CN115844994B - Bletilla striata ointment and preparation method and application thereof - Google Patents
Bletilla striata ointment and preparation method and application thereof Download PDFInfo
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- CN115844994B CN115844994B CN202211704927.4A CN202211704927A CN115844994B CN 115844994 B CN115844994 B CN 115844994B CN 202211704927 A CN202211704927 A CN 202211704927A CN 115844994 B CN115844994 B CN 115844994B
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- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 3
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an bletilla striata paste and a preparation method and application thereof. The bletilla striata paste provided by the invention comprises the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of bletilla tuber products; the rhizoma bletilla product comprises rhizoma bletilla powder or rhizoma bletilla polysaccharide; when the bletilla striata product is bletilla striata powder, the oil phase comprises stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax; when the bletilla striata product is bletilla striata polysaccharide, the oil phase comprises white vaseline, simethicone, stearic acid, paraffin and tween. The bletilla striata ointment provided by the invention has higher content of the bletilla striata products, can fully utilize pharmacological activities of hemostasis and wound healing, anti-inflammatory, antibacterial, antiviral and antioxidation, and on the basis, the ointment is prepared by adjusting the component proportion, and the obtained ointment has good stability and affinity, can reduce microbial pollution and can better retain the medicinal effect of the bletilla striata products.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an bletilla striata paste and a preparation method and application thereof.
Background
The rhizoma bletilla is one of the genus rhizoma bletilla of the family Orchidaceae, has the functions of astringing to stop bleeding, detumescence and promoting granulation, and can be used for stopping bleeding and healing wound, resisting inflammation, resisting bacteria and viruses, preventing and treating digestive tract ulcer, whitening skin, resisting oxygen, chapped skin, treating burns and scalds, etc. Depending on unique geographical climate conditions, the bletilla striata in Guizhou occupies absolute dominant positions in the aspects of germplasm resources, planting areas and annual output, and has good market prospect. The bletilla striata industry has a plurality of problems in the aspects of production place processing and product research and development at present: such as irregular processing technology in the production area, active ingredient loss caused by repeated production technology, high processing cost, delay in developing new products, etc. The development of the bletilla striata new product is delayed to restrict the development of the bletilla striata industry, and the early-stage layout of the bletilla striata industry and the healthy and sustainable development of the industry ecology are seriously influenced, so that the bletilla striata product which is suitable for the needs of daily life is developed on the basis of the wide application of the bletilla striata raw material, and the bletilla striata new product has important economic value and social significance.
Chinese patent CN 111467433A discloses an external traditional Chinese medicine composition and paste for promoting wound healing and a preparation method thereof, wherein the external traditional Chinese medicine composition comprises various traditional Chinese medicines such as pseudo-ginseng, rosewood heart wood, folium callicarpae, garden burnet root, pearl, rhizoma bletillae, radix salviae miltiorrhizae and the like, has the effects of stopping bleeding, diminishing inflammation, relieving swelling and pain, removing blood stasis and promoting granulation, and can effectively improve the blood circulation of local wound tissues and enhance the immune function. However, the stability of the dosage form is poor, and the dosage form is easily influenced by complex environments, so that the loss and deterioration of medicinal ingredients are caused.
Disclosure of Invention
The invention aims to provide an bletilla striata paste, a preparation method and application thereof.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides an bletilla striata paste which comprises the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of bletilla tuber products;
the rhizoma bletilla product comprises rhizoma bletilla powder or rhizoma bletilla polysaccharide;
when the bletilla striata product is bletilla striata powder, the oil phase is a first oil phase, wherein the first oil phase comprises stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax;
when the bletilla striata product is bletilla striata polysaccharide, the oil phase is a second oil phase, and the second oil phase comprises white vaseline, simethicone, stearic acid, paraffin and tween.
Preferably, the mass ratio of stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax in the first oil phase is 4-5: 1-2: 4 to 5:4 to 5:2 to 2.5:4 to 5:3 to 4.
Preferably, when the bletilla striata product is a bletilla striata powder, the aqueous phase is a first aqueous phase comprising glycerol, ethylparaben and water.
Preferably, the mass ratio of the glycerin, the ethylparaben and the water in the first aqueous phase is 18-19: 1-2: 52 to 55.
Preferably, the mass ratio of white vaseline, simethicone, stearic acid, paraffin and tween in the second oil phase is 3-5: 1-2: 0.5 to 1:1 to 3:1 to 2.
Preferably, when the bletilla striata product is bletilla striata polysaccharide, the aqueous phase is a second aqueous phase comprising propylene glycol, ethylparaben, glycerol and water.
Preferably, the mass ratio of the propylene glycol, the ethylparaben, the glycerol and the water in the second aqueous phase is 5-7: 0.1 to 0.5:5 to 6:60 to 63.
The invention also provides a preparation method of the bletilla striata paste according to the technical scheme, which comprises the following steps:
heating and melting the oil phase and the water phase respectively, and then performing first mixing to obtain a pasty matrix;
and (3) carrying out second mixing on the bletilla striata product and the pasty matrix to obtain the bletilla striata paste.
Preferably, the temperature of the oil phase and the water phase which are heated and melted is 79-90 ℃ independently.
The invention also provides application of the bletilla striata paste in face cream.
The invention provides an bletilla striata paste which comprises the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of bletilla tuber products; the rhizoma bletilla product comprises rhizoma bletilla powder or rhizoma bletilla polysaccharide; when the bletilla striata product is bletilla striata powder, the oil phase comprises stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax; when the bletilla striata product is bletilla striata polysaccharide, the oil phase comprises white vaseline, simethicone, stearic acid, paraffin and tween. The bletilla striata ointment provided by the invention consists of an oil phase, a water phase and a bletilla striata product, wherein the bletilla striata product has higher content, can fully utilize pharmacological activities of hemostasis and healing, anti-inflammatory, antibacterial, antiviral and antioxidant of the bletilla striata, and on the basis, the ointment is prepared by adjusting the selection and the proportion of the oil phase components, and the obtained ointment has good stability and affinity, is convenient to carry, is simple and convenient to use, is clean, can reduce microbial pollution, and can better retain the medicinal effect of the bletilla striata product.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions of the prior art, the drawings that are needed in the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is an external appearance of the ointment of example 1;
FIG. 2 is a comparison of appearance of different matrices of the bletilla striata paste of example 1;
FIG. 3 shows the appearance of the ointment obtained in example 2.
Detailed Description
The invention provides an bletilla striata paste which comprises the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of bletilla tuber products;
the rhizoma bletilla product comprises rhizoma bletilla powder or rhizoma bletilla polysaccharide.
In the present invention, all raw material components are commercially available products well known to those skilled in the art, unless otherwise specified.
In the present invention, when the bletilla striata product is bletilla striata powder:
the bletilla striata paste comprises, by mass, 6-29 parts of a first oil phase, preferably 10-27 parts, and more preferably 20-25 parts.
In the present invention, the first oil phase preferably includes stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax; the mass ratio of the stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax is preferably 4-5: 1-2: 4 to 5:4 to 5:2 to 2.5:4 to 5:3 to 4, more preferably 4 to 4.5:1 to 1.5:4 to 4.5:4 to 4.5:2 to 2.5:4 to 4.5:3.5 to 4. In the invention, the span is preferably span-80; the polysorbate is preferably polysorbate-80; the paraffin is preferably liquid paraffin.
The bletilla striata paste comprises 71-77 parts, preferably 72-75 parts, more preferably 73-74 parts of the first aqueous phase based on the parts by weight of the first oil phase.
In the present invention, the first aqueous phase preferably comprises glycerin, ethylparaben, and water; the mass ratio of the glycerol to the ethylparaben to the water is preferably 18-19: 1-2: 52 to 55, more preferably 18 to 18.5:1 to 1.5: 53-54. In the present invention, the water is preferably purified water.
The bletilla striata paste comprises 2-18 parts, preferably 2-8 parts, more preferably 2-5 parts of bletilla striata powder based on the mass part of the first oil phase.
In the present invention, the particle size of the bletilla striata powder is preferably 200 to 300 mesh, more preferably 220 to 280 mesh, and most preferably 240 to 260 mesh.
In the present invention, when the bletilla striata product is bletilla striata polysaccharide:
the bletilla striata paste comprises, by mass, 6-29 parts of a second oil phase, preferably 7-20 parts, more preferably 8-15 parts.
In the present invention, the second oil phase preferably includes white vaseline, simethicone, stearic acid, paraffin wax and tween; the mass ratio of the white vaseline, the simethicone, the stearic acid, the paraffin and the tween is preferably 3-5: 1-2: 0.5 to 1:1 to 3:1 to 2, more preferably 4 to 5:1 to 1.5:0.5 to 1: 2-3: 1 to 2. The tween is preferably tween-60.
The bletilla striata paste comprises 71-77 parts by weight of the second aqueous phase, preferably 72-75 parts by weight, more preferably 72-74 parts by weight, based on the parts by weight of the second oil phase.
In the present invention, the second aqueous phase preferably comprises propylene glycol, ethylparaben, glycerol and water; the mass ratio of the propylene glycol to the ethylparaben to the glycerol to the water is preferably 5-7: 0.1 to 0.5:5 to 6:60 to 63, more preferably 6 to 7:0.1 to 0.5:5.5 to 6:62 to 63.
The bletilla striata paste comprises, based on the mass portion of the second oil phase, 2-18 parts of bletilla striata polysaccharide, preferably 10-18 parts, more preferably 15-18 parts.
The bletilla striata ointment provided by the invention consists of an oil phase, a water phase and a bletilla striata product, wherein the bletilla striata product has higher content, can fully utilize pharmacological activities of hemostasis and healing, anti-inflammatory, antibacterial, antiviral and antioxidant, is prepared by adjusting the component proportion, is uniform, fine and smooth and glossy, has no granular sensation, does not cause oil-water separation, has no macroscopic individual particles or bubbles when being coated on a glass plate, has good stability and affinity, is convenient to carry, is simple and convenient to use, is clean, can reduce microbial pollution, and can better retain the medicinal effect of the bletilla striata product.
The invention also provides a preparation method of the bletilla striata paste according to the technical scheme, which comprises the following steps:
heating and melting the oil phase and the water phase respectively, and then performing first mixing to obtain a pasty matrix;
and (3) carrying out second mixing on the bletilla striata product and the pasty matrix to obtain the bletilla striata paste.
According to the invention, the oil phase and the water phase are respectively heated and melted, and then are subjected to first mixing to obtain the pasty matrix.
In the invention, the heating and melting are preferably water bath heating; the temperature of the oil phase and the water phase for heating and melting is independently preferably 79-90 ℃, more preferably 80-87 ℃ and most preferably 82-85 ℃; the time for the heating and melting is not particularly limited in the present invention, and the oil phase and the water phase may be sufficiently dissolved by using a time well known to those skilled in the art.
In the present invention, the first mixing is preferably adding an aqueous phase to an oil phase; the first mixing is preferably carried out while the aqueous phase is added to the oil phase; when the bletilla striata product is bletilla striata powder, the stirring time is preferably more than 5min, more preferably 10-30 min, and most preferably 15-20 min; when the bletilla striata product is bletilla striata polysaccharide, the stirring time is preferably 8-15 min, more preferably 10-13 min.
After the pasty matrix is obtained, the bletilla striata product and the pasty matrix are subjected to second mixing to obtain the bletilla striata paste.
In the present invention, when the bletilla striata product is bletilla striata powder, the second mixing is preferably performed under room temperature conditions; the second mixing preferably adopts equal incremental mode to add rhizoma bletilla powder; after the second mixing is completed, the present invention also preferably includes grinding; the grinding process is not particularly limited, and the bletilla striata paste is uniformly mixed by a method well known to those skilled in the art.
In the present invention, when the bletilla striata product is bletilla striata polysaccharide, the temperature of the second mixing is preferably 55-70 ℃, more preferably 58-68 ℃, and most preferably 60-65 ℃; the second mixing is preferably performed by stirring; the stirring process is not particularly limited, and the bletilla striata paste is uniformly mixed by a method well known to a person skilled in the art.
The preparation method of the bletilla striata paste provided by the invention has the advantages of simple preparation process, low cost and wide application prospect.
The invention also provides application of the bletilla striata paste in face cream.
The process of the application is not particularly limited, and may be performed in a manner well known to those skilled in the art.
For further explanation of the present invention, the bletilla striata paste, the preparation method and application thereof provided by the present invention are described in detail below with reference to the accompanying drawings and examples, but they should not be construed as limiting the scope of the present invention.
Example 1-1
The oil phase (4.2% of stearic acid, span-801.3%, polysorbate-804.2%, glyceryl monostearate 4.3%, white vaseline 2.1%, liquid paraffin 4.3%, beeswax 3.8%) and the water phase (glycerin 18.3%, purified water 54%, and ethylparaben 1%) were heated in a water bath to 83 ℃ respectively, stirred until all solids melted, the water phase was added to the oil phase in a trickle form, heated for 10min continuously with stirring, and kept at room temperature with continuous stirring until condensation. Adding 2.5% rhizoma bletilla superfine powder into matrix by equal incremental method, and grinding to obtain rhizoma bletilla paste, which is white paste with properties shown in figure 1. The obtained rhizoma bletilla paste is uniform, fine and smooth, has no granular feel, is free of oil-water separation, and has no single particles or bubbles visible to naked eyes when being coated on a glass plate.
Examples 1 to 2
The preparation method of the embodiment 1-1 is characterized in that the oil phase is glyceryl monostearate, white vaseline, liquid paraffin, beeswax, stearic acid, span-80 and polysorbate-80, and the mass ratio is 30:15:30:26:20:6:20.
examples 1 to 3
The preparation method of the embodiment 1-2 is used for preparing the bletilla striata ointment, wherein the mass ratio of the stearic acid, span-80 and polysorbate-80 to the oil phase is 1:2.
examples 1 to 4
The preparation method of the embodiment 1-2 is used for preparing the bletilla striata ointment, wherein the mass ratio of the stearic acid, span-80 and polysorbate-80 to the oil phase is 2:5.
examples 1 to 5
The preparation of the bletilla striata paste was carried out as described in examples 1-2, except that the emulsification time was 10min and the temperature was 80 ℃.
Examples 1 to 6
The preparation of the bletilla striata paste was carried out as described in examples 1-2, except that the emulsification time was 30min and the temperature was 80 ℃.
Examples 1 to 7
The preparation of the bletilla striata paste was carried out as described in examples 1-2, except that the emulsification time was 10min and the temperature was 90 ℃.
Examples 1 to 8
An ointment of bletilla striata was prepared according to the preparation method described in examples 1-2, except that the emulsification time was 30min and the temperature was 90 ℃.
Comparative examples 1 to 1
The preparation method of the embodiment 1-1 is characterized in that the oil phase is glyceryl monostearate, white vaseline, liquid paraffin, beeswax, lanolin and span-80, and the mass ratio is 14:4:26:26:20:2.
comparative examples 1 to 2
The preparation method of the embodiment 1-1 is characterized in that the oil phase is glyceryl monostearate, white vaseline, beeswax, span-80 and polysorbate-80, and the mass ratio is 20:6:26:6:20.
comparative examples 1 to 3
The preparation method of the embodiment 1-1 is characterized in that the oil phase is glycerin monostearate, white vaseline, beeswax, stearic acid and polysorbate-80, and the mass ratio is 60:20:26:5:4:8.
comparative examples 1 to 4
The preparation method of the embodiment 1-2 is used for preparing the bletilla striata ointment, wherein the mass ratio of the stearic acid, span-80 and polysorbate-80 to the oil phase is 1:5.
comparative examples 1 to 5
The preparation method of the embodiment 1-2 is used for preparing the bletilla striata ointment, wherein the mass ratio of the stearic acid, span-80 and polysorbate-80 to the oil phase is 3:5.
comparative examples 1 to 6
An ointment of bletilla striata was prepared according to the preparation method described in examples 1-2, except that the emulsification time was 5min and the temperature was 70 ℃.
Comparative examples 1 to 7
An ointment of bletilla striata was prepared according to the preparation method described in examples 1-2, except that the emulsification time was 10min and the temperature was 70 ℃.
Comparative examples 1 to 8
An ointment of bletilla striata was prepared according to the preparation method described in examples 1-2, except that the emulsification time was 30min and the temperature was 70 ℃.
Comparative examples 1 to 9
The preparation of the bletilla striata paste was carried out as described in examples 1-2, except that the emulsifying time was 5min and the temperature was 80 ℃.
Comparative examples 1 to 10
The preparation of the bletilla striata paste was carried out as described in examples 1-2, except that the emulsifying time was 5min and the temperature was 90 ℃.
Test example 1-1
Screening oil phase components in proportion: oil phase components are selected from glyceryl monostearate, liquid paraffin, white vaseline, beeswax and lanoline, and emulsifying agent is selected from span-80, polysorbate-80 and stearic acid. The resulting bletilla ointment was initially evaluated from the following: a. appearance characteristics: the substrate should be uniform, fine and smooth, glossy, free of granular feel, free of oil-water separation, and free of macroscopic individual particles or bubbles when coated on a glass plate; b. consistency and spreadability: should be easy to spread on the skin; c. physical stability: proper amount of cream is taken and put into a 1mL centrifuge tube, and is centrifuged for 30min at 2500r/min, so that the phenomenon of oil-water delamination does not occur; the product is placed at 55 ℃ for 6 hours and at-15 ℃ for 24 hours, and the phenomena of hardening, demulsification, foaming and the like are not observed. The results are shown in Table 1 and FIG. 2.
Table 1 evaluation of oil phase component proportions
As can be seen from Table 1 and FIG. 2, the formulation matrix of comparative example 1-1 is difficult to coat and has a grainy feel; the formulas of comparative examples 1-2 showed oil-water separation and were unstable; the oil-water separation phenomenon occurs in the formulas of comparative examples 1-3, and the matrix of examples 1-2 is uniform, fine and stable in property and meets the basic requirements of the paste matrix.
Test examples 1 to 2
And (3) determining the proportion of the emulsifier: the emulsifier is an important factor affecting paste formation, and the ratio of the emulsifier (stearic acid, span-80, polysorbate-80) to the oil phase in examples 1-2 is set to be 1:5. 1:2. 2:5. 3:5 investigation, preliminary evaluation of the resulting bletilla striata paste was made in terms of appearance, consistency and spreadability and physical stability, and the results are shown in table 2.
TABLE 2 evaluation of emulsifier ratio
As can be seen from Table 2, the pastes were more uniform and finer and the coatability was better at the ratios of examples 1 to 3 and examples 1 to 4.
Test examples 1 to 3
Optimizing the process flow: and designing orthogonal experiments to examine two factors of the emulsification temperature and the emulsification time. The paste base was prepared according to the optimal base recipe and the effect of different emulsification temperatures and emulsification times on the paste base formability was examined, and the results are shown in tables 3 and 4.
TABLE 3 orthogonal test design of emulsion factors
TABLE 4 evaluation of influence of emulsion factors
As can be seen from tables 3 and 4, oil-water separation easily occurs when the emulsification time is less than or equal to 5min, macroscopic particles are arranged in the matrix at the emulsification temperature of less than 80 ℃, and the influence on the ointment matrix at the temperature of between 80 and 90 ℃ is not obvious.
Example 2-1
The oil phase (white vaseline 4%, simethicone 1%, stearic acid 0.5%, liquid paraffin 2% and tween-60% 2%) and the water phase (propylene glycol 6%, ethylparaben 0.1%, glycerol 6% and purified water 60.8%) were heated in a water bath respectively to 85 ℃ and stirred until all solids melted, the water phase was added to the oil phase in a trickle form and stirred for 10min, stirring was continued at room temperature to 60 ℃, and 17.6% of bletilla polysaccharide was added and stirred until condensed to make a white paste, the behavior of which is shown in fig. 1. The obtained rhizoma bletilla ointment is uniform, fine and smooth, has no granular feel, is free of oil-water separation, and has no macroscopic individual particles or bubbles when being coated on skin.
Example 2-2
The preparation method of the embodiment 2-1 is characterized in that the oil phase is white vaseline, simethicone, stearic acid, liquid paraffin and tween-60, and the mass ratio is 4:1:1:2:2.
examples 2 to 3
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsifying time was 5min and the temperature was 80 ℃.
Examples 2 to 4
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsifying time was 10min and the temperature was 80 ℃.
Examples 2 to 5
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsification time was 5min and the temperature was 90 ℃.
Examples 2 to 6
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsification time was 10min and the temperature was 90 ℃.
Comparative example 2-1
The preparation method of the embodiment 2-1 is characterized in that the oil phase is lanolin, simethicone, stearic acid, liquid paraffin and tween-60, and the mass ratio is 4:1:1:2:2.
comparative examples 2 to 2
The preparation method of the embodiment 2-1 is characterized in that the oil phase is white vaseline, simethicone, stearic acid, liquid paraffin, tween-60 and cetyl alcohol, and the mass ratio is 4:1:1:2:1:1.
comparative examples 2 to 3
An bletilla striata paste was prepared according to the preparation method described in example 2-1, except that the stearic acid content was 1%.
Comparative examples 2 to 4
An bletilla striata paste was prepared according to the preparation method described in example 2-1, except that the stearic acid content was 2%.
Comparative examples 2 to 5
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsifying time was 5min and the temperature was 70 ℃.
Comparative examples 2 to 6
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsification time was 10min and the temperature was 70 ℃.
Comparative examples 2 to 7
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsifying time was 30min and the temperature was 70 ℃.
Comparative examples 2 to 8
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsifying time was 30min and the temperature was 80 ℃.
Comparative examples 2 to 9
An ointment of bletilla striata was prepared according to the preparation method described in example 2-2, except that the emulsification time was 30min and the temperature was 90 ℃.
Comparative examples 2 to 10
An bletilla striata paste was prepared according to the preparation method described in example 2-2, except that the bletilla striata polysaccharide was added at 80 ℃.
Comparative examples 2 to 11
An bletilla striata paste was prepared according to the preparation method described in example 2-2, except that the bletilla striata polysaccharide was added at a temperature of 40 ℃.
Test example 2-1
Screening oil phase components in proportion: screening from white vaseline, liquid paraffin, stearic acid, cetyl alcohol, simethicone, tween-60, lanolin, and the like. The resulting bletilla striata paste was initially evaluated in terms of appearance, physical stability and consistency and spreadability, and the results are shown in table 5.
Table 5 evaluation of oil phase component proportions
As can be seen from Table 5, the formulations of comparative examples 2-1 and 2-2 had a grainy feel when applied to the skin, and the formulations of example 2-2 had a uniform and fine appearance and good stable physical properties and spreadability, and met the basic requirements of a cream.
Test example 2-2
And (3) determining the proportion of the emulsifier: the amount of the emulsifier has a large influence on the matrix, and the amount of the emulsifier is determined. The resulting bletilla striata paste was initially evaluated in terms of appearance, consistency and spreadability and physical stability, and the results are shown in table 6.
TABLE 6 evaluation of emulsifier ratio
| Sequence number | Content of | Appearance of | Physical stability | Consistency and coatability |
| Example 2-1 | 0.5％ | Uniform and fine | Stabilization | Easy to apply |
| Comparative examples 2 to 3 | 1％ | Uniform and fine | Oil-water separation | Easy to apply |
| Comparative examples 2 to 4 | 2％ | Uniform and fine | Stabilization | Thicker and easy to coat |
As is clear from Table 6, the physical properties were unstable when the content of the emulsifier was 1%, the oil-water separation phenomenon occurred by centrifugation, the paste was thicker when the content was 2%, the paste was not easy to store, and the appearance was uniform and fine when the content of the stearic acid was 0.5%, and the coating uniformity was stable.
Test examples 2 to 3
Optimizing the process flow: and designing orthogonal experiments to examine two factors of the emulsification temperature and the emulsification time. The paste base was prepared according to the optimal base recipe and the effect of different emulsification temperatures and emulsification times on the paste base formability was examined, and the results are shown in tables 3 and 7.
TABLE 7 evaluation of influence of emulsion factors
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As can be seen from tables 3 and 7, the matrix at an emulsification temperature of 70℃had a granular feel, and bubbles appeared when the emulsification time was too long, and the influence of other conditions was not great.
Test examples 2 to 4
Determination of the addition temperature of bletilla striata polysaccharide: the rhizoma bletilla extract is white crystalline powder, is soluble in water, swells in water, and is liquid or semisolid before being added into the extract. The matrix temperature was set at 80, 60, 40 ℃ when the extract was added, and the bletilla polysaccharide addition temperature was examined, and the evaluation results are shown in table 8.
TABLE 8 evaluation of polysaccharide addition temperature
| Sequence number | Temperature (. Degree. C.) | Appearance characteristics | Consistency and coatability | Stability of |
| Example 2-2 | 80 | With bubbles | Easy to apply | Stabilization |
| Comparative examples 2 to 10 | 60 | Uniform and fine | Easy to apply | Stabilization |
| Comparative examples 2 to 11 | 40 | Has granular feel | Easy to apply | Stabilization |
As can be seen from Table 8, bubbles were generated when the cream was added to the extract of bletilla striata at 80℃and the cream was applied to the skin at 40℃to give a feeling of particles, and the extract of bletilla striata was applied at 60℃to give a stable coating.
According to the embodiment, the bletilla striata paste provided by the invention consists of the oil phase, the water phase and the bletilla striata product, wherein the bletilla striata product has higher content, can fully utilize pharmacological activities of hemostasis and healing, anti-inflammation, antibacterial, antiviral and antioxidation, is prepared by adjusting the component proportion, is uniform, fine and smooth and glossy, has no granular feel, does not have oil-water separation, has no macroscopic individual particles or bubbles when being coated on a glass plate, has good stability and affinity, is convenient to carry, is simple and convenient to use, is clean, can reduce microbial pollution, and can better retain the medicinal effect of the bletilla striata product.
The preparation method of the bletilla striata paste provided by the invention has the advantages of simple preparation process, low cost and wide application prospect.
Although the foregoing embodiments have been described in some, but not all embodiments of the invention, other embodiments may be obtained according to the present embodiments without departing from the scope of the invention.
Claims (8)
1. The bletilla striata ointment is characterized by comprising the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of bletilla tuber products;
the rhizoma bletillae product is rhizoma bletillae powder or rhizoma bletillae polysaccharide;
when the bletilla striata product is bletilla striata powder, the oil phase is a first oil phase, wherein the first oil phase is stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax; the mass ratio of stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax in the first oil phase is 4-5: 1-2: 4 to 5:4 to 5:2 to 2.5:4 to 5:3 to 4;
when the bletilla striata product is bletilla striata polysaccharide, the oil phase is a second oil phase, and the second oil phase is white vaseline, simethicone, stearic acid, paraffin and tween; the mass ratio of white vaseline, simethicone, stearic acid, paraffin and tween in the second oil phase is 3-5: 1-2: 0.5 to 1:1 to 3:1 to 2.
2. The bletilla striata paste of claim 1, wherein when the bletilla striata product is a bletilla striata powder, the aqueous phase is a first aqueous phase comprising glycerin, ethylparaben, and water.
3. The bletilla striata paste according to claim 2, wherein the mass ratio of glycerin, ethylparaben and water in the first aqueous phase is 18-19: 1-2: 52 to 55.
4. The bletilla striata paste of claim 1, wherein when the bletilla striata product is a bletilla striata polysaccharide, the aqueous phase is a second aqueous phase comprising propylene glycol, ethylparaben, glycerin, and water.
5. The bletilla striata paste according to claim 4, wherein the mass ratio of propylene glycol, ethylparaben, glycerol and water in the second aqueous phase is 5-7: 0.1 to 0.5:5 to 6:60 to 63.
6. The method for preparing the bletilla striata paste according to any one of claims 1 to 5, comprising the steps of:
heating and melting the oil phase and the water phase respectively, and then performing first mixing to obtain a pasty matrix;
and (3) carrying out second mixing on the bletilla striata product and the pasty matrix to obtain the bletilla striata paste.
7. The method of claim 6, wherein the oil phase and the water phase are independently melted at 79-90 ℃.
8. Use of the bletilla striata paste of any one of claims 1-5 in the preparation of a face cream.
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