CO6680668A2 - Ensayos biomarcadores para detectar o medir inhibición de actividad quinasa tor - Google Patents
Ensayos biomarcadores para detectar o medir inhibición de actividad quinasa torInfo
- Publication number
- CO6680668A2 CO6680668A2 CO13038904A CO13038904A CO6680668A2 CO 6680668 A2 CO6680668 A2 CO 6680668A2 CO 13038904 A CO13038904 A CO 13038904A CO 13038904 A CO13038904 A CO 13038904A CO 6680668 A2 CO6680668 A2 CO 6680668A2
- Authority
- CO
- Colombia
- Prior art keywords
- tor kinase
- kinase activity
- detect
- measure inhibition
- biomarker assays
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
La invención proporciona métodos para detectar y/o medir la inhibición de la actividad quinasa TOR en un sujeto y su uso asociado con el mismo. El método comprende el uso de citometría de flujo para medir la cantidad de 4EBP1 fosforilada en una muestra biológica del sujeto antes y después de la administración de un inhibidor de quinasa TOR. La invención tiene utilidad en la inhibición de quinasa TOR en un sujeto para el tratamiento de cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36945510P | 2010-07-30 | 2010-07-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6680668A2 true CO6680668A2 (es) | 2013-05-31 |
Family
ID=45527332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13038904A CO6680668A2 (es) | 2010-07-30 | 2013-02-26 | Ensayos biomarcadores para detectar o medir inhibición de actividad quinasa tor |
Country Status (21)
Country | Link |
---|---|
US (1) | US20120028972A1 (es) |
EP (1) | EP2598885B1 (es) |
JP (1) | JP2013535684A (es) |
KR (1) | KR20130136970A (es) |
CN (1) | CN103119445B (es) |
AU (1) | AU2011282553B2 (es) |
BR (1) | BR112013002279A2 (es) |
CA (1) | CA2807147A1 (es) |
CO (1) | CO6680668A2 (es) |
CR (1) | CR20130070A (es) |
EC (1) | ECSP13012461A (es) |
ES (1) | ES2591135T3 (es) |
MX (1) | MX337907B (es) |
MY (1) | MY170983A (es) |
NI (1) | NI201300013A (es) |
NZ (1) | NZ606495A (es) |
RU (1) | RU2587040C2 (es) |
SG (1) | SG187659A1 (es) |
UA (1) | UA111724C2 (es) |
WO (1) | WO2012016113A1 (es) |
ZA (1) | ZA201300921B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100047338A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
CN102686600A (zh) | 2009-02-05 | 2012-09-19 | 托凯药业股份有限公司 | 甾体cyp17抑制剂/抗雄激素物质的新型药物前体 |
EA034512B1 (ru) | 2011-10-19 | 2020-02-14 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Лечение злокачественной опухоли ингибиторами tor-киназы |
AU2013202305B2 (en) | 2012-02-24 | 2015-03-12 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
KR102122617B1 (ko) * | 2012-03-15 | 2020-06-12 | 시그날 파마소티칼 엘엘씨 | Tor 키나제 억제자를 사용하는 암의 치료 |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
AU2014207641A1 (en) | 2013-01-16 | 2015-08-06 | Signal Pharmaceuticals, Llc | Substituted Pyrrolopyrimidine Compounds, compositions thereof, and methods of treatment therewith |
EP2968370A4 (en) | 2013-03-14 | 2016-09-21 | Univ Maryland | AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF |
EP2986322A1 (en) * | 2013-04-17 | 2016-02-24 | Signal Pharmaceuticals, LLC | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
CN105324381A (zh) | 2013-04-17 | 2016-02-10 | 西格诺药品有限公司 | 有关1-乙基-7-(2-甲基-6-(1H-1,2,4-***-3-基)吡啶-3-基)-3,4-二氢吡嗪并[2,3-b]吡嗪-2(1H)-酮的药物制剂、程序、固体形式和使用方法 |
ES2944478T3 (es) * | 2013-04-17 | 2023-06-21 | Signal Pharm Llc | 1-etil-7-(2-metil-6-(1H-1,2,4-triazol-3-il)piridin-3-il)-3,4-dihidropirazino[2,3-b]pirazin-2(1H)-ona para tratar el glioblastoma multiforme |
KR102223060B1 (ko) * | 2013-04-17 | 2021-03-05 | 시그날 파마소티칼 엘엘씨 | 암 치료를 위한 TOR 키나제 억제제 및 IMiD 화합물을 포함하는 조합요법 |
CN105392499B (zh) * | 2013-04-17 | 2018-07-24 | 西格诺药品有限公司 | 用于治疗癌症的包含tor激酶抑制剂和胞苷类似物的组合疗法 |
MX2015014455A (es) * | 2013-04-17 | 2016-07-21 | Signal Pharm Llc | Terapia de combinacion que comprende un inhibidor de tor cinasa y n-(3-(5-fluoro-2-(4-(2-metoxietoxi)fenilamino)pirimidin-4-ilamino )fenil)acrilamida para tratar cancer. |
AU2014254058B2 (en) * | 2013-04-17 | 2019-06-06 | Signal Pharmaceuticals, Llc | Combination therapy comprising a Dihydropyrazino-Pyrazine Compound and an androgen receptor antagonist for treating prostate cancer |
NZ629411A (en) * | 2013-04-17 | 2017-06-30 | Signal Pharm Llc | Treatment of cancer with dihydropyrazino-pyrazines |
CA3143529A1 (en) | 2013-05-29 | 2014-12-04 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions 0f 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
JP2016528252A (ja) | 2013-08-12 | 2016-09-15 | トーカイ ファーマシューティカルズ, インコーポレイテッド | アンドロゲン標的治療を使用する新生物障害の処置のためのバイオマーカー |
US9512129B2 (en) | 2014-04-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer |
NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
ES2823756T3 (es) | 2014-04-16 | 2021-05-10 | Signal Pharm Llc | Métodos para tratar el cáncer usando terapia de combinación de inhibidores de quinasa TOR |
US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
EA201790189A1 (ru) | 2014-07-14 | 2017-11-30 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе |
NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
CN110996955A (zh) | 2017-06-22 | 2020-04-10 | 细胞基因公司 | 以乙型肝炎病毒感染为特征的肝细胞癌的治疗 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7135298B2 (en) * | 2003-03-26 | 2006-11-14 | The Burnham Institute For Medical Research | Screening assay for agents that alter target of Rapamycin activity |
EP1899463A4 (en) * | 2005-05-09 | 2009-11-25 | Ariad Pharma Inc | BIOMARKERS FOR EVALUATING THE PROBABILITY THAT A TUMOR IS SENSITIVE TO A MTOR INHIBITOR |
GB0509748D0 (en) * | 2005-05-13 | 2005-06-22 | Univ Glasgow | Materials and methods relating to cell based therapies |
SI1951724T1 (sl) * | 2005-11-17 | 2011-09-30 | Osi Pharmaceuticals Llc | Kondenzirani biciklični mTOR inhibitorji |
AR057960A1 (es) * | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
JP5513118B2 (ja) * | 2006-10-19 | 2014-06-04 | シグナル ファーマシューティカルズ,エルエルシー | ヘテロアリール化合物、その組成物、及びプロテインキナーゼ阻害剤としてのそれらの使用 |
US8110578B2 (en) * | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
-
2011
- 2011-07-28 US US13/192,792 patent/US20120028972A1/en not_active Abandoned
- 2011-07-29 JP JP2013523221A patent/JP2013535684A/ja active Pending
- 2011-07-29 KR KR1020137005078A patent/KR20130136970A/ko not_active Application Discontinuation
- 2011-07-29 ES ES11813229.9T patent/ES2591135T3/es active Active
- 2011-07-29 BR BR112013002279A patent/BR112013002279A2/pt not_active IP Right Cessation
- 2011-07-29 MY MYPI2013700174A patent/MY170983A/en unknown
- 2011-07-29 RU RU2013108840/15A patent/RU2587040C2/ru not_active IP Right Cessation
- 2011-07-29 UA UAA201302458A patent/UA111724C2/uk unknown
- 2011-07-29 CN CN201180046288.0A patent/CN103119445B/zh active Active
- 2011-07-29 SG SG2013007547A patent/SG187659A1/en unknown
- 2011-07-29 WO PCT/US2011/045842 patent/WO2012016113A1/en active Application Filing
- 2011-07-29 NZ NZ606495A patent/NZ606495A/en not_active IP Right Cessation
- 2011-07-29 CA CA2807147A patent/CA2807147A1/en not_active Abandoned
- 2011-07-29 AU AU2011282553A patent/AU2011282553B2/en not_active Ceased
- 2011-07-29 EP EP11813229.9A patent/EP2598885B1/en active Active
- 2011-07-29 MX MX2013001293A patent/MX337907B/es active IP Right Grant
-
2013
- 2013-01-30 NI NI201300013A patent/NI201300013A/es unknown
- 2013-02-04 ZA ZA2013/00921A patent/ZA201300921B/en unknown
- 2013-02-20 CR CR20130070A patent/CR20130070A/es unknown
- 2013-02-26 CO CO13038904A patent/CO6680668A2/es unknown
- 2013-02-26 EC ECSP13012461 patent/ECSP13012461A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20130136970A (ko) | 2013-12-13 |
ECSP13012461A (es) | 2013-03-28 |
EP2598885B1 (en) | 2016-07-20 |
AU2011282553B2 (en) | 2015-04-02 |
MX337907B (es) | 2016-03-28 |
NZ606495A (en) | 2014-08-29 |
EP2598885A1 (en) | 2013-06-05 |
NI201300013A (es) | 2013-04-19 |
ZA201300921B (en) | 2014-04-30 |
MY170983A (en) | 2019-09-23 |
US20120028972A1 (en) | 2012-02-02 |
CN103119445A (zh) | 2013-05-22 |
AU2011282553A1 (en) | 2013-03-14 |
EP2598885A4 (en) | 2014-03-26 |
CR20130070A (es) | 2013-05-20 |
MX2013001293A (es) | 2013-04-29 |
WO2012016113A1 (en) | 2012-02-02 |
UA111724C2 (uk) | 2016-06-10 |
RU2587040C2 (ru) | 2016-06-10 |
RU2013108840A (ru) | 2014-09-10 |
JP2013535684A (ja) | 2013-09-12 |
BR112013002279A2 (pt) | 2018-04-24 |
SG187659A1 (en) | 2013-03-28 |
CA2807147A1 (en) | 2012-02-02 |
ES2591135T3 (es) | 2016-11-25 |
CN103119445B (zh) | 2015-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6680668A2 (es) | Ensayos biomarcadores para detectar o medir inhibición de actividad quinasa tor | |
BR112018069849A2 (pt) | kit, dispositivo e método para a detecção de câncer pancreático precoce ou de lesão precursora do câncer pancreático | |
ES2570380T3 (es) | Método para determinar la aptitud de inhibidores de EZH2 humano en tratamiento | |
MX2019015016A (es) | Ensayos para la deteccion de una sola molecula y uso de los mismos. | |
EP3971299A3 (en) | Colorectal cancer detection kit or device, and detection method | |
ECSP13012394A (es) | Nuevas formas de dosificación de liberación modificada de un inhibidor de la xantina oxidorreductasa o de inhibidores de xantina oxidasa | |
EA201600085A1 (ru) | Набор для обнаружения соевого события syht0h2 | |
BR112013010952A2 (pt) | sistemas de rmn e métodos para a detecção rápida de analisados | |
BR112016028944A2 (pt) | kit ou dispositivo para a detecção de câncer do trato biliar e método de detecção | |
CL2012003048A1 (es) | Compuestos derivados de n-fenil-3-(1h-pirazol-4-il)quinoxalin-6-amina, inhibidores de tirosino quinasa fgfr; proceso de preparación; composición farmacéutica; y su uso en la prevención o tratamiento de cáncer. | |
MX349561B (es) | Método para detectar nucleosomas que contienen variantes de histonas. | |
SMT201600231B (it) | Metodo per misurare la concentrazione di alcool nel respiro e relativo apparecchio | |
MX2013007835A (es) | Combinacion de sirosingopina e inhibidores mitocondriales para el tratamiento de cancer e inmunosupresion. | |
MX371379B (es) | Deteccion de la actividad de corte de una enzima. | |
MX348655B (es) | Biomarcadores para pronosticar sensibilidad a tratamientos contra el cancer. | |
PH12015501778A1 (en) | Markers associated with wnt inhibitors | |
BR112014015037A2 (pt) | método, sistema e dispositivo eletrônico para determinar a trajetória de um fluxo aquoso, e sonda autônoma | |
MX2012011326A (es) | Sistema y metodo para evaluacion de farmaco anticanceroso candidato. | |
GB201206323D0 (en) | Methods and arrays for use in the same | |
BR112015020054A2 (pt) | Método de detectar resistência aos efeitos terapêuticos de um inibidor de akt em uma célula cancerosa | |
TR201902547T4 (tr) | Oksi̇dati̇f stresli̇ hastalarda parati̇roi̇d hormonunun ölçüm araçlari ve yöntemleri̇ | |
BR112013010481A2 (pt) | método para medir a capacitância de um sensor que tem uma capacitância e uma resistência e uso | |
CY1121482T1 (el) | Ευαισθητη πολυπλεκτικη ανοσοδοκιμασια για τους διαλυτους υποδοχεις των αυξητικων παραγοντων των ινοβλαστων | |
FI20115342A0 (fi) | Menetelmä putkiston kunnon mittaamiseksi ja sekvenssiohjattu näytteenottopumppu | |
CL2009001907A1 (es) | Metodo de deteccion precoz de cancer gastrico que comprende detectar la presencia de marcadores especificos de cancer gastrico en muestras de plasma. |