CY1118376T1 - Υδροχλωριδιο παραγωγου πουρινονης - Google Patents
Υδροχλωριδιο παραγωγου πουρινονηςInfo
- Publication number
- CY1118376T1 CY1118376T1 CY20161101227T CY161101227T CY1118376T1 CY 1118376 T1 CY1118376 T1 CY 1118376T1 CY 20161101227 T CY20161101227 T CY 20161101227T CY 161101227 T CY161101227 T CY 161101227T CY 1118376 T1 CY1118376 T1 CY 1118376T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hydrochloride
- purinoni
- producer
- compound
- cell
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- UQYDCIJFACDXSG-GMUIIQOCSA-N 6-amino-9-[(3r)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one;hydrochloride Chemical compound Cl.C1N(C(=O)C#CC)CC[C@H]1N1C(=O)N(C=2C=CC(OC=3C=CC=CC=3)=CC=2)C2=C(N)N=CN=C21 UQYDCIJFACDXSG-GMUIIQOCSA-N 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 210000003630 histaminocyte Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- UFZNZKGKBWOSJG-UHFFFAOYSA-N purin-2-one Chemical class O=C1N=CC2=NC=NC2=N1 UFZNZKGKBWOSJG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Ένα υδροχλωρίδιο 6-αμινο-9-[(3R)-1-(2-βουτυνοϋλ)-3-πυρρολιδινυλ]-7-(4-φαινοξυφαινυλ)-7,9-διϋδρο-8Η-πουριν-8-όνης, το οποίο είναι ένα παράγωγο πουρινόνης, είναι μια ένωση η οποία έχει εκλεκτική ανασταλτική δραστικότητα Btk και άριστη μεταβολική σταθερότητα, ικανή να διαλυτοποιεί και να απορροφά μια ελεύθερη βάση ικανοποιητικά, και ικανή να κρυσταλλώνεται. Συνεπώς, η ένωση μπορεί να χρησιμοποιηθεί ως θεραπευτικός παράγοντας για ασθένειες που συνδέονται με ένα Β κύτταρο ή ένα μαστοκύτταρο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011259662 | 2011-11-29 | ||
PCT/JP2012/080769 WO2013081016A1 (ja) | 2011-11-29 | 2012-11-28 | プリノン誘導体塩酸塩 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118376T1 true CY1118376T1 (el) | 2017-06-28 |
Family
ID=48535467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161101227T CY1118376T1 (el) | 2011-11-29 | 2016-11-25 | Υδροχλωριδιο παραγωγου πουρινονης |
Country Status (30)
Country | Link |
---|---|
US (8) | US9199997B2 (el) |
EP (1) | EP2786996B1 (el) |
JP (1) | JP5704252B2 (el) |
KR (3) | KR102021651B1 (el) |
CN (1) | CN103958513B (el) |
AU (2) | AU2012344839B2 (el) |
BR (2) | BR122022001235B1 (el) |
CA (1) | CA2857150C (el) |
CY (1) | CY1118376T1 (el) |
DK (1) | DK2786996T3 (el) |
ES (1) | ES2601219T3 (el) |
HK (1) | HK1197819A1 (el) |
HR (1) | HRP20161377T1 (el) |
HU (1) | HUE031094T2 (el) |
IL (1) | IL232822B (el) |
LT (1) | LT2786996T (el) |
MX (1) | MX353548B (el) |
MY (1) | MY170062A (el) |
NZ (1) | NZ626750A (el) |
PH (1) | PH12014501503A1 (el) |
PL (1) | PL2786996T3 (el) |
PT (1) | PT2786996T (el) |
RS (1) | RS55542B1 (el) |
RU (2) | RU2750538C2 (el) |
SG (1) | SG11201402658YA (el) |
SI (1) | SI2786996T1 (el) |
SM (1) | SMT201600426B (el) |
TW (1) | TW201329078A (el) |
WO (1) | WO2013081016A1 (el) |
ZA (1) | ZA201404792B (el) |
Families Citing this family (97)
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US7366522B2 (en) | 2000-02-28 | 2008-04-29 | Thomas C Douglass | Method and system for location tracking |
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US9049571B2 (en) | 2002-04-24 | 2015-06-02 | Ipventure, Inc. | Method and system for enhanced messaging |
EP2578585B1 (en) | 2010-05-31 | 2016-07-20 | ONO Pharmaceutical Co., Ltd. | Purinone derivative as btk kinase inhibitor |
DK2786996T3 (en) | 2011-11-29 | 2016-12-19 | Ono Pharmaceutical Co | Hydrochloride PURINONDERIVAT |
CN105377842A (zh) | 2013-07-25 | 2016-03-02 | 巴斯夫欧洲公司 | 呈无定形形式的达沙替尼的盐 |
CN105408329A (zh) * | 2013-07-25 | 2016-03-16 | 巴斯夫欧洲公司 | 呈晶体形式的达沙替尼的盐 |
EP3066126B1 (en) * | 2013-11-07 | 2019-03-27 | F. Hoffmann-La Roche AG | Combination therapy of an anti cd20 antibody with a btk inhibitor |
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TW201618774A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | 使用btk抑制劑透過調變腫瘤微環境來治療實體腫瘤及其他疾病之方法 |
TW201618775A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | Btk抑制劑、pi3k抑制劑、jak-2抑制劑、pd-1抑制劑及/或pd-l1抑制劑之治療組合物 |
WO2016024230A1 (en) | 2014-08-11 | 2016-02-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 inhibitor |
WO2016087994A1 (en) | 2014-12-05 | 2016-06-09 | Acerta Pharma B.V. | Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment |
KR102335970B1 (ko) | 2015-03-04 | 2021-12-07 | 길리애드 사이언시즈, 인코포레이티드 | 톨 유사 수용체 조정제 화합물 |
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ES2878030T3 (es) * | 2015-06-03 | 2021-11-18 | Principia Biopharma Inc | Inhibidores de tirosina cinasa |
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