BRPI0719920A2 - Derivados de quinolina antibacterianos. - Google Patents

Derivados de quinolina antibacterianos.

Info

Publication number: BRPI0719920A2
Authority: BR; Brazil
Prior art keywords: quinoline derivatives; antibacterial quinoline; antibacterial; derivatives; quinoline
Prior art date: 2006-12-06

Application number

BRPI0719920-1A2A

Other languages

English (en)

Inventor

Jerome Emile Georges Guillemont

Koenraad Jozef Lodewijk Marcel Andries

Anil Koul

Ismet Dorange

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-06

Filing date

2007-12-04

Publication date

2014-03-04

2007-12-04 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2014-03-04 Publication of BRPI0719920A2 publication Critical patent/BRPI0719920A2/pt

2020-08-04 Publication of BRPI0719920B1 publication Critical patent/BRPI0719920B1/pt

2021-05-25 Publication of BRPI0719920B8 publication Critical patent/BRPI0719920B8/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0719920A 2006-12-06 2007-12-04 derivado de quinolina, sua composição farmacêutica, seu uso, seu processo de preparação, combinação e produto compreendendo o mesmo e composto intermediário BRPI0719920B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP06125546		2006-12-06
EP06125546.9		2006-12-06
PCT/EP2007/063312 WO2008068266A1 (en)	2006-12-06	2007-12-04	Antibacterial quinoline derivatives

Publications (3)

Publication Number	Publication Date
BRPI0719920A2 true BRPI0719920A2 (pt)	2014-03-04
BRPI0719920B1 BRPI0719920B1 (pt)	2020-08-04
BRPI0719920B8 BRPI0719920B8 (pt)	2021-05-25

Family

ID=38038656

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0719920A BRPI0719920B8 (pt)	2006-12-06	2007-12-04	derivado de quinolina, sua composição farmacêutica, seu uso, seu processo de preparação, combinação e produto compreendendo o mesmo e composto intermediário

Country Status (34)

Country	Link
US (1)	US20100069366A1 (pt)
EP (1)	EP2099762B1 (pt)
JP (1)	JP5356244B2 (pt)
KR (1)	KR101514992B1 (pt)
CN (1)	CN101547907B (pt)
AP (1)	AP2478A (pt)
AR (1)	AR064153A1 (pt)
AT (1)	ATE467619T1 (pt)
AU (1)	AU2007328980B2 (pt)
BR (1)	BRPI0719920B8 (pt)
CA (1)	CA2668515C (pt)
CL (1)	CL2007003519A1 (pt)
CY (1)	CY1111188T1 (pt)
DE (1)	DE602007006553D1 (pt)
DK (1)	DK2099762T3 (pt)
EA (1)	EA200970534A1 (pt)
ES (1)	ES2345463T3 (pt)
HK (1)	HK1137441A1 (pt)
HR (1)	HRP20100428T1 (pt)
IL (1)	IL199079A (pt)
JO (1)	JO2684B1 (pt)
ME (1)	ME01127B (pt)
MX (1)	MX2009005982A (pt)
MY (1)	MY145924A (pt)
NO (1)	NO341996B1 (pt)
NZ (1)	NZ576863A (pt)
PL (1)	PL2099762T3 (pt)
PT (1)	PT2099762E (pt)
RS (1)	RS51382B (pt)
SI (1)	SI2099762T1 (pt)
TW (1)	TWI484959B (pt)
UA (1)	UA101305C2 (pt)
WO (1)	WO2008068266A1 (pt)
ZA (1)	ZA200903947B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5857511B2 (ja) *	2010-08-10	2016-02-10	住友化学株式会社	植物病害防除組成物およびその用途
DK2841425T3 (en)	2012-04-27	2016-06-27	Janssen Pharmaceutica Nv	ANTIBACTERIAL QUINOLIN DERIVATIVES
EA038350B1 (ru)	2012-04-27	2021-08-12	Янссен Фармацевтика Нв	Антибактериальные хинолиновые производные
CN105017147B (zh) *	2014-04-30	2019-02-01	中国医学科学院药物研究所	一种回收和利用Bedaquiline立体化学异构体的方法
CN105330595B (zh) *	2014-07-14	2019-12-10	上海嘉坦医药科技有限公司	吡啶衍生物及其作为抗分支杆菌的应用
US9878982B2 (en)	2014-07-14	2018-01-30	Cisen Pharmaceutical Co., Ltd.	Pyridine derivatives and anti-mycobacterial use thereof
CN108473428B (zh) *	2016-01-13	2021-07-23	上海嘉坦医药科技有限公司	一种吡啶衍生物类化合物的制备方法及其中间体和晶型
CN109069514B (zh) *	2016-03-07	2023-12-29	结核病药物开发全球联盟公司	抗菌化合物及其用途
CN109384716B (zh) *	2017-08-11	2021-06-29	海创药业股份有限公司	一种氘代喹啉化合物及其制备和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001503411A (ja) *	1996-10-28	2001-03-13	ディパートメントオブジアーミー，ユー．エス．ガバメント	抗生物質耐性感染症の処置のための化合物、組成物および方法
SI1527050T1 (sl) *	2002-07-25	2010-08-31	Janssen Pharmaceutica Nv	Kinolinski derivati in njihova uporaba kot mikobakterijski inhibitorji
BRPI0507065B8 (pt) *	2004-01-23	2021-05-25	Janssen Pharmaceutica Nv	derivados de quinolina, composição que os compreende, seu processo de preparação e seu uso como inibidores micobacterianos
US7338949B2 (en) *	2004-01-23	2008-03-04	Janssen Pharmaceutica N.V.	Mycobacterial inhibitors
JP4919810B2 (ja) *	2004-01-29	2012-04-18	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	マイコバクテリア抑制剤としての使用のためのキノリン誘導体
JO2524B1 (en) *	2004-05-28	2010-03-17	جانسن فارمسيتكا ان في	Use of substituted quinoline derivatives to treat drug-resistant microbial diseases
EP1677083A1 (fr) *	2004-12-22	2006-07-05	Roxer Industries S.A.	Capteur de niveau d'un liquide.
CA2528849C (en) *	2005-06-08	2014-01-14	Janssen Pharmaceutica N.V.	Quinoline derivatives as antibacterial agents

2007
- 2007-11-29 JO JO2007503A patent/JO2684B1/en active
- 2007-12-04 MX MX2009005982A patent/MX2009005982A/es active IP Right Grant
- 2007-12-04 US US12/515,593 patent/US20100069366A1/en not_active Abandoned
- 2007-12-04 DK DK07857252.6T patent/DK2099762T3/da active
- 2007-12-04 EA EA200970534A patent/EA200970534A1/ru unknown
- 2007-12-04 ES ES07857252T patent/ES2345463T3/es active Active
- 2007-12-04 UA UAA200904216A patent/UA101305C2/ru unknown
- 2007-12-04 BR BRPI0719920A patent/BRPI0719920B8/pt active IP Right Grant
- 2007-12-04 KR KR1020097013405A patent/KR101514992B1/ko active IP Right Grant
- 2007-12-04 AP AP2009004872A patent/AP2478A/xx active
- 2007-12-04 MY MYPI20092285A patent/MY145924A/en unknown
- 2007-12-04 AT AT07857252T patent/ATE467619T1/de active
- 2007-12-04 PT PT07857252T patent/PT2099762E/pt unknown
- 2007-12-04 RS RSP-2010/0351A patent/RS51382B/en unknown
- 2007-12-04 PL PL07857252T patent/PL2099762T3/pl unknown
- 2007-12-04 DE DE602007006553T patent/DE602007006553D1/de active Active
- 2007-12-04 CN CN200780044917XA patent/CN101547907B/zh active Active
- 2007-12-04 JP JP2009539737A patent/JP5356244B2/ja not_active Expired - Fee Related
- 2007-12-04 EP EP07857252A patent/EP2099762B1/en active Active
- 2007-12-04 NZ NZ576863A patent/NZ576863A/en unknown
- 2007-12-04 SI SI200730306T patent/SI2099762T1/sl unknown
- 2007-12-04 ME MEP-2010-128A patent/ME01127B/me unknown
- 2007-12-04 CA CA2668515A patent/CA2668515C/en active Active
- 2007-12-04 AU AU2007328980A patent/AU2007328980B2/en not_active Ceased
- 2007-12-04 WO PCT/EP2007/063312 patent/WO2008068266A1/en active Application Filing
- 2007-12-05 CL CL200703519A patent/CL2007003519A1/es unknown
- 2007-12-05 AR ARP070105446A patent/AR064153A1/es unknown
- 2007-12-05 TW TW096146219A patent/TWI484959B/zh active
2009
- 2009-06-02 IL IL199079A patent/IL199079A/en active IP Right Grant
- 2009-06-05 ZA ZA200903947A patent/ZA200903947B/xx unknown
- 2009-07-06 NO NO20092539A patent/NO341996B1/no unknown
2010
- 2010-02-04 HK HK10101244.0A patent/HK1137441A1/xx unknown
- 2010-08-02 HR HR20100428T patent/HRP20100428T1/hr unknown
- 2010-08-09 CY CY20101100742T patent/CY1111188T1/el unknown

Also Published As

Publication number	Publication date
EP2099762A1 (en)	2009-09-16
CN101547907B (zh)	2013-01-02
ES2345463T3 (es)	2010-09-23
KR101514992B1 (ko)	2015-04-24
EA200970534A1 (ru)	2009-10-30
ZA200903947B (en)	2010-08-25
TW200840575A (en)	2008-10-16
HRP20100428T1 (hr)	2010-09-30
UA101305C2 (ru)	2013-03-25
PT2099762E (pt)	2010-08-04
AR064153A1 (es)	2009-03-18
BRPI0719920B8 (pt)	2021-05-25
HK1137441A1 (en)	2010-07-30
JO2684B1 (en)	2013-03-03
AP2478A (en)	2012-09-27
AU2007328980A1 (en)	2008-06-12
AP2009004872A0 (en)	2009-06-30
IL199079A (en)	2013-06-27
DK2099762T3 (da)	2010-08-30
WO2008068266A1 (en)	2008-06-12
CY1111188T1 (el)	2015-06-11
AU2007328980B2 (en)	2013-04-18
MX2009005982A (es)	2009-06-16
NO341996B1 (no)	2018-03-12
EP2099762B1 (en)	2010-05-12
CN101547907A (zh)	2009-09-30
ME01127B (me)	2013-03-20
JP5356244B2 (ja)	2013-12-04
MY145924A (en)	2012-05-15
CA2668515C (en)	2016-03-29
NZ576863A (en)	2011-09-30
CL2007003519A1 (es)	2008-07-11
KR20090090360A (ko)	2009-08-25
SI2099762T1 (sl)	2010-09-30
PL2099762T3 (pl)	2010-10-29
CA2668515A1 (en)	2008-06-12
JP2010511667A (ja)	2010-04-15
RS51382B (en)	2011-02-28
TWI484959B (zh)	2015-05-21
US20100069366A1 (en)	2010-03-18
DE602007006553D1 (de)	2010-06-24
ATE467619T1 (de)	2010-05-15
BRPI0719920B1 (pt)	2020-08-04
NO20092539L (no)	2009-09-04

Legal Events

Date	Code	Title	Description
2018-03-20	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2020-01-28	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-02-11	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-06-02	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2020-08-04	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/08/2020, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/12/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

Publication	Publication Date	Title
BRPI0720220A2 (pt)	2013-12-24	Derivados de quinolinas antibacterianos
BRPI0719920A2 (pt)	2014-03-04	Derivados de quinolina antibacterianos.
AP2322A (en)	2011-11-18	Antibacterial quinoline derivatives.
BRPI0816679A2 (pt)	2015-03-17	Derivados de ftalazinona.
IL241548A0 (en)	2015-11-30	Antibacterial quinoline derivatives
DK2099759T3 (da)	2011-08-15	Antibakterielle chinolinderivater
ATE465994T1 (de)	2010-05-15	Antibakterielle chinolinderivate
BRPI0719915A2 (pt)	2014-03-04	Derivados de quinolina antibacterianos