PA8843701A1 - Derivados de indolina y métodos para usarlos - Google Patents
Derivados de indolina y métodos para usarlosInfo
- Publication number
- PA8843701A1 PA8843701A1 PA20098843701A PA8843701A PA8843701A1 PA 8843701 A1 PA8843701 A1 PA 8843701A1 PA 20098843701 A PA20098843701 A PA 20098843701A PA 8843701 A PA8843701 A PA 8843701A PA 8843701 A1 PA8843701 A1 PA 8843701A1
- Authority
- PA
- Panama
- Prior art keywords
- methods
- indoline derivatives
- compounds
- indoline
- compositions
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/30—Psychoses; Psychiatry
Abstract
DERIVADOS DE INDOL Y DE INDOLINA DE FÓRMULA(I),(II),(III),(IV),(V)O(VI)DONDE A,R1,R2,R3,R4,R5,U,V,W,X,Y y Z SON COMO SE LOS DEFINE EN LA MEMORIA DESCRIPTIVA.COMPOSICIONES QUE COMPRENDEN ESTOS COMPUESTOS,MÉTODOS PARA TRATAR CONDICIONES DE ENFERMEDAD MEDIANTE EL USO DE ESTOS COMPUESTOS Y DE ESTAS COMPOSICIONES Y MÉTODOS PAR IDENTIFICAR ESTOS COMPUESTOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10105408P | 2008-09-29 | 2008-09-29 | |
US22545209P | 2009-07-14 | 2009-07-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8843701A1 true PA8843701A1 (es) | 2010-05-26 |
Family
ID=42060424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20098843701A PA8843701A1 (es) | 2008-09-29 | 2009-09-28 | Derivados de indolina y métodos para usarlos |
Country Status (11)
Country | Link |
---|---|
US (2) | US9063126B2 (es) |
EP (1) | EP2344505A2 (es) |
JP (1) | JP2012504137A (es) |
CN (1) | CN102227431A (es) |
AR (1) | AR073701A1 (es) |
CA (1) | CA2737031A1 (es) |
MX (1) | MX2011003435A (es) |
PA (1) | PA8843701A1 (es) |
TW (1) | TW201018694A (es) |
UY (1) | UY32147A (es) |
WO (1) | WO2010036998A2 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
TWI450900B (zh) | 2008-03-24 | 2014-09-01 | Medivation Technologies Inc | 橋聯雜環化合物及使用方法 |
US9625475B2 (en) * | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
AR073924A1 (es) | 2008-10-31 | 2010-12-09 | Medivation Technologies Inc | Azepino[4, 5-b]indoles, una composicion farmaceutica y kits que los comprenden y su uso en la modulacion de un receptor de histamina. |
CN102480955B (zh) | 2009-04-29 | 2015-08-05 | 梅迪维新技术公司 | 吡啶并[4,3-b]吲哚类和使用方法 |
JP5779183B2 (ja) | 2009-09-23 | 2015-09-16 | メディベイション テクノロジーズ, インコーポレイテッド | ピリド[4,3−b]インドールおよび使用方法 |
CN102724875B (zh) | 2009-09-23 | 2015-05-27 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚化合物及其使用方法 |
CN102711466A (zh) | 2009-09-23 | 2012-10-03 | 梅迪维新技术公司 | 桥连杂环化合物及其使用方法 |
WO2011084433A2 (en) * | 2009-12-17 | 2011-07-14 | Abbott Laboratories | Aza-bridged ring-fused indoles and indolines |
TWI485152B (zh) * | 2009-12-17 | 2015-05-21 | Abbvie Inc | 橋頭胺環稠合之吲哚及二氫吲哚 |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
WO2011103485A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9187471B2 (en) * | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
JP2014505737A (ja) | 2011-02-18 | 2014-03-06 | メディベイション テクノロジーズ, インコーポレイテッド | 糖尿病を処置する化合物および方法 |
US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
WO2012112962A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
US20140303144A1 (en) | 2011-02-18 | 2014-10-09 | Medivation Technologies, Inc. | Compounds and methods of treating hypertension |
US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
WO2013057944A1 (ja) | 2011-10-19 | 2013-04-25 | 興和株式会社 | 新規なスピロインドリン化合物、及びそれを含有する医薬 |
CA2855994A1 (en) * | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Phosphate esters of noribogaine |
CA2855990A1 (en) * | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Sulfate esters of noribogaine |
WO2013177241A1 (en) | 2012-05-22 | 2013-11-28 | Trustees Of Dartmouth College | Method for synthesizing cycloalkanyl(b}indoles, cycloalkanyl(b) benzofurans, cycloalkanyl(b)benzothiophenes, compounds and methods of use |
US9783535B2 (en) | 2012-12-20 | 2017-10-10 | Demerx, Inc. | Substituted noribogaine |
CN114409680B (zh) * | 2018-01-19 | 2023-11-21 | 上海怡立舍生物技术有限公司 | Ppar激动剂及其应用 |
CN113121543B (zh) * | 2021-04-26 | 2022-03-15 | 重庆理工大学 | 一种吖庚环并[4,5-b]吲哚化合物的制备方法 |
CN116589726B (zh) * | 2023-07-11 | 2023-09-22 | 中北大学 | 一种检测酪氨酸的复合膜传感器的制备方法 |
Family Cites Families (36)
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US3409628A (en) | 1966-05-12 | 1968-11-05 | Hoffmann La Roche | 5-(3-pyridylethyl)pyridoindole derivatives |
DE2854941A1 (de) | 1978-12-20 | 1980-07-10 | Troponwerke Gmbh & Co Kg | Indolo eckige klammer auf 3.2-b eckige klammer zu chinuclidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4591983A (en) | 1984-07-09 | 1986-05-27 | Teknowledge, Inc. | Hierarchical knowledge system |
DE3856594D1 (de) | 1987-05-04 | 2008-11-27 | Bonnie Davis | Mittel zur behandlung der alzheimer-krankheit |
US5250537A (en) | 1992-03-13 | 1993-10-05 | Scios Nova Inc. | 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole,-6,7,8,9,10-hexahydro-7,11-imino-5H-cyclooct[b]indole and substituted derivatives |
US5688807A (en) | 1994-03-11 | 1997-11-18 | Eli Lilly And Company | Method for treating 5HT2B receptor related conditions |
RU2106864C1 (ru) | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
DE19615265A1 (de) | 1996-04-18 | 1997-12-04 | Bayer Ag | Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole |
US5811551A (en) | 1996-08-13 | 1998-09-22 | Merck & Co., Inc. | Palladium catalyzed indolization |
NZ516031A (en) | 1999-06-15 | 2003-10-31 | Bristol Myers Squibb Pharma Co | Substituted heterocycle fused gamma-carbolines |
EP1219607B1 (en) | 1999-09-02 | 2011-04-06 | Shionogi & Co., Ltd. | Integrase inhibitors containing aromatic heterocycle derivatives |
CO5300399A1 (es) | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen |
PE20020510A1 (es) | 2000-09-20 | 2002-06-12 | Upjohn Co | DERIVADOS DE AZEPILO [4,5b] INDOLINA SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE SEROTONINA (5-HT) |
ATE360422T1 (de) | 2001-06-05 | 2007-05-15 | Lilly Icos Llc | Tetrazyklische verbindungen als pde5-inhibitoren |
EP1414819B1 (en) | 2001-08-08 | 2005-10-12 | Pharmacia & Upjohn Company LLC | THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES |
WO2004063156A1 (en) | 2003-01-08 | 2004-07-29 | Biovitrum Ab | Novel indole derivates as fabp-4 inhibitors |
US20050137220A1 (en) * | 2003-07-23 | 2005-06-23 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
US7309699B2 (en) | 2003-12-22 | 2007-12-18 | Abbott Laboratories | 3-Quinuclidinyl amino-substituted biaryl derivatives |
NZ550148A (en) | 2004-03-09 | 2010-07-30 | Boehringer Ingelheim Pharma | 3-'4-heterocyclyl-1,2,3,-triazol-1-yl-N-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases |
US7592454B2 (en) | 2004-04-14 | 2009-09-22 | Bristol-Myers Squibb Company | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists |
AU2006275694A1 (en) | 2005-07-28 | 2007-02-08 | Bristol-Myers Squibb Company | Substituted tetrahydro-1H-pyrido(4,3,b)indoles as serotonin receptor agonists and antagonists |
EP1747779A1 (en) | 2005-07-28 | 2007-01-31 | Laboratorios Del Dr. Esteve, S.A. | Tetrahydro-b-carbolin-sulfonamide derivatives as 5-HT6 ligands |
JP5495206B2 (ja) | 2006-10-24 | 2014-05-21 | コンジエニア・ソシエタ・ア・レスポンサビリタ・リミタータ | 変性性組織障害をmptの阻害により防止するための薬剤としてのフェニル置換マレイミド |
JP2010507672A (ja) | 2006-10-27 | 2010-03-11 | メディベイション ニューロロジー, インコーポレイテッド | アルツハイマー病を治療するための方法および組み合わせ治療 |
RU2329044C1 (ru) | 2006-11-16 | 2008-07-20 | Андрей Александрович Иващенко | Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство |
FR2911142A1 (fr) * | 2007-01-05 | 2008-07-11 | Servier Lab | Nouveaux derives aminopyrrolo[1,2-a]indole et aminopyridazino[1,6-a]indole,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
TW200848417A (en) * | 2007-02-22 | 2008-12-16 | Organon Nv | Indole derivatives |
BRPI0808090A2 (pt) * | 2007-03-06 | 2014-06-17 | Astrazeneca Ab | Composto, composição farmacêutica, e, método in vivo para medir depósitos de amilóide em um paciente |
KR102372149B1 (ko) | 2007-03-12 | 2022-03-07 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
BRPI0813306A2 (pt) | 2007-06-26 | 2017-05-16 | Astrazeneca Ab | composto, composição farmacêutica, método para produzir a inibição de uma cisteína protease em um mamífero, e, uso de um composto. |
CA2700160A1 (en) | 2007-09-20 | 2009-03-26 | D2E, Llc | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
TWI450900B (zh) | 2008-03-24 | 2014-09-01 | Medivation Technologies Inc | 橋聯雜環化合物及使用方法 |
CN104387382A (zh) | 2008-03-24 | 2015-03-04 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚和应用方法 |
CN102711466A (zh) * | 2009-09-23 | 2012-10-03 | 梅迪维新技术公司 | 桥连杂环化合物及其使用方法 |
TWI485152B (zh) | 2009-12-17 | 2015-05-21 | Abbvie Inc | 橋頭胺環稠合之吲哚及二氫吲哚 |
-
2009
- 2009-09-28 TW TW098132802A patent/TW201018694A/zh unknown
- 2009-09-28 WO PCT/US2009/058553 patent/WO2010036998A2/en active Application Filing
- 2009-09-28 JP JP2011529302A patent/JP2012504137A/ja not_active Withdrawn
- 2009-09-28 CN CN2009801478287A patent/CN102227431A/zh active Pending
- 2009-09-28 AR ARP090103731A patent/AR073701A1/es unknown
- 2009-09-28 MX MX2011003435A patent/MX2011003435A/es not_active Application Discontinuation
- 2009-09-28 UY UY0001032147A patent/UY32147A/es not_active Application Discontinuation
- 2009-09-28 US US12/568,085 patent/US9063126B2/en not_active Expired - Fee Related
- 2009-09-28 EP EP09793046A patent/EP2344505A2/en not_active Withdrawn
- 2009-09-28 CA CA2737031A patent/CA2737031A1/en not_active Abandoned
- 2009-09-28 PA PA20098843701A patent/PA8843701A1/es unknown
-
2015
- 2015-05-18 US US14/715,330 patent/US20150353550A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US9063126B2 (en) | 2015-06-23 |
CN102227431A (zh) | 2011-10-26 |
TW201018694A (en) | 2010-05-16 |
JP2012504137A (ja) | 2012-02-16 |
WO2010036998A3 (en) | 2011-03-03 |
MX2011003435A (es) | 2011-05-02 |
US20100087471A1 (en) | 2010-04-08 |
CA2737031A1 (en) | 2010-04-01 |
UY32147A (es) | 2010-04-30 |
EP2344505A2 (en) | 2011-07-20 |
WO2010036998A2 (en) | 2010-04-01 |
AR073701A1 (es) | 2010-11-24 |
US20150353550A1 (en) | 2015-12-10 |
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