CY1107276T1 - Μεταλλαγμενη ολοτοξινη χολερας ως ενα ανοσοενισχυτικο - Google Patents
Μεταλλαγμενη ολοτοξινη χολερας ως ενα ανοσοενισχυτικοInfo
- Publication number
- CY1107276T1 CY1107276T1 CY20081100125T CY081100125T CY1107276T1 CY 1107276 T1 CY1107276 T1 CY 1107276T1 CY 20081100125 T CY20081100125 T CY 20081100125T CY 081100125 T CY081100125 T CY 081100125T CY 1107276 T1 CY1107276 T1 CY 1107276T1
- Authority
- CY
- Cyprus
- Prior art keywords
- amino acid
- cholera
- allotoxin
- chlora
- immune
- Prior art date
Links
- 235000001014 amino acid Nutrition 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 206010008631 Cholera Diseases 0.000 abstract 3
- 239000002671 adjuvant Substances 0.000 abstract 2
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 239000003053 toxin Substances 0.000 abstract 2
- 231100000765 toxin Toxicity 0.000 abstract 2
- 108700012359 toxins Proteins 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 229930186900 holotoxin Natural products 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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- A—HUMAN NECESSITIES
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- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Biological Depolymerization Polymers (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Μια μεταλλαγμένη ολοτοξίνη χολέρας η οποία παρουσιάζει μια σημειακή μετάλλαξη στο αμινοξύ 29 της Α υπομονάδας, όπου το κατάλοιπο γλουταμινικού οξέος αντικαθίσταται από ένα αμινοξύ διαφορετικό του ασπαρτικού οξέος, είναι χρήσιμη ως ένα ανοσοενισχυτικό σε μια αντιγονική σύνθεση για ενίσχυση της άνοσης απόκρισης σε έναν σπονδυλωτό ξενιστή προς ένα επιλεγμένο αντιγόνο από ένα παθογόνο βακτήριο, ιό, μύκητα ή παράσιτο. Σε μια συγκεκριμένη υλοποίηση, το αμινοξύ 29 είναι ιστιδίνη. Η μεταλλαγμένη ολοτοξίνη χολέρας μπορεί να περιέχει μία επιπρόσθετη μετάλλαξη στην Α υπομονάδα σε μια θέση διαφορετική από αυτή του αμινοξέος 29. Η αντιγονική σύνθεση μπορεί να περιλαμβάνει ένα δεύτερο ανοσοενισχυτικό εκτός από την μεταλλαγμένη ολοτοξίνη χολέρας.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10243098P | 1998-09-30 | 1998-09-30 | |
EP99951639A EP1117435B1 (en) | 1998-09-30 | 1999-09-30 | Mutant cholera holotoxin as an adjuvant |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107276T1 true CY1107276T1 (el) | 2012-11-21 |
Family
ID=22289805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100125T CY1107276T1 (el) | 1998-09-30 | 2008-02-01 | Μεταλλαγμενη ολοτοξινη χολερας ως ενα ανοσοενισχυτικο |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1117435B1 (el) |
JP (1) | JP4673974B2 (el) |
KR (1) | KR100659803B1 (el) |
CN (1) | CN1197618C (el) |
AT (1) | ATE378066T1 (el) |
AU (1) | AU770333B2 (el) |
BR (1) | BR9914160A (el) |
CA (1) | CA2344740C (el) |
CY (1) | CY1107276T1 (el) |
DE (1) | DE69937571T2 (el) |
DK (1) | DK1117435T3 (el) |
ES (1) | ES2293735T3 (el) |
IL (2) | IL142231A0 (el) |
MX (1) | MXPA01003228A (el) |
PT (1) | PT1117435E (el) |
WO (1) | WO2000018434A1 (el) |
Families Citing this family (70)
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GB9513371D0 (en) | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
ATE275970T1 (de) | 1993-10-05 | 2004-10-15 | Celltech Pharmaceuticals Ltd | Impfstoffzusammensetzungen |
GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
GB9622660D0 (en) | 1996-10-31 | 1997-01-08 | Biocine Spa | Immunogenic detoxified mutant toxin |
US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
US7115730B1 (en) | 1999-04-27 | 2006-10-03 | Chiron Srl | Immunogenic detoxified mutant E. coli LT-A-toxin |
EP1294892B1 (en) | 2000-06-23 | 2007-10-17 | Wyeth Holdings Corporation | Assembly of wild-type and chimeric influenza virus-like particles (vlps) |
DE60144198D1 (de) | 2000-12-28 | 2011-04-21 | Wyeth Llc | Rekombinantes schutzprotein aus streptococcus pneumoniae |
KR100886095B1 (ko) | 2001-04-16 | 2009-02-27 | 와이어쓰 홀딩스 코포레이션 | 폴리펩티드 항원을 암호화하는 신규한 스트렙토코쿠스 뉴모니애 개방형 판독 프레임 및 이를 포함하는 조성물 |
CN1541111A (zh) | 2001-06-07 | 2004-10-27 | ���Ͽع�����˾ | 作为佐剂的霍乱全毒素的突变形式 |
IL159210A0 (en) | 2001-06-07 | 2004-06-01 | Wyeth Corp | Mutant forms of cholera holotoxin as an adjuvant |
AU2002355197A1 (en) | 2001-07-27 | 2003-02-17 | Chiron Srl | Meningococcus adhesins nada, app and orf 40 |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
GB0129007D0 (en) * | 2001-12-04 | 2002-01-23 | Chiron Spa | Adjuvanted antigenic meningococcal compositions |
CN100593544C (zh) | 2002-03-15 | 2010-03-10 | 惠氏控股有限公司 | 酶活性减少的非典型流感嗜血杆菌的p4蛋白突变体 |
US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
EP1603950A2 (en) * | 2003-03-17 | 2005-12-14 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
EP1618185A4 (en) * | 2003-04-16 | 2009-05-27 | Wyeth Corp | NEW IMMUNOLOGICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCCOULAR DISEASE |
WO2005020902A2 (en) | 2003-08-21 | 2005-03-10 | Cytokine Pharmasciences, Inc. | Compositions and methods for treating and diagnosing irritable bowel syndrome |
PT1701968E (pt) | 2003-12-17 | 2015-09-11 | Wyeth Llc | Conjugados de transportadores de péptidos imunogénicos e métodos para produzir os mesmos |
DK2336147T3 (da) | 2003-12-17 | 2014-06-10 | Wyeth Llc | Beta-immunogen-peptid-bærerkonjugater og fremgangsmåder til fremstilling deraf |
GB0410220D0 (en) | 2004-05-07 | 2004-06-09 | Kirkham Lea Ann | Mutant pneumolysin proteins |
AU2005247910A1 (en) | 2004-05-21 | 2005-12-08 | Wyeth | Altered fibronectin-binding protein of Staphylococcus aureus |
TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
AU2005294528B2 (en) | 2004-10-06 | 2011-04-07 | Medimmune, Llc | Refrigerator-temperature stable influenza vaccine compositions |
AU2005333603A1 (en) | 2004-10-21 | 2007-01-04 | Wyeth | Immunogenic compositions of Staphylococcus epidermidis polypeptide antigens |
US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
EP2425854A1 (en) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
CN104878064A (zh) | 2006-07-13 | 2015-09-02 | 惠氏公司 | 糖蛋白的产生 |
EP2064315B1 (en) | 2006-11-03 | 2015-05-13 | Wyeth LLC | Glycolysis-inhibiting substances in cell culture |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
DK2115126T3 (en) | 2007-03-02 | 2015-05-04 | Wyeth Llc | Use of copper and glutamate in cell culture for the preparation of polypeptides |
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MX2011004755A (es) | 2008-11-05 | 2011-10-10 | Wyeth Llc | Composicion inmunogenica multicomponente para la prevencion de enfermedad estreptococica beta-hemolitica (bhs). |
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KR20130086154A (ko) | 2010-05-19 | 2013-07-31 | 바이오프로퍼티스 피티와이 엘티디 | 약독화된 미코플라스마와 관련된 방법 |
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KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
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IL101715A (en) * | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
GB9513371D0 (en) * | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
JPH11510164A (ja) * | 1995-07-26 | 1999-09-07 | マキシム ファーマシューティカルズ | ポリヌクレオチドの粘膜送達 |
GB9603314D0 (en) * | 1996-02-16 | 1996-04-17 | Biocine Spa | Immunogenic detoxified mutant toxins |
WO1998045324A1 (en) * | 1997-04-04 | 1998-10-15 | The Uab Research Foundation | Use of cholera toxin mutants as mucosal adjuvants |
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1999
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- 1999-09-30 BR BR9914160-4A patent/BR9914160A/pt not_active Application Discontinuation
- 1999-09-30 DK DK99951639T patent/DK1117435T3/da active
- 1999-09-30 CA CA2344740A patent/CA2344740C/en not_active Expired - Fee Related
- 1999-09-30 ES ES99951639T patent/ES2293735T3/es not_active Expired - Lifetime
- 1999-09-30 PT PT99951639T patent/PT1117435E/pt unknown
- 1999-09-30 IL IL14223199A patent/IL142231A0/xx unknown
- 1999-09-30 AU AU64039/99A patent/AU770333B2/en not_active Ceased
- 1999-09-30 EP EP99951639A patent/EP1117435B1/en not_active Expired - Lifetime
- 1999-09-30 JP JP2000571951A patent/JP4673974B2/ja not_active Expired - Fee Related
- 1999-09-30 DE DE69937571T patent/DE69937571T2/de not_active Expired - Lifetime
- 1999-09-30 KR KR1020017003968A patent/KR100659803B1/ko not_active IP Right Cessation
- 1999-09-30 CN CNB998115576A patent/CN1197618C/zh not_active Expired - Fee Related
- 1999-09-30 WO PCT/US1999/022520 patent/WO2000018434A1/en active IP Right Grant
- 1999-09-30 AT AT99951639T patent/ATE378066T1/de not_active IP Right Cessation
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CA2344740C (en) | 2011-11-22 |
WO2000018434A1 (en) | 2000-04-06 |
CN1320043A (zh) | 2001-10-31 |
IL142231A0 (en) | 2002-03-10 |
EP1117435A1 (en) | 2001-07-25 |
CA2344740A1 (en) | 2000-04-06 |
ATE378066T1 (de) | 2007-11-15 |
PT1117435E (pt) | 2008-02-21 |
DK1117435T3 (da) | 2008-03-17 |
CN1197618C (zh) | 2005-04-20 |
IL142231A (en) | 2010-05-31 |
KR20010085859A (ko) | 2001-09-07 |
BR9914160A (pt) | 2001-06-26 |
DE69937571D1 (de) | 2007-12-27 |
AU6403999A (en) | 2000-04-17 |
DE69937571T2 (de) | 2008-09-04 |
MXPA01003228A (es) | 2003-06-24 |
ES2293735T3 (es) | 2008-03-16 |
JP2002525093A (ja) | 2002-08-13 |
KR100659803B1 (ko) | 2006-12-19 |
EP1117435B1 (en) | 2007-11-14 |
AU770333B2 (en) | 2004-02-19 |
JP4673974B2 (ja) | 2011-04-20 |
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