CN112402362A - Compound salicylic acid water-soluble antibacterial cream and preparation method thereof - Google Patents
Compound salicylic acid water-soluble antibacterial cream and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
The invention discloses a compound salicylic acid water-soluble antibacterial cream and a preparation method thereof, and aims to solve the technical problem of poor application effect caused by poor water solubility of salicylic acid products in the prior art. The compound salicylic acid water-soluble bacteriostatic cream is prepared from salicylic acid, conazole, octadecanol, vaseline, stearic acid, glyceryl monostearate, ethylparaben, liquid paraffin, sodium dodecyl sulfate, 2, 6-tert-butyl-p-cresol, peregal O, glycerol, urea, dimethyl sulfoxide, water and the like. The salicylic acid is dissolved in an organic solvent, then prepared into an oil-in-water dosage form, and finally emulsified to form the cream, so that the problem of poor water solubility of the salicylic acid is solved, the salicylic acid is in a soluble molecular state in an aqueous solution, and the salicylic acid can be directly added into a water-based product.
Description
Technical Field
The invention relates to the technical field of sanitation and disinfection, and particularly relates to a compound salicylic acid water-soluble antibacterial cream and a preparation method thereof.
Background
Salicylic acid, also known as 2-hydroxybenzoic acid, is a monohydroxybenzoic acid, often found in nature in free or glucoside form. Salicylic acid has antibacterial and anti-inflammatory effects, and can be used for treating dermatogic diseases such as skin superficial fungal infection, seborrheic dermatitis, acne, wart, etc.
Salicylic acid products in the market at present are mostly salicylic acid ointment, and the conventional method is to grind salicylic acid crystals, then pass through a 100-mesh sieve, and then uniformly grind the salicylic acid crystals and vaseline to prepare the ointment. The salicylic acid in the ointment prepared by the method can not be dissolved, is still fine crystals, can not be fully dissolved and dispersed in a carrier material, and is not beneficial to the bioavailability utilization of the salicylic acid; therefore, the skin is not easy to permeate after being smeared and used, and the antibacterial treatment effect is poor; in addition, salicylic acid is fat-soluble organic acid, has poor water solubility, is hardly dissolved in water, and cannot be directly added into a water-based product, so that the popularization and application of the salicylic acid in skin bacteriostasis and cosmetic production are limited.
Disclosure of Invention
The invention aims to solve the technical problem of providing a compound salicylic acid water-soluble antibacterial cream and a preparation method thereof, and aims to solve the technical problem of poor bioavailability caused by poor water solubility and poor dispersibility of active ingredients in a salicylic acid product in the prior art.
In order to solve the technical problems, the invention adopts the following technical scheme:
a compound salicylic acid water-soluble antibacterial cream is developed, and is prepared from the following raw materials in percentage by mass: 2.5-3.5% of salicylic acid, 0.8-1.2% of ketoconazole, 3.0-3.6% of octadecanol, 3.0-3.6% of glyceryl monostearate, 2.5-3.5% of stearic acid, 4.5-6.5% of liquid paraffin, 2.5-3.5% of vaseline, 0.18-0.22% of ethylparaben, 0.18-0.22% of sodium dodecyl sulfate, 0.2-0.3% of 2, 6-tert-butyl-p-cresol, 1.8-2.2% of peregal O, 8-12% of glycerol, 4.0-6.0% of wetting agent, 0.18-0.25% of penetrating agent and the balance of water.
The bacteriostatic cream is formed by organically combining bacteriostatic components (salicylic acid and ketoconazole), oil phase components (octadecanol, glyceryl monostearate, stearic acid, liquid paraffin, vaseline and ethylparaben), water phase components (sodium dodecyl sulfate, 2, 6-tert-butyl-p-cresol, peregal O and glycerin), penetrating agents (such as dimethyl sulfoxide and the like), wetting agents (such as urea and the like) and the like; the salicylic acid and the ketoconazole in the bacteriostatic component are both insoluble in water, and the emulsion is prepared by the process, so that the problem of poor biological effectiveness of the salicylic acid and the ketoconazole is effectively solved; function of oil phase component: octadecanol is used as a dispersing agent, stearic acid is used as a stabilizing agent and a dispersing agent, ethylparaben is used as a preservative and a bacteriostatic agent, glyceryl monostearate is used as an emulsifier, and vaseline and liquid paraffin are used as oil phases to increase the lubrication degree of the matrix and adjust the consistency of the matrix; effect of the aqueous phase ingredients: sodium dodecyl sulfate is an emulsifier in a water phase, 2, 6-tert-butyl-p-cresol (BHT) is used as an antioxidant, glycerin is used for moisturizing a substrate and has a lubricating effect, and peregal O has a good oil-in-water emulsifying effect.
Preferably, the feed additive is prepared from the following raw materials in percentage by mass: 3% of salicylic acid, 1% of ketoconazole, 3.5% of octadecanol, 3% of vaseline, 3% of stearic acid, 3.5% of glyceryl monostearate, 0.2% of ethylparaben, 6% of liquid paraffin, 0.2% of sodium dodecyl sulfate, 0.25% of 2, 6-tert-butyl-p-cresol, peregal O2%, 10% of glycerol, 5% of urea, 0.2% of dimethyl sulfoxide and the balance of water.
The preparation method of the compound salicylic acid water-soluble antibacterial cream comprises the following steps:
(1) weighing the raw materials according to the proportion for later use;
(2) mixing octadecanol, glyceryl monostearate, stearic acid, liquid paraffin, vaseline and ethylparaben, heating to dissolve completely, sequentially adding 2, 6-di-tert-butyl-p-cresol and ketoconazole, stirring, and keeping the temperature to obtain the oil phase preparation.
(3) Mixing water and glycerol, heating to 86-90 ℃, adding sodium dodecyl sulfate and peregal O, stirring uniformly, and keeping the temperature to obtain the water-phase preparation.
(4) Preheating 1/4-1/2 of the water phase preparation, adding the oil phase preparation while stirring, adding the rest water phase preparation, and uniformly stirring to obtain a mixture.
(5) And when the temperature of the mixture is reduced to 60-65 ℃, sequentially adding salicylic acid, a wetting agent (urea) and a penetrating agent (dimethyl sulfoxide), stirring and homogenizing, and discharging after the temperature is reduced.
Preferably, in the step (2), the heating temperature is controlled to be 80-90 ℃.
Preferably, in the step (4), the preheating temperature is controlled to be 65-70 ℃; and adding the rest of the water phase preparation, and stirring at the speed of 30-35 rpm for 15-20 minutes.
Preferably, in the step (5), the stirring and homogenizing time is 10 to 15 minutes.
Compared with the prior art, the invention has the main beneficial technical effects that:
1. the antibacterial salicylic acid is dissolved in an organic solvent by utilizing the fat solubility of the antibacterial component salicylic acid, then is prepared into an oil-in-water dosage form, and finally is emulsified to form the emulsifiable paste, so that the problems of poor solubility and dispersibility of the salicylic acid are solved, the salicylic acid is in a soluble molecular state in an aqueous solution, and the salicylic acid can be directly added into a water-based product for use.
2. The salicylic acid gel not only contains dissolved salicylic acid molecules, but also is directly dissolved and dispersed in water in an oil-in-water form, has good stability and dispersibility, can enable the salicylic acid to quickly permeate into the skin, greatly improves the bioavailability of the salicylic acid, and improves the effects of inhibiting bacteria, killing bacteria and removing cuticles of the salicylic acid.
3. The other bacteriostatic component, namely ketoconazole, is dissolved in an organic solvent, is almost insoluble in water, so that the clinical application of the ketoconazole is limited, and the cream disclosed by the invention overcomes the problem that the topical application is hardly absorbed by skin and can promote the ketoconazole to exert the effect; on the other hand, through a large amount of long-term researches, the reasonable matching ratio (2.5-3.5: 1) of salicylic acid and ketoconazole under the dosage form is found out, and the effect of inhibiting bacteria and fungi is obvious.
Drawings
Fig. 1 is a photograph of a finished product of the compound salicylic acid water-soluble bacteriostatic cream in the embodiment of the invention.
Fig. 2 is a photograph of the compound salicylic acid water-soluble antibacterial cream after being placed at high temperature and low temperature for a long time.
Fig. 3 is a photograph of the compound salicylic acid water-soluble antibacterial cream after shaking centrifugation by adding water and shaking by adding oil.
FIG. 4 is a photograph of the bacteriostatic test of the compound salicylic acid water-soluble bacteriostatic cream; in the figure, A is the condition that the cream with different dilution concentrations inhibits staphylococcus aureus, and B is the condition that the cream with different dilution concentrations inhibits candida albicans.
Detailed Description
The following examples are intended to illustrate the present invention in detail and should not be construed as limiting the scope of the present invention in any way.
The instruments and devices referred to in the following examples are conventional instruments and devices unless otherwise specified; the related reagents are all conventional reagents in the market, if not specifically indicated; the test methods involved are conventional methods unless otherwise specified.
Example 1: a compound salicylic acid water-soluble antibacterial cream is prepared from the following raw materials:
3.6 kg of salicylic acid, 1.2 kg of ketoconazole, 4.2 kg of octadecanol, 3.6 kg of white vaseline, 3.6 kg of stearic acid, 4.2 kg of glyceryl monostearate, 0.24 kg of ethylparaben, 7.2 kg of liquid paraffin, 0.24 kg of sodium dodecyl sulfate, 0.3 kg of 2, 6-tert-butyl p-cresol, 2.4 kg of peregal, 12 kg of glycerin, 0.25 kg of dimethyl sulfoxide, 6 kg of urea and 70.97 kg of purified water.
Example 2: a compound salicylic acid water-soluble antibacterial cream is prepared from the following raw materials:
3.6 kg of salicylic acid, 1.2 kg of ketoconazole, 4.1 kg of octadecanol, 3.5 kg of white vaseline, 3.5 kg of stearic acid, 4.1 kg of glyceryl monostearate, 0.23 kg of ethylparaben, 7.1 kg of liquid paraffin, 0.23 kg of sodium dodecyl sulfate, 0.25 kg of 2, 6-tert-butyl p-cresol, 2.3 kg of peregal, 11.5 kg of glycerin, 5.8 kg of urea, 0.24 kg of dimethyl sulfoxide and 72.35 kg of purified water.
Example 3: the preparation method of the compound salicylic acid water-soluble antibacterial cream comprises the following steps:
(1) preparing the raw materials according to the mixture ratio of the embodiment 1 for later use;
(2) preparation of the oil phase
Mixing octadecanol, glyceryl monostearate, stearic acid, liquid paraffin, white vaseline and ethylparaben, heating to 85 + -2 deg.C for completely dissolving, sequentially adding 2, 6-di-tert-butyl-p-cresol (BHT) and ketoconazole into oil phase, stirring, and keeping temperature to obtain oil phase preparation.
(3) Preparation of aqueous phase
Then mixing purified water and glycerol, heating to 88 +/-2 ℃, adding sodium dodecyl sulfate and peregal O, continuously heating to 88 +/-2 ℃, uniformly stirring, and preserving heat to obtain the water-phase preparation.
(4) Emulsification
1/3 water-phase preparation is transferred to an emulsification stirring pot preheated to 65 ℃, oil-phase preparation is rapidly added into the emulsification pot while stirring, the rest water-phase preparation is added into the emulsification stirring pot, stirring and mixing are continuously carried out for 20 minutes at 35 revolutions per minute, and cooling water in the emulsification pot is started to cool;
② when the temperature is reduced to 60 ℃, salicylic acid, dimethyl sulfoxide and urea are added in turn, and the mixture is stirred and homogenized for 20 minutes;
and thirdly, when the temperature is reduced to 40 ℃, closing the cooling water, closing the stirring, and opening the discharge valve to discharge.
The prepared water-soluble antibacterial compound salicylic acid cream is shown in figure 1, is white in color, is uniform in texture, has no peculiar smell, and has no visible impurities; the pH was measured to be 5.5.
Example 4: the preparation method of the compound salicylic acid water-soluble antibacterial cream comprises the following steps:
(1) the raw materials are prepared according to the mixture ratio of the embodiment 2 for standby
(2) Preparation of the oil phase
Mixing octadecanol, glyceryl monostearate, stearic acid, liquid paraffin, white vaseline and ethylparaben, heating to 85 + -2 deg.C to completely dissolve, sequentially adding 2, 6-di-tert-butyl-p-cresol (BHT) and ketoconazole into oil phase, stirring, and keeping temperature to obtain oil phase preparation.
(3) Preparation of aqueous phase
Heating purified water and glycerol to 88 + -2 deg.C, adding sodium dodecyl sulfate and peregal O, stirring, and maintaining temperature to obtain water phase preparation.
(4) Emulsification
1/3 water-phase preparation is transferred to an emulsification stirring pot preheated to 68 ℃, oil-phase preparation is rapidly added into the emulsification pot while stirring, the rest water-phase preparation is added into the emulsification stirring pot, stirring and mixing are continuously carried out for 15 minutes at 30 r/min, and cooling water in the emulsification pot is started to cool;
② stirring for 5 minutes at 2600 r/min, and homogenizing for 15 minutes;
thirdly, when the temperature is reduced to 65 ℃, salicylic acid, urea and dimethyl sulfoxide which are prepared according to the proportion in the embodiment 1 are sequentially added, and the mixture is continuously stirred and homogenized for 15 minutes;
and fourthly, when the temperature is reduced to 40 ℃, closing the cooling water, closing the stirring, and opening the discharge valve to discharge.
The prepared water-soluble antibacterial compound salicylic acid cream is white in color, uniform in texture, free of peculiar smell and free of impurities visible to naked eyes; the pH was measured to be 5.6.
Test example 1:
(1) and (3) stability test: the compound salicylic acid water-soluble antibacterial cream prepared in example 3 is stored at-20 ℃ and 30 ℃ for 1 month, taken out and observed to analyze the stability state of the cream, and the result is shown in figure 2. As can be seen from figure 2, after 1 month of storage at low temperature (-20 ℃) and high temperature (30 ℃), the salicylic acid cream has no phenomena of layering and emulsion breaking, and the uniformity and the dispersibility are still kept better.
(2) Hydrophilicity test:
adding 1-fold volume of water into the compound salicylic acid antibacterial cream prepared in the example 4, oscillating the mixture on an oscillating suspension at medium frequency for 5 min, centrifuging the mixture at 3000 rpm for 10 min, taking out and observing: the cream has no layering and demulsification phenomena, which shows that the cream has better hydrophilicity and good stability (see the left picture in figure 3);
adding the compound salicylic acid antibacterial cream prepared in example 4 into an oil solution, and oscillating the mixture for 5 min at medium frequency on an oscillating suspension device, taking out the mixture, and observing the mixture: the cream remained agglomerated and did not disperse, indicating incompatibility with the oil, and was in the form of an oil-in-water formulation (see right panel in FIG. 3).
(3) And (3) bacteriostatic test: after the salicylic acid cream prepared in example 4 is diluted with sterile water in the concentration of 2 times, 4 times, 6 times and 8 times in sequence, the inhibition of staphylococcus aureus and candida albicans are respectively detected by a tube-plate method, and the result is shown in fig. 4, wherein: after being diluted by 6 times, the salicylic acid emulsifiable paste still has better inhibition effect on bacteria and fungi.
The invention is explained in detail above with reference to the drawings and the embodiments; however, those skilled in the art will understand that various changes in the above embodiments, or related materials and equivalents thereof, may be made without departing from the spirit of the invention, so as to form a plurality of embodiments, which are all common variations of the invention, and therefore, detailed description thereof is omitted.
Claims (9)
1. The compound salicylic acid water-soluble antibacterial cream is characterized by being prepared from the following raw materials in percentage by mass:
2.5-3.5% of salicylic acid, 0.8-1.2% of ketoconazole, 3.0-3.6% of octadecanol, 3.0-3.6% of glyceryl monostearate, 2.5-3.5% of stearic acid, 4.5-6.5% of liquid paraffin, 2.5-3.5% of vaseline, 0.18-0.22% of ethylparaben, 0.18-0.22% of sodium dodecyl sulfate, 0.2-0.3% of 2, 6-tert-butyl-p-cresol, 1.8-2.2% of peregal O, 8-12% of glycerol, 4.0-6.0% of wetting agent, 0.18-0.25% of penetrating agent and the balance of water.
2. The compound salicylic acid water-soluble antibacterial cream according to claim 1, which is prepared from the following raw materials:
3% of salicylic acid, 1% of ketoconazole, 3.5% of octadecanol, 3.5% of glyceryl monostearate, 3% of stearic acid, 6% of liquid paraffin, 3% of vaseline, 0.2% of ethylparaben, 0.2% of sodium dodecyl sulfate, 0.25% of 2, 6-tert-butyl-p-cresol, peregal O2%, 10% of glycerol, 5% of a wetting agent, 0.2% of a penetrating agent and the balance of water.
3. The compound salicylic acid water-soluble bacteriostatic cream according to claim 1 or 2, wherein the humectant is urea.
4. The compound salicylic acid water-soluble bacteriostatic cream according to claim 1 or 2, wherein the penetrant is dimethyl sulfoxide.
5. The preparation method of the compound salicylic acid water-soluble bacteriostatic cream disclosed by claim 1, which is characterized by comprising the following steps of:
(1) preparing raw materials according to the raw material proportion of claim 1 for later use;
(2) mixing octadecanol, glyceryl monostearate, stearic acid, liquid paraffin, vaseline and ethylparaben, heating to completely melt, sequentially adding 2, 6-di-tert-butyl-p-cresol and ketoconazole, stirring uniformly, and keeping the temperature to obtain an oil phase preparation;
(3) mixing water and glycerol, heating to 85-90 ℃, adding sodium dodecyl sulfate and peregal O, stirring uniformly, and keeping the temperature to obtain a water-phase preparation;
(4) preheating 1/4-1/2 of the water phase preparation, adding the oil phase preparation while stirring, adding the rest water phase preparation, and uniformly stirring to obtain a mixture;
(5) and when the temperature of the mixture is reduced to 60-65 ℃, adding salicylic acid, a wetting agent and a penetrating agent, stirring and homogenizing, and discharging after the temperature is reduced.
6. The preparation method of the compound salicylic acid water-soluble antibacterial cream according to claim 5, wherein in the step (2), the heating temperature is controlled to be 80-90 ℃.
7. The preparation method of the compound salicylic acid water-soluble antibacterial cream according to claim 5, wherein in the step (4), the preheating temperature is controlled to be 65-70 ℃.
8. The preparation method of the compound salicylic acid water-soluble antibacterial cream according to claim 5, wherein in the step (4), the rest of the water-phase preparation is added, and then the mixture is stirred at the speed of 30-35 rpm for 15-20 minutes.
9. The preparation method of the compound salicylic acid water-soluble antibacterial cream according to claim 5, wherein in the step (5), the stirring and homogenizing time is 10-15 minutes.
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| CN202011086206.2A CN112402362A (en) | 2020-10-12 | 2020-10-12 | Compound salicylic acid water-soluble antibacterial cream and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631369A (en) * | 2003-12-23 | 2005-06-29 | 高克 | Cream for treating skin disease |
| US20060246098A1 (en) * | 2005-03-16 | 2006-11-02 | Srinivasa Rao | Stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same |
| CN105560167A (en) * | 2015-12-23 | 2016-05-11 | 湖北医药学院附属人民医院 | Universal O / W type emulsion type matrix and preparation technology thereof |
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2020
- 2020-10-12 CN CN202011086206.2A patent/CN112402362A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631369A (en) * | 2003-12-23 | 2005-06-29 | 高克 | Cream for treating skin disease |
| US20060246098A1 (en) * | 2005-03-16 | 2006-11-02 | Srinivasa Rao | Stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same |
| CN105560167A (en) * | 2015-12-23 | 2016-05-11 | 湖北医药学院附属人民医院 | Universal O / W type emulsion type matrix and preparation technology thereof |
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| 孙丽: "酮康唑软膏的制备工艺与质量标准研究", 黑龙江科技信息, no. 7, pages 65 * |
| 田华等: "复方酮康唑醑的制备及质量控制", 中国药业, vol. 7, no. 3, pages 25 * |
| 盛国荣: "混合促渗剂对肤康涂膜剂中水杨酸和酮康唑透皮效果的影响", 中国药业, vol. 14, no. 4, pages 29 - 31 * |
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