CY1115188T1 - Πολυκυκλικες ετεροαρυλ-υποκατεστημενες τριαζολες χρησιμες ως αναστολεις του axl - Google Patents

Πολυκυκλικες ετεροαρυλ-υποκατεστημενες τριαζολες χρησιμες ως αναστολεις του axl

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Publication number
CY1115188T1
CY1115188T1 CY20141100312T CY141100312T CY1115188T1 CY 1115188 T1 CY1115188 T1 CY 1115188T1 CY 20141100312 T CY20141100312 T CY 20141100312T CY 141100312 T CY141100312 T CY 141100312T CY 1115188 T1 CY1115188 T1 CY 1115188T1
Authority
CY
Cyprus
Prior art keywords
axl
polycyclic heteroaryl
suspensions
substituted triazoles
triazoles useful
Prior art date
Application number
CY20141100312T
Other languages
English (en)
Inventor
Dane Goff
Jing Zhang
Rajinder Singh
Sacha Holland
Jiaxin Yu
Thilo Heckrodt
Pingyu Ding
Joane Litvak
Original Assignee
Rigel Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals, Inc. filed Critical Rigel Pharmaceuticals, Inc.
Publication of CY1115188T1 publication Critical patent/CY1115188T1/el

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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  • Chemical & Material Sciences (AREA)
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Abstract

Αποκαλύπτονται πολυκυκλικές ετεραρυλ-υποκατεστημένες τριαζόλες και φαρμακευτικές συνθέσεις που περιέχουν τις ενώσεις, οι οποίες είναι χρήσιμες στην αναστολή της ενεργότητας του υποδοχέα πρωτεϊνικής κινάσης τυροσίνης Axl. Αποκαλύπτονται επίσης μέθοδοι για χρήση των ενώσεων στη θεραπεία ασθενειών και καταστάσεων που σχετίζονται με την ενεργότητα του Axl.
CY20141100312T 2006-12-29 2014-04-28 Πολυκυκλικες ετεροαρυλ-υποκατεστημενες τριαζολες χρησιμες ως αναστολεις του axl CY1115188T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88285006P 2006-12-29 2006-12-29
US89540007P 2007-03-16 2007-03-16
US97093107P 2007-09-07 2007-09-07
EP07870107.5A EP2078010B1 (en) 2006-12-29 2007-12-29 Polycyclic heteroaryl substituted triazoles useful as axl inhibitors

Publications (1)

Publication Number Publication Date
CY1115188T1 true CY1115188T1 (el) 2017-01-04

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CY20141100312T CY1115188T1 (el) 2006-12-29 2014-04-28 Πολυκυκλικες ετεροαρυλ-υποκατεστημενες τριαζολες χρησιμες ως αναστολεις του axl

Country Status (17)

Country Link
US (5) US7709482B2 (el)
EP (1) EP2078010B1 (el)
JP (2) JP5546250B2 (el)
CN (1) CN101622246B (el)
AU (1) AU2007341937B2 (el)
CA (1) CA2710234C (el)
CY (1) CY1115188T1 (el)
DK (1) DK2078010T3 (el)
ES (1) ES2460894T3 (el)
HK (1) HK1132737A1 (el)
HR (1) HRP20140378T1 (el)
ME (1) ME01832B (el)
PL (1) PL2078010T3 (el)
PT (1) PT2078010E (el)
RS (1) RS53281B (el)
SI (1) SI2078010T1 (el)
WO (1) WO2008083367A2 (el)

Families Citing this family (52)

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Publication number Priority date Publication date Assignee Title
CA2612788A1 (en) * 2005-06-24 2006-12-28 Steven Cesar Alfons De Jonghe Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c
WO2007030680A2 (en) * 2005-09-07 2007-03-15 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as axl inhibitors
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections
TW200840584A (en) * 2006-12-26 2008-10-16 Gilead Sciences Inc Pyrido(3,2-d)pyrimidines useful for treating viral infections
RS53281B (en) 2006-12-29 2014-08-29 Rigel Pharmaceuticals Inc. POLYCYCLIC HETEROaryl SUBSTITUTED TRIAZOLES USED AS AXL INHIBITORS
PL2114955T3 (pl) * 2006-12-29 2013-06-28 Rigel Pharmaceuticals Inc Triazole podstawione mostkowanym bicyklicznym arylem oraz mostkowanym bicyklicznym heteroarylem użyteczne jako inhibitory Axl
JP5567837B2 (ja) * 2006-12-29 2014-08-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用なＮ３−ヘテロアリール置換トリアゾールおよびＮ５−ヘテロアリール置換トリアゾール
ES2406930T3 (es) * 2006-12-29 2013-06-10 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico y heteroarilo bicíclico útiles como inhibidores de AXL
CA2946305C (en) 2006-12-29 2019-09-17 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors
US7935693B2 (en) * 2007-10-26 2011-05-03 Rigel Pharmaceuticals, Inc. Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
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