CN107375305A - A kind of medicinal fish composition that can reduce antibiotic residue - Google Patents
A kind of medicinal fish composition that can reduce antibiotic residue Download PDFInfo
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- CN107375305A CN107375305A CN201710497645.4A CN201710497645A CN107375305A CN 107375305 A CN107375305 A CN 107375305A CN 201710497645 A CN201710497645 A CN 201710497645A CN 107375305 A CN107375305 A CN 107375305A
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- 241000251468 Actinopterygii Species 0.000 title claims abstract description 36
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 12
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 claims abstract description 24
- 229940063650 terramycin Drugs 0.000 claims abstract description 24
- 229940024606 amino acid Drugs 0.000 claims abstract description 21
- 235000001014 amino acid Nutrition 0.000 claims abstract description 21
- -1 compound amino acid Chemical class 0.000 claims abstract description 15
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 10
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960001305 cysteine hydrochloride Drugs 0.000 claims abstract description 6
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004471 Glycine Substances 0.000 claims abstract description 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims abstract description 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract description 5
- 235000004279 alanine Nutrition 0.000 claims abstract description 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229930182817 methionine Natural products 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 241000252210 Cyprinidae Species 0.000 claims description 5
- 241000252233 Cyprinus carpio Species 0.000 claims description 4
- 239000013505 freshwater Substances 0.000 claims description 4
- 241000252230 Ctenopharyngodon idella Species 0.000 claims description 2
- 241000252234 Hypophthalmichthys nobilis Species 0.000 claims description 2
- 241001275898 Mylopharyngodon piceus Species 0.000 claims description 2
- 241000276701 Oreochromis mossambicus Species 0.000 claims description 2
- 241000755266 Kathetostoma giganteum Species 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 238000009360 aquaculture Methods 0.000 description 4
- 244000144974 aquaculture Species 0.000 description 4
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical group C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 208000010824 fish disease Diseases 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Birds (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
A kind of medicinal fish composition that can reduce antibiotic residue, the terramycin by bait and as active component form with compound amino acid, and the mass ratio of the terramycin and compound amino acid is 1：0.5~2, described compound amino acid by percentage by weight 11%~13% methionine, the histidine of percentage by weight 15%~18%, the alanine of percentage by weight 15%~18%, the L-aminobutanedioic acid of percentage by weight 11%~13%, the cysteine hydrochloride of percentage by weight 2~3%, the tyrosine of percentage by weight 1%~1.5% and the glycine composition of surplus.
Description
Technical field
The invention belongs to Medicines in Aquaculture, more particularly to a kind of medicinal fish composition.
Background technology
Terramycin is widely used as the antibiotic that a kind of cost is cheap, curative effect determines in aquaculture,
It can both be used as water body bacteriostatic agent, can add again in bait, but because it belongs to tetracycline antibiotics, human body intake
" " tetracycline pigmentation teeth can be produced after terramycin " etc. the problem of being difficult to cure, in existing aquaculture technology, in application terramycin one
As need the off-drug period up to 30d that its residual in aquatic products body can just be down to below 100 μ g/kg, terramycin is in aquatic products
Cultivation application there is more serious limitation, therefore provide it is a kind of can reduce terramycin remained in aquatic products body it is new
Fish medicine turns into urgent problem to be solved in the prior art.
The content of the invention
To solve aforementioned technical problem, the invention provides a kind of medicinal fish combination that can reduce antibiotic residue
Thing, it is characterized in that terramycin of the medicinal fish composition by bait and as active component forms with compound amino acid, institute
The mass ratio for stating terramycin and compound amino acid is 1：0.5~2, described compound amino acid by percentage by weight 11%-~
13% methionine, the histidine of percentage by weight 15%~18%, the alanine of percentage by weight 15%~18%, weight
The L-aminobutanedioic acid of percentage 11%~13%, the cysteine hydrochloride of percentage by weight 2~3%, percentage by weight 1%~
1.5% tyrosine and the glycine composition of surplus.
A kind of described medicinal fish composition that can reduce antibiotic residue, it is characterized in that the terramycin with
The mass ratio of compound amino acid is 1:0.8~1.2.
Described a kind of medicinal fish composition that can reduce antibiotic residue, it is characterized in that the compounded amino
Acid is by the methionine by percentage by weight 12%, percentage by weight 16%-17% histidine, percentage by weight 16%-
17% alanine, the L-aminobutanedioic acid of percentage by weight 12%, the cysteine hydrochloride of percentage by weight 2~3%, weight percent
The glycine composition of tyrosine and surplus than 1%~1.5%.
Described a kind of fish medicine, it is characterized in that the fish medicine is used for the cultivation of the fresh-water fishes of Cyprinidae.
A kind of described fish medicine, it is characterized in that the preferred black carp of the fresh-water fishes of the Cyprinidae, grass carp, silver carp, bighead, carp,
Crucian, Tilapia mossambica.
A kind of medicinal fish composition that can reduce antibiotic residue provided by the invention, by preferred terramycin and again
Each amino acid ligand ratio in proportioning and the compound amino acid between amino acid is closed, is found surprisingly that answering specific preferably prescription
, can when being mixed and made into fish medicine with the bait of routine again after closing amino acid and terramycin composition compound and being treated and prevented for fish disease
Significantly to reduce fish only internal Determination of oxytetracycline residues, the bait containing compound amino acid is individually given after terramycin administration terminates
During material, then terramycin can be further improved in fish only internal accretion rate, so as to which terramycin medicine is greatly reduced
Off-drug period when applied to aquaculture, a small amount of cysteine hydrochloride and tyrosine are especially added in compound amino acid
The effect above becomes apparent afterwards.
Embodiment
A kind of fish medicine provided by the invention, is prepared in the following manner,
1) mixed as the terramycin of active component, amino acid with bait
2) it will be suppressed in the mixture of step 1) plus after water mixing and produce medicinal fish group of the invention after drying into strips
Compound.
The bait formula used in present embodiment for：
Fish meal 8%, dregs of beans 13%, peanut meal 18.8%, cotton dregs 13%, rapeseed dregs 13%, soya-bean oil 4%, premix 1%,
Flour 13%, rice bran 7%, wheat bran 8%, (above percentage is the weight percent that each component accounts for bait in bait to medical stone 1.2%
Than)
The premix uses the premix of carp 1% of biological feedstuff Co., Ltd of Beijing BDCom production, contains per g premixes
There is following nutritional ingredient：
Vitamin A >=400IU, vitamin D3100~300IU, vitamin E >=7mg, vitamin K3>=0.2mg, vitamin
B1>=0.3mg, vitamin B2>=0.5mg, vitamin B6>=0.22mg, niacinamide >=2.5mg, calcium pantothenate >=2mg, folic acid >=
0.2mg, vitamin C >=8mg, inositol >=7mg, 8~75mg of iron, 0.875~2.5mg of copper, 7~20mg of zinc, 2~10mg of manganese, iodine
>=0.03mg, 0.01~0.05mg of selenium, 0.01~0.2mg of cobalt.
The formula of embodiment 1~6 is as follows
Comparative example 1~6, it is identical with the formula of embodiment 1~6 respectively, but it is added without terramycin.
Pharmacological Examples
Using the childhood carp of health, 13.51 ± 0.67g of original body mass, it is divided into experimental group 1~6 and control group
Experimental group 1~6 feeds the medicinal fish composition that embodiment 1~6 obtains respectively, and control group only feeds bait
The experiment pool is 86cm × 56cm × 48cm plastics pond, and 25 tail carps, every group of 1 pond are put in a suitable place to breed per pond.Feeding method is
Fed daily using manufactured composition as bait twice, the time is respectively 9:00 and 18:00, the amount of feeding is about fish body weight every time
3%, equivalent terramycin dosage is 60mh/kg body weight, Feeding time 5d, tests and takes 5 tail test fish at random per pond after terminating,
Internal oxytetracycline residues detection is carried out to it, then experimental group 1~6 is continued to feed the comparative example fish medicine without terramycin, it is right
Continue only to feed bait according to group, every group takes the experiment of 5 tails to carry out internal oxytetracycline residues detection with fish at random again after lasting 5d, with reality
Test group after raising 5d control group fish only inside the average residual quantity of terramycin be 100, oxytetracycline residues knot in experimental group 1~6
Fruit such as following table.
| Numbering | Experimental group 1 | Experimental group 2 | Experimental group 3 | Experimental group 4 | Experimental group 5 | Experimental group 6 | Control group |
| 5d residual quantities | 47 | 42 | 41 | 39 | 45 | 48 | 100 |
| 10d residual quantities | 0.35 | 0.15 | 0.14 | 0.13 | 0.25 | 0.31 | 3.08 |
When as can be seen here, using the medicinal fish composition of the present invention, it is only internal in fish that terramycin can be substantially reduced
Residual, and when further feeding only has the comparative example of compound amino acid and bait after drug withdrawal, can also significantly improve terramycin
Metabolic rate.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
All any modification, equivalent and improvement made within principle etc., are all contained within protection scope of the present invention.
Claims (5)
- A kind of 1. medicinal fish composition that can reduce antibiotic residue, it is characterized in that the medicinal fish composition is by bait Formed with the terramycin as active component and compound amino acid, the mass ratio of the terramycin and compound amino acid is 1：0.5 ~2, described compound amino acid by percentage by weight 11%-~13% methionine, percentage by weight 15%~18% Histidine, the alanine of percentage by weight 15%~18%, the L-aminobutanedioic acid of percentage by weight 11%~13%, percentage by weight 2~3% cysteine hydrochloride, the tyrosine of percentage by weight 1%~1.5% and the glycine composition of surplus.
- A kind of 2. medicinal fish composition that can reduce antibiotic residue as claimed in claim 1, it is characterized in that the soil The mass ratio of mycin and compound amino acid is 1:0.8~1.2.
- A kind of 3. medicinal fish composition that can reduce antibiotic residue as claimed in claim 1, it is characterized in that described multiple Amino acid is closed by the methionine of percentage by weight 12%, percentage by weight 16%-17% histidine, percentage by weight 16%-17% alanine, the L-aminobutanedioic acid of percentage by weight 12%, the cysteine hydrochloride of percentage by weight 2~3%, weight Measure the tyrosine of percentage 1%~1.5% and the glycine composition of surplus.
- A kind of 4. medicinal fish composition that can reduce antibiotic residue as claimed in claim 1, it is characterized in that the fish Pharmaceutical composition is used for the cultivation of the fresh-water fishes of Cyprinidae.
- A kind of 5. fish medicine as claimed in claim 1, it is characterized in that the preferred black carp of the fresh-water fishes of the Cyprinidae, grass carp, silver carp, flathead Fish, carp, crucian, Tilapia mossambica.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710497645.4A CN107375305A (en) | 2017-06-27 | 2017-06-27 | A kind of medicinal fish composition that can reduce antibiotic residue |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710497645.4A CN107375305A (en) | 2017-06-27 | 2017-06-27 | A kind of medicinal fish composition that can reduce antibiotic residue |
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| CN201710497645.4A Pending CN107375305A (en) | 2017-06-27 | 2017-06-27 | A kind of medicinal fish composition that can reduce antibiotic residue |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110338280A (en) * | 2019-07-09 | 2019-10-18 | 中国水产科学研究院珠江水产研究所 | A kind of medicinal fish feed that can reduce antibiotic residue |
| CN110960541A (en) * | 2019-12-13 | 2020-04-07 | 西南大学 | Pharmaceutical composition for penaeus vannamei boone |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105192372A (en) * | 2015-09-28 | 2015-12-30 | 全椒县花溪湖特种水产合作社 | Black carp premixed feedstuff and preparation method thereof |
-
2017
- 2017-06-27 CN CN201710497645.4A patent/CN107375305A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105192372A (en) * | 2015-09-28 | 2015-12-30 | 全椒县花溪湖特种水产合作社 | Black carp premixed feedstuff and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 付同禄等: "饲料添加剂现状及在鱼虾饲料中的利用", 《饲料工业》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110338280A (en) * | 2019-07-09 | 2019-10-18 | 中国水产科学研究院珠江水产研究所 | A kind of medicinal fish feed that can reduce antibiotic residue |
| CN110960541A (en) * | 2019-12-13 | 2020-04-07 | 西南大学 | Pharmaceutical composition for penaeus vannamei boone |
| CN110960541B (en) * | 2019-12-13 | 2022-10-28 | 西南大学 | Pharmaceutical composition for penaeus vannamei |
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