en) | 2010-02-25 |
SMP200800059B (it) | 2009-09-07 |
TW200808739A (en) | 2008-02-16 |
CN101454294A (zh) | 2009-06-10 |
AU2007235339A1 (en) | 2007-10-18 |
CA2648529A1 (en) | 2007-10-18 |
WO2007117607A9 (en) | 2008-03-06 |
MA30358B1 (fr) | 2009-04-01 |
US7932262B2 (en) | 2011-04-26 |
KR20080111114A (ko) | 2008-12-22 |
WO2007117607A2 (en) | 2007-10-18 |
AU2007235339A8 (en) | 2008-11-20 |
SMAP200800059A (it) | 2008-11-12 |
NO20084665L (no) | 2009-01-06 |
GT200800202A (es) | 2009-06-25 |
WO2007117607A3 (en) | 2007-12-21 |
MX2008012852A (es) | 2008-11-28 |
PE20080059A1 (es) | 2008-03-05 |
BRPI0710521A2 (pt) | 2012-03-13 |
AR060358A1 (es) | 2008-06-11 |
CR10427A (es) | 2009-01-27 |
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