MXPA03011135A - Formas mutantes de holotoxina de colera como adyuvante. - Google Patents

Formas mutantes de holotoxina de colera como adyuvante.

Info

Publication number
MXPA03011135A
MXPA03011135A MXPA03011135A MXPA03011135A MXPA03011135A MX PA03011135 A MXPA03011135 A MX PA03011135A MX PA03011135 A MXPA03011135 A MX PA03011135A MX PA03011135 A MXPA03011135 A MX PA03011135A MX PA03011135 A MXPA03011135 A MX PA03011135A
Authority
MX
Mexico
Prior art keywords
adjuvant
mutant forms
cholera holotoxin
cholera
mutant
Prior art date
Application number
MXPA03011135A
Other languages
English (en)
Inventor
G Jobling Michael
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA03011135A publication Critical patent/MXPA03011135A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan holotoxinas mutantes de colera que tienen sustituciones o inserciones de aminoacidos sencillas o dobles que presentan toxicidad reducida en comparacion con la holotoxina de colera de tipo silvestre. Las holotoxinas de colera mutantes son utiles como adyuvantes en composiciones antigenicas para mejorar la respuesta inmunologica en un hospedador vertebrado a un antigeno seleccionado a partir de una bacteria, virus, hongo o parasito patogenico, una celula cancerosa, una celula tumoral, un alergeno o una molecula propia.
MXPA03011135A 2001-06-07 2002-06-05 Formas mutantes de holotoxina de colera como adyuvante. MXPA03011135A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29653101P 2001-06-07 2001-06-07
PCT/US2002/021008 WO2002098369A2 (en) 2001-06-07 2002-06-05 Mutant forms of cholera holotoxin as an adjuvant

Publications (1)

Publication Number Publication Date
MXPA03011135A true MXPA03011135A (es) 2004-09-08

Family

ID=23142408

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011135A MXPA03011135A (es) 2001-06-07 2002-06-05 Formas mutantes de holotoxina de colera como adyuvante.

Country Status (11)

Country Link
US (3) US7332174B2 (es)
EP (1) EP1404279A4 (es)
JP (2) JP2005508143A (es)
KR (2) KR20080078717A (es)
CN (1) CN1541111A (es)
AU (1) AU2002322380B2 (es)
BR (1) BR0210216A (es)
CA (1) CA2449670A1 (es)
IL (2) IL159209A0 (es)
MX (1) MXPA03011135A (es)
WO (1) WO2002098369A2 (es)

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Also Published As

Publication number Publication date
WO2002098369A3 (en) 2003-02-20
IL159209A0 (en) 2004-06-01
CN1541111A (zh) 2004-10-27
EP1404279A2 (en) 2004-04-07
KR20040044412A (ko) 2004-05-28
BR0210216A (pt) 2004-06-08
IL159209A (en) 2010-04-29
KR100877258B1 (ko) 2009-01-12
US20080311144A1 (en) 2008-12-18
WO2002098369A2 (en) 2002-12-12
JP2005508143A (ja) 2005-03-31
US20040176571A1 (en) 2004-09-09
CA2449670A1 (en) 2002-12-12
EP1404279A4 (en) 2007-08-08
JP2009112301A (ja) 2009-05-28
AU2002322380B2 (en) 2006-11-02
KR20080078717A (ko) 2008-08-27
US7332174B2 (en) 2008-02-19
US20070122428A1 (en) 2007-05-31
US7658931B2 (en) 2010-02-09

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