CO2020015437A2 - Derivados de tetrahidro-imidazo[4,5-c]piridina como inmunomoduladores pd-l1 - Google Patents

Derivados de tetrahidro-imidazo[4,5-c]piridina como inmunomoduladores pd-l1

Info

Publication number
CO2020015437A2
CO2020015437A2 CONC2020/0015437A CO2020015437A CO2020015437A2 CO 2020015437 A2 CO2020015437 A2 CO 2020015437A2 CO 2020015437 A CO2020015437 A CO 2020015437A CO 2020015437 A2 CO2020015437 A2 CO 2020015437A2
Authority
CO
Colombia
Prior art keywords
immunomodulators
imidazo
tetrahydro
pyridine derivatives
compounds
Prior art date
Application number
CONC2020/0015437A
Other languages
English (en)
Inventor
Kaijiong Xiao
Wenqing Yao
Liangxing Wu
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66625434&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2020015437(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CO2020015437A2 publication Critical patent/CO2020015437A2/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de la Fórmula (I), métodos para el uso de los compuestos como inmunomoduladores y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos son útiles para el tratamiento, prevención o mejora de enfermedades o trastornos tales como cánceres o infecciones.
CONC2020/0015437A 2018-05-11 2020-12-10 Derivados de tetrahidro-imidazo[4,5-c]piridina como inmunomoduladores pd-l1 CO2020015437A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862670249P 2018-05-11 2018-05-11
US201862688164P 2018-06-21 2018-06-21
PCT/US2019/031728 WO2019217821A1 (en) 2018-05-11 2019-05-10 Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators

Publications (1)

Publication Number Publication Date
CO2020015437A2 true CO2020015437A2 (es) 2021-01-18

Family

ID=66625434

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0015437A CO2020015437A2 (es) 2018-05-11 2020-12-10 Derivados de tetrahidro-imidazo[4,5-c]piridina como inmunomoduladores pd-l1

Country Status (30)

Country Link
US (4) US10618916B2 (es)
EP (2) EP4219492A1 (es)
JP (2) JP7328995B2 (es)
KR (1) KR20210018282A (es)
CN (1) CN112752756B (es)
AU (2) AU2019267824B2 (es)
BR (1) BR112020022936A2 (es)
CA (1) CA3099994A1 (es)
CL (2) CL2020002922A1 (es)
CO (1) CO2020015437A2 (es)
CR (1) CR20200614A (es)
DK (1) DK3790877T3 (es)
EC (1) ECSP20079887A (es)
ES (1) ES2943028T3 (es)
FI (1) FI3790877T3 (es)
HR (1) HRP20230306T1 (es)
HU (1) HUE061503T2 (es)
JO (1) JOP20200288A1 (es)
LT (1) LT3790877T (es)
MD (1) MD3790877T2 (es)
MX (1) MX2020012045A (es)
PE (1) PE20211918A1 (es)
PH (1) PH12020551927A1 (es)
PL (1) PL3790877T3 (es)
PT (1) PT3790877T (es)
RS (1) RS64188B1 (es)
SG (1) SG11202011165TA (es)
SI (1) SI3790877T1 (es)
TW (1) TWI821288B (es)
WO (1) WO2019217821A1 (es)

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