CN1200734C - 用表皮生长因子拮抗物治疗顽固性的人肿瘤 - Google Patents
用表皮生长因子拮抗物治疗顽固性的人肿瘤 Download PDFInfo
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- CN1200734C CN1200734C CNB008103216A CN00810321A CN1200734C CN 1200734 C CN1200734 C CN 1200734C CN B008103216 A CNB008103216 A CN B008103216A CN 00810321 A CN00810321 A CN 00810321A CN 1200734 C CN1200734 C CN 1200734C
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- 229940063683 taxotere Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
- 229960000303 topotecan Drugs 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 238000002689 xenotransplantation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
病人 | 治疗前处理 | 综合反应 |
1 | 顺铂 | CR |
2 | Ad p53 | PR |
3 | 顺铂 | PR |
4 | 顺铂 | PR |
5 | 仅放射治疗 | PR |
6 | 化学治疗 | PR |
7 | 仅放射治疗 | MR |
C225/CPT周剂量,mg/m2 | C225/CPT-11实际剂量,mg | C225输注时间(分钟) | CPT-11输注时间(分钟) |
400/125 | 576/180 | 120 | 90 |
250/125 | 360/180 | 60 | 90 |
250/CPT-11保持 | 360/0 | 60 | N/A |
250/94 | 360/135 | 50 | 75 |
250/69 | 360/100 | 60 | 85 |
250/69 | 360/100 | 60 | 75 |
Claims (31)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31228499A | 1999-05-14 | 1999-05-14 | |
US09/312,284 | 1999-05-14 | ||
US37402899A | 1999-08-13 | 1999-08-13 | |
US09/374,028 | 1999-08-13 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200510055865 Division CN1720994A (zh) | 1999-05-14 | 2000-05-01 | 用表皮生长因子受体拮抗物治疗顽固性的人肿瘤 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1361700A CN1361700A (zh) | 2002-07-31 |
CN1200734C true CN1200734C (zh) | 2005-05-11 |
Family
ID=26978320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008103216A Expired - Fee Related CN1200734C (zh) | 1999-05-14 | 2000-05-01 | 用表皮生长因子拮抗物治疗顽固性的人肿瘤 |
Country Status (20)
Country | Link |
---|---|
US (3) | US20020012663A1 (zh) |
EP (2) | EP1218032A4 (zh) |
JP (2) | JP2003520195A (zh) |
KR (1) | KR20020000223A (zh) |
CN (1) | CN1200734C (zh) |
AU (1) | AU782994C (zh) |
BG (1) | BG106110A (zh) |
BR (1) | BR0010524A (zh) |
CA (1) | CA2373815A1 (zh) |
CZ (1) | CZ20014083A3 (zh) |
EE (1) | EE200100603A (zh) |
HK (1) | HK1047236A1 (zh) |
HU (1) | HUP0201480A3 (zh) |
IL (1) | IL146480A0 (zh) |
MX (1) | MXPA01011632A (zh) |
NO (1) | NO20015546L (zh) |
PL (1) | PL365999A1 (zh) |
RU (1) | RU2294761C2 (zh) |
SK (1) | SK16522001A3 (zh) |
WO (1) | WO2000069459A1 (zh) |
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BR0010524A (pt) | 2002-05-28 |
BG106110A (bg) | 2002-04-30 |
US20050112120A1 (en) | 2005-05-26 |
SK16522001A3 (sk) | 2002-10-08 |
KR20020000223A (ko) | 2002-01-05 |
EP1218032A1 (en) | 2002-07-03 |
MXPA01011632A (es) | 2002-11-07 |
HUP0201480A2 (en) | 2002-08-28 |
JP2009120583A (ja) | 2009-06-04 |
AU782994B2 (en) | 2005-09-15 |
CZ20014083A3 (cs) | 2002-08-14 |
US20030157104A1 (en) | 2003-08-21 |
WO2000069459A1 (en) | 2000-11-23 |
JP2003520195A (ja) | 2003-07-02 |
PL365999A1 (en) | 2005-01-24 |
EP2042194A3 (en) | 2009-04-22 |
RU2294761C2 (ru) | 2007-03-10 |
AU782994C (en) | 2006-08-24 |
EE200100603A (et) | 2003-02-17 |
IL146480A0 (en) | 2002-07-25 |
EP1218032A4 (en) | 2005-05-25 |
AU4687100A (en) | 2000-12-05 |
NO20015546D0 (no) | 2001-11-13 |
HK1047236A1 (zh) | 2003-02-14 |
EP2042194A2 (en) | 2009-04-01 |
CA2373815A1 (en) | 2000-11-23 |
CN1361700A (zh) | 2002-07-31 |
US20020012663A1 (en) | 2002-01-31 |
HUP0201480A3 (en) | 2009-03-30 |
NO20015546L (no) | 2002-01-14 |
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