DE60144198D1 - Rekombinantes schutzprotein aus streptococcus pneumoniae - Google Patents
Rekombinantes schutzprotein aus streptococcus pneumoniaeInfo
- Publication number
- DE60144198D1 DE60144198D1 DE60144198T DE60144198T DE60144198D1 DE 60144198 D1 DE60144198 D1 DE 60144198D1 DE 60144198 T DE60144198 T DE 60144198T DE 60144198 T DE60144198 T DE 60144198T DE 60144198 D1 DE60144198 D1 DE 60144198D1
- Authority
- DE
- Germany
- Prior art keywords
- streptococcus pneumoniae
- recombinant
- ppp
- acid sequences
- protection protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000193998 Streptococcus pneumoniae Species 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56944—Streptococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Otolaryngology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25884100P | 2000-12-28 | 2000-12-28 | |
PCT/US2001/049650 WO2002053761A2 (en) | 2000-12-28 | 2001-12-28 | Recombinant protective protein from $i(streptococcus pneumoniae) |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60144198D1 true DE60144198D1 (de) | 2011-04-21 |
Family
ID=22982345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60144198T Expired - Lifetime DE60144198D1 (de) | 2000-12-28 | 2001-12-28 | Rekombinantes schutzprotein aus streptococcus pneumoniae |
Country Status (15)
Country | Link |
---|---|
US (4) | US7118756B2 (de) |
EP (2) | EP2402359A1 (de) |
JP (2) | JP4445200B2 (de) |
KR (1) | KR20030074680A (de) |
CN (1) | CN100422210C (de) |
AT (1) | ATE501161T1 (de) |
AU (1) | AU2002227450B2 (de) |
BR (1) | BR0116756A (de) |
CA (1) | CA2432426A1 (de) |
DE (1) | DE60144198D1 (de) |
DK (1) | DK1355918T5 (de) |
ES (1) | ES2359625T3 (de) |
IL (1) | IL155726A0 (de) |
MX (1) | MXPA03005386A (de) |
WO (1) | WO2002053761A2 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE501161T1 (de) * | 2000-12-28 | 2011-03-15 | Wyeth Llc | Rekombinantes schutzprotein aus streptococcus pneumoniae |
EP2261241A1 (de) | 2001-04-16 | 2010-12-15 | Wyeth Holdings Corporation | Polypeptidantigene codierende offene leseraster aus streptococcus pneumoniae und verwendungen davon |
ME01334B (me) | 2005-04-08 | 2013-12-20 | Wyeth Llc | Polivalentni pripravak konjugata pneumokoknog polisaharida s proteinom |
US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
EP2091968A2 (de) | 2006-10-26 | 2009-08-26 | Novo Nordisk A/S | Il-21-varianten |
KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
KR20140075201A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
WO2015056187A1 (en) * | 2013-10-18 | 2015-04-23 | Dr. Reddy’S Laboratories Limited | In-vitro method for determining fate of polypeptide variant |
WO2015095868A1 (en) | 2013-12-20 | 2015-06-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
SG11201900794PA (en) | 2016-08-05 | 2019-02-27 | Sanofi Pasteur Inc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
CA3031797A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
EP3576759A4 (de) | 2017-01-31 | 2020-11-11 | Merck Sharp & Dohme Corp. | Verfahren zur herstellung von kapselpolysaccharidproteinkonjugaten aus streptococcus pneumoniae serotyp 19f |
AU2018328037B2 (en) | 2017-09-07 | 2024-03-07 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
SG11202005255PA (en) | 2017-12-06 | 2020-07-29 | Merck Sharp & Dohme | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
TWI788610B (zh) | 2018-12-19 | 2023-01-01 | 美商默沙東有限責任公司 | 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法 |
CA3148824A1 (en) | 2019-07-31 | 2021-02-04 | Sanofi Pasteur Inc. | Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same |
TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
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-
2001
- 2001-12-28 AT AT01996301T patent/ATE501161T1/de active
- 2001-12-28 JP JP2002555266A patent/JP4445200B2/ja not_active Expired - Fee Related
- 2001-12-28 ES ES01996301T patent/ES2359625T3/es not_active Expired - Lifetime
- 2001-12-28 KR KR10-2003-7008585A patent/KR20030074680A/ko active IP Right Grant
- 2001-12-28 WO PCT/US2001/049650 patent/WO2002053761A2/en active Application Filing
- 2001-12-28 IL IL15572601A patent/IL155726A0/xx unknown
- 2001-12-28 BR BR0116756-1A patent/BR0116756A/pt not_active IP Right Cessation
- 2001-12-28 AU AU2002227450A patent/AU2002227450B2/en not_active Ceased
- 2001-12-28 DK DK01996301.6T patent/DK1355918T5/da active
- 2001-12-28 US US10/433,385 patent/US7118756B2/en not_active Expired - Fee Related
- 2001-12-28 EP EP10184194A patent/EP2402359A1/de not_active Withdrawn
- 2001-12-28 CA CA002432426A patent/CA2432426A1/en not_active Abandoned
- 2001-12-28 CN CNB018215564A patent/CN100422210C/zh not_active Expired - Fee Related
- 2001-12-28 EP EP01996301A patent/EP1355918B9/de not_active Expired - Lifetime
- 2001-12-28 DE DE60144198T patent/DE60144198D1/de not_active Expired - Lifetime
- 2001-12-28 MX MXPA03005386A patent/MXPA03005386A/es active IP Right Grant
-
2006
- 2006-08-31 US US11/513,418 patent/US8124750B2/en not_active Expired - Fee Related
- 2006-08-31 US US11/513,417 patent/US8114417B2/en not_active Expired - Fee Related
-
2009
- 2009-06-18 JP JP2009145654A patent/JP2009201527A/ja active Pending
-
2012
- 2012-01-11 US US13/347,830 patent/US20120141522A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1355918B1 (de) | 2011-03-09 |
EP1355918B9 (de) | 2012-01-25 |
EP1355918A2 (de) | 2003-10-29 |
ES2359625T3 (es) | 2011-05-25 |
IL155726A0 (en) | 2003-11-23 |
KR20030074680A (ko) | 2003-09-19 |
JP2005504501A (ja) | 2005-02-17 |
ATE501161T1 (de) | 2011-03-15 |
US8114417B2 (en) | 2012-02-14 |
US7118756B2 (en) | 2006-10-10 |
US20120141522A1 (en) | 2012-06-07 |
EP2402359A1 (de) | 2012-01-04 |
US20040052816A1 (en) | 2004-03-18 |
AU2002227450B2 (en) | 2008-02-28 |
WO2002053761A2 (en) | 2002-07-11 |
JP2009201527A (ja) | 2009-09-10 |
DK1355918T3 (da) | 2011-05-16 |
US8124750B2 (en) | 2012-02-28 |
CA2432426A1 (en) | 2002-07-11 |
JP4445200B2 (ja) | 2010-04-07 |
CN100422210C (zh) | 2008-10-01 |
ES2359625T9 (es) | 2012-02-16 |
EP1355918A4 (de) | 2006-07-19 |
WO2002053761A3 (en) | 2003-03-27 |
AU2002227450A2 (en) | 2002-07-16 |
BR0116756A (pt) | 2005-01-04 |
DK1355918T5 (da) | 2012-02-20 |
US20070129322A1 (en) | 2007-06-07 |
CN1529710A (zh) | 2004-09-15 |
MXPA03005386A (es) | 2004-04-20 |
US20070141085A1 (en) | 2007-06-21 |
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