CN107212155A - A kind of pharmaceutical composition for Cyprinidae man's fish culture - Google Patents
A kind of pharmaceutical composition for Cyprinidae man's fish culture Download PDFInfo
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- CN107212155A CN107212155A CN201710455383.5A CN201710455383A CN107212155A CN 107212155 A CN107212155 A CN 107212155A CN 201710455383 A CN201710455383 A CN 201710455383A CN 107212155 A CN107212155 A CN 107212155A
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- tetracycline
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/22—Animal feeding-stuffs from material of animal origin from fish
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Physiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Marine Sciences & Fisheries (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Insects & Arthropods (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A kind of pharmaceutical composition for Cyprinidae man's fish culture, by the amino acid composition and tetracycline as active component, and available for the auxiliary material composition for making bait, the amino acid composition by percentage by weight 23%~27% isoleucine, the threonine of percentage by weight 15%~18%, the arginine of percentage by weight 4%~6%, the histidine and surplus glycine composition of the tyrosine of percentage by weight 0.5%~1%, percentage by weight 2% 3%, the weight ratio of the tetracycline and amino acid composition is 1:0.7~1.3.
Description
Technical field
The invention belongs to Medicines in Aquaculture, more particularly to a kind of fish medicine.
Background technology
When tetracycline is used for aquaculture, it can both be added again in bait, but be due to as water body bacteriostatic agent
The problem of " tetracycline pigmentation teeth " etc. is difficult to healing can be produced after human body intake tetracycline, thus it is banned for human body.For this aquatic products
In cultural technique, the residual that being generally required in application tetracycline can just make it in aquatic products body up to 30d off-drug period drops
To below 100 μ g/kg, this curative effect determination of tetracycline, cheap antibiotic is set to be existed more in aquaculture application
Serious limitation, especially in the cultivation of Cyprinidae chinese carp, this contradiction is especially prominent, therefore offer one kind can reduce Fourth Ring
The pharmaceutical composition for Cyprinidae man's fish culture that element is remained in aquatic products body turns into urgent problem to be solved in the prior art.
The content of the invention
To solve aforementioned technical problem, the invention provides a kind of pharmaceutical composition for Cyprinidae man's fish culture, it is special
Levy be described pharmaceutical composition by the amino acid composition and tetracycline as active component, and available for make bait it is auxiliary
Material composition, the amino acid composition is by the isoleucine of percentage by weight 23%~27%, percentage by weight 15%~18%
Threonine, the arginine of percentage by weight 4%~6%, tyrosine, the percentage by weight of percentage by weight 0.5%~1%
2%-3% histidine and surplus glycine composition, the weight ratio of the tetracycline and amino acid composition is 1:0.7~1.3.
Described a kind of pharmaceutical composition for Cyprinidae man's fish culture, it is characterized in that the amino acid composition is by weight
The isoleucine of percentage 25%, percentage by weight 14%-16% threonine, percentage by weight 0.5%-1% arginine,
Tyrosine, percentage by weight 2%-3% histidine and the surplus glycine composition of percentage by weight 0.5%~1%.
Described a kind of pharmaceutical composition for Cyprinidae man's fish culture, it is characterized in that the tetracycline and combination of amino acids
The weight ratio of thing is 1:0.9~1.1.
Described a kind of pharmaceutical composition for Cyprinidae man's fish culture, it is characterized in that described can be used for making the auxiliary of bait
Expect one kind in fish meal, dregs of beans, peanut meal, cotton dregs, rapeseed dregs, soya-bean oil, premix, flour, rice bran, wheat bran, medical stone
Or it is several.
A kind of pharmaceutical composition for Cyprinidae man's fish culture that the present invention is provided, passes through preferred tetracycline and amino acid group
Each amino acid ligand ratio in proportioning and amino acid composition between compound, is found surprisingly that and makes active component with can be used for
When the auxiliary material mixing for making bait carries out feeding administration to aquaculture fish, except the antibiotic that can normally play tetracycline is made
With outer, additionally it is possible to significant reduction fish only internal tetracycline residue, individually given after tetracycline administration terminates containing amino
During the bait of acid composition, then tetracycline can be further improved in fish only internal accretion rate, so as to significantly subtract
Few off-drug period of tetracycline medicine when applied to aquaculture.Problem of the prior art is solved, especially applied to Cyprinidae
The cultivation of fresh-water fishes, in addition by the as shown by data of embodiment, in currently preferred data area, the effect above is more bright
It is aobvious.
Embodiment
A kind of pharmaceutical composition for aquaculture that the present invention is provided, is prepared in the following manner,
1) it will be mixed as the tetracycline of active component, amino acid with can be used for making the auxiliary material of bait
2) by step 1) mixture in add water mix after suppress into strips dry after produce the present invention pharmaceutical composition.
Used in present embodiment can be used for make bait accessory formula for：
Fish meal 8%, dregs of beans 13%, peanut meal 18.8%, cotton dregs 13%, rapeseed dregs 13%, soya-bean oil 4%, premix 1%,
Flour 13%, rice bran 7%, wheat bran 8%, (above percentage accounts for the weight percent of bait for each component in bait to medical stone 1.2%
Than)
The premix uses the premix of carp 1% that biological feedstuff Co., Ltd of Beijing BDCom produces, and contains per g premixes
There is following nutritional ingredient：
Vitamin A >=400IU, vitamin D3100~300IU, vitamin E >=7mg, vitamin K3>=0.2mg, vitamin
B1>=0.3mg, vitamin B2>=0.5mg, vitamin B6>=0.22mg, niacinamide >=2.5mg, calcium pantothenate >=2mg, folic acid >=
0.2mg, vitamin C >=8mg, inositol >=7mg, 8~75mg of iron, 0.875~2.5mg of copper, 7~20mg of zinc, 2~10mg of manganese, iodine
>=0.03mg, 0.01~0.05mg of selenium, 0.01~0.2mg of cobalt.
The formula of embodiment 1~6 is as follows
Comparative example 1~6, it is identical with the formula of embodiment 1~6 respectively, but it is added without tetracycline
Pharmacological Examples
Using the childhood carp of health, 15.28 ± 0.52g of original body mass is divided into experimental group 1~6 and control group,
Experimental group 1~6 feeds the pharmaceutical composition that embodiment 1~6 is obtained respectively, and control group is by available for making bait
Auxiliary material is fed as conventional bait.
The experiment pool is 86cm × 56cm × 48cm plastics pond, and 15 tail carps, every group of 1 pond are put in a suitable place to breed per pond.Feeding method is
The pharmaceutical composition being made is fed twice daily as bait, the time is respectively 9:00 and 18:00, the amount of feeding is about fish body every time
The 3% of weight, it is 60mh/kg body weight to convert into tetracycline dosage, and Feeding time is 5d, and experiment takes 5 tails to try at random after terminating per pond
Fish is tested, internal Tetracycline Residues detection is carried out to it, then experimental group 1~6 is continued to feed the comparative example group without tetracycline
Compound, control group continues only to feed conventional bait, and every group takes the experiment of 5 tails to carry out internal tetracycline residue with fish at random again after lasting 5d
Amount detection, so that the average residual quantity of the internal tetracycline of control group fish only is 100 after experimental group raising 5d, Fourth Ring in experimental group 1~6
Plain residual quantity result such as following table.
| Numbering | Experimental group 1 | Experimental group 2 | Experimental group 3 | Experimental group 4 | Experimental group 5 | Experimental group 6 | Control group |
| 5d residual quantities | 59 | 43 | 44 | 39 | 58 | 53 | 100 |
| 10d residual quantities | 0.59 | 0.38 | 0.35 | 0.37 | 0.45 | 0.43 | 1.97 |
As can be seen here, using the pharmaceutical composition of the present invention, tetracycline can be substantially reduced in fish only internal residual, and
And when further feeding only has the comparative example of compound amino acid and bait after drug withdrawal, can also significantly improve the metabolism of tetracycline
Rate.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Any modifications, equivalent substitutions and improvements made within principle etc., are all contained within protection scope of the present invention.
Claims (4)
1. a kind of pharmaceutical composition for Cyprinidae man's fish culture, it is characterized in that described pharmaceutical composition is by being used as active component
Amino acid composition and tetracycline, and available for the auxiliary material composition for making bait, the amino acid composition is by weight percent
Isoleucine than 23%~27%, the threonine of percentage by weight 15%~18%, the smart ammonia of percentage by weight 4%~6%
Acid, tyrosine, percentage by weight 2%-3% histidine and the surplus glycine composition of percentage by weight 0.5%~1%, institute
The weight ratio for stating tetracycline and amino acid composition is 1:0.7~1.3.
2. a kind of pharmaceutical composition for Cyprinidae man's fish culture as claimed in claim 1, it is characterized in that the amino acid group
Compound is by the isoleucine of percentage by weight 25%, percentage by weight 14%-16% threonine, percentage by weight 0.5%-
1% arginine, tyrosine, percentage by weight 2%-3% histidine and the sweet ammonia of surplus of percentage by weight 0.5%~1%
Acid composition.
3. a kind of pharmaceutical composition for Cyprinidae man's fish culture as claimed in claim 1, it is characterized in that the tetracycline and
The weight ratio of amino acid composition is 1:0.9~1.1.
4. a kind of pharmaceutical composition for Cyprinidae man's fish culture as claimed in claim 1, it is characterized in that described can be used for making
The auxiliary material for making bait is selected from fish meal, dregs of beans, peanut meal, cotton dregs, rapeseed dregs, soya-bean oil, premix, flour, rice bran, wheat bran, wheat meal
One or more in stone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710455383.5A CN107212155B (en) | 2017-06-16 | 2017-06-16 | Pharmaceutical composition for carp breeding |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710455383.5A CN107212155B (en) | 2017-06-16 | 2017-06-16 | Pharmaceutical composition for carp breeding |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107212155A true CN107212155A (en) | 2017-09-29 |
| CN107212155B CN107212155B (en) | 2019-12-17 |
Family
ID=59949722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710455383.5A Active CN107212155B (en) | 2017-06-16 | 2017-06-16 | Pharmaceutical composition for carp breeding |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107212155B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002024911A2 (en) * | 2000-09-19 | 2002-03-28 | Millennium Pharmaceuticals, Inc. | 63760, a novel human transporter and uses thereof |
| US20050176140A1 (en) * | 2004-02-10 | 2005-08-11 | Benedict Daniel J. | Method and apparatus for cell culture using a two liquid phase bioreactor |
| WO2010049807A2 (en) * | 2008-10-30 | 2010-05-06 | Gene Bridges Gmbh | Method for recombinant expression of polypeptides |
| CN105192372A (en) * | 2015-09-28 | 2015-12-30 | 全椒县花溪湖特种水产合作社 | Black carp premixed feedstuff and preparation method thereof |
-
2017
- 2017-06-16 CN CN201710455383.5A patent/CN107212155B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002024911A2 (en) * | 2000-09-19 | 2002-03-28 | Millennium Pharmaceuticals, Inc. | 63760, a novel human transporter and uses thereof |
| US20050176140A1 (en) * | 2004-02-10 | 2005-08-11 | Benedict Daniel J. | Method and apparatus for cell culture using a two liquid phase bioreactor |
| WO2010049807A2 (en) * | 2008-10-30 | 2010-05-06 | Gene Bridges Gmbh | Method for recombinant expression of polypeptides |
| CN105192372A (en) * | 2015-09-28 | 2015-12-30 | 全椒县花溪湖特种水产合作社 | Black carp premixed feedstuff and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| NIHAL N DE SILVA ET AL: "Effect of tetracycline antibiotics on the proteolysis of fish muscle", 《NATRUE》 * |
| 付同禄: "饲料添加剂现状及在鱼虾饲料中的利用", 《饲料工业》 * |
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| Publication number | Publication date |
|---|---|
| CN107212155B (en) | 2019-12-17 |
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