CN105560167A - Universal O / W type emulsion type matrix and preparation technology thereof - Google Patents
Universal O / W type emulsion type matrix and preparation technology thereof Download PDFInfo
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- CN105560167A CN105560167A CN201510980140.4A CN201510980140A CN105560167A CN 105560167 A CN105560167 A CN 105560167A CN 201510980140 A CN201510980140 A CN 201510980140A CN 105560167 A CN105560167 A CN 105560167A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The present invention discloses a universal O / W type emulsion type matrix, comprising the following components by mass: 3 to 3.5 parts of stearic acid, 2.4 to 3 parts of glycerin monostearate, 3 to 3.5 parts of octadecanol, 1.8 to 2.2 parts of dimeticone, 1.8 to 2.2 parts of white vaseline, 3 to 3.5 parts of liquid paraffin, 4.5 to 5.2 parts of glycerol, 0.3 to 0.5 part of triethanolamine, 0.08 to 0.12 part of butyl hydroxybenzoate, 0.08 to 0.12 part of ethylparaben and 75 to 78 parts of purified water. The present invention also discloses a preparation technology of the universal O / W type emulsion type matrix, and the universal O / W type emulsion type matrix is cheap and readily available in materials in the formula, low in cost, strong in transdermal absorption, suitable for a variety of drugs, free of thickening and dryness after placement at room temperature for 6 months, proper in consistency, easy to coat and good in stability. The preparation technology of the universal O / W type emulsion type matrix is simple, process parameters are easy to control, and the preparation technology of the universal O / W type emulsion type matrix is especially suitable for large production scale of more than 50kg.
Description
Technical field
The present invention relates to the preparation field of ointment, be specially a kind of universal O/W type emulsion-type substrate and preparation technology thereof.
Background technology
Ointment means the semi-solid external preparation that medicine and appropriate substrate are mixed.Conventional substrate is divided into oil, water solublity and emulsion-type substrate.Emulsion-type substrate is mixed with water after referring to the oil phase heat fused by solid, under the effect of emulsifying agent, form Emulsion, finally at room temperature becomes semisolid substrate, is often divided into O/W type and w/o type.O/W type emulsifying agent has soda soap, triethanolamine soap class, fatty alcohol sulphuric acid (ester) sodium class and poly yamanashi esters; W/o type emulsifying agent has calcium soap, lanoline, monoglyceride, aliphatic alcohols.Emulsion-type substrate does not stop secretion and the moisture evaporation of skin surface secretions, less on the normal function impact of skin.Such substrate particularly the release of O/W type substrate Chinese medicine and Transdermal absorption very fast.
The character of emulsion-type substrate directly will have influence on the drug effect of principal agent, the absorbability of principal agent and mobility, in the work of reality, do not have quality standard can reference, the emulsifiable paste matrix that Mei Jia hospital adopts is all different, in Chinese Pharmacopoeia and civilian hospital medical institutions quality standard, the prescription of emulsifiable paste matrix is not provided yet, so in real work, need a kind of denseness to be suitable for, be easily coated with, the versatility substrate of good stability.
Summary of the invention
The technical problem to be solved in the present invention overcomes existing emulsion-type substrate not have fixed standard, the defect that nature difference is larger, provides a kind of denseness to be suitable for, is easily coated with, the versatility O/W type emulsion-type substrate of good stability.
In order to solve the problems of the technologies described above, the invention provides following technical scheme:
A kind of universal O/W type emulsion-type substrate comprises each component of following mass fraction: stearic acid 3 ~ 3.5 parts, glyceryl monostearate 2.4 ~ 3 parts, octadecanol 3 ~ 3.5 parts, simethicone 1.8 ~ 2.2 parts, white vaseline 1.8 ~ 2.2 parts, liquid paraffin 3 ~ 3.5 parts, glycerol 4.5 ~ 5.2 parts, triethanolamine 0.3 ~ 0.5 part, butyl hydroxybenzoate 0.08 ~ 0.12 part, ethyl hydroxybenzoate 0.08 ~ 0.12 part, purified water 75 ~ 78 parts.
Further, a kind of universal O/W type emulsion-type substrate comprises each component of following mass fraction: stearic acid 3.2 parts, glyceryl monostearate 2.6 parts, octadecanol 3.2 parts, simethicone 2 parts, white vaseline 2 parts, liquid paraffin 3.2 parts, glycerol 5 parts, triethanolamine 0.4 part, butyl hydroxybenzoate 0.1 part, ethyl hydroxybenzoate 0.1 part, purified water 75 ~ 78 parts.
A preparation technology for universal O/W type emulsion-type substrate, is characterized in that, comprise following step:
1) take stearic acid, glyceryl monostearate, octadecanol, simethicone, white vaseline, liquid paraffin, in proportion, magnetic force heating stirrer is heated to fusing, obtained oil phase;
2) take glycerol, triethanolamine, butyl hydroxybenzoate, ethyl hydroxybenzoate, in proportion, purified water, magnetic force heating stirrer is heated to fusing, obtained aqueous phase;
3), in vacuum emulsifying machine aqueous phase is slowly added in oil phase, homogenizing 3 ~ 6 minutes, then vacuum emulsification 30 ~ 40 minutes; Be stirred to condensation again, the O/W type emulsion-type substrate that must state.
Preferably, described step 1) in heating-up temperature be 85 DEG C, described step 2) in heating-up temperature be 85 DEG C;
Preferably, described step 3) in the emulsifying temperature of vacuum emulsifying machine be 80 DEG C, the time of emulsifying is 35 minutes, and too high temperature can extend the time needed for emulsifying, and too low temperature causes the quality of substrate coarse.
Preferably, stirring frequency during emulsifying is 55 ~ 60 turns/min, the bubble that the too fast meeting of speed of agitator makes Medium Culture preservation a large amount of, and make substrate easily oxidized in use, speed of agitator is excessively slow, then make emulsification times extend, emulsion quality is poor.
Universal O/W type emulsion-type substrate of the present invention, formula material is cheap and easy to get, and cost is low, and Transdermal absorption is strong, and be applicable to multi-medicament, ambient temperatare puts 6 months acomia thick dry-out phenomenon, and denseness is suitable for, be easily coated with, the versatility emulsion-type substrate of good stability.Emulsion-type substrate processing technology of the present invention is simple, and procedure parameter easily controls, and is particularly suitable for the large batch of production scale of more than 50kg.
Detailed description of the invention
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein is only for instruction and explanation of the present invention, is not intended to limit the present invention.
Embodiment
Substrate of the present invention applied in Vitamin E Cream prescription, the scale of production is 60kg, and the proportioning of each raw material is as shown in table 1:
Table 1 Vitamin E Cream prescription
The processing technology of the present embodiment is:
1), by table 1 take stearic acid, glyceryl monostearate, octadecanol, simethicone, white vaseline, liquid paraffin, magnetic force heating stirrer is heated to fusing, obtained oil phase; Heating-up temperature is 85 DEG C;
2), by table 1 take glycerol, triethanolamine, butyl hydroxybenzoate, ethyl hydroxybenzoate, purified water, magnetic force heating stirrer is heated to fusing, obtained aqueous phase; Heating-up temperature is 85 DEG C;
3), in vacuum emulsifying machine aqueous phase is slowly added in oil phase, homogenizing 4 minutes, then vacuum emulsification 30 minutes; Emulsifying temperature is 80 DEG C, and the time of emulsifying is 35 minutes, and stirring frequency during emulsifying is 55 ~ 60 turns/min;
4), by the substrate of emulsifying gained be stirred to temperature and be down to 55 ± 5 DEG C, add vitamin E, continue to stir about 40min, until be condensed into paste, to obtain final product.
The Vitamin E Cream of this preparation, observes its granularity and is less than 50 μm under 50-100 power microscope, suitable, the easy coating of denseness, good stability, ambient temperatare puts 6 months acomia thick dry-out phenomenon.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. a universal O/W type emulsion-type substrate, it is characterized in that, comprise each component of following mass fraction: stearic acid 3 ~ 3.5 parts, glyceryl monostearate 2.4 ~ 3 parts, octadecanol 3 ~ 3.5 parts, simethicone 1.8 ~ 2.2 parts, white vaseline 1.8 ~ 2.2 parts, liquid paraffin 3 ~ 3.5 parts, glycerol 4.5 ~ 5.2 parts, triethanolamine 0.3 ~ 0.5 part, butyl hydroxybenzoate 0.08 ~ 0.12 part, ethyl hydroxybenzoate 0.08 ~ 0.12 part, purified water 75 ~ 78 parts.
2. a kind of universal O/W type emulsion-type substrate as claimed in claim 1, it is characterized in that, comprise each component of following mass fraction: stearic acid 3.2 parts, glyceryl monostearate 2.6 parts, octadecanol 3.2 parts, simethicone 2 parts, white vaseline 2 parts, liquid paraffin 3.2 parts, glycerol 5 parts, triethanolamine 0.4 part, butyl hydroxybenzoate 0.1 part, ethyl hydroxybenzoate 0.1 part, purified water 75 ~ 78 parts.
3. a preparation technology for universal O/W type emulsion-type substrate according to claim 1, is characterized in that, comprise following step:
1) take stearic acid, glyceryl monostearate, octadecanol, simethicone, white vaseline, liquid paraffin, in proportion, magnetic force heating stirrer is heated to fusing, obtained oil phase;
2) take glycerol, triethanolamine, butyl hydroxybenzoate, ethyl hydroxybenzoate, in proportion, purified water, magnetic force heating stirrer is heated to fusing, obtained aqueous phase;
3), in vacuum emulsifying machine aqueous phase is slowly added in oil phase, homogenizing 3 ~ 6 minutes, then vacuum emulsification 30 ~ 40 minutes, then be stirred to condensation, obtain described O/W type emulsion-type substrate.
4. the preparation technology of universal O/W type emulsion-type substrate as claimed in claim 3, is characterized in that, described step 1) in heating-up temperature be 85 DEG C, described step 2) in heating-up temperature be 85 DEG C.
5. the preparation technology of universal O/W type emulsion-type substrate as claimed in claim 3, is characterized in that, described step 3) in the emulsifying temperature of vacuum emulsifying machine be 80 DEG C.
6. the preparation technology of universal O/W type emulsion-type substrate as claimed in claim 3, is characterized in that, described step 3) in vacuum emulsifying machine the time of emulsifying be 35 minutes.
7. the preparation technology of universal O/W type emulsion-type substrate as claimed in claim 3, is characterized in that, described step 3) in emulsifying time stirring frequency be 55 ~ 60 turns/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510980140.4A CN105560167A (en) | 2015-12-23 | 2015-12-23 | Universal O / W type emulsion type matrix and preparation technology thereof |
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| CN201510980140.4A CN105560167A (en) | 2015-12-23 | 2015-12-23 | Universal O / W type emulsion type matrix and preparation technology thereof |
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| CN105560167A true CN105560167A (en) | 2016-05-11 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112402362A (en) * | 2020-10-12 | 2021-02-26 | 河南牧业经济学院 | Compound salicylic acid water-soluble antibacterial cream and preparation method thereof |
| CN114958820A (en) * | 2022-05-11 | 2022-08-30 | 西南石油大学 | Water-soluble natural wax dissolving agent and preparation method and application thereof |
| CN115844994A (en) * | 2022-12-29 | 2023-03-28 | 遵义医科大学 | Rhizoma bletillae ointment and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397241A (en) * | 2010-09-08 | 2012-04-04 | 朱云利 | Method for preparing medicinal oil-in-water emulsifiable paste |
-
2015
- 2015-12-23 CN CN201510980140.4A patent/CN105560167A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397241A (en) * | 2010-09-08 | 2012-04-04 | 朱云利 | Method for preparing medicinal oil-in-water emulsifiable paste |
Non-Patent Citations (1)
| Title |
|---|
| 韦超等: "《药剂学》", 31 August 2012, 河南科学技术出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112402362A (en) * | 2020-10-12 | 2021-02-26 | 河南牧业经济学院 | Compound salicylic acid water-soluble antibacterial cream and preparation method thereof |
| CN114958820A (en) * | 2022-05-11 | 2022-08-30 | 西南石油大学 | Water-soluble natural wax dissolving agent and preparation method and application thereof |
| CN114958820B (en) * | 2022-05-11 | 2023-10-31 | 西南石油大学 | Water-soluble natural wax-dissolving agent and preparation method and application thereof |
| CN115844994A (en) * | 2022-12-29 | 2023-03-28 | 遵义医科大学 | Rhizoma bletillae ointment and preparation method and application thereof |
| CN115844994B (en) * | 2022-12-29 | 2024-02-02 | 遵义医科大学 | Bletilla striata ointment and preparation method and application thereof |
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Application publication date: 20160511 |
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