CY1114593T1 - Συνδυασμοι οι οποιοι περιλαμβανουν αναστολεις διπεπτιδυλ-διπεπτιδασης-iv kai αντιδιαβητικους παραγοντες - Google Patents
Συνδυασμοι οι οποιοι περιλαμβανουν αναστολεις διπεπτιδυλ-διπεπτιδασης-iv kai αντιδιαβητικους παραγοντεςInfo
- Publication number
- CY1114593T1 CY1114593T1 CY20131100996T CY131100996T CY1114593T1 CY 1114593 T1 CY1114593 T1 CY 1114593T1 CY 20131100996 T CY20131100996 T CY 20131100996T CY 131100996 T CY131100996 T CY 131100996T CY 1114593 T1 CY1114593 T1 CY 1114593T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitors
- phosphatase
- insulin
- glucose
- gfat
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 7
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 abstract 2
- 208000002705 Glucose Intolerance Diseases 0.000 abstract 2
- 102000003638 Glucose-6-Phosphatase Human genes 0.000 abstract 2
- 108010086800 Glucose-6-Phosphatase Proteins 0.000 abstract 2
- 102000007390 Glycogen Phosphorylase Human genes 0.000 abstract 2
- 108010046163 Glycogen Phosphorylase Proteins 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 102000053067 Pyruvate Dehydrogenase Acetyl-Transferring Kinase Human genes 0.000 abstract 2
- 101710159466 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial Proteins 0.000 abstract 2
- 239000003888 alpha glucosidase inhibitor Substances 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 201000009104 prediabetes syndrome Diseases 0.000 abstract 2
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 abstract 2
- VFFZWMWTUSXDCB-ZDUSSCGKSA-N 6-[2-[[2-[(2s)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile Chemical compound N1([C@@H](CCC1)C#N)C(=O)CNCCNC1=CC=C(C#N)C=N1 VFFZWMWTUSXDCB-ZDUSSCGKSA-N 0.000 abstract 1
- 208000010444 Acidosis Diseases 0.000 abstract 1
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 abstract 1
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 abstract 1
- 229940122904 Glucagon receptor antagonist Drugs 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 208000007976 Ketosis Diseases 0.000 abstract 1
- 206010027417 Metabolic acidosis Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 206010070834 Sensitisation Diseases 0.000 abstract 1
- 101710098414 Tyrosine-protein phosphatase Proteins 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 abstract 1
- 230000004155 insulin signaling pathway Effects 0.000 abstract 1
- 230000004140 ketosis Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229930029653 phosphoenolpyruvate Natural products 0.000 abstract 1
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003934 phosphoprotein phosphatase inhibitor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000008313 sensitization Effects 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
- 229960001254 vildagliptin Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Η εφεύρεση σχετίζεται με έναν συνδυασμό ο οποίος περιλαμβάνει έναν αναστολέα DPP-IV (κατά προτίμηση ΝVΡ LAF237 (βιλδαγλιπτίνη) ή ΝVΡ-DPΡ728) και τουλάχιστον μια ακόμη αντιδιαβητική ένωση, κατά προτίμηση επιλεγμένη από την ομάδα εκείνη που αποτελείται από ρυθμιστές σηματοδοτικού μονοπατιού ινσουλίνης, όπως είναι οι αναστολείς πρωτεϊνικών φωσφατασών τυροσίνης (ΡΤΡases), οι μιμητικές ενώσεις όχι μικρών μορίων και οι αναστολείς αμιδοτρανσφεράσης γλουταμίνης-φρουκτόζης-6-φωσφατάσης (GFAT), ενώσεις οι οποίες επηρεάζουν μια μη ρυθμιζόμενη παραγωγή ηπατικής γλυκόζης, όπως είναι οι αναστολείς γλυκόζης-6-φωσφατάσης (G6Pase), οι αναστολείς φρουκτόζης-1,6-δι-φωσφατάσης (F-1,6-ΒΡase), οι αναστολείς φωσφορυλάσης γλυκογόνου (GΡ), οι ανταγωνιστές υποδοχέα γλυκαγόνου και οι αναστολείς φωσφοενολπυρουβικής καρβοξυκινάσης (ΡΕΡCΚ), οι αναστολείς κινάσης πυρουβικής αφυδρογονάσης (ΡDΗΚ), τα ενισχυτικά ευαισθησίας στην ινσουλίνη, τα ενισχυτικά έκκρισης ινσουλίνης, οι αναστολείς α-γλυκοσιδάσης, οι αναστολείς γαστρικής κένωσης, η ινσουλίνη και οι α2-αδρενεργικοί ανταγωνιστές, για ταυτόχρονη, ξεχωριστή ή διαδοχική χρήση, στην πρόληψη, στην καθυστέρηση της εξέλιξης ή στη θεραπεία καταστάσεων όπως είναι ο σακχαρώδης διαβήτης τύπου 2, η διαταραγμένη ανοχή στη γλυκόζη (ΙGΤ), το διαταραγμένο σάκχαρο νηστείας, η μεταβολική οξέωση, η κέτωση, η αρθρίτιδα, η παχυσαρκία και η οστεοπόρωση.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48923400A | 2000-01-21 | 2000-01-21 | |
US61926200A | 2000-07-19 | 2000-07-19 | |
EP06121896.2A EP1741447B1 (en) | 2000-01-21 | 2001-01-19 | Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114593T1 true CY1114593T1 (el) | 2016-10-05 |
Family
ID=27049636
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101859T CY1106303T1 (el) | 2000-01-21 | 2006-12-29 | Συνδυασμοι οι οποιοι πepιλαμβανουν αναστολεις πεπτιδυλικης διπεπτιδασης-iv και αντιδιαβητικους παραγοντες |
CY20081100459T CY1107423T1 (el) | 2000-01-21 | 2008-04-24 | Ενωσεις που περιλαμβανουν αναστολεις διπεπτυδυλοπεπτιδασης-iv και αντιδιαβητικους παραγοντες |
CY200800010C CY2008010I2 (el) | 2000-01-21 | 2008-05-12 | Ενωσεις που περιλαμβανουν αναστολεις διπεπτυδυλοπεπτιδασης-iv και αντιδιαβητικους παραγοντες |
CY20131100877T CY1114466T1 (el) | 2000-01-21 | 2013-10-09 | Συνδυασμοι οι οποιοι περιλαμβανουν αναστολεις διπεπτιδυλ-διπεπτιδασης-ιv και αντιδιαβητικους παραγοντες |
CY20131100996T CY1114593T1 (el) | 2000-01-21 | 2013-11-08 | Συνδυασμοι οι οποιοι περιλαμβανουν αναστολεις διπεπτιδυλ-διπεπτιδασης-iv kai αντιδιαβητικους παραγοντες |
CY20141100633T CY1115449T1 (el) | 2000-01-21 | 2014-08-08 | Συνδυασμοι οι οποιοι περιλαμβανουν αναστολεις διπεπτιδυλ-πεπτιδασης-iv και αντιδιαβητικους παραγοντες |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101859T CY1106303T1 (el) | 2000-01-21 | 2006-12-29 | Συνδυασμοι οι οποιοι πepιλαμβανουν αναστολεις πεπτιδυλικης διπεπτιδασης-iv και αντιδιαβητικους παραγοντες |
CY20081100459T CY1107423T1 (el) | 2000-01-21 | 2008-04-24 | Ενωσεις που περιλαμβανουν αναστολεις διπεπτυδυλοπεπτιδασης-iv και αντιδιαβητικους παραγοντες |
CY200800010C CY2008010I2 (el) | 2000-01-21 | 2008-05-12 | Ενωσεις που περιλαμβανουν αναστολεις διπεπτυδυλοπεπτιδασης-iv και αντιδιαβητικους παραγοντες |
CY20131100877T CY1114466T1 (el) | 2000-01-21 | 2013-10-09 | Συνδυασμοι οι οποιοι περιλαμβανουν αναστολεις διπεπτιδυλ-διπεπτιδασης-ιv και αντιδιαβητικους παραγοντες |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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CY20141100633T CY1115449T1 (el) | 2000-01-21 | 2014-08-08 | Συνδυασμοι οι οποιοι περιλαμβανουν αναστολεις διπεπτιδυλ-πεπτιδασης-iv και αντιδιαβητικους παραγοντες |
Country Status (18)
Country | Link |
---|---|
US (1) | US20030139434A1 (el) |
EP (5) | EP1741445B1 (el) |
JP (7) | JP2003520226A (el) |
CN (3) | CN1400908A (el) |
AT (2) | ATE346613T1 (el) |
AU (1) | AU2001237321A1 (el) |
BR (1) | BRPI0107715B8 (el) |
CA (2) | CA2673615C (el) |
CY (6) | CY1106303T1 (el) |
DE (3) | DE60132723T2 (el) |
DK (5) | DK1741446T3 (el) |
ES (5) | ES2275654T5 (el) |
FR (1) | FR08C0017I2 (el) |
HK (4) | HK1102422A1 (el) |
LU (1) | LU91436I2 (el) |
NL (1) | NL300346I1 (el) |
PT (5) | PT1248604E (el) |
WO (1) | WO2001052825A2 (el) |
Families Citing this family (135)
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AU6452098A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
WO2000014095A1 (en) | 1998-09-09 | 2000-03-16 | Metabasis Therapeutics, Inc. | Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase |
AU6044699A (en) * | 1998-09-17 | 2000-04-03 | Akesis Pharmaceuticals, Inc. | Compositions and methods for treatment of glucose metabolism disorders |
JP2003520226A (ja) * | 2000-01-21 | 2003-07-02 | ノバルティス アクチエンゲゼルシャフト | ジペプチジルペプチダーゼ−iv阻害剤および抗糖尿病薬剤を含む組合せ物 |
IL151248A0 (en) | 2000-03-08 | 2003-04-10 | Metabasis Therapeutics Inc | Novel aryl fructose-1,6-bisphosphatase inhibitors |
US7078397B2 (en) | 2000-06-19 | 2006-07-18 | Smithkline Beecham Corporation | Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus |
GB0014969D0 (en) * | 2000-06-19 | 2000-08-09 | Smithkline Beecham Plc | Novel method of treatment |
PL365779A1 (en) * | 2000-07-06 | 2005-01-10 | Metabasis Therapeutics, Inc. | A combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes |
EP2404603A1 (en) * | 2000-10-23 | 2012-01-11 | Glaxosmithkline LLC | Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds for the treatment of CSBP/p38 kinase mediated diseases |
HUP0400321A2 (hu) | 2001-06-27 | 2004-08-30 | Smithkline Beecham Corp. | Fluorpirrolidin-származékok mint dipeptidil-dipeptidáz inhibitorok és ezeket tartalmazó gyógyszerkészítmények |
DE60223920T2 (de) | 2001-06-27 | 2008-11-13 | Smithkline Beecham Corp. | Pyrrolidine als dipeptidyl-peptidase-inhibitoren |
US7183290B2 (en) | 2001-06-27 | 2007-02-27 | Smithkline Beecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205176D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
EP1496838B1 (en) | 2002-03-12 | 2010-11-03 | Merck Sharp & Dohme Corp. | Substituted amides |
US7524885B2 (en) * | 2002-04-01 | 2009-04-28 | The Governors Of The University Of Alberta | Compounds that stimulate glucose utilization and methods of use |
GB0212412D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Combination of organic compounds |
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