CY1111188T1 - Αντιβακτηριακα παραγωγα κινολινης - Google Patents

Αντιβακτηριακα παραγωγα κινολινης

Info

Publication number
CY1111188T1
CY1111188T1 CY20101100742T CY101100742T CY1111188T1 CY 1111188 T1 CY1111188 T1 CY 1111188T1 CY 20101100742 T CY20101100742 T CY 20101100742T CY 101100742 T CY101100742 T CY 101100742T CY 1111188 T1 CY1111188 T1 CY 1111188T1
Authority
CY
Cyprus
Prior art keywords
compounds
formula
pharmaceutically acceptable
kinolin
producers
Prior art date
Application number
CY20101100742T
Other languages
English (en)
Inventor
Jérôme Emile Georges Guillemont
Ismet Dorange
Koenraad Jozef Lodewijk Marcel Andries
Anil Koul
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CY1111188T1 publication Critical patent/CY1111188T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε νέα υποκατεστημένα παράγωγα κινολίνης σύμφωνα με το γενικό Τύπο (la) ή το Τύπο (lb): συμπεριλαμβάνοντας οποιαδήποτε στερεοχημικά ισομερή μορφή αυτών, όπου το 10 Q αντιπροσωπεύει μία ρίζα του τύπου ενός N-οξειδίου αυτών, ένα φαρμακευτικά αποδεκτό άλας αυτών ή ένα επιδιαλυτωμένο σύμπλοκο αυτών. Οι ενώσεις που αξιώνονται είναι χρήσιμες στη θεραπευτική αντιμετώπιση μίας βακτηριακής λοίμωξης. Επίσης, αξιώνεται μία σύνθεση που περιλαμβάνει ένα φαρμακευτικώς αποδεκτό φορέα και, ως δραστικό συστατικό, μία θεραπευτικώς αποτελεσματική ποσότητα των ενώσεων που αξιώνονται, η χρήση των ενώσεων που αξιώνονται ή των συνθέσεων για την παρασκευή ενός φαρμάκου για τη θεραπευτική αντιμετώπιση μίας βακτηριακής λοίμωξης και μία διαδικασία για την παρασκευή των ενώσεων που αξιώνονται.
CY20101100742T 2006-12-06 2010-08-09 Αντιβακτηριακα παραγωγα κινολινης CY1111188T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125546 2006-12-06
EP07857252A EP2099762B1 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (1)

Publication Number Publication Date
CY1111188T1 true CY1111188T1 (el) 2015-06-11

Family

ID=38038656

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100742T CY1111188T1 (el) 2006-12-06 2010-08-09 Αντιβακτηριακα παραγωγα κινολινης

Country Status (34)

Country Link
US (1) US20100069366A1 (el)
EP (1) EP2099762B1 (el)
JP (1) JP5356244B2 (el)
KR (1) KR101514992B1 (el)
CN (1) CN101547907B (el)
AP (1) AP2478A (el)
AR (1) AR064153A1 (el)
AT (1) ATE467619T1 (el)
AU (1) AU2007328980B2 (el)
BR (1) BRPI0719920B8 (el)
CA (1) CA2668515C (el)
CL (1) CL2007003519A1 (el)
CY (1) CY1111188T1 (el)
DE (1) DE602007006553D1 (el)
DK (1) DK2099762T3 (el)
EA (1) EA200970534A1 (el)
ES (1) ES2345463T3 (el)
HK (1) HK1137441A1 (el)
HR (1) HRP20100428T1 (el)
IL (1) IL199079A (el)
JO (1) JO2684B1 (el)
ME (1) ME01127B (el)
MX (1) MX2009005982A (el)
MY (1) MY145924A (el)
NO (1) NO341996B1 (el)
NZ (1) NZ576863A (el)
PL (1) PL2099762T3 (el)
PT (1) PT2099762E (el)
RS (1) RS51382B (el)
SI (1) SI2099762T1 (el)
TW (1) TWI484959B (el)
UA (1) UA101305C2 (el)
WO (1) WO2008068266A1 (el)
ZA (1) ZA200903947B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5857511B2 (ja) * 2010-08-10 2016-02-10 住友化学株式会社 植物病害防除組成物およびその用途
DK2841425T3 (en) 2012-04-27 2016-06-27 Janssen Pharmaceutica Nv ANTIBACTERIAL QUINOLIN DERIVATIVES
EA038350B1 (ru) 2012-04-27 2021-08-12 Янссен Фармацевтика Нв Антибактериальные хинолиновые производные
CN105017147B (zh) * 2014-04-30 2019-02-01 中国医学科学院药物研究所 一种回收和利用Bedaquiline立体化学异构体的方法
CN105330595B (zh) * 2014-07-14 2019-12-10 上海嘉坦医药科技有限公司 吡啶衍生物及其作为抗分支杆菌的应用
US9878982B2 (en) 2014-07-14 2018-01-30 Cisen Pharmaceutical Co., Ltd. Pyridine derivatives and anti-mycobacterial use thereof
CN108473428B (zh) * 2016-01-13 2021-07-23 上海嘉坦医药科技有限公司 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
CN109069514B (zh) * 2016-03-07 2023-12-29 结核病药物开发全球联盟公司 抗菌化合物及其用途
CN109384716B (zh) * 2017-08-11 2021-06-29 海创药业股份有限公司 一种氘代喹啉化合物及其制备和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503411A (ja) * 1996-10-28 2001-03-13 ディパートメント オブ ジ アーミー，ユー．エス．ガバメント 抗生物質耐性感染症の処置のための化合物、組成物および方法
SI1527050T1 (sl) * 2002-07-25 2010-08-31 Janssen Pharmaceutica Nv Kinolinski derivati in njihova uporaba kot mikobakterijski inhibitorji
BRPI0507065B8 (pt) * 2004-01-23 2021-05-25 Janssen Pharmaceutica Nv derivados de quinolina, composição que os compreende, seu processo de preparação e seu uso como inibidores micobacterianos
US7338949B2 (en) * 2004-01-23 2008-03-04 Janssen Pharmaceutica N.V. Mycobacterial inhibitors
JP4919810B2 (ja) * 2004-01-29 2012-04-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイコバクテリア抑制剤としての使用のためのキノリン誘導体
JO2524B1 (en) * 2004-05-28 2010-03-17 جانسن فارمسيتكا ان في Use of substituted quinoline derivatives to treat drug-resistant microbial diseases
EP1677083A1 (fr) * 2004-12-22 2006-07-05 Roxer Industries S.A. Capteur de niveau d'un liquide.
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents

Also Published As

Publication number Publication date
EP2099762A1 (en) 2009-09-16
BRPI0719920A2 (pt) 2014-03-04
CN101547907B (zh) 2013-01-02
ES2345463T3 (es) 2010-09-23
KR101514992B1 (ko) 2015-04-24
EA200970534A1 (ru) 2009-10-30
ZA200903947B (en) 2010-08-25
TW200840575A (en) 2008-10-16
HRP20100428T1 (hr) 2010-09-30
UA101305C2 (ru) 2013-03-25
PT2099762E (pt) 2010-08-04
AR064153A1 (es) 2009-03-18
BRPI0719920B8 (pt) 2021-05-25
HK1137441A1 (en) 2010-07-30
JO2684B1 (en) 2013-03-03
AP2478A (en) 2012-09-27
AU2007328980A1 (en) 2008-06-12
AP2009004872A0 (en) 2009-06-30
IL199079A (en) 2013-06-27
DK2099762T3 (da) 2010-08-30
WO2008068266A1 (en) 2008-06-12
AU2007328980B2 (en) 2013-04-18
MX2009005982A (es) 2009-06-16
NO341996B1 (no) 2018-03-12
EP2099762B1 (en) 2010-05-12
CN101547907A (zh) 2009-09-30
ME01127B (me) 2013-03-20
JP5356244B2 (ja) 2013-12-04
MY145924A (en) 2012-05-15
CA2668515C (en) 2016-03-29
NZ576863A (en) 2011-09-30
CL2007003519A1 (es) 2008-07-11
KR20090090360A (ko) 2009-08-25
SI2099762T1 (sl) 2010-09-30
PL2099762T3 (pl) 2010-10-29
CA2668515A1 (en) 2008-06-12
JP2010511667A (ja) 2010-04-15
RS51382B (en) 2011-02-28
TWI484959B (zh) 2015-05-21
US20100069366A1 (en) 2010-03-18
DE602007006553D1 (de) 2010-06-24
ATE467619T1 (de) 2010-05-15
BRPI0719920B1 (pt) 2020-08-04
NO20092539L (no) 2009-09-04

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