CO6251313A2 - Proceso para la preparacion de pirazoles - Google Patents

Proceso para la preparacion de pirazoles

Info

Publication number
CO6251313A2
CO6251313A2 CO09142558A CO09142558A CO6251313A2 CO 6251313 A2 CO6251313 A2 CO 6251313A2 CO 09142558 A CO09142558 A CO 09142558A CO 09142558 A CO09142558 A CO 09142558A CO 6251313 A2 CO6251313 A2 CO 6251313A2
Authority
CO
Colombia
Prior art keywords
hal
formula
compound
preparation
pirazoles
Prior art date
Application number
CO09142558A
Other languages
English (en)
Inventor
Martin Charles Bowden
Brian David Gott
David Anthony Jackson
Original Assignee
Syngenta Participations Ag
Syngenta Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38812166&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6251313(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syngenta Participations Ag, Syngenta Ltd filed Critical Syngenta Participations Ag
Publication of CO6251313A2 publication Critical patent/CO6251313A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1.- Un proceso para la preparación de un compuesto de la fórmula (I)en la cual Hal y Hal' son en forma independiente CI o F, y R1 es H, CI o F, el cual comprende los siguientes pasosi) Hacer reaccionar un compuesto de la fórmula (II)en la cual Hal, Hal' y R1 son tal como se definieron anteriormente , y LG es un grupo saliente, con un éter de enol de la fórmula (III)Para proporcionar un compuesto de la fórmula (IV)En la cual Hal, Hal' y R1 son tal como se definieron anteriormente, y ii) hacer reaccionar el compuesto de la fórmula (IV) con metilhidrazina para proporcionar un pirazol de la fórmula (I). 2.- Un proceso de acuerdo con la reivindicación 1, el cual comprende un paso adicional de halogenación del compuesto de la fórmula (I) para proporcionar un 4- halopirazol de la fórmula (V)En la cual Hal, Hal' y R1 son tal como se definieron en la reivindicación 1 y X es Cl, Br o l.
CO09142558A 2007-06-27 2009-12-14 Proceso para la preparacion de pirazoles CO6251313A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07012546A EP2008996A1 (en) 2007-06-27 2007-06-27 Process for the production of pyrazoles

Publications (1)

Publication Number Publication Date
CO6251313A2 true CO6251313A2 (es) 2011-02-21

Family

ID=38812166

Family Applications (2)

Application Number Title Priority Date Filing Date
CO09142558A CO6251313A2 (es) 2007-06-27 2009-12-14 Proceso para la preparacion de pirazoles
CO09142556A CO6251314A2 (es) 2007-06-27 2009-12-14 Procesos para la preparacion de pirazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
CO09142556A CO6251314A2 (es) 2007-06-27 2009-12-14 Procesos para la preparacion de pirazoles

Country Status (18)

Country Link
US (3) US20100256390A1 (es)
EP (3) EP2008996A1 (es)
JP (2) JP5563449B2 (es)
KR (2) KR20100025531A (es)
CN (3) CN101687806A (es)
AR (2) AR067355A1 (es)
AU (2) AU2008267472A1 (es)
BR (2) BRPI0813284B1 (es)
CA (2) CA2689218A1 (es)
CL (2) CL2008001896A1 (es)
CO (2) CO6251313A2 (es)
CR (2) CR11162A (es)
EC (2) ECSP099818A (es)
IL (2) IL202419A0 (es)
MX (2) MX2009013592A (es)
RU (2) RU2010102137A (es)
TW (2) TW200916445A (es)
WO (2) WO2009000441A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2008996A1 (en) * 2007-06-27 2008-12-31 Syngeta Participations AG Process for the production of pyrazoles
EP2133341A1 (de) * 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
KR20110066201A (ko) 2008-09-30 2011-06-16 솔베이(소시에떼아노님) 할로겐화 환형 화합물의 합성 방법
GB0908435D0 (en) * 2009-05-15 2009-06-24 Syngenta Ltd Processes
WO2012025469A1 (en) * 2010-08-24 2012-03-01 Solvay Sa Improved process for the preparation of esters of 1-h-pyrazole-4-carboxylic acids
FR2975992B1 (fr) * 2011-06-01 2013-11-08 Rhodia Operations Procede de preparation d'un compose fluoromethylpyrazole sous forme acide carboxylique ou derivee
FR2975990B1 (fr) 2011-06-01 2013-05-24 Rhodia Operations Procede de preparation d'un compose organique fluore
BR112014028292B1 (pt) * 2012-05-14 2021-07-20 Bayer Cropscience Ag Método de preparação de cloretos de 1-alquil-3-fluoroalquil-1h-pirazol-4-carbonila
US8871947B2 (en) 2013-02-04 2014-10-28 KingChem LLC Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester
JP6458022B2 (ja) 2013-10-23 2019-01-23 バイエル・クロップサイエンス・アクチェンゲゼルシャフト ハロゲンケトン類を製造する方法
CN103570623B (zh) * 2013-11-12 2015-05-20 湖南化工研究院 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的制备方法
WO2015085464A1 (en) 2013-12-09 2015-06-18 King Chem, Llc Process for preparing alkyl 3-difluoromethyl-1-methyl-1h-pyrazole-4-carboxylate and its analogs
CN103787977B (zh) * 2014-01-21 2016-05-25 南通雅本化学有限公司 一种空气氧化制备3-氟代烷基-1-取代吡唑-4-羧酸的方法
CN105541716B (zh) 2015-03-26 2024-02-23 Ａｇｃ株式会社 吡唑衍生物的制造方法
CN104945325B (zh) * 2015-06-19 2017-04-05 浙江永太科技股份有限公司 一种吡唑甲酸衍生物的制备方法
US10407413B2 (en) 2015-06-19 2019-09-10 Zhejiang Yongtai Technology Co., Ltd. Method for preparing pyrazolecarboxylic acid derivative, and intermediate thereof
WO2017054112A1 (zh) * 2015-09-28 2017-04-06 常州市卜弋科研化工有限公司 3-氟代烷基-1-甲基吡唑-4-羧酸的制备方法
CN106554311B (zh) * 2015-09-28 2019-03-01 常州市卜弋科研化工有限公司 3-氟代烷基-1-甲基吡唑-4-羧酸的制备方法
CN112041303A (zh) 2018-05-21 2020-12-04 Pi工业有限公司 制备取代的杂环化合物的方法
CN109232425A (zh) * 2018-10-16 2019-01-18 山东省农药科学研究院 一种苯丙烯氟菌唑中间体3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的合成方法
CN110577503A (zh) 2019-08-02 2019-12-17 宿迁市科莱博生物化学有限公司 一种卤素取代化合物及其制备方法和应用
CN111233768B (zh) * 2020-03-18 2021-08-03 徐州圣元化工有限公司 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法
CN111303035A (zh) * 2020-03-18 2020-06-19 徐州圣元化工有限公司 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的制备方法
WO2022233129A1 (en) 2021-05-05 2022-11-10 Fujian Yongjing Technology Co., Ltd New process for the synthesis of 5-fluoro-3- (difuoromethyl) -5-fluoro-1-methyl-1h-pyrazole-4-carboxylic acid derivatives and the free acid thereof
CN114195715B (zh) * 2021-12-31 2024-05-10 福建永晶科技股份有限公司 1-甲基-3-二氟甲基-4-吡唑酸和1-甲基-3-三氟甲基-4-吡唑酸的制备方法
CN117384096A (zh) * 2023-12-13 2024-01-12 山东国邦药业有限公司 一种二氟吡唑酸的制备方法
CN117447401B (zh) * 2023-12-26 2024-04-19 山东国邦药业有限公司 一种二氟吡唑酸的合成方法

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JPH0759557B2 (ja) * 1987-12-25 1995-06-28 三井東圧化学株式会社 １，３−ジアルキルピラゾール−４−アルデヒド誘導体の製造方法
JPH0759558B2 (ja) * 1987-12-25 1995-06-28 三井東圧化学株式会社 １，３−ジアルキルピラゾール−４−アルデヒド類の製造法
JPH089599B2 (ja) * 1988-08-02 1996-01-31 三井東圧化学株式会社 ピラゾールカルボン酸類の製造方法
JP2006519755A (ja) * 2002-11-20 2006-08-31 ロレアル ピラゾール−カルボキシアミドを含有する毛髪の手入れ用又は睫毛用の組成物、毛髪及び睫毛の成長を刺激し、及び／又は抜毛を防止するためのそれらの使用
DE10349500A1 (de) * 2003-10-23 2005-06-02 Bayer Cropscience Ag Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern
ATE471320T1 (de) * 2004-02-27 2010-07-15 Lilly Co Eli 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme
EP1761498A1 (de) * 2004-06-18 2007-03-14 Basf Aktiengesellschaft 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid
AU2005273619B2 (en) * 2004-08-18 2009-05-28 Pfizer Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
EP1854788B8 (en) * 2005-02-25 2012-12-26 Sagami Chemical Research Institute Method for producing 1-substituted-3-fluoroalkyl pyrazole-4-carboxylate
TW200804292A (en) * 2005-09-16 2008-01-16 Syngenta Participations Ag Process for the production of amides
SI2164831T1 (sl) * 2007-06-01 2013-09-30 Basf Se Postopek za proizvodnjo N-substituiranih(3-dihalometil-1-metil- pirazole-4-il) karboksamidov
EP2008996A1 (en) * 2007-06-27 2008-12-31 Syngeta Participations AG Process for the production of pyrazoles

Also Published As

Publication number Publication date
IL202664A (en) 2014-07-31
WO2009000441A8 (en) 2010-01-14
TW200914428A (en) 2009-04-01
CR11161A (es) 2010-05-19
BRPI0813284B1 (pt) 2017-10-31
TW200916445A (en) 2009-04-16
IL202419A0 (en) 2010-06-30
WO2009000442A8 (en) 2010-01-21
AU2008267472A1 (en) 2008-12-31
ECSP099818A (es) 2010-01-29
EP2167461B1 (en) 2012-08-08
CN101796021A (zh) 2010-08-04
KR20100025533A (ko) 2010-03-09
CA2690246A1 (en) 2008-12-31
RU2010102137A (ru) 2011-08-10
JP2010531314A (ja) 2010-09-24
US8785657B2 (en) 2014-07-22
EP2170832A2 (en) 2010-04-07
CL2008001896A1 (es) 2009-03-06
AU2008267473A1 (en) 2008-12-31
MX2009013592A (es) 2010-01-20
MX2009013591A (es) 2010-01-20
US20100256390A1 (en) 2010-10-07
US20130023668A1 (en) 2013-01-24
US20100240907A1 (en) 2010-09-23
ECSP099817A (es) 2010-01-29
AR067356A1 (es) 2009-10-07
IL202664A0 (en) 2010-06-30
BRPI0813284A2 (pt) 2014-12-30
BRPI0813903A2 (pt) 2014-12-30
JP2010531315A (ja) 2010-09-24
JP5563449B2 (ja) 2014-07-30
EP2008996A1 (en) 2008-12-31
CN101687806A (zh) 2010-03-31
RU2010102135A (ru) 2011-08-10
WO2009000442A3 (en) 2009-07-23
CO6251314A2 (es) 2011-02-21
BRPI0813284A8 (pt) 2017-04-04
KR20100025531A (ko) 2010-03-09
CN102516175A (zh) 2012-06-27
US8269020B2 (en) 2012-09-18
WO2009000441A1 (en) 2008-12-31
CR11162A (es) 2010-04-21
CL2008001897A1 (es) 2009-01-02
AR067355A1 (es) 2009-10-07
EP2167461A1 (en) 2010-03-31
CA2689218A1 (en) 2008-12-31
WO2009000442A2 (en) 2008-12-31

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