CY1113579T1 - Παραγωγα κινολινης ως αντιβακτηριακοι παραγοντες - Google Patents
Παραγωγα κινολινης ως αντιβακτηριακοι παραγοντεςInfo
- Publication number
- CY1113579T1 CY1113579T1 CY20121101090T CY121101090T CY1113579T1 CY 1113579 T1 CY1113579 T1 CY 1113579T1 CY 20121101090 T CY20121101090 T CY 20121101090T CY 121101090 T CY121101090 T CY 121101090T CY 1113579 T1 CY1113579 T1 CY 1113579T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- hydrogen
- het
- alkyloxy
- hydroxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
Abstract
Χρήση μιας ένωσης για την κατασκευή ενός φαρμάκου για τη θεραπευτική αγωγή μιας βακτηριακής μόλυνσης δεδομένου ότι η βακτηριακή μόλυνση είναι διαφορετική από μια Μυκοβακτηριακή μόλυνση, με την εν λόγω ένωση να είναι μια ένωση του τύπου (la) ή (lb) ένα φαρμακευτικώς αποδεκτό άλας προσθήκης οξέων ή βάσεων αυτής, μια στερεοχημικώς ισομερής μορφή αυτής, μια ταυτομερική μορφή αυτής ή μια μορφή Ν-οξειδίου αυτής, όπου το R1 είναι υδρογόνο, αλογονο, αλογονοαλκυλ, κυανο, υδροξυ, Ar, Het, αλκυλ, αλκυλοξυ, αλκυλθειο, αλκυλοξυαλκυλ, αλκυλθειοαλκυλ, Ar-αλκυλ ή δι(Αr)αλκυλ, το p είναι 1, 2, 3 ή 4, το R2 είναι υδρογόνο, υδροξυ, μερκαπτο, αλκυλοξυ, αλκυλοξυαλκυλοξυ, αλκυλθειο, μονο ή δι(αλκυλ)αμινο ή μια ρίζα του τύπου, το R3 είναι αλκυλ, Ar, Ar-αλκυλ, Het ή Het-αλκυλ, το q είναι 1, 2 ή 3, τα R4 και R5 είναι υδρογόνο, αλκυλ ή βενζυλ, ή τα R4 και R5 μαζί και συμπεριλαμβανομένου του Ν στο οποίο είναι προσαρτημένα μπορεί να σχηματίσουν έναν δακτύλιο, το R6 είναι υδρογόνο, αλογονο, αλογονοαλκυλ, υδροξυ, Ar, αλκυλ, αλκυλοξυ, αλκυλθειο, αλκυλοξυαλκυλ, αλκυλθειοαλκυλ, Ar-αλκυλ ή δι(Αr)αλκυλ, ή δυο γειτονικές R6 ρίζες μπορεί να λαμβάνονται μαζί για να σχηματίσουν μια δισθενή ρίζα του τύπου -CH=CH-CH=CH-, το r είναι 1, 2, 3, 4 ή 5, το R7 είναι υδρογόνο, αλκυλ, Ar ή Het, το R8 είναι υδρογόνο ή αλκυλ, το R9 είναι οξο, ή τα R8 και R9 μαζί σχηματίζουν τη ρίζα -CH=CH-N=.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105762 | 2005-06-28 | ||
| EP06763889A EP1898914B1 (en) | 2005-06-28 | 2006-06-26 | Quinoline derivatives as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113579T1 true CY1113579T1 (el) | 2016-06-22 |
Family
ID=34940244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121101090T CY1113579T1 (el) | 2005-06-28 | 2012-11-14 | Παραγωγα κινολινης ως αντιβακτηριακοι παραγοντες |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8841321B2 (el) |
| EP (1) | EP1898914B1 (el) |
| JP (1) | JP5193858B2 (el) |
| KR (1) | KR101329585B1 (el) |
| CN (1) | CN101247811B (el) |
| AP (1) | AP2386A (el) |
| AR (1) | AR054626A1 (el) |
| AU (1) | AU2006263883B2 (el) |
| BR (1) | BRPI0612498A8 (el) |
| CA (1) | CA2612619C (el) |
| CY (1) | CY1113579T1 (el) |
| DK (1) | DK1898914T3 (el) |
| EA (1) | EA014423B1 (el) |
| ES (1) | ES2393203T3 (el) |
| HK (1) | HK1122730A1 (el) |
| HR (1) | HRP20120912T1 (el) |
| IL (1) | IL188393A0 (el) |
| JO (1) | JO2752B1 (el) |
| ME (1) | ME01484B (el) |
| MX (1) | MX2008000081A (el) |
| MY (1) | MY153291A (el) |
| NO (1) | NO342701B1 (el) |
| NZ (1) | NZ564379A (el) |
| PA (1) | PA8683801A1 (el) |
| PL (1) | PL1898914T3 (el) |
| PT (1) | PT1898914E (el) |
| RS (1) | RS52517B (el) |
| SI (1) | SI1898914T1 (el) |
| TW (1) | TWI387457B (el) |
| UA (1) | UA92175C2 (el) |
| WO (1) | WO2007000435A1 (el) |
| ZA (1) | ZA200711165B (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| EA038350B1 (ru) | 2012-04-27 | 2021-08-12 | Янссен Фармацевтика Нв | Антибактериальные хинолиновые производные |
| ES2576491T3 (es) | 2012-04-27 | 2016-07-07 | Janssen Pharmaceutica, N.V. | Derivados de quinolina antibacterianos |
| EP3237383B1 (en) | 2014-12-23 | 2019-12-04 | Albemarle Corporation | One-step process for the synthesis of alkylated metyrapone analogs |
| CN106928139B (zh) * | 2017-05-08 | 2019-06-25 | 福建省微生物研究所 | 一种贝达喹啉杂质的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19937116A1 (de) * | 1999-08-06 | 2001-02-08 | Bayer Ag | Moxifloxacin Kochsalzformulierung |
| PL222801B1 (pl) * | 2002-07-25 | 2016-09-30 | Janssen Pharmaceutica Nv | Pochodne chinoliny, ich zastosowanie, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca je |
| PL1675852T3 (pl) | 2003-09-22 | 2009-07-31 | Janssen Pharmaceutica Nv | 7-amino-alkilidenylo-heterocykliczne chinolony i naftrydony |
| EP1753427B1 (en) * | 2004-05-28 | 2008-04-02 | Janssen Pharmaceutica N.V. | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| BRPI0613999B8 (pt) | 2005-06-28 | 2021-05-25 | Janssen Pharmaceutica Nv | uso de um composto derivado de quinolina, o referido composto, sua combinação, composição farmacêutica, uso da referida combinação, e produto |
-
2006
- 2006-06-25 JO JO2006188A patent/JO2752B1/en active
- 2006-06-26 KR KR1020087002107A patent/KR101329585B1/ko active IP Right Grant
- 2006-06-26 ES ES06763889T patent/ES2393203T3/es active Active
- 2006-06-26 EP EP06763889A patent/EP1898914B1/en active Active
- 2006-06-26 JP JP2008518810A patent/JP5193858B2/ja not_active Expired - Fee Related
- 2006-06-26 DK DK06763889.0T patent/DK1898914T3/da active
- 2006-06-26 BR BRPI0612498A patent/BRPI0612498A8/pt not_active Application Discontinuation
- 2006-06-26 AU AU2006263883A patent/AU2006263883B2/en not_active Ceased
- 2006-06-26 PT PT06763889T patent/PT1898914E/pt unknown
- 2006-06-26 ME MEP-2012-127A patent/ME01484B/me unknown
- 2006-06-26 MX MX2008000081A patent/MX2008000081A/es active IP Right Grant
- 2006-06-26 EA EA200800154A patent/EA014423B1/ru unknown
- 2006-06-26 US US11/993,145 patent/US8841321B2/en not_active Expired - Fee Related
- 2006-06-26 RS RS20120480A patent/RS52517B/en unknown
- 2006-06-26 NZ NZ564379A patent/NZ564379A/en not_active IP Right Cessation
- 2006-06-26 CA CA2612619A patent/CA2612619C/en not_active Expired - Fee Related
- 2006-06-26 AP AP2008004303A patent/AP2386A/xx active
- 2006-06-26 CN CN2006800310552A patent/CN101247811B/zh not_active Expired - Fee Related
- 2006-06-26 PL PL06763889T patent/PL1898914T3/pl unknown
- 2006-06-26 SI SI200631468T patent/SI1898914T1/sl unknown
- 2006-06-26 WO PCT/EP2006/063553 patent/WO2007000435A1/en active Application Filing
- 2006-06-26 UA UAA200714927A patent/UA92175C2/ru unknown
- 2006-06-27 MY MYPI20063044A patent/MY153291A/en unknown
- 2006-06-27 TW TW095123127A patent/TWI387457B/zh not_active IP Right Cessation
- 2006-06-28 PA PA20068683801A patent/PA8683801A1/es unknown
- 2006-06-28 AR ARP060102787A patent/AR054626A1/es unknown
-
2007
- 2007-12-20 ZA ZA2007/11165A patent/ZA200711165B/en unknown
- 2007-12-25 IL IL188393A patent/IL188393A0/en active IP Right Grant
-
2008
- 2008-01-28 NO NO20080501A patent/NO342701B1/no not_active IP Right Cessation
- 2008-12-24 HK HK08113967.4A patent/HK1122730A1/xx not_active IP Right Cessation
-
2012
- 2012-11-13 HR HRP20120912TT patent/HRP20120912T1/hr unknown
- 2012-11-14 CY CY20121101090T patent/CY1113579T1/el unknown
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