AR064153A1 - Derivados de quinolina antibacterianos. procesos de obtencion y composiciones farmaceuticas. - Google Patents
Derivados de quinolina antibacterianos. procesos de obtencion y composiciones farmaceuticas.Info
- Publication number
- AR064153A1 AR064153A1 ARP070105446A ARP070105446A AR064153A1 AR 064153 A1 AR064153 A1 AR 064153A1 AR P070105446 A ARP070105446 A AR P070105446A AR P070105446 A ARP070105446 A AR P070105446A AR 064153 A1 AR064153 A1 AR 064153A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- het
- mono
- radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
También se reivindica una composicion que comprende un portador farmacéuticamente aceptable y, como ingrediente activo, una cantidad terapéuticamente efectiva de los compuestos reivindicados, al uso de los compuestos o composiciones reivindicados para la preparacion de un medicamento para el tratamiento de una infeccion bacteriana y a un proceso para preparar los compuestos reivindicados. Reivindicacion 1: Un compuesto de la formula (1a) o (1b) incluyendo cualquiera de sus formas estereoquímicamente isoméricas, en donde Q representa un radical de la formula (2), (3) o (4); p es un numero entero igual a 1, 2, 3 o 4; q es un numero entero igual a cero, 1, 2, 3 o 4; R1 es hidrogeno, ciano, formilo, carboxilo, halo, alquilo, alquenilo C2-6, alquinilo C2-6, haloalquilo, hidroxi, alquiloxi, alquiltio, alquiltioalquilo, -C=N-OR11, amino, mono- o di(alquil)amino, aminoalquilo, mono- o di(alquil)aminoalquilo, alquilcarbonilaminoalquilo, aminocarbonilo, mono- o di(alquil)aminocarbonilo, arilalquilo, arilcarbonilo, R5aR4aNalquilo, di(aril)alquilo, arilo, R5aR4aN-, R5aR4aN-C(=O)-, o Het; R2 es hidrogeno, alquiloxi, arilo, ariloxi, hidroxi, mercapto, alquiloxialquiloxi, alquiltio, mono- o di(alquil)amino, pirrolidino o un radical de formula (2) en donde Y es CH2, O, S, NH o N-alquilo; R3 es alquilo, arilalquilo, aril-O-alquilo, aril-alquil-O-alquilo, arilo, aril-arilo, Het, Het-alquilo, Het-O-alquilo, Het-alquil-O-alquilo o un radical de formula (3); R3a es H, ciano, alquilo, arilalquilo, aril-O-alquilo, aril-alquil-O-alquilo, arilo, aril-arilo, Het, Het-alquilo, Het-O-alquilo, o Het-alquil-O-alquilo; R4 y R5 cada uno es, de modo independiente, hidrogeno; alquilo; alquiloxialquilo; arilalquilo; Het-alquilo; mono- o dialquilaminoalquilo; biciclo[2,2,1]heptilo; Het; arilo; o -C(=NH)-NH2; o R4 y R5 junto con el átomo de nitrogeno al que están unidos forman un radical seleccionado del grupo que consiste en pirrolidino, piperidino, piperazino, morfolino, 4-tiomorfolino, 1,1-dioxido-2-tiomorfolinilo, azetidinilo, 2,3-dihidroisoindol-1-ilo, tiazolidin-3-ilo, 1,2,3,6-tetrahidropiridilo, hexahidro-1H-azepinilo, hexahidro-1H-1,4-diazepinilo, hexahidro-1,4-oxazepinilo, 12,3,4- tetrahidroisoquinolin-2-ilo, 2,5-diazabiciclo[2,2,1]heptilo, pirrolinilo, pirrolilo, imidazolidinilo, pirazolidinilo, 2-imidazolinilo, 2-pirazolinilo, imidazolilo, pirazolilo, triazolilo, piridinilo, piridazinilo, pirimidinilo, pirazinilo y triazinilo, cada radical opcionalmente sustituido con 1 2, 3 o 4 sustituyentes, cada sustituyente seleccionado, de modo independiente, de alquilo, haloalquilo, alquilcarbonilo, halo, arilalquilo, hidroxi, alquiloxi, amino, mono- o dialquilamino, aminoalquilo, mono- o dialquilaminoalquilo, alquiltio, alquiltioalquilo, arilo, piridilo, pirimidinilo, piperidinilo opcionalmente sustituido con alquilo o pirrolidinilo opcionalmente sustituido con arilalquilo; R4a y R5a junto con el átomo de nitrogeno al que están unidos forman un radical seleccionado del grupo que consiste en pirrolidino, piperidino, piperazino, morfolino, 4-tiomorfolino, 2,3-dihidroisoindol-1-ilo, tiazolidin-3-ilo, 1,2,3,6-tetrahidropiridilo, hexahidro-1H-azepinilo, hexahidro-1H-1,4-diazepinilo, hexahidro-1,4-oxazepinilo, 1,2,3,4-tetrahidroisoquinolin-2-ilo, pirrolinilo, pirrolilo, imidazolidinilo, pirazolidinilo, 2-imidazolinilo, 2-pirazolinilo, imidazolilo, pirazolilo, triazolilo, piridinilo, piridazinilo, pirimidinilo, pirazinilo y triazinilo, cada radical opcionalmente sustituido con 1, 2, 3 o 4 sustituyentes, cada sustituyente seleccionado, de modo independiente, de alquilo, haloalquilo, halo, arilalquilo, hidroxi, alquiloxi, amino, mono- o dialquilamino, alquiltio, alquiltioalquilo, arilo, piridilo o pirimidinilo; R6 es arilo1 o Het; R7 es hidrogeno, halo, alquilo, arilo o Het; R8 es hidrogeno o alquilo; R9 es oxo; o R8 y R9 forman juntos el radical -CH=CH-N=; R11 es hidrogeno o alquilo; arilo es un homociclo seleccionado de fenilo, naftilo, acenaftilo o tetrahidronaftilo, cada uno opcionalmente sustituido con 1, 2 o 3 sustituyentes, estando cada sustituyente seleccionado, de modo independiente, de hidroxi, halo, ciano, nitro, amino, mono- o dialquilamino, alquilo, alquenilo C2-6 opcionalmente sustituido con fenilo, haloalquilo, alquiloxi, haloalquiloxi, carboxilo, alquiloxicarbonilo, aminocarbonilo, morfolinilo o mono- o dialquilaminocarbonilo; arilo1 es un homociclo seleccionado de fenilo, naftilo, acenaftilo o tetrahidronaftilo, cada uno opcionalmente sustituido con 1, 2 o 3 sustituyentes, estando cada sustituyente seleccionado en modo independiente, de hidroxi, halo, ciano, nitro, amino, mono- o dialquilamino, alquilo, haloalquilo, alquiloxi, alquiltio, haloalquiloxi, carboxilo, alquiloxicarbonilo, aminocarbonilo, morfolinilo, Het o mono- o dialquilaminocarbonilo; Het es un heterociclo monocíclico seleccionado de N-fenoxipiperidinilo, piperidinilo, pirrolilo, pirazolilo, imidazolilo, furanilo, tienilo, oxazolilo, isoxazolilo, tiazolilo, isotiazolilo, piridinilo, pirimidinilo, pirazinilo o piridazinilo; o un heterociclo bicíclico seleccionado de quinolinilo, quinoxalinilo, indolilo, bencimidazolilo, benzoxazolilo, benzisoxazolilo, benzotiazolilo, benzisotiazolilo, benzofuranilo, benzotienilo, 2,3-dihidrobenzo[1,4]dioxinilo o benzo[1,3]dioxolilo; estando cada heterociclo monocíclico y bicíclico opcionalmente sustituido con 1, 2 o 3 sustituyentes, cada sustituyente seleccionado de modo independiente, de halo, hidroxi, alquilo o alquiloxi; uno de sus N-oxidos, una de sus sales farmacéuticamente aceptables o uno de sus solvatos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125546 | 2006-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064153A1 true AR064153A1 (es) | 2009-03-18 |
Family
ID=38038656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105446A AR064153A1 (es) | 2006-12-06 | 2007-12-05 | Derivados de quinolina antibacterianos. procesos de obtencion y composiciones farmaceuticas. |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US20100069366A1 (es) |
| EP (1) | EP2099762B1 (es) |
| JP (1) | JP5356244B2 (es) |
| KR (1) | KR101514992B1 (es) |
| CN (1) | CN101547907B (es) |
| AP (1) | AP2478A (es) |
| AR (1) | AR064153A1 (es) |
| AT (1) | ATE467619T1 (es) |
| AU (1) | AU2007328980B2 (es) |
| BR (1) | BRPI0719920B8 (es) |
| CA (1) | CA2668515C (es) |
| CL (1) | CL2007003519A1 (es) |
| CY (1) | CY1111188T1 (es) |
| DE (1) | DE602007006553D1 (es) |
| DK (1) | DK2099762T3 (es) |
| EA (1) | EA200970534A1 (es) |
| ES (1) | ES2345463T3 (es) |
| HK (1) | HK1137441A1 (es) |
| HR (1) | HRP20100428T1 (es) |
| IL (1) | IL199079A (es) |
| JO (1) | JO2684B1 (es) |
| ME (1) | ME01127B (es) |
| MX (1) | MX2009005982A (es) |
| MY (1) | MY145924A (es) |
| NO (1) | NO341996B1 (es) |
| NZ (1) | NZ576863A (es) |
| PL (1) | PL2099762T3 (es) |
| PT (1) | PT2099762E (es) |
| RS (1) | RS51382B (es) |
| SI (1) | SI2099762T1 (es) |
| TW (1) | TWI484959B (es) |
| UA (1) | UA101305C2 (es) |
| WO (1) | WO2008068266A1 (es) |
| ZA (1) | ZA200903947B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5857511B2 (ja) * | 2010-08-10 | 2016-02-10 | 住友化学株式会社 | 植物病害防除組成物およびその用途 |
| ES2607879T3 (es) | 2012-04-27 | 2017-04-04 | Janssen Pharmaceutica N.V. | Derivados de quinolina antibacterianos |
| JP6153604B2 (ja) | 2012-04-27 | 2017-06-28 | ヤンセン ファーマシューティカ エヌ．ベー． | 抗菌性キノリン誘導体 |
| CN105017147B (zh) * | 2014-04-30 | 2019-02-01 | 中国医学科学院药物研究所 | 一种回收和利用Bedaquiline立体化学异构体的方法 |
| CN105330595B (zh) * | 2014-07-14 | 2019-12-10 | 上海嘉坦医药科技有限公司 | 吡啶衍生物及其作为抗分支杆菌的应用 |
| CA2954872C (en) * | 2014-07-14 | 2019-08-13 | Cisen Pharmaceutical Co., Ltd. | Pyridine derivatives and anti-mycobacterial use thereof |
| CN108473428B (zh) * | 2016-01-13 | 2021-07-23 | 上海嘉坦医药科技有限公司 | 一种吡啶衍生物类化合物的制备方法及其中间体和晶型 |
| JP6997095B2 (ja) * | 2016-03-07 | 2022-02-03 | ザ グローバル アライアンス フォー ティービー ドラッグ デベロップメント， インコーポレイテッド | 抗菌性化合物およびその使用 |
| CN109384716B (zh) * | 2017-08-11 | 2021-06-29 | 海创药业股份有限公司 | 一种氘代喹啉化合物及其制备和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2270123A1 (en) * | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| DE60332023D1 (de) * | 2002-07-25 | 2010-05-20 | Janssen Pharmaceutica Nv | Chinolinderivate und deren verwendung als mycobakterielle inhibitoren |
| KR101150172B1 (ko) * | 2004-01-23 | 2012-05-25 | 얀센 파마슈티카 엔.브이. | 치환된 퀴놀린 및 마이코박테리아 저해제로서의 용도 |
| ATE444068T1 (de) * | 2004-01-23 | 2009-10-15 | Janssen Pharmaceutica Nv | Chinolinderivate und ihre verwendung als mycobakterielle inhibitoren |
| MXPA06008596A (es) * | 2004-01-29 | 2006-08-28 | Janssen Pharmaceutica Nv | Derivados de quinolina para uso como inhibidores micobacterianos. |
| PT1753427E (pt) * | 2004-05-28 | 2008-07-04 | Janssen Pharmaceutica Nv | Utilização de derivados quinolina substituídos para o tratamento de doenças micobacterianas resistentes a fármacos |
| EP1677083A1 (fr) * | 2004-12-22 | 2006-07-05 | Roxer Industries S.A. | Capteur de niveau d'un liquide. |
| EE05697B1 (et) * | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
-
2007
- 2007-11-29 JO JO2007503A patent/JO2684B1/en active
- 2007-12-04 US US12/515,593 patent/US20100069366A1/en not_active Abandoned
- 2007-12-04 KR KR1020097013405A patent/KR101514992B1/ko active IP Right Grant
- 2007-12-04 BR BRPI0719920A patent/BRPI0719920B8/pt active IP Right Grant
- 2007-12-04 UA UAA200904216A patent/UA101305C2/ru unknown
- 2007-12-04 PT PT07857252T patent/PT2099762E/pt unknown
- 2007-12-04 EP EP07857252A patent/EP2099762B1/en active Active
- 2007-12-04 DE DE602007006553T patent/DE602007006553D1/de active Active
- 2007-12-04 NZ NZ576863A patent/NZ576863A/en unknown
- 2007-12-04 ES ES07857252T patent/ES2345463T3/es active Active
- 2007-12-04 CN CN200780044917XA patent/CN101547907B/zh active Active
- 2007-12-04 PL PL07857252T patent/PL2099762T3/pl unknown
- 2007-12-04 CA CA2668515A patent/CA2668515C/en active Active
- 2007-12-04 SI SI200730306T patent/SI2099762T1/sl unknown
- 2007-12-04 MX MX2009005982A patent/MX2009005982A/es active IP Right Grant
- 2007-12-04 EA EA200970534A patent/EA200970534A1/ru unknown
- 2007-12-04 DK DK07857252.6T patent/DK2099762T3/da active
- 2007-12-04 RS RSP-2010/0351A patent/RS51382B/en unknown
- 2007-12-04 ME MEP-2010-128A patent/ME01127B/me unknown
- 2007-12-04 AT AT07857252T patent/ATE467619T1/de active
- 2007-12-04 AU AU2007328980A patent/AU2007328980B2/en not_active Ceased
- 2007-12-04 JP JP2009539737A patent/JP5356244B2/ja not_active Expired - Fee Related
- 2007-12-04 WO PCT/EP2007/063312 patent/WO2008068266A1/en active Application Filing
- 2007-12-04 AP AP2009004872A patent/AP2478A/xx active
- 2007-12-04 MY MYPI20092285A patent/MY145924A/en unknown
- 2007-12-05 AR ARP070105446A patent/AR064153A1/es unknown
- 2007-12-05 CL CL200703519A patent/CL2007003519A1/es unknown
- 2007-12-05 TW TW096146219A patent/TWI484959B/zh active
-
2009
- 2009-06-02 IL IL199079A patent/IL199079A/en active IP Right Grant
- 2009-06-05 ZA ZA200903947A patent/ZA200903947B/xx unknown
- 2009-07-06 NO NO20092539A patent/NO341996B1/no unknown
-
2010
- 2010-02-04 HK HK10101244.0A patent/HK1137441A1/xx unknown
- 2010-08-02 HR HR20100428T patent/HRP20100428T1/hr unknown
- 2010-08-09 CY CY20101100742T patent/CY1111188T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR064153A1 (es) | Derivados de quinolina antibacterianos. procesos de obtencion y composiciones farmaceuticas. | |
| AR064151A1 (es) | Derivados de quinolina antibacterianos, composiciones farmaceuticas que los contienen y metodo de preparacion. | |
| RS52431B (en) | QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS | |
| AR054889A1 (es) | Derivados de quinolina como agentes bacterianos | |
| AR049127A1 (es) | Uso de derivados quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos | |
| TW200626138A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626154A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626139A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626592A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626153A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626155A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| WO2006078621A3 (en) | 2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders | |
| TW200624427A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626572A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| AR051790A1 (es) | Tratamiento de tuberculosis latente | |
| RS52990B (en) | 1H BENZIMIDAZOL-4-CARBOXAMIDES SUBSTITUTED WITH QUATERNER CARBON IN POSITION-2 AS INHIBITORS FOR USE IN CANCER TREATMENT | |
| NZ597533A (en) | Apoptosis signal-regulating kinase inhibitors | |
| BRPI0413059A (pt) | derivados de piridila e seu uso como agentes terapêuticos | |
| MX2007000028A (es) | Derivados de nicotinamida y su uso como agentes terapeuticos. | |
| AR052019A1 (es) | COMPUESTOS HETEROCICLICOS, PROCESOS DE PREPARACIoN Y MÉTODO PARA TRATAR ENFERMEDADES HIPERPROLIFERATIVAS | |
| MX2009012613A (es) | Tiazoles substituidos por heteroarilo y su uso como agentes antivirales. | |
| AR054587A1 (es) | Derivados de quinolina antibacterianos | |
| HRP20110540T1 (hr) | Antibakterijski derivati kinolina | |
| JP2010511667A5 (es) | ||
| AR064150A1 (es) | Derivados antibacterianos de quinolina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |