CN105169462B - Improve the mixed method of neomycinsulphate dispersing uniformity in vaseline - Google Patents
Improve the mixed method of neomycinsulphate dispersing uniformity in vaseline Download PDFInfo
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- CN105169462B CN105169462B CN201510684357.0A CN201510684357A CN105169462B CN 105169462 B CN105169462 B CN 105169462B CN 201510684357 A CN201510684357 A CN 201510684357A CN 105169462 B CN105169462 B CN 105169462B
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Abstract
The invention discloses the mixed method for improving neomycinsulphate dispersing uniformity in vaseline, belong to pharmaceutical technology field, including：1）Neomycinsulphate powder is fitted into container, ethanol is added into the container, is uniformly mixed at room temperature, the mixture of neomycinsulphate and ethanol is obtained；2）The mixture of neomycinsulphate and ethanol is poured into the vaseline melted completely, vaseline mixture is obtained；3）Vaseline mixture is shaken in ultrasonic oscillation device；4）After concussion terminates, stirred under 60 °C of 90 °C of constant temperature, obtain mixture after ultrasonic vibration；5）To mixture after ultrasonic vibration, the vaseline for being less than 90 DEG C with melting and temperature is diluted to mixture, adjusted to required concentration.The present invention realizes neomycinsulphate powder and the mixed uniformly purpose of vaseline, can significantly improve the effective content of neomycinsulphate in liquid, paste vaseline, improve the resistance to settling of mixture；Simultaneously simple to operate, using conventional equipment, process cycle is short.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to improve neomycinsulphate dispersing uniformity in vaseline
Mixed method.
Background technology
Ventolin dressing is widely used in the burning of skin, scald and the protection of Post operation wound tissue in.Mesh
Preceding ventolin dressing is often with production technology：Non-woven fabrics is used for base fabric, is impregnated in liquid vaseline, passes through scraper plate and tensioning
Power control realizes that vaseline is uniformly smeared in base fabric.This features simple and practical process, control of product quality are easily, domestic at present raw
Production producer uses this technique substantially（Zhang Xilin, vaseline dip coating apparatus, utility model patent, CN202860766U）.With
Economic and society development, it is clinical it is continuous to this kind of product propose higher requirement, in order to improve dressing antibiotic property, it is necessary to
Antibiotic is added in production process.Neomycinsulphate is the common medicine for preventing the infection of skin trauma face, therefore in ventolin dressing
Middle introducing neomycinsulphate can significantly improve the pre- aseptic ability of dressing（William T.Newmanet al. Neomycin
sulfate dressing for meshed split-thickness skin grafts. Journal of Burn Care
& Research, 1987, 8: 23-24.）.
However, neomycinsulphate is a kind of aminoglycoside antibiotics, it is polar molecule, is easily dissolved in water, it is water-soluble
Liquid shows dextrorotation photosensitiveness, and almost insoluble in ethanol, ether, acetone or chloroform.Neomycinsulphate ventolin dressing is carried to produce
Cheng Zhong, by proportion be 0.2% neomycinsulphate powder add melting petrolatum liquid after, powder rapidly in stirred tank bottom deposit,
Caking, or even be attached in stirring sheet, thereby result in the actual drugloading rate of dressing and decline, carry medicine lack of uniformity.In order to ensure load
Dose and load medicine uniformity, existing neomycinsulphate externally applied drug are generally ointment.Moreover, in order to prevent neomycinsulphate from flocculating,
Separate out, emulsifiable paste typically by albolene, octadecyl alcolol, glycerin monostearate, glycerine, polysorbate, methyl p-hydroxybenzoate,
The emulsification such as propylparaben, dimethyl sulfoxide, propane diols, purified water is formed（The compound triamcinolone acetonide creams such as Shen Hong
Prepare and quality control [J].Anhui medicine, 2006,10:731-732；Li Pu column front derivation-HPLC methods determine compound ketone health
The practical preventive medicine of content [J] of neomycinsulphate, 2010,04 in azoles emulsifiable paste:767-769；Li Jian and grade neomycin oxygen
Change preparation and quality control [J] contemporary Chinese medical journals of zinc paste, 2012,30:44-48.）.This kind of ointment has certain viscous
Degree, is typically used in room temperature environment, and in order to ensure effect of impregnation, increase vaseline mobility, improves production efficiency, all scholars
The coating of woods non-woven fabrics needs carrying out at 60 DEG C.Viscosity of liquid is decreased obviously at a temperature of this, and neomycinsulphate will be analysed again
Go out, therefore emulsion process can not overcome above mentioned problem.
In summary, not yet find to realize that high-quality fraction neomycinsulphate is dispersed in vaseline melting at present
Method in liquid is seen in report.
The content of the invention
Goal of the invention：It is an object of the invention to provide improve neomycinsulphate dispersing uniformity in vaseline
Mixed method, realize that high-quality fraction neomycinsulphate is dispersed in vaseline fused solution.
Technical scheme：For achieving the above object, the present invention is adopted the following technical scheme that：
Improve the mixed method of neomycinsulphate dispersing uniformity in vaseline, comprise the following steps：
1）Neomycinsulphate powder is fitted into container, ethanol is added into the container, is uniformly mixed at room temperature, is obtained
To neomycinsulphate and the mixture of ethanol；
2）The mixture of neomycinsulphate and ethanol is poured into the vaseline melted completely, and tentatively stir 1 minute with
On, obtain vaseline mixture；
3）Vaseline mixture is all put into container, vaseline mixture is put into 50 DEG C -90 °C together with container
In hot water, water level exceedes the surface of mixture in container, is shaken in ultrasonic oscillator, and the time is more than 5 minutes；
4）After concussion terminates, ensureing vaseline melting and temperature is less than under 90 DEG C of constant temperature and continues to stir mixture to mixed
Close uniform, obtain mixture after ultrasonic vibration；
5）To mixture after ultrasonic vibration, the vaseline for being less than 90 DEG C with melting and temperature is diluted to mixture, adjusted
Whole to required concentration, is again stirring for being well mixed.
Step 1）In, addition and the neomycinsulphate powder proportions of described ethanol are the ml/g of 5 ml/g- 15.
Step 2）In, the quality of neomycinsulphate accounts for vaseline quality in described neomycinsulphate and the mixture of ethanol
50% within.
Described ethanol is absolute ethyl alcohol.
Step 3）In, during ultrasonic oscillation, vaseline mixture should be in the water-bath in 50 °C ~ 90 DEG C temperature.
Step 4）In, mixture whipping temp is 60 °C ~ 90 DEG C after ultrasonic vibration.
Step 5）In, the dilution temperature of mixture is 60 °C ~ 90 DEG C after ultrasonic vibration.
Beneficial effect：Compared with prior art, improvement neomycinsulphate dispersing uniformity in vaseline of the invention
Mixed method, realizes neomycinsulphate powder and the mixed uniformly purpose of vaseline, can significantly improve in liquid, paste vaseline
The effective content of neomycinsulphate, improves the resistance to settling of mixture；It is simultaneously simple to operate, use conventional equipment, processing week
Phase is short, is adapted to production application, possesses good practicality.
Embodiment
Below by way of embodiment, the present invention is described further.
Improve the mixed method of neomycinsulphate dispersing uniformity in vaseline, comprise the following steps：
1）Neomycinsulphate powder is fitted into container, ethanol is added into the container, is uniformly mixed at room temperature, its
In, addition and the neomycinsulphate powder proportions of ethanol are the ml/g of 5 ml/g- 15, specifically, per 1g neomycinsulphate powder
End uses absolute ethyl alcohol 5-15 ml, neomycinsulphate powder is changed into pasty state, obtains the mixture of neomycinsulphate and ethanol；
2）The mixture of neomycinsulphate and ethanol is poured into the vaseline melted completely, neomycinsulphate and ethanol
The quality of neomycinsulphate is accounted within the 50% of vaseline quality in mixture；And it is mixed tentatively to stir 1 minute vaseline derived above
Compound；Vaseline melting temperature is below 90 DEG C, the fusing point that vaseline is not fixed, different vaseline product fusing points 45 °C ~
60 DEG C of changes；
3 are put into vaseline mixture together with container in more than 50 DEG C of hot water, and water level exceedes the table of mixture in container
Face, is shaken in ultrasonic oscillator, and the time is more than 5 minutes；
4）After concussion terminates, ensureing vaseline melting and temperature is less than under 90 DEG C of constant temperature and continues to stir mixture to mixed
Close uniform, obtain mixture after ultrasonic vibration；
5）To mixture after ultrasonic vibration, the vaseline for being less than 90 DEG C with melting and temperature is diluted to mixture, adjusted
Whole to required concentration, is again stirring for being well mixed；Dilution step is specially：According to aimed concn, all scholars of melting are calculated respectively
Woods consumption and amount of mixture, both are mixed, below 90 DEG C, and constant temperature is stirred under vaseline molten condition, until
It is well mixed, you can to obtain the mixture that neomycinsulphate content is 0-50%.
Step 1）In, the ethanol of decentralized medium is absolute ethyl alcohol.
Step 2）In, vaseline is medical, industrial albolene or yellow petroleum jelly, and wherein medical ventolin meets《In
Magnificent people's republic's pharmacopeia》（2010 editions）It is required that.
Step 1）、2）In, the mixture of neomycinsulphate and ethanol should have good fluidity.Step 2）Before, it should ensure that
Vaseline is melted completely, transparent liquid.
Step 3）In, during ultrasonic oscillation, vaseline mixture temperature is 50 °C ~ 90 DEG C；
Step 4）In, mixture is sufficiently stirred at a temperature of should be at 60 °C ~ 90 DEG C after ultrasonic vibration.
Step 5）In, the dilution of mixture, concentration adjustment should be carried out at a temperature of 60 °C ~ 90 DEG C, and filled after ultrasonic vibration
Divide stirring.
Embodiment 1
The medical albolene of 35g is weighed, is put into beaker, is positioned on electromagnetic agitation constent temperature heater, setting temperature is
60 DEG C, held for some time makes vaseline melt completely, transparent liquid.Neomycinsulphate powder is weighed according to 0.2% proportion,
That is 0.07g, adds 0.35 ml absolute ethyl alcohols according to 5 ml/g ratio, stirs 1 minute at room temperature.By neomycinsulphate-ethanol
Mixture is poured into the vaseline melted completely at 60 DEG C and tentatively stirred with glass bar 1 minute.The mixture is transferred to perseverance
Shaken in tepidarium ultrasonic oscillator, bath temperature is 60 DEG C, the time is 5 minutes.After concussion terminates, electric stirring is used
Device continues stirring mixture 5min under 60 DEG C of constant temperature, you can obtain uniform mixture.
Reference examples 1
The medical albolene of 35g is weighed, is put into beaker, is positioned on electromagnetic agitation constent temperature heater, setting temperature is
60 DEG C, held for some time makes vaseline melt completely, transparent liquid.Neomycinsulphate powder is weighed according to 0.2% proportion,
That is 0.07g, pours into the vaseline melted completely at 60 DEG C and is tentatively stirred with glass bar 1 minute.Electric mixing is directly used afterwards
Mix device to continue to stir mixture 30min under 60 DEG C of constant temperature, powder agglomeration is serious, fails to access uniform mixture.
Embodiment 2
Blend step is substantially the same manner as Example 1, and difference is：Neomycinsulphate proportion improves 50 times, that is, accounts for all scholars
The 10% of woods weight, absolute ethyl alcohol adding proportion is 10 ml/g；Vaseline temperature is 70 DEG C；Ultrasonic oscillation 5 minutes, ultrasound shake
Bath temperature is swung for 70 DEG C.
After ultrasonic vibration terminates, continue stirring mixture 5min under 70 DEG C of constant temperature with electric mixer, you can obtain
Even mixture.
Comparative example 2
Implementation steps are substantially the same manner as Example 2, and difference is, without ethanol in neomycinsulphate powder, and
Directly mixed with melting vaseline, ultrasonic vibration 5 minutes.
After concussion, continued with electric mixer under 70 DEG C of constant temperature after stirring mixture 30 min, part of sulfuric acid neomycin
Walls of beaker and bottom are sticked to, fails to access uniform mixture.
Comparative example 3
Implementation steps are substantially the same manner as Example 2, and difference is, without ultrasonic oscillation after preliminary mixing.
Continued with electric mixer under 70 DEG C of constant temperature after stirring mixture 30 min, part of sulfuric acid neomycin sticks to burning
Wall of cup and bottom, fail to access uniform mixture.
Embodiment 3
Blend step is substantially the same manner as Example 1, and difference is：Neomycinsulphate proportion improves 100 times, that is, accounts for all scholars
The 20% of woods weight, absolute ethyl alcohol adding proportion is 15 ml/g；Vaseline temperature is 80 DEG C；Ultrasonic oscillation 5 minutes, ultrasound shake
Bath temperature is swung for 80 DEG C.
After ultrasonic vibration terminates, continue stirring mixture 5min under 80 DEG C of constant temperature with electric mixer, you can obtain
Even mixture.
This mixture is stayed overnight at room temperature in placement, yellow paste is obtained, the concentration of neomycinsulphate is from top to bottom
There is gradient increase phenomenon.After melting and be again stirring for through 60 DEG C of heated at constant temperature, uniform mixture is re-formed.
Embodiment 4
Neomycinsulphate content and blend step are same as Example 3, and difference is that vaseline temperature is 90 DEG C, ultrasound
Shaking water bath temperature is 90 DEG C.20ml mixtures are taken with suction pipe in whipping process after well mixed, 380ml, 90 DEG C is transferred to
Vaseline in, stirring 2min can obtain 400ml neomycinsulphates content be 1% mixture.
Compared from embodiment 1 with reference examples 1, neomycinsulphate is dispersed very poor in vaseline, even if quality
Fraction as little as 0.2%, does not can be uniformly dispersed still.And the technical program is mixed using absolute ethyl alcohol and ultrasonic oscillation then can be real
Existing neomycinsulphate is uniformly distributed.
Embodiment 2 illustrates, neomycinsulphate can ensured in the equally distributed premise of vaseline using the technical program
Under, the neomycinsulphate drugloading rate in vaseline is greatly improved.
Comparative example 2 and comparative example 3 illustrate that addition absolute ethyl alcohol and ultrasonic oscillation are that the technical program can be obtained well
The key of effect.
Embodiment 3 illustrates that the neomycinsulphate prepared using the technical program-vaseline mixture is heavy after cooled and solidified
New heating stirring, can obtain homogeneous mixture, meet produce reality requirement.
Embodiment 4 illustrates that the high sulfuric acid Determination of neomycin mixture prepared using the technical program may be used as mother liquor,
For allocating the mixture of various concentrations.
In summary, the inventive method realizes neomycinsulphate powder and the mixed uniformly purpose of vaseline, can significantly carry
The effective content of neomycinsulphate, improves the resistance to settling of mixture in high liquid, paste vaseline.Meanwhile, present invention side
Method is simple to operate, using conventional equipment, and process cycle is short, is adapted to production application.
Claims (6)
1. improve the mixed method of neomycinsulphate dispersing uniformity in vaseline, it is characterised in that comprise the following steps：
1) neomycinsulphate powder is fitted into container, absolute ethyl alcohol is added into the container, is uniformly mixed at room temperature, is obtained
To neomycinsulphate and the mixture of ethanol；
2) mixture of neomycinsulphate and absolute ethyl alcohol is poured into the vaseline melted completely, and tentatively stir 1 minute with
On, obtain vaseline mixture；
3) vaseline mixture is all put into container, vaseline mixture is put into 50 DEG C -90 DEG C of hot water together with container
In, water level exceedes the surface of mixture in container, is shaken in ultrasonic oscillator, and the time is more than 5 minutes；
4) after concussion terminates, melted in guarantee vaseline and continue to stir mixture extremely mixing under constant temperature of the temperature less than 90 DEG C
It is even, obtain mixture after ultrasonic vibration；
5) to mixture after ultrasonic vibration, be less than 90 DEG C of vaseline with melting and temperature and mixture be diluted, adjust to
Required concentration, is again stirring for being well mixed.
2. according to claim 1 improve the mixed method of neomycinsulphate dispersing uniformity in vaseline, its feature
It is：Step 1) in, addition and the neomycinsulphate powder proportions of described absolute ethyl alcohol are 5ml/g-15ml/g.
3. according to claim 1 improve the mixed method of neomycinsulphate dispersing uniformity in vaseline, its feature
It is：Step 2) described in neomycinsulphate and absolute ethyl alcohol mixture in the quality of neomycinsulphate account for vaseline quality
50% within.
4. according to claim 1 improve the mixed method of neomycinsulphate dispersing uniformity in vaseline, its feature
It is：Step 3) in, during ultrasonic oscillation, vaseline mixture should be in 50 DEG C~90 DEG C of temperature.
5. according to claim 1 improve the mixed method of neomycinsulphate dispersing uniformity in vaseline, its feature
It is：Step 4) in, mixture whipping temp is 60 DEG C~90 DEG C after ultrasonic vibration.
6. according to claim 1 improve the mixed method of neomycinsulphate dispersing uniformity in vaseline, its feature
It is：Step 5) in, the dilution temperature of mixture is 60 DEG C~90 DEG C after ultrasonic vibration.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306823A (en) * | 2000-01-25 | 2001-08-08 | 宗希乙 | Ointment for treating dermatosis and its preparation |
| CN1686573A (en) * | 2005-05-13 | 2005-10-26 | 褚省吾 | Lipid hydro colloid polymer anti bacterial dressing and its preparation method |
| CN101596204A (en) * | 2009-06-04 | 2009-12-09 | 青岛康地恩药业有限公司 | A kind of compound fluconazole ointment and preparation method thereof |
| CN103432148A (en) * | 2013-08-14 | 2013-12-11 | 天津药业集团新郑股份有限公司 | Method for preparing compound ketoconazole cream |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004009081A1 (en) * | 2002-07-18 | 2004-01-29 | Pedro Cuevas Sanchez | Use of neomycin in the preparation of medicaments that are used in the treatment of diseases caused by hyperactivation of kinase proteins activated by mitogens (mapk) or by transcription factors |
| PL191525B1 (en) * | 2002-08-12 | 2006-06-30 | Grabowicz Wlodzimierz | Pharmaceutical agent |
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- 2015-10-22 CN CN201510684357.0A patent/CN105169462B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306823A (en) * | 2000-01-25 | 2001-08-08 | 宗希乙 | Ointment for treating dermatosis and its preparation |
| CN1686573A (en) * | 2005-05-13 | 2005-10-26 | 褚省吾 | Lipid hydro colloid polymer anti bacterial dressing and its preparation method |
| CN101596204A (en) * | 2009-06-04 | 2009-12-09 | 青岛康地恩药业有限公司 | A kind of compound fluconazole ointment and preparation method thereof |
| CN103432148A (en) * | 2013-08-14 | 2013-12-11 | 天津药业集团新郑股份有限公司 | Method for preparing compound ketoconazole cream |
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Application publication date: 20151223 Assignee: Center for technology transfer Jiangsu University of Science and Technology Assignor: JIANGSU University OF SCIENCE AND TECHNOLOGY Contract record no.: X2021980006173 Denomination of invention: Mixing method for improving dispersion uniformity of neomycin sulfate in Vaseline Granted publication date: 20171017 License type: Common License Record date: 20210714 |
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Assignee: Center for technology transfer Jiangsu University of Science and Technology Assignor: JIANGSU University OF SCIENCE AND TECHNOLOGY Contract record no.: X2021980006173 Date of cancellation: 20210826 |
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