CN115844994A - Rhizoma bletillae ointment and preparation method and application thereof - Google Patents
Rhizoma bletillae ointment and preparation method and application thereof Download PDFInfo
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- CN115844994A CN115844994A CN202211704927.4A CN202211704927A CN115844994A CN 115844994 A CN115844994 A CN 115844994A CN 202211704927 A CN202211704927 A CN 202211704927A CN 115844994 A CN115844994 A CN 115844994A
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- rhizoma bletillae
- bletilla striata
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Images
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a rhizoma bletillae ointment as well as a preparation method and application thereof. The bletilla striata ointment provided by the invention comprises the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of rhizoma bletillae product; the rhizoma bletillae product comprises rhizoma bletillae powder or rhizoma bletillae polysaccharide; when the rhizoma bletillae product is rhizoma bletillae powder, the oil phase comprises stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax; when the bletilla striata product is bletilla striata polysaccharide, the oil phase comprises white vaseline, dimethyl silicone oil, stearic acid, paraffin and tween. The bletilla striata paste provided by the invention is high in content of bletilla striata products, pharmacological activities of hemostasis and wound healing, anti-inflammation, antibiosis, antivirus and antioxidation of bletilla striata can be fully utilized, on the basis, the paste is prepared by adjusting the component proportion, the stability and the affinity of the obtained paste are good, the microbial pollution can be reduced, and the medicinal effect of the bletilla striata products can be well reserved.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a rhizoma bletillae ointment as well as a preparation method and application thereof.
Background
Rhizoma Bletillae is a kind of rhizoma Bletillae of Orchidaceae, and has effects of astringing, stopping bleeding, relieving swelling, promoting granulation, stopping bleeding, healing wound, resisting inflammation, resisting bacteria and virus, preventing and treating digestive tract ulcer, whitening skin, resisting oxidation, chapped skin, scald due to hot water and fire, etc. Based on the unique geographical climate conditions, the bletilla striata in Guizhou occupies an absolute dominant position in the aspects of germplasm resources, planting area and annual output, and has good market prospect. However, the current common bletilla pseudobulb industry has a plurality of problems in the aspects of producing area processing and product research and development: such as the problems of loss of effective components caused by non-standard production process of the producing area, cross and repeated production process, high processing cost, lagging development of new rhizoma bletillae products and the like. The development lag of the new rhizoma bletillae products restricts the development of the rhizoma bletillae industry, and seriously influences the early-stage layout of the rhizoma bletillae industry and the healthy and continuous development of industrial ecology, so the rhizoma bletillae products which are suitable for daily life needs are developed on the basis of wide application of the rhizoma bletillae serving as the raw materials, and the rhizoma bletillae products have important economic value and social significance.
Chinese patent CN 111467433A discloses an external traditional Chinese medicine composition and ointment for promoting wound healing and a preparation method thereof, which is composed of a plurality of traditional Chinese medicines such as pseudo-ginseng, dalbergia wood, beautyberry leaf, sanguisorba, pearl, bletilla striata and salvia miltiorrhiza, and has the effects of stopping bleeding, diminishing inflammation, reducing swelling, relieving pain, removing stasis and promoting granulation, and can effectively improve the blood circulation of local wound tissues and enhance the immunologic function. However, the preparation formulation has poor stability and is easily affected by complex environment, which causes the loss and deterioration of medicinal components.
Disclosure of Invention
The invention aims to provide a bletilla striata ointment and a preparation method and application thereof.
In order to achieve the above purpose, the invention provides the following technical scheme:
the invention provides a bletilla striata ointment which comprises the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of rhizoma bletillae product;
the rhizoma bletillae product comprises rhizoma bletillae powder or rhizoma bletillae polysaccharide;
when the rhizoma bletillae product is rhizoma bletillae powder, the oil phase is a first oil phase, and the first oil phase comprises stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax;
when the rhizoma bletillae product is rhizoma bletillae polysaccharide, the oil phase is a second oil phase, and the second oil phase comprises white vaseline, dimethyl silicone oil, stearic acid, paraffin and tween.
Preferably, the mass ratio of stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax in the first oil phase is 4-5: 1 to 2:4 to 5:4 to 5: 2-2.5: 4 to 5:3 to 4.
Preferably, when the rhizoma bletillae product is rhizoma bletillae powder, the aqueous phase is a first aqueous phase comprising glycerol, ethylparaben and water.
Preferably, the mass ratio of the glycerol to the ethylparaben to the water in the first aqueous phase is 18-19: 1 to 2:52 to 55.
Preferably, the mass ratio of white vaseline, dimethyl silicone oil, stearic acid, paraffin and tween in the second oil phase is 3-5: 1 to 2:0.5 to 1:1 to 3:1 to 2.
Preferably, when the bletilla striata product is bletilla striata polysaccharide, the aqueous phase is a second aqueous phase comprising propylene glycol, ethylparaben, glycerin and water.
Preferably, the mass ratio of the propylene glycol, the ethylparaben, the glycerol and the water in the second aqueous phase is 5-7: 0.1 to 0.5:5 to 6:60 to 63.
The invention also provides a preparation method of the bletilla striata ointment in the technical scheme, which comprises the following steps:
respectively heating and melting the oil phase and the water phase, and then carrying out first mixing to obtain a paste matrix;
and secondly, mixing the rhizoma bletillae product with a paste matrix to obtain the rhizoma bletillae paste.
Preferably, the temperature for heating and melting the oil phase and the water phase is 79-90 ℃.
The invention also provides application of the bletilla striata ointment in the technical scheme in face cream.
The invention provides a bletilla striata ointment which comprises the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of rhizoma bletillae product; the rhizoma bletillae product comprises rhizoma bletillae powder or rhizoma bletillae polysaccharide; when the rhizoma bletillae product is rhizoma bletillae powder, the oil phase comprises stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax; when the bletilla striata product is bletilla striata polysaccharide, the oil phase comprises white vaseline, dimethyl silicone oil, stearic acid, paraffin and tween. The bletilla striata ointment provided by the invention consists of an oil phase, a water phase and a bletilla striata product, wherein the content of the bletilla striata product is high, the pharmacological activities of hemostasis and healing, anti-inflammation, antibiosis, antivirus and antioxidation of the bletilla striata can be fully utilized, on the basis, the ointment is prepared by adjusting the selection and the proportion of the components of the oil phase, and the obtained ointment has good stability and affinity, is convenient to carry, is simple and clean to use, can reduce the microbial pollution, and can better retain the medicinal effect of the bletilla striata product.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise.
FIG. 1 shows the appearance of the bletilla striata paste obtained in example 1;
figure 2 is a comparison of the appearance and morphology of different matrices of the bletilla striata paste of example 1;
fig. 3 shows the appearance of the bletilla striata paste obtained in example 2.
Detailed Description
The invention provides a bletilla striata paste which comprises the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of rhizoma bletillae product;
the rhizoma bletillae product comprises rhizoma bletillae powder or rhizoma bletillae polysaccharide.
In the present invention, all the raw material components are commercially available products well known to those skilled in the art, unless otherwise specified.
In the present invention, when the rhizoma bletillae preparation is rhizoma bletillae powder:
the common bletilla pseudobulb ointment comprises, by mass, 6-29 parts of a first oil phase, preferably 10-27 parts, and more preferably 20-25 parts.
In the present invention, the first oil phase preferably comprises stearic acid, span, polysorbate, glyceryl monostearate, white petrolatum, paraffin and beeswax; the mass ratio of stearic acid, span, polysorbate, glycerin monostearate, white vaseline, paraffin and beeswax is preferably 4-5: 1 to 2:4 to 5:4 to 5: 2-2.5: 4 to 5:3 to 4, more preferably 4 to 4.5:1 to 1.5: 4-4.5: 4-4.5: 2-2.5: 4-4.5: 3.5 to 4. In the present invention, the span is preferably span-80; the polysorbate is preferably polysorbate-80; the paraffin is preferably liquid paraffin.
The rhizoma bletillae ointment comprises 71-77 parts of a first water phase, preferably 72-75 parts, and more preferably 73-74 parts by mass of a first oil phase.
In the present invention, the first aqueous phase preferably comprises glycerol, ethylparaben and water; the mass ratio of the glycerol to the ethylparaben to the water is preferably 18-19: 1 to 2:52 to 55, more preferably 18 to 18.5:1 to 1.5:53 to 54. In the present invention, the water is preferably purified water.
Based on the mass part of the first oil phase, the rhizoma bletillae ointment comprises 2 to 18 parts of rhizoma bletillae powder, preferably 2 to 8 parts of rhizoma bletillae powder, and more preferably 2 to 5 parts of rhizoma bletillae powder.
In the present invention, the particle size of the bletilla striata powder is preferably 200 to 300 mesh, more preferably 220 to 280 mesh, and most preferably 240 to 260 mesh.
In the present invention, when the rhizoma bletillae preparation is rhizoma bletillae polysaccharide:
the rhizoma bletillae ointment comprises, by mass, 6-29 parts of the second oil phase, preferably 7-20 parts of the second oil phase, and more preferably 8-15 parts of the second oil phase.
In the present invention, the second oil phase preferably includes white petrolatum, dimethicone, stearic acid, paraffin, and tween; the mass ratio of white vaseline to dimethyl silicone oil to stearic acid to paraffin to tween is preferably 3-5: 1 to 2:0.5 to 1:1 to 3:1 to 2, more preferably 4 to 5:1 to 1.5:0.5 to 1:2 to 3:1 to 2. The tween is preferably tween-60.
The rhizoma bletillae ointment comprises 71-77 parts of a second water phase, preferably 72-75 parts, and more preferably 72-74 parts by mass of a second oil phase.
In the present invention, the second aqueous phase preferably comprises propylene glycol, ethylparaben, glycerol and water; the mass ratio of the propylene glycol, the ethylparaben, the glycerol and the water is preferably 5-7: 0.1 to 0.5:5 to 6:60 to 63, more preferably 6 to 7:0.1 to 0.5: 5.5-6: 62 to 63.
Based on the mass parts of the second oil phase, the rhizoma bletillae ointment comprises 2-18 parts of rhizoma bletillae polysaccharide, preferably 10-18 parts of rhizoma bletillae polysaccharide, and more preferably 15-18 parts of rhizoma bletillae polysaccharide.
The bletilla striata ointment provided by the invention is composed of an oil phase, a water phase and a bletilla striata product, wherein the content of the bletilla striata product is high, the pharmacological activities of hemostasis and wound healing, anti-inflammation, antibiosis, antivirus and antioxidation of the bletilla striata can be fully utilized, on the basis, the ointment is prepared by adjusting the component proportion, the obtained ointment is uniform, fine and glossy, has no granular sensation and no oil-water separation, is coated on a glass plate, has no independent granules or bubbles visible to naked eyes, has good stability and affinity, is convenient to carry, is simple and clean to use, can reduce microbial pollution, and can better retain the medicinal effect of the bletilla striata product.
The invention also provides a preparation method of the bletilla striata ointment in the technical scheme, which comprises the following steps:
respectively heating and melting the oil phase and the water phase, and then carrying out first mixing to obtain a paste matrix;
and secondly, mixing the bletilla striata product with a paste matrix to obtain the bletilla striata paste.
The oil phase and the water phase are respectively heated and melted and then are mixed for the first time to obtain the pasty matrix.
In the invention, the heating for melting is preferably water bath heating; the temperature for heating and melting the oil phase and the water phase is preferably 79-90 ℃, more preferably 80-87 ℃, and most preferably 82-85 ℃; the time for melting by heating is not particularly limited in the present invention, and the oil phase and the water phase are sufficiently dissolved by using a time known to those skilled in the art.
In the present invention, the first mixing is preferably adding the aqueous phase to the oil phase; the first mixing is preferably carried out while the aqueous phase is added to the oil phase with stirring; when the rhizoma bletillae product is rhizoma bletillae powder, the stirring time is preferably more than 5min, more preferably 10-30 min, and most preferably 15-20 min; when the rhizoma bletillae product is rhizoma bletillae polysaccharide, the stirring time is preferably 8-15 min, and more preferably 10-13 min.
After the pasty matrix is obtained, the bletilla striata product and the pasty matrix are subjected to second mixing to obtain the bletilla striata paste.
In the present invention, when the rhizoma bletillae preparation is rhizoma bletillae powder, the second mixing is preferably performed at room temperature; preferably, the bletilla striata powder is added in the second mixing in an equivalent increasing mode; after the second mixing is complete, the present invention also preferably includes grinding; the grinding process is not limited in any way, and the common bletilla pseudobulb paste can be uniformly mixed by adopting a method well known to a person skilled in the art.
In the invention, when the rhizoma bletillae product is rhizoma bletillae polysaccharide, the temperature of the second mixing is preferably 55-70 ℃, more preferably 58-68 ℃, and most preferably 60-65 ℃; the second mixing is preferably carried out in a stirring manner; the stirring process is not limited in any way, and the common bletilla pseudobulb paste can be uniformly mixed by adopting a method well known to a person skilled in the art.
The preparation method of the bletilla striata paste provided by the invention is simple in preparation process, low in cost and wide in application prospect.
The invention also provides application of the bletilla striata ointment in the technical scheme in face cream.
The process of the present invention is not particularly limited to the application described herein, and may be performed in a manner well known to those skilled in the art.
For further illustration of the present invention, the following description of the present invention will be made in detail with reference to the accompanying drawings and examples, but the present invention should not be construed as limited to the scope of the present invention.
Examples 1 to 1
Heating an oil phase (4.2% of stearic acid, span-801.3% of polysorbate-804.2% of glyceryl monostearate, 2.1% of white vaseline, 4.3% of liquid paraffin and 3.8% of beeswax) and a water phase (18.3% of glycerin, 54% of purified water and 1% of ethylparaben) in a water bath kettle to 83 ℃ respectively, stirring until all solids are melted, adding the water phase into the oil phase in a trickle mode, continuously heating for 10min and stirring continuously, and placing at room temperature and continuously stirring until the solids are condensed. Adding 2.5% rhizoma Bletillae micropowder into matrix by equivalent incremental method, and grinding to obtain rhizoma Bletillae paste, which is white paste with properties shown in figure 1. The obtained rhizoma bletillae paste is uniform, fine, glossy, free of granular feel and free of oil-water separation, and is coated on a glass plate without single granules or bubbles visible to naked eyes.
Examples 1 to 2
The rhizoma bletillae ointment is prepared according to the preparation method described in example 1-1, wherein the difference is that the oil phase comprises glyceryl monostearate, white vaseline, liquid paraffin, beeswax, stearic acid, span-80 and polysorbate-80, and the mass ratio of the glyceryl monostearate to the white vaseline to the liquid paraffin is 30:15:30:26:20:6:20.
examples 1 to 3
The rhizoma bletillae paste is prepared according to the preparation method of the embodiment 1-2, wherein the weight ratio of the stearic acid, the span-80 and the polysorbate-80 to the oil phase is 1:2.
examples 1 to 4
The rhizoma bletillae paste is prepared according to the preparation method of the embodiment 1-2, wherein the preparation method is characterized in that the mass ratio of the stearic acid, the span-80 and the polysorbate-80 to the oil phase is 2:5.
examples 1 to 5
The preparation method of the bletilla striata paste as described in example 1-2 is carried out, except that the emulsification time is 10min and the temperature is 80 ℃.
Examples 1 to 6
The preparation method of the bletilla striata paste as described in example 1-2 is carried out with the difference that the emulsification time is 30min and the temperature is 80 ℃.
Examples 1 to 7
The preparation method of the bletilla striata paste as described in example 1-2 is carried out with the difference that the emulsification time is 10min and the temperature is 90 ℃.
Examples 1 to 8
The preparation method of the bletilla striata paste as described in example 1-2 is carried out with the difference that the emulsification time is 30min and the temperature is 90 ℃.
Comparative examples 1 to 1
The bletilla striata ointment is prepared according to the preparation method of the embodiment 1-1, except that the oil phase is glyceryl monostearate, white vaseline, liquid paraffin, beeswax, lanolin and span-80, and the mass ratio is 14:4:26:26:20:2.
comparative examples 1 to 2
The common bletilla pseudobulb ointment is prepared according to the preparation method described in the embodiment 1-1, and is characterized in that the oil phase is glyceryl monostearate, white vaseline, beeswax, span-80 and polysorbate-80, and the mass ratio of the oil phase to the ointment is 20:6:26:6:20.
comparative examples 1 to 3
The rhizoma bletillae ointment is prepared according to the preparation method described in example 1-1, wherein the oil phase is glyceryl monostearate, white vaseline, beeswax, stearic acid and polysorbate-80, and the mass ratio of the glyceryl monostearate to the white vaseline to the beeswax is 60:20:26:5:4:8.
comparative examples 1 to 4
The rhizoma bletillae paste is prepared according to the preparation method of the embodiment 1-2, wherein the weight ratio of the stearic acid, the span-80 and the polysorbate-80 to the oil phase is 1:5.
comparative examples 1 to 5
The rhizoma bletillae paste is prepared according to the preparation method of the embodiment 1-2, wherein the weight ratio of the stearic acid, the span-80 and the polysorbate-80 to the oil phase is 3:5.
comparative examples 1 to 6
The preparation method of rhizoma Bletillae paste as described in example 1-2 was carried out with the difference that the emulsification time was 5min and the temperature was 70 ℃.
Comparative examples 1 to 7
The preparation method of the common bletilla pseudobulb ointment according to the embodiment 1-2 is characterized in that the emulsifying time is 10min and the temperature is 70 ℃.
Comparative examples 1 to 8
The preparation method of the bletilla striata paste as described in example 1-2 is carried out, except that the emulsification time is 30min and the temperature is 70 ℃.
Comparative examples 1 to 9
The preparation method of rhizoma Bletillae paste as described in example 1-2 was carried out with the difference that the emulsification time was 5min and the temperature was 80 ℃.
Comparative examples 1 to 10
The common bletilla pseudobulb ointment was prepared according to the preparation method described in example 1-2, except that the emulsification time was 5min and the temperature was 90 ℃.
Test examples 1-1
And (3) oil phase component proportion screening: oil phase components are selected from glyceryl monostearate, liquid paraffin, white vaseline, cera flava, and lanolin, and emulsifier is selected from span-80, polysorbate-80, and stearic acid. The resulting bletilla striata paste was initially evaluated from the following points: a. appearance property: the substrate is uniform, fine and glossy, has no granular sensation, is free from oil-water separation, and has no independent granules or bubbles visible to naked eyes when being coated on a glass plate; b. consistency and spreadability: should be easy to spread on the skin; c. physical stability: taking a proper amount of cream to be placed in a 1mL centrifuge tube, centrifuging for 30min at 2500r/min, and avoiding oil-water stratification; the product is allowed to stand at 55 deg.C for 6 hr and-15 deg.C for 24 hr, and no phenomena such as hardening, demulsification, and foaming should be observed. The results are shown in table 1 and fig. 2.
TABLE 1 evaluation of oil phase component ratios
As can be seen from Table 1 and FIG. 2, the formulation of comparative example 1-1 had a granular feel with the substrate being difficult to coat; the formula of the comparative example 1-2 has oil-water separation phenomenon and is unstable; the formula of the comparative example 1-3 has the oil-water separation phenomenon, and the matrix of the example 1-2 is uniform, fine and stable in property and meets the basic requirement of the matrix of the paste.
Test examples 1 to 2
And (3) determining the proportion of the emulsifier: the emulsifier is an important factor influencing the paste forming, and the setting ratio of the emulsifier (stearic acid, span-80, polysorbate-80) to the oil phase in example 1-2 is 1:5. 1:2. 2:5. 3:5 investigation of the resulting bletilla striata paste was initially evaluated in terms of appearance, consistency and spreadability and physical stability, the results are shown in Table 2.
TABLE 2 emulsifier ratio evaluation
As can be seen from Table 2, the pastes were more uniform and finer and had better spreadability in the formulations of examples 1 to 3 and examples 1 to 4.
Test examples 1 to 3
Optimizing the process flow: an orthogonal experiment is designed to investigate two factors of emulsification temperature and emulsification time. Cream bases were prepared according to the optimal base recipe and the effect of different emulsification temperatures and emulsification times on cream base formability was examined and the results are shown in tables 3 and 4.
TABLE 3 emulsification factor orthogonal test design
TABLE 4 evaluation of influence of emulsification factors
As can be seen from tables 3 and 4, oil-water separation is likely to occur when the emulsification time is less than or equal to 5min, macroscopic particles are present in the ointment base at the emulsification temperature of less than 80 ℃, and the influence of the temperature between 80 ℃ and 90 ℃ on the ointment base is not significant.
Example 2-1
Heating oil phase (white vaseline 4%, dimethyl silicone oil 1%, stearic acid 0.5%, liquid paraffin 2% and tween-60 2%), and water phase (propylene glycol 6%, ethylparaben 0.1%, glycerol 6% and purified water 60.8%) in water bath to 85 deg.C respectively, stirring until all solids are melted, adding water phase into oil phase in form of fine flow, stirring for 10min, stirring at room temperature to 60 deg.C, adding 17.6% rhizoma bletilla polysaccharide, stirring, and condensing to obtain white paste, with properties shown in figure 1. The obtained rhizoma Bletillae paste is uniform, fine, glossy, free of granular sensation and oil-water separation, and has no visible single granule or bubble when being coated on skin.
Examples 2 to 2
The bletilla striata ointment is prepared according to the preparation method of the embodiment 2-1, and the difference is that the oil phase is white vaseline, dimethyl silicone oil, stearic acid, liquid paraffin and tween-60, and the mass ratio of the white vaseline to the dimethyl silicone oil to the stearic acid is 4:1:1:2:2.
examples 2 to 3
The preparation method of the bletilla striata paste as described in example 2-2 is carried out, except that the emulsification time is 5min and the temperature is 80 ℃.
Examples 2 to 4
The preparation method of the bletilla striata paste as described in example 2-2 is carried out, except that the emulsification time is 10min and the temperature is 80 ℃.
Examples 2 to 5
The preparation method of the bletilla striata paste as described in example 2-2 is carried out with the difference that the emulsification time is 5min and the temperature is 90 ℃.
Examples 2 to 6
The preparation method of the bletilla striata paste as described in example 2-2 is carried out with the difference that the emulsification time is 10min and the temperature is 90 ℃.
Comparative example 2 to 1
The bletilla striata ointment is prepared according to the preparation method of the embodiment 2-1, and the difference is that the oil phase is lanolin, dimethyl silicone oil, stearic acid, liquid paraffin and tween-60, and the mass ratio is 4:1:1:2:2.
comparative examples 2 to 2
The bletilla striata ointment is prepared according to the preparation method of the embodiment 2-1, and the difference is that the oil phase is white vaseline, dimethyl silicone oil, stearic acid, liquid paraffin, tween-60 and hexadecanol, the mass ratio is 4:1:1:2:1:1.
comparative examples 2 to 3
The preparation method of the bletilla striata paste according to example 2-1 is carried out, except that the content of stearic acid is 1%.
Comparative examples 2 to 4
The preparation method of the bletilla striata paste according to example 2-1 is carried out, except that the content of stearic acid is 2%.
Comparative examples 2 to 5
The preparation method of the bletilla striata paste as described in example 2-2 is carried out, except that the emulsification time is 5min and the temperature is 70 ℃.
Comparative examples 2 to 6
The common bletilla pseudobulb ointment was prepared according to the preparation method described in example 2-2, except that the emulsification time was 10min and the temperature was 70 ℃.
Comparative examples 2 to 7
The common bletilla pseudobulb ointment was prepared according to the preparation method described in example 2-2, except that the emulsification time was 30min and the temperature was 70 ℃.
Comparative examples 2 to 8
The preparation method of the bletilla striata paste as described in example 2-2 is carried out, except that the emulsification time is 30min and the temperature is 80 ℃.
Comparative examples 2 to 9
The preparation method of the bletilla striata paste as described in example 2-2 is carried out with the difference that the emulsification time is 30min and the temperature is 90 ℃.
Comparative examples 2 to 10
The preparation method of the bletilla striata ointment in the embodiment 2-2 is characterized in that the bletilla striata polysaccharide is added at the temperature of 80 ℃.
Comparative examples 2 to 11
The preparation method of the bletilla striata ointment in the embodiment 2-2 is carried out, wherein the addition temperature of the bletilla striata polysaccharide is 40 ℃.
Test example 2-1
And (3) screening the oil phase components in proportion: screening white vaseline, liquid paraffin, stearic acid, hexadecanol, simethicone, tween-60, and lanolin. The resulting bletilla striata pastes were initially evaluated in terms of appearance, physical stability and consistency and spreadability and the results are shown in table 5.
TABLE 5 evaluation of oil phase component ratios
As can be seen from Table 5, the formulations of comparative examples 2-1 and 2-2 have a granular feel when applied to the skin, and the formulations of examples 2-2 have a uniform and fine appearance, stable physical properties and good spreadability, and meet the basic requirements of an ointment.
Test examples 2 to 2
And (3) determining the proportion of the emulsifier: the dosage of the emulsifier has great influence on the matrix and is determined. The resulting bletilla striata pastes were initially evaluated in terms of appearance, consistency and spreadability and physical stability and the results are shown in table 6.
TABLE 6 evaluation of emulsifier ratio
| Serial number | Content (wt.) | Appearance of the product | Physical stability | Consistency and spreadability |
| Example 2-1 | 0.5％ | Is uniform and fine | Stabilization | Easy coating |
| Comparative examples 2 to 3 | 1％ | Is uniform and fine | Oil-water separation | Easy coating |
| Comparative examples 2 to 4 | 2％ | Is uniform and fine | Stabilization of | Is relatively thick and easy to be coated |
As can be seen from Table 6, the physical properties were unstable at an emulsifier content of 1%, oil-water separation occurred by centrifugation, the paste was thick and not easy to store at a content of 2%, and the appearance was uniform and fine at a stearic acid content of 0.5%, and the coating was uniform and stable.
Test examples 2 to 3
Optimizing the process flow: an orthogonal experiment is designed to investigate two factors, namely emulsification temperature and emulsification time. Ointment bases were prepared according to the optimal base prescription, and the influence of different emulsification temperatures and emulsification times on the moldability of the ointment bases was examined, and the results are shown in tables 3 and 7.
TABLE 7 evaluation of influence of emulsification factors
As can be seen from tables 3 and 7, the substrate had a granular feel at an emulsification temperature of 70 ℃, bubbles appeared when the emulsification time was too long, and the influence of other conditions was small.
Test examples 2 to 4
Determination of adding temperature of rhizoma bletillae polysaccharide: the rhizoma bletilla extract is white crystalline powder, is soluble in water and swells in water, and the matrix is in liquid or semisolid state before adding the extract. The matrix temperature at the time of addition of the extract was set to 80, 60, and 40 ℃, and the addition temperature of bletilla striata polysaccharide was examined, and the evaluation results are shown in table 8.
TABLE 8 evaluation of rhizoma Bletillae polysaccharide addition temperature
| Serial number | Temperature (. Degree.C.) | Appearance character | Consistency and spreadability | Stability of |
| Examples 2 to 2 | 80 | With air bubbles | Easy coating | Stabilization of |
| Comparative examples 2 to 10 | 60 | Is uniform and fine | Easy coating | Stabilization of |
| Comparative examples 2 to 11 | 40 | Has granular feeling | Easy coating | Stabilization |
As shown in Table 8, when added into the face cream at 80 deg.C, air bubbles are generated, when added at 40 deg.C, the skin has granular feeling, and when added at 60 deg.C, the rhizoma bletilla extract has stable property and good coating property.
The rhizoma bletillae ointment provided by the invention is prepared from an oil phase, a water phase and a rhizoma bletillae product, wherein the rhizoma bletillae product is high in content, the pharmacological activities of the rhizoma bletillae in hemostasis and healing, anti-inflammation, antibiosis, antivirus and antioxidation can be fully utilized, on the basis, the rhizoma bletillae ointment is prepared by adjusting the component proportion, the obtained ointment is uniform, fine, smooth and glossy, does not have granular sensation and oil-water separation, is coated on a glass plate, does not have independent granules or bubbles visible to naked eyes, is good in stability and affinity, is convenient to carry, is simple and clean to use, can reduce microbial pollution, and can well keep the medicinal effect of the rhizoma bletillae product.
The preparation method of the bletilla striata paste provided by the invention is simple in preparation process, low in cost and wide in application prospect.
Although the above embodiments have been described in detail, they are only a part of the embodiments of the present invention, not all of the embodiments, and other embodiments can be obtained without inventive step according to the embodiments, and all of the embodiments belong to the protection scope of the present invention.
Claims (10)
1. The bletilla striata ointment is characterized by comprising the following components in parts by mass: 6-29 parts of oil phase, 71-77 parts of water phase and 2-18 parts of rhizoma bletillae product;
the rhizoma bletillae product comprises rhizoma bletillae powder or rhizoma bletillae polysaccharide;
when the rhizoma bletillae product is rhizoma bletillae powder, the oil phase is a first oil phase, and the first oil phase 5 comprises stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax;
when the rhizoma bletillae product is rhizoma bletillae polysaccharide, the oil phase is a second oil phase, and the second oil phase comprises white vaseline, dimethicone, stearic acid, paraffin and tween.
2. The bletilla striata paste according to claim 1, wherein the mass ratio of stearic acid, span, polysorbate, glyceryl monostearate, white vaseline, paraffin and beeswax in the first oil phase is 4-5: 1 to 2:4 to 5:4 to 5: 2-2.5: 4 to 5:3 to 4.
3. The rhizoma bletilla paste of claim 1 or 2, wherein when the rhizoma bletilla product is rhizoma bletilla powder, the aqueous phase is a first aqueous phase comprising glycerol, ethylparaben and water.
4. The bletilla striata ointment according to claim 3, wherein the mass ratio of the glycerol 5 oil, the ethylparaben and the water in the first aqueous phase is 18-19: 1 to 2:52 to 55.
5. The bletilla striata paste according to claim 1, wherein the mass ratio of white vaseline, dimethyl silicone oil, stearic acid, paraffin and tween in the second oil phase is 3-5: 1 to 2:0.5 to 1:1 to 3:1 to 2.
6. The rhizoma bletilla paste of claim 1 or 5, wherein when the rhizoma bletilla product 0 is rhizoma bletilla polysaccharide, the aqueous phase is a second aqueous phase comprising propylene glycol, ethylparaben, glycerin, and water.
7. The bletilla striata paste according to claim 6, wherein the mass ratio of the propylene glycol, the ethylparaben, the glycerol and the water in the second aqueous phase is 5-7: 0.1 to 0.5:5 to 6:60 to 63.
8. The process for preparing a bletilla striata paste as claimed in any one of claims 1 to 7, which comprises the following steps of 5:
respectively heating and melting the oil phase and the water phase, and then carrying out first mixing to obtain a paste matrix;
and secondly, mixing the bletilla striata product with a paste matrix to obtain the bletilla striata paste.
9. The preparation method according to claim 8, wherein the temperature for heating and melting the oil phase and the water phase is 79-90 ℃ independently.
10. Use of the bletilla striata paste according to any one of claims 1 to 7 in a cream.
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