CY1116042T1 - Ενα παρεμποδιστικο μονοκλωνικο αντισωμα εναντι της ανθρωπινης αλφα 1 i περιοχης toy vla-1, και η χρηση του για τη θεραπεια φλεγμονωδων διαταραχων - Google Patents

Ενα παρεμποδιστικο μονοκλωνικο αντισωμα εναντι της ανθρωπινης αλφα 1 i περιοχης toy vla-1, και η χρηση του για τη θεραπεια φλεγμονωδων διαταραχων

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Publication number
CY1116042T1
CY1116042T1 CY20151100186T CY151100186T CY1116042T1 CY 1116042 T1 CY1116042 T1 CY 1116042T1 CY 20151100186 T CY20151100186 T CY 20151100186T CY 151100186 T CY151100186 T CY 151100186T CY 1116042 T1 CY1116042 T1 CY 1116042T1
Authority
CY
Cyprus
Prior art keywords
treatment
vla
region
toy
traffic
Prior art date
Application number
CY20151100186T
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English (en)
Inventor
Fougerolles Antonin De
Philip Gotwals
Roy R Lobb
Victor E Koteliansky
Original Assignee
Biogen Idec Ma Inc.
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Filing date
Publication date
Application filed by Biogen Idec Ma Inc. filed Critical Biogen Idec Ma Inc.
Publication of CY1116042T1 publication Critical patent/CY1116042T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

Μια μέθοδος για τη θεραπεία φλεγμονωδών διαταραχών περιγράφεται, και ιδιαίτερα για τη θεραπεία μιας αγγειοπάθειας. Η μέθοδος περιλαμβάνει τη χορήγηση ενός αντισώματος παρεμπόδισης λειτουργίας που είναι ικανό να συνδέεται με έναν επίτοπο πάνω στην α1 I- περιοχή του VLA-1.
CY20151100186T 1999-06-01 2015-02-20 Ενα παρεμποδιστικο μονοκλωνικο αντισωμα εναντι της ανθρωπινης αλφα 1 i περιοχης toy vla-1, και η χρηση του για τη θεραπεια φλεγμονωδων διαταραχων CY1116042T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13703899P 1999-06-01 1999-06-01
US18533600P 2000-02-29 2000-02-29
EP10185467.7A EP2314315B1 (en) 1999-06-01 2000-06-01 A blocking monoclonal antibody to the human alpha1 I-domain of VLA-1, and its use for the treatment of inflammatory disorders

Publications (1)

Publication Number Publication Date
CY1116042T1 true CY1116042T1 (el) 2017-01-25

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CY20151100186T CY1116042T1 (el) 1999-06-01 2015-02-20 Ενα παρεμποδιστικο μονοκλωνικο αντισωμα εναντι της ανθρωπινης αλφα 1 i περιοχης toy vla-1, και η χρηση του για τη θεραπεια φλεγμονωδων διαταραχων

Country Status (28)

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US (5) US6955810B2 (el)
EP (3) EP1181054A1 (el)
JP (6) JP4817503B2 (el)
CN (1) CN1309419C (el)
AU (2) AU783989B2 (el)
BG (1) BG65579B1 (el)
BR (1) BR0011250A (el)
CA (1) CA2375827C (el)
CY (1) CY1116042T1 (el)
CZ (1) CZ300710B6 (el)
DK (2) DK1488806T3 (el)
EA (1) EA011384B1 (el)
EE (1) EE200100651A (el)
ES (2) ES2557768T3 (el)
GE (1) GEP20063774B (el)
HK (2) HK1043320A1 (el)
HU (1) HUP0202568A3 (el)
IL (2) IL146508A0 (el)
IS (1) IS6179A (el)
MX (1) MXPA01012388A (el)
NO (1) NO20015864L (el)
NZ (1) NZ515686A (el)
PT (2) PT1488806E (el)
SI (2) SI1488806T1 (el)
SK (1) SK17232001A3 (el)
TR (1) TR200103432T2 (el)
WO (1) WO2000072881A1 (el)
YU (1) YU85501A (el)

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