CO6511238A2 - Método para la producción enzimática de ácido 3 hidroxi-s metilbutírico a partir de acetona y acetil-coa - Google Patents
Método para la producción enzimática de ácido 3 hidroxi-s metilbutírico a partir de acetona y acetil-coaInfo
- Publication number
- CO6511238A2 CO6511238A2 CO12044045A CO12044045A CO6511238A2 CO 6511238 A2 CO6511238 A2 CO 6511238A2 CO 12044045 A CO12044045 A CO 12044045A CO 12044045 A CO12044045 A CO 12044045A CO 6511238 A2 CO6511238 A2 CO 6511238A2
- Authority
- CO
- Colombia
- Prior art keywords
- acetone
- hydroxy
- methylbutyric acid
- compound
- enzyme
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/52—Propionic acid; Butyric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
- C12Y203/0301—Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03004—Hydroxymethylglutaryl-CoA lyase (4.1.3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- C12R2001/12—Bacillus polymyxa ; Paenibacillus polymyxa
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/145—Clostridium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/38—Pseudomonas
- C12R2001/40—Pseudomonas putida
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/838—Bacillus polymyxa
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/842—Clostridium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/874—Pseudomonas
- Y10S435/877—Pseudomonas putida
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describe un método para la producción de ácido 3-hidroxi-3-metilbutírico (también denominado como beta-hidroxiisovalerato o HiV) a partir de acetona y un compuesto que proporciona un grupo acetilo activado que comprende la conversión enzimática de la acetona y un compuesto que proporciona un grupo acetilo activado en ácido 3-hidroxi-3-metilbutírico. La conversión hace uso de una enzima que es capaz de catalizar la formación de un enlace covalente entre el átomo de carbono del grupo oxo (es decir el C=O) de la acetona y el grupo metilo del compuesto que proporciona un grupo acetilo activado. Preferiblemente, la enzima empleada en el proceso es una enzima con la actividad de una sintasa HMG CoA (EC 2.3.3.10) y/o una proteína PksG y/o una enzima con la actividad de una división del enlace C-C/condensación liasa, tal como una HMG CoA liasa (EC 4.1.3.4). También se describen organismos que son capaces para producir ácido 3-hidroxi-3-metilbutírico a partir de acetona, un compuesto que proporciona un grupo acetilo activado, el uso de las enzimas anteriormente mencionadas y organismos para la producción de ácido 3-hidroxi-3- metilbutírico así como el uso de acetona para la producción de ácido 3-hidroxi- 3-metilbutírico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09170312A EP2295593A1 (en) | 2009-09-15 | 2009-09-15 | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6511238A2 true CO6511238A2 (es) | 2012-08-31 |
Family
ID=41682449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12044045A CO6511238A2 (es) | 2009-09-15 | 2012-03-14 | Método para la producción enzimática de ácido 3 hidroxi-s metilbutírico a partir de acetona y acetil-coa |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9017977B2 (es) |
| EP (3) | EP2295593A1 (es) |
| JP (1) | JP5767641B2 (es) |
| KR (1) | KR101774064B1 (es) |
| CN (1) | CN102597254B (es) |
| AU (1) | AU2010297362C1 (es) |
| BR (1) | BR112012005737A8 (es) |
| CA (1) | CA2772279C (es) |
| CO (1) | CO6511238A2 (es) |
| DK (1) | DK2478109T3 (es) |
| ES (1) | ES2536548T3 (es) |
| HK (1) | HK1171250A1 (es) |
| HU (1) | HUE025695T2 (es) |
| IL (1) | IL218245A (es) |
| MX (1) | MX2012003224A (es) |
| MY (1) | MY159420A (es) |
| PE (1) | PE20121436A1 (es) |
| PL (1) | PL2478109T3 (es) |
| RU (1) | RU2573389C2 (es) |
| WO (1) | WO2011032934A1 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295593A1 (en) * | 2009-09-15 | 2011-03-16 | Philippe Marliere | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA |
| BR112014000495A2 (pt) | 2011-07-12 | 2017-02-21 | Scientist Of Fortune Sa | micro-organismos recombinante para a produção de metabólitos úteis |
| DE102012105879A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Isononylderivaten |
| DE102012105878A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Isopentanderivaten |
| DE102012105876A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Terephthalsäure und ihren Derivaten |
| DE102012105874A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Isononansäurevinylestern |
| DE102012105877A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Diisobuten |
| IN2015DN01365A (es) | 2012-08-28 | 2015-07-03 | Lanzatech New Zealand Ltd | |
| US20150329877A1 (en) | 2012-12-07 | 2015-11-19 | Global Bioenergies | Fermentation method |
| EP2929036A1 (en) | 2012-12-07 | 2015-10-14 | Global Bioenergies | Fermentative production of a hydrocarbon |
| WO2015101493A1 (en) * | 2013-12-31 | 2015-07-09 | Global Bioenergies | 3-hydroxyisovalerate (hiv) synthase variants |
| US20170260548A1 (en) | 2014-09-17 | 2017-09-14 | Scientist of Fortune, S.A. | Method for producing isobutene from 3-methylcrotonyl-coa |
| WO2016042012A1 (en) * | 2014-09-17 | 2016-03-24 | Global Bioenergies | Methods for producing 3-hydroxy-3-methylbutyric acid |
| US11426386B2 (en) | 2014-12-05 | 2022-08-30 | Case Western Reserve University | Compositions and methods of modulating S-nitrosylation |
| EP3226859A4 (en) * | 2014-12-05 | 2018-12-12 | Case Western Reserve University | Compositions and methods of modulating s-nitrosylation |
| EP3313998B1 (en) | 2015-06-26 | 2019-09-11 | Global Bioenergies | Method for the enzymatic production of isoamyl alcohol |
| WO2017017124A1 (en) | 2015-07-28 | 2017-02-02 | Global Bioenergies | Hiv kinase variants |
| MX2022003568A (es) | 2015-10-13 | 2023-06-13 | Lanzatech Nz Inc | Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía. |
| CA3002609C (en) | 2015-11-17 | 2023-09-05 | Global Bioenergies | Methods for producing isobutene from 3-methylcrotonic acid |
| US20190112620A1 (en) | 2016-03-22 | 2019-04-18 | Global Bioenergies | Method for producing isobutene from 3-methylcrotonyl-coa |
| CN107095885A (zh) * | 2017-04-28 | 2017-08-29 | 青岛东海药业有限公司 | 酪酸梭菌在制备预防或治疗慢性阻塞性肺疾病制剂中的应用 |
| WO2018206262A1 (en) | 2017-05-10 | 2018-11-15 | Global Bioenergies | Improved methods for producing isobutene from 3-methylcrotonic acid |
| EP3688163A4 (en) | 2017-09-25 | 2022-12-14 | Case Western Reserve University | COMPOSITIONS AND METHODS FOR REDUCING SERUM CHOLESTEROL AND PCSK9 |
| EP3502216A1 (en) | 2017-12-21 | 2019-06-26 | Global Bioenergies | Gasoline composition enabling reduced particulate emissions |
| WO2020005938A1 (en) | 2018-06-25 | 2020-01-02 | Case Western Reserve University | Compositions and methods for treating tissue injury |
| WO2020021051A1 (en) | 2018-07-27 | 2020-01-30 | Global Bioenergies | Method for producing fructose-6-phosphate from dihydroxyacetone phosphate and glyceraldehyde-3-phosphate |
| US11518748B2 (en) | 2018-09-21 | 2022-12-06 | Case Western Reserve University | Aldoketo reductase inhibitors and uses thereof |
| CN109251940B (zh) * | 2018-10-30 | 2020-10-16 | 浙江华睿生物技术有限公司 | 一种产β-羟基-β-甲基丁酸工程菌的构建方法 |
| WO2020188033A1 (en) | 2019-03-20 | 2020-09-24 | Global Bioenergies | Improved means and methods for producing isobutene from acetyl-coa |
| WO2021063958A1 (en) | 2019-09-30 | 2021-04-08 | Global Bioenergies | Improved means and methods for increasing the yield of acetyl-coa from glucose |
| US11059633B2 (en) | 2019-10-31 | 2021-07-13 | Cheer Pack North America | Flip-top closure for container |
| FR3110081B1 (fr) | 2020-05-14 | 2022-09-09 | Global Bioenergies | Composition cosmétique à base d’isododécane biosourcé et son procédé de préparation |
| FR3112477B1 (fr) | 2020-07-15 | 2022-08-26 | Global Bioenergies | Composition cosmétique à base d’isododécane présentant une teneur élévée en 2,2,4,6,6-pentaméthylheptane |
| CA3214563A1 (en) * | 2021-04-06 | 2022-10-13 | Christopher D. Snow | Synthesis of beta-hydroxyisovalerate and methods of use |
| CN117980473A (zh) | 2021-09-06 | 2024-05-03 | 环球生物能源公司 | 产生较少巴豆酸的生物体 |
| EP4144838A1 (en) | 2021-09-06 | 2023-03-08 | Global Bioenergies | Organisms producing less crotonic acid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2245365C2 (ru) * | 1994-01-03 | 2005-01-27 | Генентек Инк. | Тромбопоэтин |
| DE50205794D1 (de) | 2001-05-18 | 2006-04-20 | Lonza Ag | Verfahren zur herstellung fester formulierungen von natrium-3-hydroxy-3-methylbutyrat |
| US20040106678A1 (en) * | 2002-09-17 | 2004-06-03 | Dobbins Thomas A | Compositions for the parenteral administration of calcium and magnesium |
| KR20120053088A (ko) * | 2006-05-26 | 2012-05-24 | 아미리스 인코퍼레이티드 | 이소프레노이드의 생산 방법 |
| EP2295593A1 (en) * | 2009-09-15 | 2011-03-16 | Philippe Marliere | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA |
-
2009
- 2009-09-15 EP EP09170312A patent/EP2295593A1/en not_active Withdrawn
-
2010
- 2010-09-14 HU HUE10765977A patent/HUE025695T2/en unknown
- 2010-09-14 DK DK10765977.3T patent/DK2478109T3/en active
- 2010-09-14 ES ES10765977.3T patent/ES2536548T3/es active Active
- 2010-09-14 PL PL10765977T patent/PL2478109T3/pl unknown
- 2010-09-14 RU RU2012114690/10A patent/RU2573389C2/ru not_active IP Right Cessation
- 2010-09-14 AU AU2010297362A patent/AU2010297362C1/en not_active Ceased
- 2010-09-14 CN CN201080041020.3A patent/CN102597254B/zh active Active
- 2010-09-14 CA CA2772279A patent/CA2772279C/en not_active Expired - Fee Related
- 2010-09-14 BR BR112012005737A patent/BR112012005737A8/pt not_active Application Discontinuation
- 2010-09-14 MX MX2012003224A patent/MX2012003224A/es active IP Right Grant
- 2010-09-14 KR KR1020127006644A patent/KR101774064B1/ko active IP Right Grant
- 2010-09-14 EP EP15161591.1A patent/EP2940141A1/en not_active Withdrawn
- 2010-09-14 MY MYPI2012000826A patent/MY159420A/en unknown
- 2010-09-14 US US13/395,293 patent/US9017977B2/en active Active
- 2010-09-14 JP JP2012528390A patent/JP5767641B2/ja active Active
- 2010-09-14 EP EP10765977.3A patent/EP2478109B1/en active Active
- 2010-09-14 WO PCT/EP2010/063460 patent/WO2011032934A1/en active Application Filing
- 2010-09-14 PE PE2012000335A patent/PE20121436A1/es not_active Application Discontinuation
-
2012
- 2012-02-22 IL IL218245A patent/IL218245A/en active IP Right Grant
- 2012-03-14 CO CO12044045A patent/CO6511238A2/es unknown
- 2012-11-22 HK HK12111958.3A patent/HK1171250A1/zh not_active IP Right Cessation
-
2015
- 2015-03-14 US US14/658,170 patent/US9556460B2/en active Active
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