CN104922626A - Traditional Chinese medicine composition for treating porcine eperythrozoonosis and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating porcine eperythrozoonosis. The traditional Chinese medicine composition is prepared by mixing the following components in parts by weight: 15-35 parts of folium artemisiae argyi, 15-35 parts of pyrrosia lingua, 15-45 parts of radix gentianae, 15-55 parts of ginger, 15-65 parts of radix paeoniae alba, 15-55 parts of radix ampelopsis, 15-75 parts of geranium wilfordii, 15-75 parts of hypericum japonicum, 15-45 parts of liquorice and 15-45 parts of fructus kochiae. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition is reasonable in formula, simple to prepare, free of toxic and side effects, free of pollution, free of medicine residues, free of medicine resistance, high in bioavailability and very obvious in curative effect, the traditional Chinese medicine composition can be super finely ground, and clinically-proven results show that the traditional Chinese medicine composition has the special treatment effect on porcine eperythrozoonosis.

Description

Chinese medicine composition for the treatment of swine eperythrozoonosis and preparation method thereof

Technical field

The present invention relates to Chinese medicine composition and preparation method thereof for the treatment of swine eperythrozoonosis, belong to field of animal, be particularly a kind ofly specifically designed to Chinese medicine composition for the treatment of swine eperythrozoonosis and preparation method thereof.

Background technology

Swine eperythrozoonosis is the boar infectious disease being feature with anemia, jaundice, heating caused by eperythrozoon suis.The pig of various age and kind all can occur, and sick temperature of pig body raises, skin rubefaction, constipation or diarrhoea, visual mucosa swelling flushing, and packed cell volume reduces, organa parenchymatosum's enlargement, xanthochromia or hyperemia; Case fatality rate is between 30%-80%.Primary disease all can occur throughout the year, is one of principal disease of harm pig industry.

This disease is all pig-raising countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug has drug residue due to life-time service and easily produces drug resistance, and worse and worse, and drug residue causes that outlet is limited and harm people are healthy to its clinical effectiveness, thus the use of antimicrobial drug is very restricted.

Therefore researching and developing a kind of drug residue free, specific medicament of producing of having no drug resistance for the treatment of swine eperythrozoonosis is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the Chinese medicine composition and preparation method thereof of effective treatment swine eperythrozoonosis of drug residue.

Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of swine eperythrozoonosis, by following component by weight mixed preparing form: Folium Artemisiae Argyi 15-35 part, Folium Pyrrosiae 15-35 part, Radix Gentianae 15-45 part, Rhizoma Zingiberis Recens 15-55 part, Radix Paeoniae Alba 15-65 part, Radix Ampelopsis 15-55 part, Herba Erodii 15-75 part, Herba Hyperici Japonici 15-75 part, Radix Glycyrrhizae 15-45 part, Fructus Kochiae 15-45 part.

Described various component optimum ratio amount is: Folium Artemisiae Argyi 25 parts, Folium Pyrrosiae 25 parts, Radix Gentianae 30 parts, 35 parts, Rhizoma Zingiberis Recens, the Radix Paeoniae Alba 40 parts, Radix Ampelopsis 35 parts, Herba Erodii 45 parts, Herba Hyperici Japonici 45 parts, 30 parts, Radix Glycyrrhizae, the Fructus Kochiae 30 parts.

Treat a preparation method for the Chinese medicine composition of swine eperythrozoonosis, carry out as follows:

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Folium Artemisiae Argyi 15-35 part, Folium Pyrrosiae 15-35 part, Radix Gentianae 15-45 part, Rhizoma Zingiberis Recens 15-55 part, Radix Paeoniae Alba 15-65 part by weight, mix 5-10 minute to even;

(3) take Radix Ampelopsis 15-55 part, Herba Erodii 15-75 part, Herba Hyperici Japonici 15-75 part, Radix Glycyrrhizae 15-45 part, Fructus Kochiae 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

The medicinal property of each component is as follows:

Folium Artemisiae Argyi: acrid, bitter, warm, returns spleen, liver, kidney channel, has the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain, infertility, frequent fetal movement etc.

Folium Pyrrosiae: sweet, bitter, be slightly cold, returns lung, urinary bladder channel, has the function of clearing away heat to stop bleeding, inducing diuresis for treating stranguria syndrome; Cure mainly pyretic stranguria, hematuria, difficulty in urination, dyspnea and cough due to lung-heat etc.

Radix Gentianae: bitter, cold, returns gallbladder, Liver Channel, has eliminating pathogen in the liver gallbladder excess-fire, function except damp-heat in lower-JIAO; Cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema pruritus etc.

Rhizoma Zingiberis Recens: pungent, tepor, returns lung, spleen, stomach warp, has the function of the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing; Cure mainly affection of exogenous wind-cold, gastrofrigid vomiting, cold-phlegm cough etc.

The Radix Paeoniae Alba: bitter, acid, to be slightly cold, returns spleen, Liver Channel, has suppressing the hyperactive liver pain relieving, the function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.

Radix Ampelopsis: bitter, be slightly cold, returns stomach, heart channel, has the function of heat-clearing and toxic substances removing, detumescence; Cure mainly that hematodiarrhoea is had blood in stool, sore, carbuncle and painful swelling, scald, burn etc.

Herba Erodii: bitter, pungent, flat, returns kidney,spleen,liver warp, has the function of wind-damp dispelling, the meridian dredging, antidiarrheal dysentery; Cure mainly anemofrigid-damp arthralgia, traumatic injury, bones and muscles pain, have loose bowels, dysentery etc.

Herba Hyperici Japonici: bitter, pungent, flat, returns liver, lung meridian, has the function of clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling; Cure mainly jaundice due to damp-heat, injury from falling down, carbuncle sore etc.

Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

The Fructus Kochiae: pungent, bitter, cold, returns kidney, urinary bladder channel, has the function of clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching; Cure mainly damp and hot stranguria with turbid discharge, skin pruritus, rubella, eczema etc.

All taste Chinese medicine is according to Chinese medical theory compatible combination above, for clinical symptoms and the pathological change of swine eperythrozoonosis, plays the effect for the treatment of both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment swine eperythrozoonosis, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.

Detailed description of the invention

Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:

Embodiment 1

A kind of Chinese medicine composition for the treatment of swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Folium Artemisiae Argyi 150 parts, Folium Pyrrosiae 150 parts, Radix Gentianae 150 parts, 150 parts, Rhizoma Zingiberis Recens, the Radix Paeoniae Alba 150 parts by weight, mix 5-10 minute to even;

(3) take Radix Ampelopsis 150 parts, Herba Erodii 150 parts, Herba Hyperici Japonici 150 parts, 150 parts, Radix Glycyrrhizae, the Fructus Kochiae 150 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Embodiment 2

A kind of Chinese medicine composition for the treatment of swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Folium Artemisiae Argyi 250 parts, Folium Pyrrosiae 250 parts, Radix Gentianae 300 parts, 350 parts, Rhizoma Zingiberis Recens, the Radix Paeoniae Alba 400 parts by weight, mix 5-10 minute to even;

(3) take Radix Ampelopsis 350 parts, Herba Erodii 450 parts, Herba Hyperici Japonici 450 parts, 300 parts, Radix Glycyrrhizae, the Fructus Kochiae 300 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Embodiment 3

A kind of Chinese medicine composition for the treatment of swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Folium Artemisiae Argyi 350 parts, Folium Pyrrosiae 350 parts, Radix Gentianae 450 parts, 550 parts, Rhizoma Zingiberis Recens, the Radix Paeoniae Alba 650 parts by weight, mix 5-10 minute to even;

(3) take Radix Ampelopsis 550 parts, Herba Erodii 750 parts, Herba Hyperici Japonici 750 parts, 450 parts, Radix Glycyrrhizae, the Fructus Kochiae 450 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Clinical trial:

Clinical experiment animal selects 120-130 age in days, and Laboratory Diagnosed is the ill pig of swine eperythrozoonosis.Ill pig isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, and experiment carries out 5 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Chinese medicine composition group of the present invention can by product of the present invention (compositions obtained by the embodiment of the present invention 2) the ill pig of feeding etc., day dose be: feed or the 400kg that drinks water by the present invention's every 100g spice 210kg, every day 2-3 time, be used in conjunction 5; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%, at the end of have symptom rate=have symptom number of animals/experimental animal number × 100%.Following table is the result at the end of experiment.

Efficacy assessment standard:

Cure: spirit is normal, drinking-water of searching for food is normal, and skin is normal, and the visual mucosas such as feces is normal, eye conjunctiva are normal, and pig blood erythrocyte has no pathogenic microorganism Eperythrozoon etc. through sessile drop method microscopy.

At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.

Table is that the Field information situation that the present invention and other medicines treat swine eperythrozoonosis contrasts:

Numbering	Group	Mortality rate %	Cure rate %	At the end of have symptom rate %
					Ⅰ	Blank group	20	6.7	73.3
Ⅱ	Attached red dissipation group	10	73.3	16.7
					Ⅲ	Present composition group	6.7	83.3	10

This clinical trial results statistical analysis, present composition group and the attached red dissipation group of pig in cure rate compared with difference extremely significantly (P < 0.01).

Safety testing:

Choose 90 age in days health pig 10,5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 2 are fed or are drunk water 10 days, during medication, health pig is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.

Above-mentioned detailed description of Chinese medicine composition of this treatment swine eperythrozoonosis and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.

Claims (3)

1. treat a Chinese medicine composition for swine eperythrozoonosis, it is characterized in that by following component by weight mixed preparing form: Folium Artemisiae Argyi 15-35 part, Folium Pyrrosiae 15-35 part, Radix Gentianae 15-45 part, Rhizoma Zingiberis Recens 15-55 part, Radix Paeoniae Alba 15-65 part, Radix Ampelopsis 15-55 part, Herba Erodii 15-75 part, Herba Hyperici Japonici 15-75 part, Radix Glycyrrhizae 15-45 part, Fructus Kochiae 15-45 part.

2. the Chinese medicine composition for the treatment of swine eperythrozoonosis according to claim 1, is characterized in that described various component optimum ratio amount is: Folium Artemisiae Argyi 25 parts, Folium Pyrrosiae 25 parts, Radix Gentianae 30 parts, 35 parts, Rhizoma Zingiberis Recens, the Radix Paeoniae Alba 40 parts, Radix Ampelopsis 35 parts, Herba Erodii 45 parts, Herba Hyperici Japonici 45 parts, 30 parts, Radix Glycyrrhizae, the Fructus Kochiae 30 parts.

3. a preparation method for the Chinese medicine composition for the treatment of swine eperythrozoonosis according to claim 1 and 2, is characterized in that carrying out as follows:

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Folium Artemisiae Argyi 15-35 part, Folium Pyrrosiae 15-35 part, Radix Gentianae 15-45 part, Rhizoma Zingiberis Recens 15-55 part, Radix Paeoniae Alba 15-65 part by weight, mix 5-10 minute to even;

(3) take Radix Ampelopsis 15-55 part, Herba Erodii 15-75 part, Herba Hyperici Japonici 15-75 part, Radix Glycyrrhizae 15-45 part, Fructus Kochiae 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.