CN110167583A - 一种治疗冠状动脉粥样硬化及其并发症的方法 - Google Patents

一种治疗冠状动脉粥样硬化及其并发症的方法 Download PDF

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CN110167583A
CN110167583A CN201780078118.8A CN201780078118A CN110167583A CN 110167583 A CN110167583 A CN 110167583A CN 201780078118 A CN201780078118 A CN 201780078118A CN 110167583 A CN110167583 A CN 110167583A
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plasminogen
atherosclerosis
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cerebral
coronary
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李季男
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Talengen Institute of Life Sciences Co Ltd
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Talengen Institute of Life Sciences Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
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  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

本发明涉及一种用于预防和/或治疗受试者冠状动脉粥样硬化及其相关病症的方法，包括给药受试者预防和/或治疗有效量的纤溶酶原，其中所述受试者患有、怀疑患有冠状动脉粥样硬化及其相关病症或具有患上冠状动脉粥样硬化及其相关病症的风险。本发明还涉及用于预防和/或治疗受试者冠状动脉粥样硬化及其相关病症的包含纤溶酶原的药物、药物组合物、制品、试剂盒。

Description

PCT国内申请，说明书已公开。

Claims (59)

  1. PCT国内申请，权利要求书已公开。
CN201780078118.8A 2016-12-15 2017-06-19 一种治疗冠状动脉粥样硬化及其并发症的方法 Pending CN110167583A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110172 2016-12-15
CNPCT/CN2016/110168 2016-12-15
CN2016110168 2016-12-15
CN2016110172 2016-12-15
PCT/CN2017/089044 WO2018107685A1 (zh) 2016-12-15 2017-06-19 一种治疗冠状动脉粥样硬化及其并发症的方法

Publications (1)

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CN110167583A true CN110167583A (zh) 2019-08-23

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CN201780078105.0A Pending CN110366425A (zh) 2016-12-15 2017-06-19 一种预防动脉粥样硬化及其并发症的方法
CN201780078127.7A Pending CN110114083A (zh) 2016-12-15 2017-06-19 一种预防和治疗脂肪肝的方法
CN201780078126.2A Pending CN110114082A (zh) 2016-12-15 2017-06-19 一种预防和治疗脂肪代谢紊乱及其相关病症的方法
CN201780078118.8A Pending CN110167583A (zh) 2016-12-15 2017-06-19 一种治疗冠状动脉粥样硬化及其并发症的方法

Family Applications Before (3)

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CN201780078105.0A Pending CN110366425A (zh) 2016-12-15 2017-06-19 一种预防动脉粥样硬化及其并发症的方法
CN201780078127.7A Pending CN110114083A (zh) 2016-12-15 2017-06-19 一种预防和治疗脂肪肝的方法
CN201780078126.2A Pending CN110114082A (zh) 2016-12-15 2017-06-19 一种预防和治疗脂肪代谢紊乱及其相关病症的方法

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US (4) US11547746B2 (zh)
EP (4) EP3556387A4 (zh)
JP (4) JP7161217B2 (zh)
CN (4) CN110366425A (zh)
CA (4) CA3047169A1 (zh)
TW (9) TW201822812A (zh)
WO (8) WO2018107687A1 (zh)

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US11207387B2 (en) 2016-12-15 2021-12-28 Talengen International Limited Method and drug for preventing and treating obesity
TW201822812A (zh) * 2016-12-15 2018-07-01 深圳瑞健生命科學硏究院有限公司 一種預防和治療肥胖症的方法
CA3046671C (en) 2016-12-15 2023-08-08 Talengen International Limited Method for preventing and treating pulmonary fibrosis
TWI677348B (zh) 2016-12-15 2019-11-21 大陸商深圳瑞健生命科學研究院有限公司 一種改善心臟病變的方法
WO2018107706A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种使胰高血糖素、胰岛素恢复正常平衡的方法
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US20230139956A1 (en) * 2020-02-26 2023-05-04 Talengen International Limited Method and drug for preventing and treating abnormal blood pressure condition
CN112056563A (zh) * 2020-09-15 2020-12-11 王胜林 用于修复脂质代谢障碍的营养素组合物及其应用
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