CN107174588A - A kind of medicine for fish culture - Google Patents
A kind of medicine for fish culture Download PDFInfo
- Publication number
- CN107174588A CN107174588A CN201710455382.0A CN201710455382A CN107174588A CN 107174588 A CN107174588 A CN 107174588A CN 201710455382 A CN201710455382 A CN 201710455382A CN 107174588 A CN107174588 A CN 107174588A
- Authority
- CN
- China
- Prior art keywords
- weight
- percentage
- medicine
- active component
- fish culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 claims abstract description 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 8
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims abstract description 8
- 235000010262 sodium metabisulphite Nutrition 0.000 claims abstract description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 6
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims abstract description 5
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims abstract description 5
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000018417 cysteine Nutrition 0.000 claims abstract description 5
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract description 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960000310 isoleucine Drugs 0.000 claims abstract description 5
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims abstract description 5
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000004471 Glycine Substances 0.000 claims abstract description 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims abstract description 4
- 241000252210 Cyprinidae Species 0.000 claims description 5
- 241000252233 Cyprinus carpio Species 0.000 claims description 4
- 239000013505 freshwater Substances 0.000 claims description 4
- 235000017060 Arachis glabrata Nutrition 0.000 claims description 3
- 244000105624 Arachis hypogaea Species 0.000 claims description 3
- 235000010777 Arachis hypogaea Nutrition 0.000 claims description 3
- 235000018262 Arachis monticola Nutrition 0.000 claims description 3
- 240000002791 Brassica napus Species 0.000 claims description 3
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims description 3
- 229920000742 Cotton Polymers 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 3
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 240000007594 Oryza sativa Species 0.000 claims description 3
- 235000007164 Oryza sativa Nutrition 0.000 claims description 3
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 3
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 3
- 235000012054 meals Nutrition 0.000 claims description 3
- 235000020232 peanut Nutrition 0.000 claims description 3
- 235000009566 rice Nutrition 0.000 claims description 3
- 239000004575 stone Substances 0.000 claims description 3
- 235000015099 wheat brans Nutrition 0.000 claims description 3
- 241000252230 Ctenopharyngodon idella Species 0.000 claims description 2
- 235000019733 Fish meal Nutrition 0.000 claims description 2
- 241000252234 Hypophthalmichthys nobilis Species 0.000 claims description 2
- 241000276701 Oreochromis mossambicus Species 0.000 claims description 2
- 239000004467 fishmeal Substances 0.000 claims description 2
- 235000013312 flour Nutrition 0.000 claims description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 claims 1
- 244000025254 Cannabis sativa Species 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 description 21
- 229960002180 tetracycline Drugs 0.000 description 21
- 229930101283 tetracycline Natural products 0.000 description 21
- 235000019364 tetracycline Nutrition 0.000 description 21
- 150000003522 tetracyclines Chemical class 0.000 description 21
- 238000009360 aquaculture Methods 0.000 description 7
- 244000144974 aquaculture Species 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 1
- 241001275898 Mylopharyngodon piceus Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- -1 compound amino acid Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
A kind of medicine for fish culture, it is characterized in that the medicine is by the first active component, the second active component and can be constituted as the excipient of bait, the mass ratio of first active component and the second active component is 1:1~3, second active component by percentage by weight 14%~16% cysteine, the isoleucine of percentage by weight 14%~16%, proline, the sodium pyrosulfite of percentage by weight 4%~6% and the surplus glycine composition of the serine of the histidine of the phenylalanine of percentage by weight 14%~16%, percentage by weight 2% 3%, percentage by weight 2% 3%, percentage by weight 2% 3%.
Description
Technical field
The invention belongs to Medicines in Aquaculture, more particularly to a kind of fish medicine.
Background technology
In high-density aquiculture, in order to keep away water body disinfection, and the bacterium infection of prevention and treatment fish only
That exempts from will use antibiotic.And tetracycline can be both added in bait therefore obtained more as water body bacteriostatic agent again
Be widely applied, but human body intake tetracycline after can produce " " tetracycline pigmentation teeth " etc. be difficult to cure the problem of, existing aquaculture
In technology, the residual that being generally required in application tetracycline can just make it in aquatic products body up to 30d off-drug period is down to 100
Below μ g/kg, cause tetracycline to there is more serious limitation in aquaculture application, and also easily Aquatic products consumption person is made
Into healthy hidden danger, therefore provide and a kind of can reduce the medicine for fish culture that tetracycline remains in aquatic products body and turn into
Urgent problem to be solved in the prior art.
The content of the invention
To solve aforementioned technical problem, the invention provides a kind of medicine for fish culture, it is characterized in that the medicine
Thing is by the first active component, the second active component and can be constituted as the excipient of bait, first active component and
The mass ratio of two active components is 1:1~3, second active component by percentage by weight 14%~16% cysteine,
The isoleucine of percentage by weight 14%~16%, phenylalanine, the percentage by weight 2%- of percentage by weight 14%~16%
3% histidine, percentage by weight 2%-3% serine, percentage by weight 2%-3% proline, percentage by weight 4%
~6% sodium pyrosulfite and surplus glycine composition.
Described a kind of medicine for fish culture, it is characterized in that second active component is by percentage by weight 15%
Cysteine, the isoleucine of percentage by weight 15%, phenylalanine, the percentage by weight 2%- of percentage by weight 15%
3% histidine, percentage by weight 2%-3% serine, percentage by weight 2%-3% proline, percentage by weight 5%
Sodium pyrosulfite and surplus glycine composition.
A kind of described medicine for fish culture, it is characterized in that first active component and the second active component
Mass ratio is 1:1.6~2.4.
Described a kind of medicine for fish culture, it is characterized in that described can be used for the auxiliary material for making bait to be selected from fish
One or more in powder, dregs of beans, peanut meal, cotton dregs, rapeseed dregs, soya-bean oil, premix, flour, rice bran, wheat bran, medical stone.
Described a kind of medicine for fish culture, it is characterized in that the medicine is used for the cultivation of the fresh-water fishes of Cyprinidae.
Described a kind of medicine for fish culture, it is characterized in that the fresh-water fishes of the Cyprinidae are selected from black carp, grass carp, silver carp
Fish, bighead, carp, crucian, Tilapia mossambica.
Provided by the present invention for the medicine of fish culture, pass through it of preferably the first active component and the second active component
Between matched with each amino acid in when the second active component with sodium pyrosulfite, be found surprisingly that by active component with it is conventional
When the excipient mixing that can be used for making bait carries out feeding administration to aquaculture fish, except can normally play Fourth Ring
The antibiotic effect of element is outer, additionally it is possible to significant reduction fish only internal tetracycline residue, after tetracycline administration terminates individually
When giving the bait containing the second active component, then tetracycline can be further improved in fish only internal accretion rate, so that
Off-drug period of tetracycline medicine when applied to aquaculture can be greatly reduced.Problem of the prior art is solved, especially
It is the sodium pyrosulfite in the second active component, although conventional to be used generally as antioxidant, but provided in the present invention
In medicine, its effect for improving tetracycline accretion rate can be dramatically increased by adding sodium pyrosulfite, and be formulated preferably
When, it has been found that become apparent using its effect during currently preferred formula.
Embodiment
A kind of pharmaceutical composition for aquaculture that the present invention is provided, is prepared in the following manner,
1) using as the tetracycline of the first active ingredient, the second active component with that can be mixed as the excipient of bait
2) by step 1) mixture in add water mix after suppress into strips dry after produce the present invention medicine.
Used in present embodiment can as the excipient formulation of bait for：
Fish meal 8%, dregs of beans 13%, peanut meal 18.8%, cotton dregs 13%, rapeseed dregs 13%, soya-bean oil 4%, premix 1%, face
Powder 13%, rice bran 7%, wheat bran 8%, medical stone 1.2% (above percentage accounts for the percentage by weight of bait for each component in bait)
The premix uses the premix of carp 1% that biological feedstuff Co., Ltd of Beijing BDCom produces, and contains per g premixes
There is following nutritional ingredient：
Vitamin A >=400IU, vitamin D3100~300IU, vitamin E >=7mg, vitamin K3>=0.2mg, vitamin
B1>=0.3mg, vitamin B2>=0.5mg, vitamin B6>=0.22mg, niacinamide >=2.5mg, calcium pantothenate >=2mg, folic acid >=
0.2mg, vitamin C >=8mg, inositol >=7mg, 8~75mg of iron, 0.875~2.5mg of copper, 7~20mg of zinc, 2~10mg of manganese, iodine
>=0.03mg, 0.01~0.05mg of selenium, 0.01~0.2mg of cobalt.
The formula of embodiment 1~6 is as follows
Comparative example 1~6, it is identical with the formula of embodiment 1~6 respectively, but it is added without tetracycline
Pharmacological Examples
Using the childhood carp of health, 14.71 ± 0.47g of original body mass is divided into experimental group 1~6 and control group,
Experimental group 1~6 feeds the pharmaceutical composition that embodiment 1~6 is obtained respectively, control group using can as bait tax
Shape agent is fed as conventional bait.
The experiment pool is 86cm × 56cm × 48cm plastics pond, and 15 tail carps, every group of 1 pond are put in a suitable place to breed per pond.Feeding method is
The medicine being made is fed twice daily as bait, the time is respectively 9:00 and 18:00, the amount of feeding is about fish body weight every time
3%, it is 60mh/kg body weight to convert into tetracycline dosage, and Feeding time is 5d, and experiment takes 5 tail test fish at random after terminating per pond,
Internal Tetracycline Residues detection is carried out to it, then experimental group 1~6 is continued to feed the comparative example composition without tetracycline,
Control group continues only to feed conventional bait, and every group takes the experiment of 5 tails to carry out internal Tetracycline Residues inspection with fish at random again after lasting 5d
Survey, so that the average residual quantity of the internal tetracycline of control group fish only is 100 after experimental group raising 5d, tetracycline is residual in experimental group 1~6
Allowance result such as following table.
| Numbering | Experimental group 1 | Experimental group 2 | Experimental group 3 | Experimental group 4 | Experimental group 5 | Experimental group 6 | Control group |
| 5d residual quantities | 42 | 46 | 45 | 33 | 61 | 42 | 100 |
| 10d residual quantities | 0.52 | 0.56 | 0.55 | 0.53 | 0.41 | 0.38 | 1.89 |
As can be seen here, using the medicine of the present invention, tetracycline can be substantially reduced in fish only internal residual, and stopping
When further feeding only has the comparative example of compound amino acid and bait after medicine, the metabolic rate of tetracycline can be also significantly improved.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Any modifications, equivalent substitutions and improvements made within principle etc., are all contained within protection scope of the present invention.
Claims (6)
1. a kind of medicine for fish culture, it is characterized in that the medicine is by the first active component, the second active component and can
Using the excipient composition as bait, the mass ratio of first active component and the second active component is 1:1~3, described
Two active components are by the cysteine of percentage by weight 14%~16%, the isoleucine of percentage by weight 14%~16%, weight
Measure phenylalanine, percentage by weight 2%-3% histidine, the percentage by weight 2%-3% silk of percentage 14%~16%
Propylhomoserin, percentage by weight 2%-3% proline, the sodium pyrosulfite of percentage by weight 4%~6% and surplus glycine group
Into.
2. a kind of medicine for fish culture as claimed in claim 1, it is characterized in that second active component is by weight
The cysteine of percentage 15%, the isoleucine of percentage by weight 15%, the phenylalanine of percentage by weight 15%, weight hundred
Histidine, percentage by weight 2%-3% serine point than 2%-3%, percentage by weight 2%-3% proline, weight
Sodium pyrosulfite and surplus the glycine composition of percentage 5%.
3. a kind of medicine for fish culture as claimed in claim 1, it is characterized in that first active component and second
The mass ratio of active component is 1:1.6~2.4.
4. a kind of medicine for fish culture as claimed in claim 1, it is characterized in that described can be used for making the auxiliary of bait
Expect one kind in fish meal, dregs of beans, peanut meal, cotton dregs, rapeseed dregs, soya-bean oil, premix, flour, rice bran, wheat bran, medical stone
Or it is several.
5. a kind of medicine for fish culture as described in Claims 1 to 4 is any, it is characterized in that the medicine is used for Cyprinidae
Fresh-water fishes cultivation.
6. a kind of medicine for fish culture as claimed in claim 5, it is characterized in that the fresh-water fishes of the Cyprinidae are selected from green grass or young crops
Fish, grass carp, silver carp, bighead, carp, crucian, Tilapia mossambica.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710455382.0A CN107174588A (en) | 2017-06-16 | 2017-06-16 | A kind of medicine for fish culture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710455382.0A CN107174588A (en) | 2017-06-16 | 2017-06-16 | A kind of medicine for fish culture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107174588A true CN107174588A (en) | 2017-09-19 |
Family
ID=59835419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710455382.0A Pending CN107174588A (en) | 2017-06-16 | 2017-06-16 | A kind of medicine for fish culture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107174588A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933050A (en) * | 2014-05-02 | 2014-07-23 | 黎作民 | Novel medicament for treating bacterial septicemia of freshwater fish |
| CN105146120A (en) * | 2015-07-14 | 2015-12-16 | 江苏爱福特科技开发有限公司 | Carp feed and preparation method thereof |
| CN105192372A (en) * | 2015-09-28 | 2015-12-30 | 全椒县花溪湖特种水产合作社 | Black carp premixed feedstuff and preparation method thereof |
-
2017
- 2017-06-16 CN CN201710455382.0A patent/CN107174588A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933050A (en) * | 2014-05-02 | 2014-07-23 | 黎作民 | Novel medicament for treating bacterial septicemia of freshwater fish |
| CN105146120A (en) * | 2015-07-14 | 2015-12-16 | 江苏爱福特科技开发有限公司 | Carp feed and preparation method thereof |
| CN105192372A (en) * | 2015-09-28 | 2015-12-30 | 全椒县花溪湖特种水产合作社 | Black carp premixed feedstuff and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Daniel | A review on replacing fish meal in aqua feeds using plant protein sources | |
| CN103039731B (en) | Mixed feed for mixed aquaculture of freshwater fish | |
| EP2880989A1 (en) | Foodstuff for cultured fish and method for promoting growth of cultured fish using same | |
| CN101766259B (en) | Composite feed additive | |
| CN101536733A (en) | Feed special for low-fat meat duck without antibiotic and fishy smell | |
| CN104256131A (en) | Piglet feed | |
| KR101532208B1 (en) | Biogas residue containing chicken formula feed and the production method thereof | |
| CN104543436A (en) | Piglet disease-resistant feed | |
| CN107375305A (en) | A kind of medicinal fish composition that can reduce antibiotic residue | |
| CN107158009A (en) | A kind of pharmaceutical composition for aquaculture | |
| KR100897488B1 (en) | Feedstuff composition including red shale | |
| CN102613434A (en) | Pig feed additive and preparation as well as use method thereof | |
| CN107279559A (en) | A kind of egg feedstuff for improving egg quality | |
| CN107281194A (en) | A kind of compound medicine for fish culture | |
| CN107281195A (en) | It is a kind of to reduce the aquaculture pharmaceutical composition of antibiotic residue | |
| CN110973406A (en) | Environment-friendly compound feed for macrobrachium rosenbergii | |
| CN109511820A (en) | A kind of health premixed feed and health mixed fodder applied to laying hen | |
| KR100811110B1 (en) | Feed additive containing alpha-lipoic acid capsule composition stabilized in water phase for increasing immunity of fish and method for using the same | |
| CN107080111A (en) | A kind of bait type medicine for aquaculture | |
| CN107174588A (en) | A kind of medicine for fish culture | |
| CN107158010A (en) | A kind of fish medicine | |
| CN104886343A (en) | Compound feed for chickens and a preparation method thereof | |
| CN103583895A (en) | Poultry feed | |
| CN107569497A (en) | A kind of bait type medicine for Cyprinidae aquaculture | |
| CN107212155A (en) | A kind of pharmaceutical composition for Cyprinidae man's fish culture |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170919 |