CN1058016A - 用于治疗与白三烯有关疾病的苯甲酸衍生物 - Google Patents

用于治疗与白三烯有关疾病的苯甲酸衍生物 Download PDF

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Publication number
CN1058016A
CN1058016A CN91104564A CN91104564A CN1058016A CN 1058016 A CN1058016 A CN 1058016A CN 91104564 A CN91104564 A CN 91104564A CN 91104564 A CN91104564 A CN 91104564A CN 1058016 A CN1058016 A CN 1058016A
Authority
CN
China
Prior art keywords
compound
aliphatic group
group
phenyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN91104564A
Other languages
English (en)
Chinese (zh)
Inventor
罗伯特·A·戴恩斯
威廉·D·金斯伯里
伊斯雷以·彭德拉克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1058016A publication Critical patent/CN1058016A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN91104564A 1990-06-07 1991-06-07 用于治疗与白三烯有关疾病的苯甲酸衍生物 Pending CN1058016A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53438890A 1990-06-07 1990-06-07
US534,388 1990-06-07

Publications (1)

Publication Number Publication Date
CN1058016A true CN1058016A (zh) 1992-01-22

Family

ID=24129833

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91104564A Pending CN1058016A (zh) 1990-06-07 1991-06-07 用于治疗与白三烯有关疾病的苯甲酸衍生物

Country Status (16)

Country Link
EP (1) EP0532550A1 (fi)
JP (1) JPH05507475A (fi)
KR (1) KR930700445A (fi)
CN (1) CN1058016A (fi)
AU (1) AU7901791A (fi)
CA (1) CA2083958A1 (fi)
FI (1) FI925544A (fi)
HU (1) HUT64748A (fi)
IE (2) IE911913A1 (fi)
IL (1) IL98388A0 (fi)
MA (1) MA22196A1 (fi)
MX (1) MX26142A (fi)
PL (1) PL290586A1 (fi)
PT (1) PT97912A (fi)
WO (1) WO1991018880A1 (fi)
ZA (1) ZA914323B (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100456944C (zh) * 2001-03-27 2009-02-04 明治制果株式会社 膨化小食品的制造方法及其制造装置

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4226493A (en) * 1992-05-01 1993-11-29 Smithkline Beecham Corporation Leukotriene antagonists
WO1995015950A1 (en) * 1993-12-08 1995-06-15 Smithkline Beecham Corporation Compounds
IL106156A0 (en) * 1992-06-30 1993-10-20 Smithkline Beecham Corp Pyridinyl compounds
WO1994014442A1 (en) * 1992-12-23 1994-07-07 Smithkline Beecham Corporation Substituted pyridyl compounds useful as leukotriene antagonists
BR9507459A (pt) * 1994-04-13 1997-11-11 Hoffmann La Roche Antagonistas á base de piridino-leucotrieno b4 substituído
ES2622522T3 (es) 2003-08-26 2017-07-06 The Regents Of The University Of Colorado, A Body Corporate Inhibidores de la actividad proteasa de serina y su uso en métodos y composiciones para el tratamiento de infecciones bacterianas
US8093253B2 (en) 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563446A (en) * 1983-07-27 1986-01-07 Takeda Chemical Industries, Ltd. Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
GB8505285D0 (en) * 1985-03-01 1985-04-03 Beecham Group Plc Compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100456944C (zh) * 2001-03-27 2009-02-04 明治制果株式会社 膨化小食品的制造方法及其制造装置

Also Published As

Publication number Publication date
EP0532550A1 (en) 1993-03-24
FI925544A0 (fi) 1992-12-07
HUT64748A (en) 1994-02-28
CA2083958A1 (en) 1991-12-08
JPH05507475A (ja) 1993-10-28
AU7901791A (en) 1991-12-31
MA22196A1 (fr) 1992-04-01
ZA914323B (en) 1992-06-24
IE911912A1 (en) 1991-12-18
IE911913A1 (en) 1991-12-18
HU9203866D0 (en) 1993-03-29
FI925544A (fi) 1992-12-07
MX26142A (es) 1994-02-28
WO1991018880A1 (en) 1991-12-12
IL98388A0 (en) 1992-07-15
PT97912A (pt) 1992-03-31
PL290586A1 (en) 1992-04-06
KR930700445A (ko) 1993-03-15

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C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication