CN103960542B - A kind of feed for preventing and treating swine eperythrozoonosis and Chinese medicine composition - Google Patents
A kind of feed for preventing and treating swine eperythrozoonosis and Chinese medicine composition Download PDFInfo
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- CN103960542B CN103960542B CN201410211241.0A CN201410211241A CN103960542B CN 103960542 B CN103960542 B CN 103960542B CN 201410211241 A CN201410211241 A CN 201410211241A CN 103960542 B CN103960542 B CN 103960542B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
The invention discloses a kind of feed, Chinese medicine composition and preparation method for preventing and treating swine eperythrozoonosis, feed comprises basal feed, vitamin premix, amino acid premix, trace mineral supplement and Chinese medicine additive, and in described feed, each composition weight mark ratio is: basal feed 100 weight portion, vitamin premix 0.0001-0.0007 weight portion, amino acid premix 0.1-0.8 weight portion, trace mineral supplement 0.001-0.01 weight portion and Chinese medicine additive 15-35 weight portion.The invention has the beneficial effects as follows: traditional Chinese medicine composition for treating swine eperythrozoonosis of the present invention, enough invigorating QI and bloods, invigorating the spleen removing jaundice, the generation of good promotion pig normal plasma cell, effective symptom management, improves immunity of organisms and the resistance of pig, reduce pig M & M, reduce antibiotic and the chemical synthetic drug medicament residue rate pig, treatment swine eperythrozoonosis short treating period, instant effect, cost price are low, and pure natural is pollution-free.
Description
Technical field
The present invention relates to technical field of animal, particularly a kind of feed, Chinese medicine composition and preparation method for preventing and treating swine eperythrozoonosis.
Background technology
Eperythrozoonosis appear at the history that there were more than 20 years in China.In recent years the eperythrozoonosis of pig has and is tending towards serious situation, and therefore a lot of pig farm suffers heavy losses.Eperythrozoon is not strict to the selection of host, and the many animals such as people, ox, pig, sheep all can infect, and infection rate is higher.Someone did investigation, and various stage infection rate of pig reaches 80-90%; The infection positive rate of people can reach 86%; And the positive rate of chicken is higher, can 90% be reached.But other animal disease except pig is not high.
Swine eperythrozoonosis can betide pig in each age, but with piglet and the good feeder pig death rate of growing way higher, the infection of sow is also more serious.Ill pig and subclinical infection pig are the important infections sources.Route of transmission is also not fully aware of at present.Pig by the material of ingest blood or band blood, as lick docking wound, to have a fist fight etc. and can directly propagate mutually.Infect indirectly is propagated by medium such as itch mite, louse, the hematophagus (as thorn fly, mosquito, tick etc.) lived.The propagation of injection needle is also very important factor, because when injection for curing or immunity inoculation, brood pig often uses a needle injection, likely causes eperythrozoon anthropochory.Eperythrozoon can be propagated through mating, also can through placenta vertical transmission.In all routes of infection, the propagation of hematophagus is most important.
Eperythrozoonosis is the disease caused by many factors, only by infecting the health pig generation acute symptom that generally can not make to raise under normal management condition, stress be the principal element causing this disease to break out.Only betide the pig that those resistances decline under normal circumstances, childbirth, overcrowding, long-distance transport, atrocious weather, feeding and management be bad, change colony house or feed and Other diseases when infecting, swinery also may break out this disease.
Swine eperythrozoonosis is because raiseeing the difference of kind and individual body condition, and clinical symptoms difference is very large.Mainly cause: piglet constitution is deteriorated, anaemia, enteron aisle and respiratory tract infection increase; Growing and fattening pigs daily gain declines, acute hemolytic anemia; Degradation under sow production performance.
Chinese veterinarian thinks, swine eperythrozoonosis belongs to " mass formed by blood stasis " category.Namely more deep understanding is had to the physiology of blood and pathology as far back as "Nei Jing"." Jing Yue's complete work blood trouble " to be contrasted to the content of blood trouble the conclusion of system, the interpretation of the cause, onset and process of an illness caused bleeding is summarised as with touching briefly on the essentials " fire is contained " and " deficiency of vital energy " two aspects." treatise on blood trouble " discusses the special book of blood trouble, all has many penetrating discussions to the etiology and pathogenesis of various blood trouble, diagnosis and treatment, the hemostasis that this book proposes, the stasis of blood that disappears, peaceful blood, enrich blood control blood four method, be the logical outline controlling blood trouble really.Being invaded by exogenous pathogen,invasion of exogenous pathogen: outer evil invasion and attack, damage train of thought and causing bleeding is wherein many with person caused by catching pathogenic heat.After prolonged illness or pyreticosis, prolonged illness or pyreticosis cause the mechanism of blood trouble to mainly contain three aspects: prolonged illness or pyreticosis make cloudy smart damage, so that fire excess from yin deficiency, compel the absurd row of blood and cause hemorrhage; Prolonged illness or pyreticosis make healthy tendency lose, failure of keeping fluid due to qi deficiency, and the blood arteries and veins that overflows is outer and cause hemorrhage; Prolonged illness people network, makes blood-vessel obstructive, hematogenous blockage, blood fails to circulate in the vessels and cause hemorrhage.
Weakness of the spleen and the stomach ferritic is weakness of the spleen and the stomach simultaneously, or overstrain, and spleen wound loses fortune, deficiency of qi and blood, the liver failing to be nourished of a specified duration, and catharsis is neglected one's duty, and causes bile Bu Xunchang road, overflows with blood, and contamination skin is sent out as jaundice.If ferritic spleen YANG deficiency, spleen sun is injured after being ill, wets by Nei Sheng from coldization, and burnt in stagnation of cold-damp, bile is obstructed, and causes bile Bu Xunchang road, overflows with blood, and contamination skin, also can send out as yellow subcutaneous ulcer.Because of liver storing blood, the spleen being in change of producing blood, the kidney generating marrow and dominating bone, thus in close relations with liver spleen kidney.Be usually fall ill because of empty, cause reality because of empty.Its empty Yin Wenre evil easy injury-gas consumption of poison and common with deficiency of both qi and yin, the deficiency of liver-yin and kidney-yin, prolonged illness is then based on deficiency of qi and blood; In fact outer heat poison, blood stasis, phlegm is turbid is trouble.Acute stage, has void to have reality, real to mark, though volt in paracmasis poisonous heresy, but based on void.Many deficient and excessive syndromes appearing togethers clinically, the interpretation of the cause, onset and process of an illness develops complicated various, as acute stage heat poison is not understood, can in telepathy bag and occur the symptom of coma and delirium; Excessive noxious heat, priming liver wind and occur that neck is strong, the disease of tic; Late period then hinders healthy tendency due to heresy, and healthy tendency day declines, and occurs the insufficiency of both the spleen and the kindey, qi-blood deficiency card.Can be summarized as the treatment of blood trouble and control fire, control gas, control blood three principles.
Doctor trained in Western medicine control swine eperythrozoonosis, strengthens feeding and management, and keep pig house, raise apparatus health, reducing distress etc. is prevent this pathogenetic key.Summer and autumn often will spray insecticidal materials, prevent insect bites swinery, cut off the infection sources.Implement such as inoculate, dock, beat the feeding and management such as overbit, castrating program time, apparatus, strict sterilization all should be changed.Buy pig and should carry out blood test, prevent from introducing disease pig or subclinical infection pig.This sick epidemic season gives prophylactic, terramycin or aureomycin additive can be added in feed, but the pathogenic microorganism that the Long-Time Service of these materials causes produces antigenicity, livestock products medicament residue, environmental pollution, causes canceration, sudden change, aberration rate to increase, serious threat human health.
Treatment by Chinese herbs has instant effect, curative effect develops immunity to drugs really, not easily, cheapness, not easily recurrence, few side effects, livestock products drug residue are low, be conducive to the advantages such as person poultry safety.Therefore select treatment by Chinese herbs swine eperythrozoonosis necessary. the side effect of Western medicine is larger, and, Western medicine only has obvious curative effect to single illness or a class illness when treating, for the disease that some illnesss are more, curative effect may be just not too obvious, usually needs out a lot of Western medicine, and, Western medicine is synthesis, and price naturally can a lot of than Chinese herbal medicine and Chinese patent drug costliness.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of feed comprising Chinese medicine composition for preventing and treating swine eperythrozoonosis, adopt the feed containing this Chinese medicine composition can overcome the defect of prior art Chinese and Western medicine and Chinese medicine, treatment swine eperythrozoonosis, enough invigorating QI and bloods, invigorating the spleen removing jaundice, the generation of good promotion pig normal plasma cell, effective symptom management, improve immunity of organisms and the resistance of pig, reduce pig M & M, reduce antibiotic and the chemical synthetic drug medicament residue rate pig, treatment swine eperythrozoonosis cure rate is high, cost price is low, pure natural is pollution-free.
In order to realize foregoing invention object, the invention provides a kind of feed for preventing and treating swine eperythrozoonosis, feed comprises basal feed, vitamin premix, amino acid premix, trace mineral supplement and Chinese medicine additive, and in described feed, each composition weight mark ratio is: basal feed 100 weight portion, vitamin premix 0.0001-0.0007 weight portion, amino acid premix 0.1-0.8 weight portion, trace mineral supplement 0.001-0.01 weight portion and Chinese medicine additive 15-35 weight portion.
Be vitamin A, vitamin D, vitamin E, vitamin K, pantothenic acid, Cobastab in described vitamin premix
12in one or more mixing.
Described amino acid premix is one or more mixing of lysine, methionine, threonine.
Described trace mineral supplement is one or more mixing in iron, manganese, zinc, copper.
In described basal feed, each component and weight are corn 50-60 weight portion, dregs of beans 30-40 weight portion, wheat 35-50 weight portion.
Described Chinese medicine additive comprises: rascal, Fructus meliae toosendan, buckeye, fiveleaf akebia fruit, Buddha's hand, Radix Codonopsis, the Radix Astragali, the bighead atractylodes rhizome, Radix Angelicae Sinensis, cultivated land, Radix Glycyrrhizae, wilsonii, gynostemma pentaphylla, rhodiola root, sea-buckthorn, the root of herbaceous peony, tarragon, adenophora tetraphylla, sealwort, eclipta, Canton love-pea vine, Sagina subulata, manyleaf meadowure rhizome and root, Chinese artichoke, radix polygonati officinalis and fern fiber crops.
In described Chinese medicine additive, the ratio of weight and number of each bulk drug is: rascal 16-37 weight portion, Fructus meliae toosendan 20-47 weight portion, buckeye 6-25 weight portion, fiveleaf akebia fruit 22-32 weight portion, Buddha's hand 12-25 weight portion, Radix Codonopsis 18-35 weight portion, Radix Astragali 17-28 weight portion, bighead atractylodes rhizome 11-25 weight portion, Radix Angelicae Sinensis 22-35 weight portion, cultivated land 21-38 weight portion, Radix Glycyrrhizae 25-39 weight portion, wilsonii 17-30 weight portion, gynostemma pentaphylla 17-35 weight portion, rhodiola root 18-32 weight portion, sea-buckthorn 13-27 weight portion, root of herbaceous peony 10-30 weight portion, tarragon 16-35 weight portion, adenophora tetraphylla 19-37 weight portion, sealwort 14-33 weight portion, eclipta 13-28 weight portion, Canton love-pea vine 10-28 weight portion, Sagina subulata 25-47 weight portion, manyleaf meadowure rhizome and root 20-38 weight portion, Chinese artichoke 14-35 weight portion, radix polygonati officinalis 18-35 weight portion and fern fiber crops 13-33 weight portion.
In described Chinese medicine additive, the ratio of weight and number of each bulk drug is: rascal 18-34 weight portion, Fructus meliae toosendan 22-40 weight portion, buckeye 8-22 weight portion, fiveleaf akebia fruit 24-32 weight portion, Buddha's hand 12-21 weight portion, Radix Codonopsis 20-30 weight portion, Radix Astragali 18-25 weight portion, bighead atractylodes rhizome 13-23 weight portion, Radix Angelicae Sinensis 25-33 weight portion, cultivated land 23-35 weight portion, Radix Glycyrrhizae 27-36 weight portion, wilsonii 19-27 weight portion, gynostemma pentaphylla 20-32 weight portion, rhodiola root 18-30 weight portion, sea-buckthorn 13-24 weight portion, root of herbaceous peony 10-26 weight portion, tarragon 16-30 weight portion, adenophora tetraphylla 19-31 weight portion, sealwort 17-31 weight portion, eclipta 15-25 weight portion, Canton love-pea vine 12-25 weight portion, Sagina subulata 29-40 weight portion, manyleaf meadowure rhizome and root 24-36 weight portion, Chinese artichoke 18-30 weight portion, radix polygonati officinalis 20-32 weight portion and fern fiber crops 15-27 weight portion.
Present invention also offers a kind of preparation method of the feed for preventing and treating swine eperythrozoonosis, comprising the following steps:
The first step, mixes in proportion by component each in described Chinese medicine additive, obtains mixture, add the water relative to mixture quality 2 times, carry out decoction process 2 hours, decoction liquor is filtered, concentration, obtain lotion, the relative density of described lotion 89 DEG C is 1.20-1.24;
Second step, being the ethanol of 71%-78% by adding relative to the determining alcohol of first step mixture quality 3 times in the lotion of acquisition, carrying out stirring 35 minutes, at 0-3 DEG C, refrigerate 1.5 hours, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 130-190 object powder, obtain Chinese medicine additive;
3rd step, in proportion the Chinese medicine additive that basal feed and vitamin premix, amino acid premix, trace mineral supplement and second step obtain is mixed, pour in spraying machine, in spraying machine, water temperature is modulated at 63-75 DEG C, open sprayer, stir 5 minutes, continue to be warming up to 91 DEG C and complete expanded;
4th step, add the product after expanded relative to its quality 1.4-1.6 water doubly, put into granulator and granulate, granulator electric current is 170A;
5th step, dry after granulating, baking temperature is 107 DEG C, drying time 30min; Then cool, cooling blower electric current is 40A, and packaging, obtains described feed.
Present invention also offers a kind of Chinese medicine composition for preventing and treating swine eperythrozoonosis, in described Chinese medicine composition, the ratio of weight and number of each bulk drug is: rascal 16-37 weight portion, Fructus meliae toosendan 20-47 weight portion, buckeye 6-25 weight portion, fiveleaf akebia fruit 22-32 weight portion, Buddha's hand 12-25 weight portion, Radix Codonopsis 18-35 weight portion, Radix Astragali 17-28 weight portion, bighead atractylodes rhizome 11-25 weight portion, Radix Angelicae Sinensis 22-35 weight portion, cultivated land 21-38 weight portion, Radix Glycyrrhizae 25-39 weight portion, wilsonii 17-30 weight portion, gynostemma pentaphylla 17-35 weight portion, rhodiola root 18-32 weight portion, sea-buckthorn 13-27 weight portion, root of herbaceous peony 10-30 weight portion, tarragon 16-35 weight portion, adenophora tetraphylla 19-37 weight portion, sealwort 14-33 weight portion, eclipta 13-28 weight portion, Canton love-pea vine 10-28 weight portion, Sagina subulata 25-47 weight portion, manyleaf meadowure rhizome and root 20-38 weight portion, Chinese artichoke 14-35 weight portion, radix polygonati officinalis 18-35 weight portion and fern fiber crops 13-33 weight portion.
The preparation method of described Chinese traditional medicine composition composition powders comprises: by each bulk drug by weight mark be broken into meal than mixing, then pulverize further, cross 50 mesh sieves, the enable fine powder amount by 50 mesh sieves is reaching 60%, collects and obtains fine powder a by the fine powder of 50 mesh sieves; Again the meal not by 50 mesh sieves is dropped into multi-function extractor and extract twice, first time adds 6 times amount soak by water 1.5-2 hour, and second time adds 5 times amount soak by water 1-2.0 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, puts into after 95 DEG C, baking oven is dried and cools, grind to form fine powder b, make powder after being mixed by fine powder a and b.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: traditional Chinese medicine composition for treating swine eperythrozoonosis of the present invention, enough invigorating QI and bloods, invigorating the spleen removing jaundice, the generation of good promotion pig normal plasma cell, effective symptom management, improves immunity of organisms and the resistance of pig, reduce pig M & M, reduce antibiotic and the chemical synthetic drug medicament residue rate pig, treatment swine eperythrozoonosis short treating period, instant effect, cost price are low, and pure natural is pollution-free.
Detailed description of the invention
The invention provides a kind of feed for preventing and treating swine eperythrozoonosis, feed comprises basal feed, vitamin premix, amino acid premix, trace mineral supplement and Chinese medicine additive, and in described feed, each composition weight mark ratio is: basal feed 100 weight portion, vitamin premix 0.0001-0.0007 weight portion, amino acid premix 0.1-0.8 weight portion, trace mineral supplement 0.001-0.01 weight portion and Chinese medicine additive 15-35 weight portion.
Chinese veterinarian thinks, The spleen and stomach provide the material basis of the acquired, main muscle and four limbs, is source of generating QI and blood, defeated cloth diet precise and tiny, with nutrition vital organs of the human body four limbs bones of the body collectively, the therefore strong fortune of temper, then diet multiplication, healthy tendency is filled certainly, nutritional sufficiency, fleshiness is strong, otherwise muscular atrophy, carcass is become thin, and native endowment is not enough, have again nurse one's health mistake degree the day after tomorrow, and more have outer heresy invasion and attack and fall ill.Based on above-mentioned theory of traditional Chinese medical science, provided by the invention being used for the treatment of in the feed of swine eperythrozoonosis with the addition of Chinese herb feed additive, with invigorating QI and blood, invigorating the spleen removing jaundice is primary treatment principle, selects prescription: Chinese medicine additive comprises: rascal, Fructus meliae toosendan, buckeye, fiveleaf akebia fruit, Buddha's hand, Radix Codonopsis, the Radix Astragali, the bighead atractylodes rhizome, Radix Angelicae Sinensis, cultivated land, Radix Glycyrrhizae, wilsonii, gynostemma pentaphylla, rhodiola root, sea-buckthorn, the root of herbaceous peony, tarragon, adenophora tetraphylla, sealwort, eclipta, Canton love-pea vine, Sagina subulata, manyleaf meadowure rhizome and root, Chinese artichoke, radix polygonati officinalis and fern fiber crops.
Wherein rascal returns liver and gall stomach warp, and soothing the liver relieving stagnant Qi, long-pendingization that disappear are stagnant; The clearing away the liver-fire of Fructus meliae toosendan energy, promoting qi circulation and relieving pain; Buckeye can dispersing stagnated hepatoqi, again can wide in and stomach, with fiveleaf akebia fruit, Buddha's hand compatibility with using; Radix Codonopsis can tonifying spleen lung qi, enrich blood, promote the production of body fluid, with compatibilities such as the Radix Astragali, the bighead atractylodes rhizome, Radix Angelicae Sinensis, cultivated lands; Radix Glycyrrhizae is invigorated the spleen and benefited qi, relieving spasm to stop pain, clearing heat and detoxicating, coordinating the drug actions of a prescription; Wilsonii can replenish qi to invigorate the spleen, and tonifies the kidney to relieve mental strain, with Radix Codonopsis compatibility; Gynostemma pentaphylla, rhodiola root, sugariness enters spleen, all can replenish qi to invigorate the spleen; Sea-buckthorn temperature can support temper, appetite-stimulating indigestion-relieving, and the sweet acid of its taste can change Yin and promoting production of body liquid again; The root of herbaceous peony is nourished blood astringe yin, easing the affected liver to relieve pain, suppressing liver-YANG, with tarragon compatibility with using; Adenophora tetraphylla energy nourishing stomach-YIN, to promote the production of body fluid to quench thirst, and clearing away the stomach-heat, sealwort boosting qi and nourishing yin, invigorating the spleen, moistening lung kidney-nourishing; Eclipta can nourishing liver and kidney, cooling blood and hemostasis; Canton love-pea vine, Sagina subulata are clearing heat and detoxicating, dampness removing removing jaundice; Manyleaf meadowure rhizome and root is bitter, cold, heat-clearing and damp-drying drug, purging intense heat and detonicating; The invigorating the spleen of Chinese artichoke qi-restoratives; Radix polygonati officinalis is nourishing Yin and moistening lung; Nourishing the stomach to improve the production of body fluid; Fern fiber crops fill blood; Strengthening the spleen and stomach.
The pharmacology of each bulk drug is as follows:
Rascal: nature and flavor toil, temperature.Return liver, courage, stomach warp.Can soothing the liver relieving stagnant Qi, long-pendingization that disappear stagnant.For sternal rib gastral cavity distending pain, acute mastitis, colic, stagnation of QI due to dyspepsia.
Fructus meliae toosendan: cold in nature, bitter.Return liver, small intestine, urinary bladder channel.
Buckeye: warm in nature, taste is sweet.Return liver, stomach warp.Regulating the flow of QI to ease the stomach, and stomach and alleviating pain., gastral cavity pain vexed for chest abdominal distension.
Fiveleaf akebia fruit: sweet, cold.Function liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Control stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, stomach energy food is slow-witted, polydipsia, dysentery, pain in the back, fiveleaf akebia fruit hypochondriac pain, hernia, dysmenorrhoea, and uterus drops.
Buddha's hand: pungent, bitter, sour, temperature.Return liver, spleen, lung channel.Liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty ruffian is full, the few vomiting of food.
Radix Codonopsis: property is put down, sweet, the micro-acid of taste.Return spleen, lung channel.Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung.Weak for the spleen deficiency syndrome of the lung, palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst.
The Radix Astragali: sweet, tepor.Return lung, spleen, liver, kidney channel.Raw with solid table, losslessly to send out, to have sweat to stop; Process with bowl spares, beneficial vigour, strong taste.Green blood, myogenic, apocenosis Neto, sore carbuncle panacea.Variola does not rise, and the deficiency of yang should it without hot person.Function shows arrest sweating admittedly, inducing diuresis for removing edema, the apocenosis of holder sore, regulating fluid apssage.
The bighead atractylodes rhizome: taste is sweet, bitter, warm in nature.Return spleen, stomach warp.There is tonifying spleen profit gas, eliminating dampness Li Shui, strengthening exterior and reducing sweat, the fortune spleen effect of moisturizing, cure mainly the caused ruffian of the dysfunction of the spleen in transport, QI failing to transform into body fluid and have one's mind filled with and rush down, phlegm and retained fluid oedema; The vexed lazyness speech of the deficiency of qi in middle-jiao, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, abnormal sweating spontaneous perspiration.
Radix Angelicae Sinensis: taste is sweet, pungent, bitter, warm in nature.Return liver, the heart, the spleen channel.Having enriches blood invigorates blood circulation, the effect of menstruction regulating and pain relieving, profit soup defaecation, sallow for the deficiency of blood, dizzy palpitaition, irregular menstruation, through closing the cards such as dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores
Cultivated land: taste is sweet, slightly warm in nature.Return liver, kidney channel.Have enriching yin of enriching blood, beneficial essence fills out the effect of marrow, sallow for the deficiency of blood; Dizzy, palpitaition, insomnia, irregular menstruation, collapses more than; Liver-kidney Yin deficiency, night sweat, sufficient knee pain, soreness and weakness of waist and knees, Hiccough and deaf, the head is dim-sighted, and seminal emission impotence, infertility, irregular menstruation, metrostaxis, poliosis, quenches one's thirst, the cards such as syndrome characterized by dyspnea of suffering from a deficiency of the kidney.
Radix Glycyrrhizae: nature and flavor are sweet, flat.Return spleen, stomach, lung channel.Can beneficial gas bowl spares, relieving spasm to stop pain, moistens the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription.Main burnout food is few, flesh thin Huang, palpitation, stomachache loose stool, and the anxious pain of four limbs contraction, hysteria, cough and asthma, abscess of throat, carbuncle sore swells and ache, infant fetal toxin, and medicine, food poisoning.
Wilsonii: taste is pungent, bitter, micro-sweet, warm in nature.Return spleen, kidney, the heart channel of Hang-Shaoyin.Have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, soft for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, be slow in action, the card such as body void is thin and weak, traumatic injury, fracture, oedema, beriberi, uncontrolled urination are itched.。
Gynostemma pentaphylla: taste is sweet, bitter, cold nature.Return lung channel, the spleen channel, kidney channel.The beneficial gas of energy, calms the nerves, hypotensive, clearing heat and detoxicating, cough-relieving apophlegmatic.
Rhodiola root: sweet is bitter, flat.Return lung, the heart channel of Hang-Shaoyin.Improving water flood, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, antifatigue, promoting blood circulation and hemostasis, removing heat from the lung to relieve cough, change become silted up detumescence, antipyreticly to bring down a fever, nourish the effects such as vigour.
Sea-buckthorn: taste acid; Puckery; Warm in nature.Relieving cough and reducing sputum; Stomach strengthening and digestion promoting; Promoting blood circulation to remove blood stasis.Main coughing with a lot of sputum; Pulmonary abscess; Indigestion; Dyspeptic abdominalgia; Stomachache; Enteritis; Amenorrhoea; Fall dozen stasis of blood to swell.
The root of herbaceous peony: bitter, acid, cold nature.Return liver, the spleen channel.To nourish blood joint venture, easing the affected liver to relieve pain, the effect of suppressing liver-YANG, is mainly used in deficiecny of liver-YIN, swollen, the dizzy tinnitus of headache brain of liver-yang hyperactivity, irritable; Deficiency of liver-blood, battalion defends the irregular menstruation of inanition, metrorrhagia and metrostaxis; The dysmenorrhoea of the empty stasis dampness of liver; Disharmony between ying and wei, the cloudy outer spontaneous sweating got over of battalion; The gastral cavity abdomen pain over the hypochondriac region of stagnation of liver qi, rushes down dysentery stomachache; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the card such as carpopedal spasm pain of supporting, and Paeoniflorin has antibacterial, antipyretic, anti-inflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, hemangiectasis, antagonism acute myocardial ischemia, Antiaggregating activity on platelet, calmness, analgesia, spasmolysis, antiulcer, adjustment blood sugar.
Tarragon: pungent, bitter, temperature.Return liver,spleen,kidney warp.Eliminating cold to stop pain, warming channel for arresting bleeding.For few abdomen crymodynia, through cold uncomfortable, palace is cold infertile, spits blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding through many, gestation hemorrhage; Control pruitus outward, decortication.
Adenophora tetraphylla: sweet, the micro-hardship of taste, cold nature.Attach to the lung and stomach meridians.Clearing heat and nourishing yin, moistens the lung and relieve the cough, the effect of nourishing the stomach to improve the production of body fluid, is mainly used in the lung-dryness syndrome due to yin deficiency, dry cough lacks phlegm, labor coughs phlegm blood, dry, the tracheitis of deficiency of stomach-Yin, mouthfeel pharynx, pertussis, cough with lung heat, the cards such as Huang is thick, the red few tongue of constipation, tongue of coughing up phlegm.
Sealwort: taste is sweet, property is put down.Return lung, spleen, kidney channel.There is enriching qi and yin, invigorating the spleen moistening lung, effect of enriching kidney essence, for taste deficiency of qi and yin, food is few unable, the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, dry cough phlegm is few, quench one's thirst and drink more, weakness of the spleen and the stomach, Spleen-Qi Deficiency or deficiency of spleen-YIN, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Eclipta: cool in nature, the sweet acid of taste.There is effect of cooling blood and hemostasis, tonifying kidney and benefiting sperm, be usually used in treatment haematemesiss, bleeding from five sense organs or subcutaneous tissue, hematuria, have blood in stool, bloody flux, knife wound are hemorrhage, under poliosis, diphtheria, stranguria with turbid discharge, band, private parts wets the disease such as to itch.
Canton love-pea vine: sweet, bitter, cool, nontoxic.The thoughts of returning home, lung, liver, stomach, kidney channel.Clearing heat and promoting diuresis, blood stasis removing analgesic.Main icteric hepatitis, stomachache, treating rheumatic ostealgia, falls and beats stasis of blood pain, breast pain.
Sagina subulata: mildly bitter flavor is sweet, cool in nature, nontoxic.Powder for clearing heat and detoxicating gas for oral administration goes to amass; External sterilizing detumescence.Enter spleen lung channel.Dysentery, hot summer weather dysentery, hinders heat heating, red eye, swell pain, infantile malnutrition, yctalopia; Control venomous snake bite outward, head snake sore, skin flies snake ovum, children's's heat furuncle.
Manyleaf meadowure rhizome and root: bitter; Cold in nature.The thoughts of returning home; Liver; Large intestine channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating.Control damp-heat dysentery, jaundice, pyreticosis is irritated, cough with lung heat, carbuncle pyogenic infections from tumour or sore, red eye, swell pain.
Chinese artichoke: taste is sweet; Property is put down.Return lung; Liver; The spleen channel.To induce sweat clearing lung-heat; Eliminating damp, detoxifying; Qi-restoratives invigorating the spleen.Main anemopyretic cold; Cough due to consumptive disease; Jaundice; Stranguria; Sore swells and ache; Venomous snake bite.
Radix polygonati officinalis: sweet; Flat.Return lung; Stomach warp.Nourishing Yin and moistening lung; Nourishing the stomach to improve the production of body fluid.Main cough caused by dryness; Labor is coughed; The dry throat and mouth of pyreticosis cloudy liquid consumption wound; Interior heat is quenched one's thirst; Deficiency of Yin diseases caused by external factors; Dizzy dizzy; Muscle arteries and veins contraction pain.
Fern fiber crops: sweet; Bitter; Cold.Return spleen; Stomach warp.Fill blood; Strengthening the spleen and stomach; Promote the production of body fluid to quench thirst.Main splenasthenic diarrhea; Anaemia after being ill; Malnutritive; Oedema; Arthralgia due to wind-dampness.
Be vitamin A, vitamin D, vitamin E, vitamin K, pantothenic acid, Cobastab in vitamin premix
12in one or more mixing.
Amino acid premix is one or more mixing of lysine, methionine, threonine.
Trace mineral supplement is one or more mixing in iron, manganese, zinc, copper.
In basal feed, each component and weight are corn 50-60 weight portion, dregs of beans 30-40 weight portion, wheat 35-50 weight portion.
Chinese medicine additive comprises: rascal, Fructus meliae toosendan, buckeye, fiveleaf akebia fruit, Buddha's hand, Radix Codonopsis, the Radix Astragali, the bighead atractylodes rhizome, Radix Angelicae Sinensis, cultivated land, Radix Glycyrrhizae, wilsonii, gynostemma pentaphylla, rhodiola root, sea-buckthorn, the root of herbaceous peony, tarragon, adenophora tetraphylla, sealwort, eclipta, Canton love-pea vine, Sagina subulata, manyleaf meadowure rhizome and root, Chinese artichoke, radix polygonati officinalis and fern fiber crops.
In Chinese medicine additive, the ratio of weight and number of each bulk drug is: rascal 16-37 weight portion, Fructus meliae toosendan 20-47 weight portion, buckeye 6-25 weight portion, fiveleaf akebia fruit 22-32 weight portion, Buddha's hand 12-25 weight portion, Radix Codonopsis 18-35 weight portion, Radix Astragali 17-28 weight portion, bighead atractylodes rhizome 11-25 weight portion, Radix Angelicae Sinensis 22-35 weight portion, cultivated land 21-38 weight portion, Radix Glycyrrhizae 25-39 weight portion, wilsonii 17-30 weight portion, gynostemma pentaphylla 17-35 weight portion, rhodiola root 18-32 weight portion, sea-buckthorn 13-27 weight portion, root of herbaceous peony 10-30 weight portion, tarragon 16-35 weight portion, adenophora tetraphylla 19-37 weight portion, sealwort 14-33 weight portion, eclipta 13-28 weight portion, Canton love-pea vine 10-28 weight portion, Sagina subulata 25-47 weight portion, manyleaf meadowure rhizome and root 20-38 weight portion, Chinese artichoke 14-35 weight portion, radix polygonati officinalis 18-35 weight portion and fern fiber crops 13-33 weight portion.
In Chinese medicine additive, the ratio of weight and number of each bulk drug is: rascal 18-34 weight portion, Fructus meliae toosendan 22-40 weight portion, buckeye 8-22 weight portion, fiveleaf akebia fruit 24-32 weight portion, Buddha's hand 12-21 weight portion, Radix Codonopsis 20-30 weight portion, Radix Astragali 18-25 weight portion, bighead atractylodes rhizome 13-23 weight portion, Radix Angelicae Sinensis 25-33 weight portion, cultivated land 23-35 weight portion, Radix Glycyrrhizae 27-36 weight portion, wilsonii 19-27 weight portion, gynostemma pentaphylla 20-32 weight portion, rhodiola root 18-30 weight portion, sea-buckthorn 13-24 weight portion, root of herbaceous peony 10-26 weight portion, tarragon 16-30 weight portion, adenophora tetraphylla 19-31 weight portion, sealwort 17-31 weight portion, eclipta 15-25 weight portion, Canton love-pea vine 12-25 weight portion, Sagina subulata 29-40 weight portion, manyleaf meadowure rhizome and root 24-36 weight portion, Chinese artichoke 18-30 weight portion, radix polygonati officinalis 20-32 weight portion and fern fiber crops 15-27 weight portion.
Present invention also offers a kind of preparation method of the feed for preventing and treating swine eperythrozoonosis, comprising the following steps:
The first step, mixes in proportion by component each in described Chinese medicine additive, obtains mixture, add the water relative to mixture quality 2 times, carry out decoction process 2 hours, decoction liquor is filtered, concentration, obtain lotion, the relative density of described lotion 89 DEG C is 1.20-1.24;
Second step, being the ethanol of 71%-78% by adding relative to the determining alcohol of first step mixture quality 3 times in the lotion of acquisition, carrying out stirring 35 minutes, at 0-3 DEG C, refrigerate 1.5 hours, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 130-190 object powder, obtain Chinese medicine additive;
3rd step, in proportion the Chinese medicine additive that basal feed and vitamin premix, amino acid premix, trace mineral supplement and second step obtain is mixed, pour in spraying machine, in spraying machine, water temperature is modulated at 63-75 DEG C, open sprayer, stir 5 minutes, continue to be warming up to 91 DEG C and complete expanded;
4th step, add the product after expanded relative to its quality 1.4-1.6 water doubly, put into granulator and granulate, granulator electric current is 170A;
5th step, dry after granulating, baking temperature is 107 DEG C, drying time 30min; Then cool, cooling blower electric current is 40A, and packaging, obtains described feed.
Present invention also offers a kind of Chinese medicine composition for preventing and treating swine eperythrozoonosis, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each bulk drug is: rascal 16-37 weight portion, Fructus meliae toosendan 20-47 weight portion, buckeye 6-25 weight portion, fiveleaf akebia fruit 22-32 weight portion, Buddha's hand 12-25 weight portion, Radix Codonopsis 18-35 weight portion, Radix Astragali 17-28 weight portion, bighead atractylodes rhizome 11-25 weight portion, Radix Angelicae Sinensis 22-35 weight portion, cultivated land 21-38 weight portion, Radix Glycyrrhizae 25-39 weight portion, wilsonii 17-30 weight portion, gynostemma pentaphylla 17-35 weight portion, rhodiola root 18-32 weight portion, sea-buckthorn 13-27 weight portion, root of herbaceous peony 10-30 weight portion, tarragon 16-35 weight portion, adenophora tetraphylla 19-37 weight portion, sealwort 14-33 weight portion, eclipta 13-28 weight portion, Canton love-pea vine 10-28 weight portion, Sagina subulata 25-47 weight portion, manyleaf meadowure rhizome and root 20-38 weight portion, Chinese artichoke 14-35 weight portion, radix polygonati officinalis 18-35 weight portion and fern fiber crops 13-33 weight portion.
The preparation method of Chinese traditional medicine composition composition powders comprises: by each bulk drug by weight mark be broken into meal than mixing, then pulverize further, cross 50 mesh sieves, the enable fine powder amount by 50 mesh sieves is reaching 60%, collects and obtains fine powder a by the fine powder of 50 mesh sieves; Again the meal not by 50 mesh sieves is dropped into multi-function extractor and extract twice, first time adds 6 times amount soak by water 1.5-2 hour, and second time adds 5 times amount soak by water 1-2.0 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, puts into after 95 DEG C, baking oven is dried and cools, grind to form fine powder b, make powder after being mixed by fine powder a and b.
The toxicity test of embodiment 1 Chinese medicine composition of the present invention
Get rascal 34g, Fructus meliae toosendan 22g, buckeye 8g, fiveleaf akebia fruit 32g, Buddha's hand 12g, Radix Codonopsis 20g, Radix Astragali 18g, bighead atractylodes rhizome 13g, Radix Angelicae Sinensis 33g, cultivated land 35g, Radix Glycyrrhizae 27g, wilsonii 27g, gynostemma pentaphylla 20g, rhodiola root 30g, sea-buckthorn 13g, root of herbaceous peony 26g, tarragon 30g, adenophora tetraphylla 19g, sealwort 31g, eclipta 15g, Canton love-pea vine 12g, Sagina subulata 40g, manyleaf meadowure rhizome and root 24g, Chinese artichoke 30g, radix polygonati officinalis 20g and fern fiber crops 27g; After mixing, pulverize, in the mixture after pulverizing, add the water of 1200g, decoct 2.5 hours, filter, the water adding 500g in filter residue decocts 1.5 hours again, filters, and by twice filtrate mixing, is evaporated to the decoction that crude drug concentration is 3g/ml.
Get ICR mouse, body weight, at 25-30 gram, by body weight random packet, often organizes 10, male and female half and half, oral administration solution administration, and dosage is only 6.0ml/.Continuous Observation 20 days after administration, all mouse of result are strong deposits, and its activity, diet, hair, excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other bad reaction.
Toxicity test proves, the not toxic effect of this medicine and bad reaction, clinical practice is safe and reliable.
Embodiment 2 Chinese medicine composition 1 of the present invention and preparation method
Get rascal 18g, Fructus meliae toosendan 40g, buckeye 22g, fiveleaf akebia fruit 24g, Buddha's hand 18g, Radix Codonopsis 27g, Radix Astragali 20g, bighead atractylodes rhizome 14g, Radix Angelicae Sinensis 32g, cultivated land 25g, Radix Glycyrrhizae 36g, wilsonii 23g, gynostemma pentaphylla 26g, rhodiola root 21g, sea-buckthorn 24g, root of herbaceous peony 12g, tarragon 25g, adenophora tetraphylla 31g, sealwort 17g, eclipta 23g, Canton love-pea vine 22g, Sagina subulata 30g, manyleaf meadowure rhizome and root 29g, Chinese artichoke 20g, radix polygonati officinalis 24g and fern fiber crops 16g; Drop into stirring in mixer, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing loaded in multi-function extractor, add relative to its quality 6 times amount water, boil 3 hours, steam pressure is 0.6Mpa process, filter, obtain the first filtered fluid and filter residue; The filter residue of acquisition is added again relative to its quality 5 times amount water, boil 2 hours, steam pressure is 1Mpa process, filter and obtain the second filtered fluid and filter residue; First filtered fluid and the second filtered fluid are merged, concentrated removing moisture, obtains and gets dry extract, and adopts super-fine powder mill to pulverize, is crushed to less than 30 μm, obtain Chinese medicine additive powder.
Embodiment 3 Chinese medicine composition 2 of the present invention and preparation method
Get rascal 30g, Fructus meliae toosendan 32g, buckeye 10g, fiveleaf akebia fruit 28g, Buddha's hand 21g, Radix Codonopsis 30g, Radix Astragali 25g, bighead atractylodes rhizome 23g, Radix Angelicae Sinensis 25g, cultivated land 23g, Radix Glycyrrhizae 33g, wilsonii 19g, gynostemma pentaphylla 32g, rhodiola root 18g, sea-buckthorn 15g, root of herbaceous peony 10g, tarragon 16g, adenophora tetraphylla 24g, sealwort 29g, eclipta 25g, Canton love-pea vine 25g, Sagina subulata 29g, manyleaf meadowure rhizome and root 36g, Chinese artichoke 18g, radix polygonati officinalis 32g and fern fiber crops 15g; Drop into stirring in mixer, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing loaded in multi-function extractor, add relative to its quality 7 times amount water, boil 4 hours, steam pressure is 0.8Mpa process, filter, obtain the first filtered fluid and filter residue; The filter residue of acquisition is added again relative to its quality 5 times amount water, boil 3 hours, steam pressure is 1Mpa process, filter and obtain the second filtered fluid and filter residue; First filtered fluid and the second filtered fluid are merged, concentrated removing moisture, obtains and gets dry extract, and adopts super-fine powder mill to pulverize, is crushed to less than 30 μm, obtain Chinese medicine additive powder.
Embodiment 4 Chinese medicine composition 3 of the present invention and preparation method
Get rascal 32g, Fructus meliae toosendan 27g, buckeye 9g, fiveleaf akebia fruit 28g, Buddha's hand 13g, Radix Codonopsis 25g, Radix Astragali 20g, bighead atractylodes rhizome 17g, Radix Angelicae Sinensis 27g, cultivated land 34g, Radix Glycyrrhizae 31g, wilsonii 23g, gynostemma pentaphylla 28g, rhodiola root 25g, sea-buckthorn 14g, root of herbaceous peony 23g, tarragon 26g, adenophora tetraphylla 21g, sealwort 26g, eclipta 19g, Canton love-pea vine 14g, Sagina subulata 33g, manyleaf meadowure rhizome and root 31g, Chinese artichoke 19g, radix polygonati officinalis 31g and fern fiber crops 16g; Drop into stirring in mixer, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing loaded in multi-function extractor, add relative to its quality 6 times amount water, boil 3 hours, steam pressure is 0.9Mpa process, filter, obtain the first filtered fluid and filter residue; The filter residue of acquisition is added again relative to its quality 6 times amount water, boil 3 hours, steam pressure is 0.9Mpa process, filter and obtain the second filtered fluid and filter residue; First filtered fluid and the second filtered fluid are merged, concentrated removing moisture, obtains and gets dry extract, and adopts super-fine powder mill to pulverize, is crushed to less than 30 μm, obtain Chinese medicine additive powder.
Embodiment 5 feed 1 of the present invention and preparation method
A kind of feed, feed comprises basal feed, vitamin premix, amino acid premix, trace mineral supplement and Chinese medicine additive, and in described feed, each composition weight mark ratio is: basal feed 100 weight portion, vitamin premix 0.0006 weight portion, amino acid premix 0.3 weight portion, trace mineral supplement 0.008 weight portion and Chinese medicine additive 25 weight portion, wherein, in basal feed, each component and weight are corn 5000g, dregs of beans 3000g, wheat 3500g, wherein, in Chinese medicine additive, the parts by weight of each bulk drug are: rascal 18 weight portion, Fructus meliae toosendan 40 weight portion, buckeye 22 weight portion, fiveleaf akebia fruit 24 weight portion, Buddha's hand 18 weight portion, Radix Codonopsis 27 weight portion, the Radix Astragali 20 weight portion, the bighead atractylodes rhizome 14 weight portion, Radix Angelicae Sinensis 32 weight portion, cultivated land 25 weight portion, Radix Glycyrrhizae 36 weight portion, wilsonii 23 weight portion, gynostemma pentaphylla 26 weight portion, rhodiola root 21 weight portion, sea-buckthorn 24 weight portion, the root of herbaceous peony 12 weight portion, tarragon 25 weight portion, adenophora tetraphylla 31 weight portion, sealwort 17 weight portion, eclipta 23 weight portion, Canton love-pea vine 22 weight portion, Sagina subulata 30 weight portion, manyleaf meadowure rhizome and root 29 weight portion, Chinese artichoke 20 weight portion, radix polygonati officinalis 24 weight portion and fern fiber crops 16 weight portions
The preparation method of feed is as follows:
The first step, mixes in proportion by component each in described Chinese medicine additive, obtains mixture, add the water relative to mixture quality 2 times, carry out decoction process 2 hours, decoction liquor is filtered, concentration, obtain lotion, the relative density of described lotion 89 DEG C is 1.20;
Second step, being the ethanol of 78% by adding relative to the determining alcohol of first step mixture quality 3 times in the lotion of acquisition, carrying out stirring 35 minutes, at 3 DEG C, refrigerate 1.5 hours, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 190 object powder, obtain Chinese medicine additive;
3rd step, Chinese medicine additive mixing basal feed, vitamin premix, amino acid premix, trace mineral supplement and second step obtained in proportion, pours in spraying machine, in spraying machine, water temperature is modulated at 75 DEG C, open sprayer, stir 5 minutes, continue to be warming up to 91 DEG C and complete expanded;
4th step, the product after expanded is added the water relative to its quality 1.6 times, and put into granulator and granulate, granulator electric current is 170A;
5th step, dry after granulating, baking temperature is 107 DEG C, drying time 30min; Then cool, cooling blower electric current is 40A, and packaging, obtains described feed.
Embodiment 6 feed 2 of the present invention and preparation method
A kind of feed, feed comprises basal feed, vitamin premix, amino acid premix, trace mineral supplement and Chinese medicine additive, and in described feed, each composition weight mark ratio is: basal feed 100 weight portion, vitamin premix 0.0005 weight portion, amino acid premix 0.4 weight portion, trace mineral supplement 0.007 weight portion and Chinese medicine additive 20 weight portion.Wherein, in basal feed, each component and weight are corn 6000g, dregs of beans 4000g, wheat 5000g, wherein, in Chinese medicine additive, the parts by weight of each bulk drug are: rascal 30 weight portion, Fructus meliae toosendan 32 weight portion, buckeye 10 weight portion, fiveleaf akebia fruit 28 weight portion, Buddha's hand 21 weight portion, Radix Codonopsis 30 weight portion, the Radix Astragali 25 weight portion, the bighead atractylodes rhizome 23 weight portion, Radix Angelicae Sinensis 25 weight portion, cultivated land 23 weight portion, Radix Glycyrrhizae 33 weight portion, wilsonii 19 weight portion, gynostemma pentaphylla 32 weight portion, rhodiola root 18 weight portion, sea-buckthorn 15 weight portion, the root of herbaceous peony 10 weight portion, tarragon 16 weight portion, adenophora tetraphylla 24 weight portion, sealwort 29 weight portion, eclipta 25 weight portion, Canton love-pea vine 25 weight portion, Sagina subulata 29 weight portion, manyleaf meadowure rhizome and root 36 weight portion, Chinese artichoke 18 weight portion, radix polygonati officinalis 32 weight portion and fern fiber crops 15 weight portions.
The preparation method of feed is as follows:
The first step, mixes in proportion by component each in described Chinese medicine additive, obtains mixture, add the water relative to mixture quality 2 times, carry out decoction process 2 hours, decoction liquor is filtered, concentration, obtain lotion, the relative density of described lotion 89 DEG C is 1.24;
Second step, being the ethanol of 71% by adding relative to the determining alcohol of first step mixture quality 3 times in the lotion of acquisition, carrying out stirring 35 minutes, at 0 DEG C, refrigerate 1.5 hours, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 130 object powder, obtain Chinese medicine additive;
3rd step, Chinese medicine additive mixing basal feed, vitamin premix, amino acid premix, trace mineral supplement and second step obtained in proportion, pours in spraying machine, in spraying machine, water temperature is modulated at 63 DEG C, open sprayer, stir 5 minutes, continue to be warming up to 91 DEG C and complete expanded;
4th step, the product after expanded is added the water relative to its quality 1.4 times, and put into granulator and granulate, granulator electric current is 170A;
5th step, dry after granulating, baking temperature is 107 DEG C, drying time 30min; Then cool, cooling blower electric current is 40A, and packaging, obtains described feed.
Embodiment 7 clinical testing
(1) for examination animal
Choose pig farm, Hebei Yutian County make a definite diagnosis after sick pig in random selecting 180 2 monthly ages sick pig as treatment contrast test object; Another from pig farm, Hebei Yutian County random selecting 180 2 monthly age health pig as prevention contrast test object.
(2) pathological material of disease is taked:
Select that there is classical symptom, without obvious complication, the sick pig not using drug therapy, collect the blood sample 10 ~ 20mL of infected Erythrocytes rate more than 80% (ammonium oxalate and the anti-freezing of potassium oxalate anti-coagulants), 4 DEG C of Cord blood are for subsequent use.
(3) contrast experiment is prevented:
180 of random choose 2 monthly age health pig are divided at random 3 groups (control group 1, control group 2 and embodiment groups), wherein, control group 1 and control group 2 use traditional pig feed to feed pig respectively, embodiment group uses the feed 1 in embodiment 5 to feed pig, feed after 7 days, carry out artificial challenge's ear vein injection pathological material of disease 4mL/ head to control group 1 and embodiment group, observed and recorded respectively organizes the incidence of disease and the death rate of pig, and result is as shown in table 1.
The table 1 preventive effect table of comparisons
Data from table 1: the feed that the present invention contains Chinese medicine composition has obvious preventive effect to swine eperythrozoonosis.
(4) contrast test is treated:
By 180 of random selecting 2 the monthly ages sick pig be divided at random 3 groups (treatment by Chinese herbs group, western medicine group, blank groups), treat with different medicine, wherein, treatment by Chinese herbs group selects the Chinese medicine composition 3 of embodiment 4, dose is 0.6g/kg every day, takes 4 days continuously; Western medicine group selects Tubifex clean (Lanzhou animal pharmaceutical factory), 3.5mg/kg, and deep intramuscular injection, once a day, is used in conjunction 2, the next day of then 1 time, then uses 2 times; Blank group does not feed any medicine.Observed and recorded respectively organizes cure rate and the death rate of pig, and result is as shown in table 2.
Curative effect determinate standard
The death rate is all at duration of test, and occur the classical symptom of eperythrozoonosis and dead, ptomatopsia has characteristic pathology, and blood examination has Infected with Eperythrozoon, can be judged to infect dead, calculate the death rate according to dead pig number.
Cure rate is all at duration of test, and after administration, the state of mind and appetite recover normal, no longer occur the symptoms such as heating, and blood examination are without Infected with Eperythrozoon, all belongs to healing, calculates cure rate according to healing number.
After efficient medication, the spirit of pig, appetite, breathing, body temperature take an evident turn for the better, and infected Erythrocytes rate obviously declines, and are all judged to effectively, calculate efficient accordingly.
The table 2 result for the treatment of table of comparisons
Data from table 2: Chinese medicine composition of the present invention is obviously better than western medicine group to swine eperythrozoonosis result for the treatment of, reduce the death rate, improve cure rate.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. one kind for preventing and treating the feed of swine eperythrozoonosis, it is characterized in that, described feed is made up of basal feed, vitamin premix, amino acid premix, trace mineral supplement and Chinese medicine additive, and in described feed, each composition weight number is: basal feed 100 weight portion, vitamin premix 0.0001-0.0007 weight portion, amino acid premix 0.1-0.8 weight portion, trace mineral supplement 0.001-0.01 weight portion and Chinese medicine additive 15-35 weight portion;
Described Chinese medicine additive is made up of following raw medicinal material: rascal, Fructus meliae toosendan, buckeye, fiveleaf akebia fruit, Buddha's hand, Radix Codonopsis, the Radix Astragali, the bighead atractylodes rhizome, Radix Angelicae Sinensis, cultivated land, Radix Glycyrrhizae, wilsonii, gynostemma pentaphylla, rhodiola root, sea-buckthorn, the root of herbaceous peony, tarragon, adenophora tetraphylla, sealwort, eclipta, Canton love-pea vine, Sagina subulata, manyleaf meadowure rhizome and root, Chinese artichoke, radix polygonati officinalis and fern fiber crops.
2. the feed for preventing and treating swine eperythrozoonosis according to claim 1, is characterized in that, is vitamin A, vitamin D, vitamin E, vitamin K, pantothenic acid, Cobastab in described vitamin premix
12in one or more mixing.
3. the feed for preventing and treating swine eperythrozoonosis according to claim 1, is characterized in that, described amino acid premix is one or more mixing of lysine, methionine, threonine.
4. the feed for preventing and treating swine eperythrozoonosis according to claim 1, is characterized in that, described trace mineral supplement is one or more mixing in iron, manganese, zinc, copper.
5. according to the arbitrary described feed for preventing and treating swine eperythrozoonosis of claim 1-4, it is characterized in that, in described Chinese medicine additive, the parts by weight of each bulk drug are: rascal 16-37 weight portion, Fructus meliae toosendan 20-47 weight portion, buckeye 6-25 weight portion, fiveleaf akebia fruit 22-32 weight portion, Buddha's hand 12-25 weight portion, Radix Codonopsis 18-35 weight portion, Radix Astragali 17-28 weight portion, bighead atractylodes rhizome 11-25 weight portion, Radix Angelicae Sinensis 22-35 weight portion, cultivated land 21-38 weight portion, Radix Glycyrrhizae 25-39 weight portion, wilsonii 17-30 weight portion, gynostemma pentaphylla 17-35 weight portion, rhodiola root 18-32 weight portion, sea-buckthorn 13-27 weight portion, root of herbaceous peony 10-30 weight portion, tarragon 16-35 weight portion, adenophora tetraphylla 19-37 weight portion, sealwort 14-33 weight portion, eclipta 13-28 weight portion, Canton love-pea vine 10-28 weight portion, Sagina subulata 25-47 weight portion, manyleaf meadowure rhizome and root 20-38 weight portion, Chinese artichoke 14-35 weight portion, radix polygonati officinalis 18-35 weight portion and fern fiber crops 13-33 weight portion.
6. according to the arbitrary described feed for preventing and treating swine eperythrozoonosis of claim 1-4, it is characterized in that, in described Chinese medicine additive, the parts by weight of each bulk drug are: rascal 18-34 weight portion, Fructus meliae toosendan 22-40 weight portion, buckeye 8-22 weight portion, fiveleaf akebia fruit 24-32 weight portion, Buddha's hand 12-21 weight portion, Radix Codonopsis 20-30 weight portion, Radix Astragali 18-25 weight portion, bighead atractylodes rhizome 13-23 weight portion, Radix Angelicae Sinensis 25-33 weight portion, cultivated land 23-35 weight portion, Radix Glycyrrhizae 27-36 weight portion, wilsonii 19-27 weight portion, gynostemma pentaphylla 20-32 weight portion, rhodiola root 18-30 weight portion, sea-buckthorn 13-24 weight portion, root of herbaceous peony 10-26 weight portion, tarragon 16-30 weight portion, adenophora tetraphylla 19-31 weight portion, sealwort 17-31 weight portion, eclipta 15-25 weight portion, Canton love-pea vine 12-25 weight portion, Sagina subulata 29-40 weight portion, manyleaf meadowure rhizome and root 24-36 weight portion, Chinese artichoke 18-30 weight portion, radix polygonati officinalis 20-32 weight portion and fern fiber crops 15-27 weight portion.
7., according to the preparation method of the arbitrary described feed for preventing and treating swine eperythrozoonosis of claim 1-6, it is characterized in that, comprise the following steps:
The first step, mixes in proportion by component each in described Chinese medicine additive, obtains mixture, add the water relative to mixture quality 2 times, carry out decoction process 2 hours, decoction liquor is filtered, concentration, obtain lotion, the relative density of described lotion 89 DEG C is 1.20-1.24;
Second step, being the ethanol of 71%-78% by adding relative to the determining alcohol of first step mixture quality 3 times in the lotion of acquisition, carrying out stirring 35 minutes, at 0-3 DEG C, refrigerate 1.5 hours, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 130-190 object powder, obtain Chinese medicine additive;
3rd step, in proportion the Chinese medicine additive that basal feed and vitamin premix, amino acid premix, trace mineral supplement and second step obtain is mixed, pour in spraying machine, in spraying machine, water temperature is modulated at 63-75 DEG C, open sprayer, stir 5 minutes, continue to be warming up to 91 DEG C and complete expanded;
4th step, add the product after expanded relative to its quality 1.4-1.6 water doubly, put into granulator and granulate, granulator electric current is 170A;
5th step, dry after granulating, baking temperature is 107 DEG C, drying time 30min; Then cool, cooling blower electric current is 40A, and packaging, obtains described feed.
8. one kind for preventing and treating the Chinese medicine composition of swine eperythrozoonosis, it is characterized in that, in described Chinese medicine composition, the parts by weight of each bulk drug are: rascal 16-37 weight portion, Fructus meliae toosendan 20-47 weight portion, buckeye 6-25 weight portion, fiveleaf akebia fruit 22-32 weight portion, Buddha's hand 12-25 weight portion, Radix Codonopsis 18-35 weight portion, Radix Astragali 17-28 weight portion, bighead atractylodes rhizome 11-25 weight portion, Radix Angelicae Sinensis 22-35 weight portion, cultivated land 21-38 weight portion, Radix Glycyrrhizae 25-39 weight portion, wilsonii 17-30 weight portion, gynostemma pentaphylla 17-35 weight portion, rhodiola root 18-32 weight portion, sea-buckthorn 13-27 weight portion, root of herbaceous peony 10-30 weight portion, tarragon 16-35 weight portion, adenophora tetraphylla 19-37 weight portion, sealwort 14-33 weight portion, eclipta 13-28 weight portion, Canton love-pea vine 10-28 weight portion, Sagina subulata 25-47 weight portion, manyleaf meadowure rhizome and root 20-38 weight portion, Chinese artichoke 14-35 weight portion, radix polygonati officinalis 18-35 weight portion and fern fiber crops 13-33 weight portion.
9. the Chinese medicine composition for preventing and treating swine eperythrozoonosis according to claim 8, it is characterized in that, the preparation method of described Chinese medicine composition comprises: by each bulk drug by weight mark be broken into meal than mixing, pulverize further again, cross 50 mesh sieves, the enable fine powder amount by 50 mesh sieves is reaching 60%, collects and obtains fine powder a by the fine powder of 50 mesh sieves; Again the meal not by 50 mesh sieves is dropped into multi-function extractor and extract twice, first time adds 6 times amount soak by water 1.5-2 hour, and second time adds 5 times amount soak by water 1-2.0 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, puts into after 95 DEG C, baking oven is dried and cools, grind to form fine powder b, make powder after being mixed by fine powder a and b.
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| CN104922626A (en) * | 2015-05-27 | 2015-09-23 | 山东迅达康兽药有限公司 | Traditional Chinese medicine composition for treating porcine eperythrozoonosis and preparation method thereof |
| CN107158067B (en) * | 2017-04-19 | 2021-02-26 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for preventing and treating swine eperythrozoonosis and preparation method and application thereof |
| CN109480107A (en) * | 2018-12-21 | 2019-03-19 | 广东驱动力生物科技股份有限公司 | A kind of feed supplementation and preparation method thereof can provide hematopoiesis nutrient meat |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101791328A (en) * | 2009-09-30 | 2010-08-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for treating swine eperythrozoonosis and preparation method thereof |
| CN103272085A (en) * | 2013-05-27 | 2013-09-04 | 东北农业大学 | Traditional Chinese medicine composition for treating eperythrozoonosis of dairy cows and preparation method thereof |
| CN103652449A (en) * | 2013-12-09 | 2014-03-26 | 山东新希望六和集团有限公司 | Feed for treating Eperythrozoon suis, and preparation method thereof |
| CN103720989A (en) * | 2012-10-12 | 2014-04-16 | 天津君合心科技发展有限公司 | Traditional Chinese medicine oral liquid for preventing and treating eperythrozoon ovis and streptococcus mixed infection |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101791328A (en) * | 2009-09-30 | 2010-08-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for treating swine eperythrozoonosis and preparation method thereof |
| CN103720989A (en) * | 2012-10-12 | 2014-04-16 | 天津君合心科技发展有限公司 | Traditional Chinese medicine oral liquid for preventing and treating eperythrozoon ovis and streptococcus mixed infection |
| CN103272085A (en) * | 2013-05-27 | 2013-09-04 | 东北农业大学 | Traditional Chinese medicine composition for treating eperythrozoonosis of dairy cows and preparation method thereof |
| CN103652449A (en) * | 2013-12-09 | 2014-03-26 | 山东新希望六和集团有限公司 | Feed for treating Eperythrozoon suis, and preparation method thereof |
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Inventor after: Hu Liping Inventor after: Zhu Ruiliang Inventor after: Li Xin Inventor after: Huang He Inventor after: Yan Lei Inventor before: Li Xin Inventor before: Huang He Inventor before: Yan Lei |
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Effective date of registration: 20210312 Address after: 541200 xiari Tianxin village, Lingcheng Town, Lingchuan County, Guilin City, Guangxi Zhuang Autonomous Region Patentee after: Guilin new hope feed Co.,Ltd. Address before: 266061 Qingdao Industrial Park, Ji Hong Tan Street, Chengyang District, Qingdao, Shandong. Patentee before: SHANDONG NEW HOPE LIUHE GROUP Co.,Ltd. |
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