CN102397241A - Method for preparing medicinal oil-in-water emulsifiable paste - Google Patents
Method for preparing medicinal oil-in-water emulsifiable paste Download PDFInfo
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- CN102397241A CN102397241A CN201010281026XA CN201010281026A CN102397241A CN 102397241 A CN102397241 A CN 102397241A CN 201010281026X A CN201010281026X A CN 201010281026XA CN 201010281026 A CN201010281026 A CN 201010281026A CN 102397241 A CN102397241 A CN 102397241A
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Abstract
The invention discloses a method for preparing medicinal oil-in-water emulsifiable paste which belongs to the pharmacy field. The prepared oil-in-water emulsifiable paste comprises the following raw materials: stearic acid, castor oil, liquid paraffin, glycerin, ethylparaben, triethanolamine, sodium dodecyl sulfate, external use essence and distilled water. The preparation method has the advantages that the process is simple, the temperature can be easily controlled, the temperature of oil phase and water phase are absolutely same, heating by two containers are not required, the product has good quality, the produced emulsifiable paste is uniform and fine, and no irritation is generated when coating on skin or mucous membrane. The emulsifiable paste can be taken as a substrate to prepare a plurality of medicines.
Description
Technical field:
Product of the present invention belongs to pharmaceutical field, it is characterized in that relating to a kind of compound method of medicinal oil-in-water emulsifiable paste.
Background technology:
Ointment is meant the semi-solid external preparation with certain denseness that medicine and suitable substrate uniform mixing are processed; That substrate commonly used is divided into is oil, water solublity and emulsion-type; The ointment of wherein processing with emulsion bases that is easy to be coated with is claimed ointment; Its substrate can be divided into oil-in-water type emulsifiable paste and water-in-oil type emulsifiable paste, and the emulsifying agent that the oil-in-water type emulsifiable paste uses has soda soap, triethanolamine, sodium alkyl sulfate class and poly yamanashi esters to be primary raw material; The emulsifying agent that water-in-oil type uses has calcium soap, lanoline, monoglyceride, aliphatic alcohol etc. to be primary raw material.Different during preparation because of medicine dispersity in substrate; The branch that solution-type ointment and suspension type ointment are arranged; The solution-type ointment is the ointment that medicine dissolution or congruent melting are processed in substrate or matrix components; The suspension type ointment is the ointment of processing in fine drug powder homodisperse and the substrate, and the requirement to the substrate emulsifiable paste during preparation ointment is: even, fine and smooth, and be applied on skin or the mucosa and answer nonirritant.The raw material that preparation oil-in-water emulsifiable paste uses has stearic acid, Oleum Ricini, liquid Paraffin, glycerol, ethyl hydroxybenzoate, triethanolamine, sodium lauryl sulphate, external essence, distilled water.Old compound method is: place vessel in heating to molten condition stearic acid, Oleum Ricini, liquid Paraffin, the glycerol of oil phase; Temperature is heated with stirring to 70 ℃-80 ℃ to the triethanolamine of water, ethyl hydroxybenzoate, sodium lauryl sulphate and distilled water, when identical with the oil phase temperature between 70 ℃-80 ℃; The oil phase raw material is added in the water raw material; Stir along single direction, rotating speed is that per minute 10 changes, and adding essence stirs and gets when being about to condensation.Time-consuming, the effort of ointment of preparation, temperature control difficulty in this way, the emulsifiable paste of being prepared is fair.Because there is certain defective in said method, the present invention will provide a kind of new method to prepare the oil-in-water emulsifiable paste.
Summary of the invention:
In order to overcome above-mentioned defective; The present invention provides a kind of compound method of new oil-in-water emulsifiable paste; It is profit phase Hybrid Heating preparation method; Simple, the easy to control temperature of the more preceding method of this method preparation, oil phase, water temperature be definitely identical, do not need that two containers are heated, the finished product quality is also better, and this method also is suitable for the preparation of most oil-in-water type emulsifiable pastes except the preparation that is suitable for product of the present invention.The raw material of producing this product use has: stearic acid 14%-16%, Oleum Ricini 6%, liquid Paraffin 4%, glycerol 10%, triethanolamine 14%-16%, sodium lauryl sulphate 2.9%, ethyl hydroxybenzoate 0.1%, external essence 3%, distilled water 44%.
The present invention can realize through following technical scheme:
A kind of method of batch preparation oil-in-water emulsifiable paste is characterized in that being made up of following steps:
1. the primary response device is but that capacity is the stainless steel cask of 100 liters heated and stirred; Add distilled water earlier; Add stearic acid, Oleum Ricini, liquid Paraffin, glycerol again; Ethyl hydroxybenzoate, sodium lauryl sulphate, limit stir, the limit is elevated to 100 ℃ to water temperature, all material in the container is dissolved be one.
2. stop heating, reduce temperature to 75 ℃ slowly, add triethanolamine, stir on the limit, the limit cooling, and the liquid in the container gradually becomes paste.
3. when temperature is reduced to 35 ℃, add essence and stir, continue to be cooled to room temperature and get product.
The beneficial effect of product of the present invention is: simple, the easy to control temperature of this compound method technology, oil phase, water temperature are definitely identical, do not need two containers to heat good product quality.
The specific embodiment:
Embodiment 1:
But the primary response device is a capacity is the stainless steel cask of 100 liters heated and stirred; Add the distilled water that accounts for total amount 44% earlier; Add again and account for the stearic acid of total amount 14%, 6% Oleum Ricini, 4% liquid Paraffin, 10% glycerol, 0.1% ethyl hydroxybenzoate, 2.9% sodium lauryl sulphate; Stir on the limit, the limit is elevated to 100 ℃ to the temperature of water, all material in the container is dissolved be one; Stop heating, reduce temperature to 75 ℃ slowly, add the triethanolamine that accounts for total amount 16%, stir on the limit, the limit cooling, and the liquid in the container gradually becomes paste; When temperature is reduced to 35 ℃, add the essence that accounts for total amount 3% and stir, continue to be cooled to room temperature and get product.
Embodiment 2:
But the primary response device is a capacity is the stainless steel cask of 100 liters heated and stirred; Add the distilled water that accounts for total amount 44% earlier; Add again and account for the stearic acid of total amount 15%, 6% Oleum Ricini, 4% liquid Paraffin, 10% glycerol, 0.1% ethyl hydroxybenzoate, 2.9% sodium lauryl sulphate; Stir on the limit, the limit is elevated to 100 ℃ to the temperature of water, all material in the container is dissolved be one; Stop heating, reduce temperature to 75 ℃ slowly, add the triethanolamine that accounts for total amount 15%, stir on the limit, the limit cooling, and the liquid in the container gradually becomes paste; When temperature is reduced to 35 ℃, add the essence that accounts for total amount 3% and stir, continue to be cooled to room temperature and get product.
Embodiment 3:
But the primary response device is a capacity is the stainless steel cask of 100 liters heated and stirred; Add the distilled water that accounts for total amount 44% earlier; Add again and account for the stearic acid of total amount 16%, 6% Oleum Ricini, 4% liquid Paraffin, 10% glycerol, 0.1% ethyl hydroxybenzoate, 2.9% sodium lauryl sulphate; Stir on the limit, the limit is elevated to 100 ℃ to the temperature of water, all material in the container is dissolved be one; Stop heating, reduce temperature to 75 ℃ slowly, add the triethanolamine that accounts for total amount 14%, stir on the limit, the limit cooling, and the liquid in the container gradually becomes paste; When temperature is reduced to 35 ℃, add the essence that accounts for total amount 3% and stir, continue to be cooled to room temperature and get product.
Claims (4)
1. the compound method of a medicinal oil-in-water emulsifiable paste; It is characterized in that: with stearic acid 14%-16%, Oleum Ricini 6%, liquid Paraffin 4%, glycerol 10%, triethanolamine 14%-16%, sodium lauryl sulphate 2.9%, ethyl hydroxybenzoate 0.1%, external essence 3%, distilled water 44% is raw material, obtains finished product through following steps.
2. the compound method of a kind of medicinal oil-in-water emulsifiable paste according to claim 1; The characteristic of its first step is: but the primary response device is a capacity is the stainless steel cask of 100 liters heated and stirred; Add distilled water earlier, add stearic acid, Oleum Ricini, liquid Paraffin, glycerol again, ethyl hydroxybenzoate, sodium lauryl sulphate; Stir on the limit, the limit is elevated to 100 ℃ to water temperature, all material in the container is dissolved be one.
3. the compound method of a kind of medicinal oil-in-water emulsifiable paste according to claim 1, the characteristic in its second step is: stop heating, reduce temperature to 75 ℃ slowly, add triethanolamine, stir on the limit, the limit cooling, and the liquid in the container gradually becomes paste.
4. the compound method of a kind of medicinal oil-in-water emulsifiable paste according to claim 1, the characteristic in its 3rd step is: when temperature is reduced to 35 ℃, add essence and stir, continue to be cooled to room temperature and get product.
Priority Applications (1)
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CN201010281026XA CN102397241A (en) | 2010-09-08 | 2010-09-08 | Method for preparing medicinal oil-in-water emulsifiable paste |
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CN201010281026XA CN102397241A (en) | 2010-09-08 | 2010-09-08 | Method for preparing medicinal oil-in-water emulsifiable paste |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102935213A (en) * | 2012-11-21 | 2013-02-20 | 吉林鑫水科技开发有限公司 | Preparation method of ointment for improving skin itch of urogenital canal |
CN105560167A (en) * | 2015-12-23 | 2016-05-11 | 湖北医药学院附属人民医院 | Universal O / W type emulsion type matrix and preparation technology thereof |
-
2010
- 2010-09-08 CN CN201010281026XA patent/CN102397241A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102935213A (en) * | 2012-11-21 | 2013-02-20 | 吉林鑫水科技开发有限公司 | Preparation method of ointment for improving skin itch of urogenital canal |
CN105560167A (en) * | 2015-12-23 | 2016-05-11 | 湖北医药学院附属人民医院 | Universal O / W type emulsion type matrix and preparation technology thereof |
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Application publication date: 20120404 |