CA2083958A1 - Benzoic acid derivatives for treating leukotriene-related disease - Google Patents

Benzoic acid derivatives for treating leukotriene-related disease

Info

Publication number
CA2083958A1
CA2083958A1 CA002083958A CA2083958A CA2083958A1 CA 2083958 A1 CA2083958 A1 CA 2083958A1 CA 002083958 A CA002083958 A CA 002083958A CA 2083958 A CA2083958 A CA 2083958A CA 2083958 A1 CA2083958 A1 CA 2083958A1
Authority
CA
Canada
Prior art keywords
aliphatic
compound
aryl
alkyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002083958A
Other languages
English (en)
French (fr)
Inventor
Robert A. Daines
William D. Kingsbury
Israil Pendrak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2083958A1 publication Critical patent/CA2083958A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002083958A 1990-06-07 1991-05-15 Benzoic acid derivatives for treating leukotriene-related disease Abandoned CA2083958A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53438890A 1990-06-07 1990-06-07
US534,388 1990-06-07

Publications (1)

Publication Number Publication Date
CA2083958A1 true CA2083958A1 (en) 1991-12-08

Family

ID=24129833

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002083958A Abandoned CA2083958A1 (en) 1990-06-07 1991-05-15 Benzoic acid derivatives for treating leukotriene-related disease

Country Status (16)

Country Link
EP (1) EP0532550A1 (fi)
JP (1) JPH05507475A (fi)
KR (1) KR930700445A (fi)
CN (1) CN1058016A (fi)
AU (1) AU7901791A (fi)
CA (1) CA2083958A1 (fi)
FI (1) FI925544A (fi)
HU (1) HUT64748A (fi)
IE (2) IE911913A1 (fi)
IL (1) IL98388A0 (fi)
MA (1) MA22196A1 (fi)
MX (1) MX26142A (fi)
PL (1) PL290586A1 (fi)
PT (1) PT97912A (fi)
WO (1) WO1991018880A1 (fi)
ZA (1) ZA914323B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4226493A (en) * 1992-05-01 1993-11-29 Smithkline Beecham Corporation Leukotriene antagonists
WO1995015950A1 (en) * 1993-12-08 1995-06-15 Smithkline Beecham Corporation Compounds
IL106156A0 (en) * 1992-06-30 1993-10-20 Smithkline Beecham Corp Pyridinyl compounds
WO1994014442A1 (en) * 1992-12-23 1994-07-07 Smithkline Beecham Corporation Substituted pyridyl compounds useful as leukotriene antagonists
BR9507459A (pt) * 1994-04-13 1997-11-11 Hoffmann La Roche Antagonistas á base de piridino-leucotrieno b4 substituído
US7297357B2 (en) * 2001-03-27 2007-11-20 Meiji Seika Kaisha, Ltd. Process for producing puffed snack and production apparatus therefor
ES2622522T3 (es) 2003-08-26 2017-07-06 The Regents Of The University Of Colorado, A Body Corporate Inhibidores de la actividad proteasa de serina y su uso en métodos y composiciones para el tratamiento de infecciones bacterianas
US8093253B2 (en) 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563446A (en) * 1983-07-27 1986-01-07 Takeda Chemical Industries, Ltd. Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
GB8505285D0 (en) * 1985-03-01 1985-04-03 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
EP0532550A1 (en) 1993-03-24
FI925544A0 (fi) 1992-12-07
HUT64748A (en) 1994-02-28
JPH05507475A (ja) 1993-10-28
AU7901791A (en) 1991-12-31
MA22196A1 (fr) 1992-04-01
ZA914323B (en) 1992-06-24
IE911912A1 (en) 1991-12-18
IE911913A1 (en) 1991-12-18
HU9203866D0 (en) 1993-03-29
FI925544A (fi) 1992-12-07
MX26142A (es) 1994-02-28
WO1991018880A1 (en) 1991-12-12
CN1058016A (zh) 1992-01-22
IL98388A0 (en) 1992-07-15
PT97912A (pt) 1992-03-31
PL290586A1 (en) 1992-04-06
KR930700445A (ko) 1993-03-15

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Legal Events

Date Code Title Description
FZDE Discontinued