CN102688389B - Traditional Chinese medicine composition for treating swine high fever syndrome, feed, as well as preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating swine high fever syndrome, feed, as well as preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating swine high fever syndrome, which comprises cortex phellodendri, polygonum cuspidatum, radix paeoniae alba, cortex dictamni, wild ginger, peppermint, potentilla discolor, fructus anisi stellati, murraya paniculata, saururus chinensis, vietnamese sophora root, Indian iphigenia bulb, rhizoma polygonati, climbing groundsel herb, glossy privet fruit, garden euphorbia herb, dangshen, largehead atractylodes rhizome, caulis spatholobi and dendrobe. The traditional Chinese medicine composition for treating the swine high fever syndrome has the advantages of being high in cure rate, rapid in taking effect, free from toxic and side effects, hard in generation of drug resistance, free from drug residue and the like.
Description
Technical field
The present invention relates to animal foodstuff technical field, relate in particular to a kind of feedstuff that is used for the treatment of pig hyperpyrexia syndrome.
Background technology
Pig hyperpyrexia syndrome is a kind of hot, the acute infectious disease by several virus or various bacteria infringement pig body, and this disease is multiple is born in the summer, autumn, and morbidity is anxious, and the course of disease of falling ill is long, and generally, about 5 ~ 20 days, sickness rate is high, and therapeutic effect is poor, and mortality rate is high.This disease Epidemic Scope is wide, involves area many, has obvious popularity and propagated, generally on a pig farm, occur after epidemic situation, within 3 ~ 5 days, propagate whole swinery, 1 ~ 2 week was spread whole pig farm, and propagate to surrounding area, after swinery morbidity, within general 7 ~ 10 days, start dead.All can there is pig hyperpyrexia syndrome in the pig of any age in days, general first therefrom large pig morbidity, mortality rate 80% ~ 100%.
Pig hyperpyrexia syndrome mostly is due to the mixed infections such as pig blue-ear disease poison, Pseudorabies virus, swine fever virus, porcine circovirus II type and swine influenza virus, and the coefficient result such as secondary infection streptococcus, Eperythrozoon, bus bacillus, Actinobacillus, mycoplasma, haemophilus parasuis and toxoplasma.
Pig hyperpyrexia syndrome initial stage symptom is, 41 ℃ ~ 42 ℃ of the high heat of burst, and appetite is absolutely useless, couches, be reluctant to stand up,, there is argol in eye conjunctiva flushing, spherical in shape then, oliguria, yellow skin, frowziness, mid-term and middle and late stage, the sick pig having is aubergine in one's ear, and body surface has petechia, and back is cerebrol shape, argol is dry, and surface is stained with mucosa, and anus is aubergine around, that some pigs breathes is abrasive, cough, be thoracoabdominal breathing, later stage temperature decline or normal, visual mucosa or skin anemia.
The pathological change of pig hyperpyrexia syndrome is that the major part pig lymph nodes of body as a whole of dying of illness has petechia, there is the petechia differing in size on kidney surface, respiratory mucosa is congested, and trachea, bronchus are full of foam, and some Gaster Sus domestica intestinal mucosa parts are congested, hemorrhage, ulcer, mucosa come off; Heart has petechia (speckle) and blood stasis; Subcutaneous have petechia (speckle) and a blood stasis; The dirty blood stasis of Pulmonis Sus domestica, edema; Liver matter is crisp, swelling, color are thin out, gallbladder swelling, bile are sticky; Blood is thin, do not solidify.
The M & M of pig hyperpyrexia syndrome is all very high, at present, once morbidity, poultry master or local veterinary use antibiotic or antibiotic to coordinate antipyretic treatment more, due to antibiotic use more, Drug resistance is serious, and effect is undesirable, particularly abuses antibiotic pig farm, cause drug intoxication, mortality rate is higher, adopts the swinery of the urgent inoculation of vaccine, also can accelerate morbidity and the death of disease pig.
In addition, many pathogenicities have determined that the specific therapy effect of western medicine and medical practitioners is undesirable, limited even invalid to virus function, the antimicrobial drug of most widely used treatment pig hyperpyrexia syndrome and antidote intelligence are for a certain specific virus, bacterial infective diseases in the market, and use such medicine to be not only unfavorable for improving carcass immunologic function, accelerate on the contrary the death of disease pig.
Along with deepening continuously of traditional Chinese medical science research, use in recent years natural drug treatment pig hyperpyrexia syndrome to make significant headway, Chinese medicine is improving carcass immunity, is regulating the aspects such as animal body and environmental balance to have the incomparable advantage of western medicine and medical practitioners, reasonably combined Chinese medicine preparation, in heat clearing away, antibacterial and antiviral while, can significantly improve the immunity muscle power of carcass, thereby there is desirable therapeutic effect.
Summary of the invention
The feedstuff that technical problem to be solved by this invention is to provide a kind of novel Chinese medicine composition and contains described Chinese medicine composition composition, adopt this Chinese medicine composition and feedstuff treatment pig hyperpyrexia syndrome to have that cure rate is high, instant effect, have no side effect, be difficult for producing drug resistance, be difficult for causing the advantage of the aspects such as drug residue.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of pig hyperpyrexia syndrome, it comprises: Cortex Phellodendri, Rhizoma Polygoni Cuspidati, the Radix Paeoniae Alba, Cortex Dictamni, Herba Asari, Herba Menthae, Herba Potentillae Discoloris, Fructus Anisi Stellati, Folium Et Cacumen Murrayae, Rhizoma Saururi (Herba Saururi), Radix Sophorae Tonkinensis, Pseudobulbus Cremastrae Seu Pleiones, Rhizoma Polygonati, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Ramulus et Folium Bauhiniae Faberi, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi and Herba Dendrobii.
Wherein, the described Chinese medicine composition that is used for the treatment of pig hyperpyrexia syndrome, the ratio of weight and number of various components also can be preferably: Cortex Phellodendri 70～80 weight portions, Rhizoma Polygoni Cuspidati 40～50 weight portions, the Radix Paeoniae Alba 15～25 weight portions, Cortex Dictamni 15～25 weight portions, Herba Asari 10～20 weight portions, Herba Menthae 5～15 weight portions, Herba Potentillae Discoloris 15～25 weight portions, Fructus Anisi Stellati 10～20 weight portions, Folium Et Cacumen Murrayae 15～25 weight portions, Rhizoma Saururi (Herba Saururi) 25～35 weight portions, Radix Sophorae Tonkinensis 25～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 10～20 weight portions, Rhizoma Polygonati 30～40 weight portions, Herba Senecionis Scandentis 15～25 weight portions, Fructus Ligustri Lucidi 30～40 weight portions, Ramulus et Folium Bauhiniae Faberi 15～25 weight portions, Radix Codonopsis 50～60 weight portions, the Rhizoma Atractylodis Macrocephalae 30～40 weight portions, Caulis Spatholobi 20～30 weight portions and Herba Dendrobii 30～40 weight portions.
Wherein, the described Chinese medicine composition that is used for the treatment of pig hyperpyrexia syndrome, the ratio of weight and number of various components also can be more preferably: Cortex Phellodendri 75～80 weight portions, Rhizoma Polygoni Cuspidati 45～50 weight portions, the Radix Paeoniae Alba 20～25 weight portions, Cortex Dictamni 20～25 weight portions, Herba Asari 15～20 weight portions, Herba Menthae 10～15 weight portions, Herba Potentillae Discoloris 20～25 weight portions, Fructus Anisi Stellati 15～20 weight portions, Folium Et Cacumen Murrayae 20～25 weight portions, Rhizoma Saururi (Herba Saururi) 30～35 weight portions, Radix Sophorae Tonkinensis 30～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 15～20 weight portions, Rhizoma Polygonati 35～40 weight portions, Herba Senecionis Scandentis 20～25 weight portions, Fructus Ligustri Lucidi 35～40 weight portions, Ramulus et Folium Bauhiniae Faberi 20～25 weight portions, Radix Codonopsis 55～60 weight portions, the Rhizoma Atractylodis Macrocephalae 35～40 weight portions, Caulis Spatholobi 25～30 weight portions and Herba Dendrobii 35～40 weight portions.
The present invention also provides the above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of pig hyperpyrexia syndrome, and it comprises:
The first step, each component in described Chinese medicine composition is mixed in proportion, be ground into 100 order～200 object powder, add the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 70～80%, heating and refluxing extraction 1～3 hour, obtain extracting solution, extracting liquid filtering, obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds the ethanol that the determining alcohol with respect to 1～3 times of its quality is 70～80%, heating and refluxing extraction 1～3 hour, extracting liquid filtering, obtains the second filtrate;
The 3rd step, merges the first filtrate and the second filtrate, and concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer, guarantee that inlet temperature is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, through super-dry, obtain described Chinese medicine composition.
The present invention also provides a kind of feedstuff, described feedstuff comprises feed vector, as the feed adhesive of starch and above-mentioned Chinese medicine composition as additive.
In described feedstuff, the percentage by weight of each component is, feed vector 50%～80%, the additive 3%～5% of described Chinese medicine composition, described starch 10%～20%.
The present invention also provides the preparation method of above-mentioned feedstuff, and it comprises:
The first step, prepares described Chinese medicine composition additive according to the above-mentioned method of preparing Chinese medicine composition, is ground into 200 order～400 object powder standby;
Second step, adds water with respect to feed adhesive 10～20 weight portions of 100 weight portions to start the starch as feed adhesive modified, and refining temperature is 60 ~ 66 ℃, after stirring, pours in spraying machine;
The 3rd step, is ground into 100 order ~ 200 object powder by described feed vector, pours in spraying machine, mixs homogeneously with the feed adhesive after modulation, stirs 1 ~ 3 minute, continues to be warming up to 80 ℃ ~ 90 ℃, completes expanded;
The 4th step, in the product after the 3rd step is expanded, adds described Chinese medicine composition additive, stirs, and puts into granulator and granulates, dry, obtains described feedstuff.
Wherein, described feed vector comprises one or more mixing in Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.
The present invention also provides the application of above-mentioned Chinese medicine composition in the food of preparation treatment pig hyperpyrexia syndrome.
Beneficial effect of the present invention:
This traditional Chinese medicine composition for treating pig hyperpyrexia syndrome provided by the invention has that cure rate is high, instant effect, has no side effect, and is difficult for producing drug resistance, is difficult for causing the advantage of the aspects such as drug residue.
The specific embodiment
Chinese veterinarian thinks, pig hyperpyrexia syndrome belongs to warm and accumulates long-pendingly, and pyretic toxicity enters due to defensive-qi-nutrient-blood, and heat-damp in summer two heresies are invaded body in an opponent's defence, strongly fragrantly turns to for a long time burning hot poison, and pathogenic heat are invaded edema caused by disorder of QI, high heat, and asthma, extreme thirst, skin is scorching hot; Pyretic toxicity is invaded pericardium, disturbs and the mind, drowsiness, and spirit is depressed; Along with the state of an illness is goed deep into pyretic toxicity invasion and attack blood system, the venation of burning, the absurd row of forcing blood, therefore see that blood trouble moves blood, skin has petechia and ecchymosis; In pathogenic fire inflammation, therefore see conjunctiva flushing, the cloudy liquid that burns in later stage pathogenic heat, causes cloudy Tianjin exhausted and dead.Based on above-mentioned theory, the Chinese medicine composition for the treatment of pig hyperpyrexia syndrome provided by the invention is with heat-clearing and toxic substances removing, and removing heat from blood YIN nourishing is principle.
The invention provides a kind of like this Chinese medicine composition that is used for the treatment of pig hyperpyrexia syndrome, it comprises: Cortex Phellodendri, Rhizoma Polygoni Cuspidati, the Radix Paeoniae Alba, Cortex Dictamni, Herba Asari, Herba Menthae, Herba Potentillae Discoloris, Fructus Anisi Stellati, Folium Et Cacumen Murrayae, Rhizoma Saururi (Herba Saururi), Radix Sophorae Tonkinensis, Pseudobulbus Cremastrae Seu Pleiones, Rhizoma Polygonati, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Ramulus et Folium Bauhiniae Faberi, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi and Herba Dendrobii.
Cortex Phellodendri: latin name Phellodendri Chinensis Cortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, effect except hectic fever due to YIN-deficiency clearind deficient heat, cures mainly damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the cards such as eczema pruritus.
Rhizoma Polygoni Cuspidati: latin name Polygoni Cuspidati Rhizoma et Radix, micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian, there is heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, the effect of relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus.
The Radix Paeoniae Alba: latin name Paeoniae Radix Alba, bitter in the mouth, acid, cool in nature; enter liver, spleen channel, there is nourishing blood to suppress the hyperactive liver, slow middle pain relieving; yin fluid astringing is received the effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache; spontaneous sweating; fever due to yin deficiency, menoxenia, metrorrhagia; be with inferior card, the Radix Paeoniae Alba has good liver-protective effect.
Cortex Dictamni: latin name Dictamni Cortex, bitter in the mouth, salty, cold in nature, return spleen channel; Lung meridian; Small intestine meridian; Stomach warp; Urinary bladder channel, has heat clearing and damp drying; Dispelling wind for relieving itching; The effect of removing toxic substances, cures mainly the rubella due to wind heat noxious dampness; Eczema; Scabies; Jaundice; The cards such as damp and hot arthralgia pain.
Herba Asari: latin name Asari Radix et Rhizoma, acrid in the mouth, warm in nature, return lung, kidney channel, there is expelling wind and cold pain relieving, the effect that warming the lung to resolve fluid-retention is sensible, cure mainly affection of exogenous wind-cold, headache, toothache, wind and cold temperature numbness, affection of exogenous wind-cold, in stop lung cold cough with asthma due to cold fluid-retention, nasal obstruction nasal sinusitis, wind-eye corneal nebula, deafness pharyngalgia, the cards such as aphtha halitosis, Herba Asari has obvious inhibitory action to cellular immunization and humoral immunization.
Herba Menthae: latin name Menthae Haplocalycis Herba, acrid in the mouth, cool in nature, returns lung, Liver Channel, has dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, the effect of dispersing the stagnated live-QI to relieve the stagnation of QI, cures mainly affection due to external wind and heat, epidemic febrile disease and sees heating, micro-evil pain, headache from the beginning of, disease, cough, headache due to pathogenic wind-heat, the many tear of conjunctival congestion, the cards such as laryngopharynx swelling and pain.
Herba Potentillae Discoloris: latin name Potentillae Discoloris Herba, sweet in the mouth, micro-hardship, property is flat, returns liver, stomach, large intestine channel, has the effect of heat-clearing and toxic substances removing, dysentery relieving hemostasis, cures mainly damp-heat dysentery, carbuncle sore tumefacting virus, the card such as heat in blood is had blood in stool, metrorrhagia.
Fructus Anisi Stellati: latin name Anisi Stellati Fructus, acrid in the mouth, warm in nature, return liver,kidney,spleen warp, there is the effect of warming YANG to expel cold, regulating QI to relieve pain, cure mainly colic of cold type stomachache, lumbago due to renal deficiency, coldness and pain in the epigastrium, the cards such as vomiting lack of appetite.
Folium Et Cacumen Murrayae: latin name Murrayae Folium et Cacumen, acrid in the mouth, micro-hardship, warm in nature, slightly poisonous, there is the effect of promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, for stomachache, rheumatic arthralgia, treating swelling and pain by traumatic injury, fracture, sore and toxic, venom, the cards such as eczema.
Rhizoma Saururi (Herba Saururi): latin name Saururi Herba, sweet in the mouth, pungent, cold in nature, return lung, urinary bladder channel, there is clearing away heat and promoting diuresis; The effect of removing toxic substances and promoting subsidence of swelling, cures mainly pyretic stranguria; Stranguria with blood; Edema; Foot gas; Jaundice; Dysentery; Leukorrhagia; Carbuncle sore tumefacting virus; Eczema; The cards such as venom.
Radix Sophorae Tonkinensis: latin name Sophorae Tonkinensis Radix et Rhizoma, bitter in the mouth, cold in nature, have and relieve inflammation or internal heat, removing toxic substances, detumescence, the effect of pain relieving, cure mainly retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, heat is swollen, tinea alba, scabies, the cards such as Serpentis, worm, lyssodexis.
Pseudobulbus Cremastrae Seu Pleiones: latin name Pleiones Pseudobulbus, sweet, micro-pungent, cool.Return liver, spleen channel, have heat-clearing and toxic substances removing, the effect of dissipating phlegm and resolving masses, cures mainly carbuncle furunculosis, scrofula sucutaneous nodule, tuberculous lymphadenitis, the cards such as snake bite and insect sting.
Rhizoma Polygonati: latin name Polygonati Rhizoma, sweet in the mouth, property is flat, enter lung, spleen, kidney channel, there is the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Herba Senecionis Scandentis: latin name Senecionis Scandentis Hebra, cold in nature, bitter in the mouth, returns lung, Liver Channel, has the effect of heat-clearing and toxic substances removing, improving eyesight dampness removing, has the cards such as carbuncle sore tumefacting virus, cold, fever, conjunctival congestion and swelling pain, dysentery, skin eczema.
Fructus Ligustri Lucidi: latin name Ligustri Lucidi Fructus, sweet in the mouth, hardship, be slightly cold, and enters liver, kidney channel, has strong liver kidney tonifying, and the effect of clearing away heat to improve acuity of vision, is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.Fructus Ligustri Lucidi can promote leukocyte, strengthens the effect of immunologic function.
Ramulus et Folium Bauhiniae Faberi: latin name Euphorbiae Hirtae Herba, mildly bitter flavor, micro-acid, cool in nature, return lung, bladder, large intestine channel, there is heat-clearing and toxic substances removing, the effect that dampness removing is antipruritic, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, skin pruritus are controlled in external.
Radix Codonopsis: latin name Codonopsis Radix, sweet in the mouth, property is flat, enter lung, spleen channel, have QI invigorating strengthening the spleen, the effect of nourishing blood to promote the production of body fluid, cure mainly deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, the cards such as cough spontaneous perspiration, Radix Codonopsis is longer than spleen reinforcing nourishing the stomach, adjusts regulating the function of middle-JIAO, has the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes the absorption of intestinal to nutrient substance.
The Rhizoma Atractylodis Macrocephalae: latin name Attractylodis Macrocephalae Rhizoma, sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, there is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized, cures mainly the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, and gastrointestinal function is had to regulating action.
Caulis Spatholobi: latin name Spatholobi Caulis, bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, there is blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, platelet aggregation is had to obvious inhibitory action, promote animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the cards such as soreness of the waist and knees, pain.
Herba Dendrobii: latin name Dendrobii Caulis, cold nature, sweet in the mouth, enters stomach, kidney channel, has reinforcing stomach reg fluid, and the effect of nourishing YIN and clearing away heat, cures mainly consumption of body fluid by heat, low grade fever excessive thirst, the few tongue of red tongue; Deficiency of stomach-Yin, thirsty and dry pharynx, vomiting is eaten less, vague epigastralgia, the few tongue of tongue light; Deficiency of kidney yin, the cards such as blurring of vision.
The described Chinese medicine composition that is used for the treatment of pig hyperpyrexia syndrome, the ratio of weight and number of various components also can be preferably: Cortex Phellodendri 70～80 weight portions, Rhizoma Polygoni Cuspidati 40～50 weight portions, the Radix Paeoniae Alba 15～25 weight portions, Cortex Dictamni 15～25 weight portions, Herba Asari 10～20 weight portions, Herba Menthae 5～15 weight portions, Herba Potentillae Discoloris 15～25 weight portions, Fructus Anisi Stellati 10～20 weight portions, Folium Et Cacumen Murrayae 15～25 weight portions, Rhizoma Saururi (Herba Saururi) 25～35 weight portions, Radix Sophorae Tonkinensis 25～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 10～20 weight portions, Rhizoma Polygonati 30～40 weight portions, Herba Senecionis Scandentis 15～25 weight portions, Fructus Ligustri Lucidi 30～40 weight portions, Ramulus et Folium Bauhiniae Faberi 15～25 weight portions, Radix Codonopsis 50～60 weight portions, the Rhizoma Atractylodis Macrocephalae 30～40 weight portions, Caulis Spatholobi 20～30 weight portions and Herba Dendrobii 30～40 weight portions.
The described Chinese medicine composition that is used for the treatment of pig hyperpyrexia syndrome, the ratio of weight and number of various components also can be more preferably: Cortex Phellodendri 75～80 weight portions, Rhizoma Polygoni Cuspidati 45～50 weight portions, the Radix Paeoniae Alba 20～25 weight portions, Cortex Dictamni 20～25 weight portions, Herba Asari 15～20 weight portions, Herba Menthae 10～15 weight portions, Herba Potentillae Discoloris 20～25 weight portions, Fructus Anisi Stellati 15～20 weight portions, Folium Et Cacumen Murrayae 20～25 weight portions, Rhizoma Saururi (Herba Saururi) 30～35 weight portions, Radix Sophorae Tonkinensis 30～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 15～20 weight portions, Rhizoma Polygonati 35～40 weight portions, Herba Senecionis Scandentis 20～25 weight portions, Fructus Ligustri Lucidi 35～40 weight portions, Ramulus et Folium Bauhiniae Faberi 20～25 weight portions, Radix Codonopsis 55～60 weight portions, the Rhizoma Atractylodis Macrocephalae 35～40 weight portions, Caulis Spatholobi 25～30 weight portions and Herba Dendrobii 35～40 weight portions.
The present invention also provides the above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of pig hyperpyrexia syndrome, and it comprises:
The first step, each component in described Chinese medicine composition is mixed in proportion, be ground into 100 order～200 object powder, add the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 70～80%, heating and refluxing extraction 1～3 hour, obtain extracting solution, extracting liquid filtering, obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds the ethanol that the determining alcohol with respect to 1～3 times of its quality is 70～80%, heating and refluxing extraction 1～3 hour, extracting liquid filtering, obtains the second filtrate;
The 3rd step, merges the first filtrate and the second filtrate, and concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer, guarantee that inlet temperature is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, through super-dry, obtain described Chinese medicine composition.
The present invention also provides a kind of feedstuff, described feedstuff comprises feed vector, as the feed adhesive of starch and described Chinese medicine composition as additive.
In described feedstuff, the percentage by weight of each component is, feed vector 50%～80%, the additive 3%～5% of described Chinese medicine composition, described starch 10%～20%.
The present invention also provides the preparation method of above-mentioned feedstuff, and it comprises:
The first step, prepares described Chinese medicine composition additive according to the above-mentioned method of preparing Chinese medicine composition, is ground into 200 order～400 object powder standby;
Second step, adds water with respect to feed adhesive 10～20 weight portions of 100 weight portions to start the starch as feed adhesive modified, and refining temperature is 60 ~ 66 ℃, after stirring, pours in spraying machine;
The 3rd step, is ground into 100 order ~ 200 object powder by described feed vector, pours in spraying machine, mixs homogeneously with the feed adhesive after modulation, stirs 1 ~ 3 minute, continues to be warming up to 80 ℃ ~ 90 ℃, completes expanded;
The 4th step, in the product after the 3rd step is expanded, adds described Chinese medicine composition additive, stirs, and puts into granulator and granulates, dry, obtains described feedstuff.
Described feed vector comprises one or more mixing in Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.
In described feedstuff, can also further add flavoring agent, the percentage by weight of described flavoring agent in described feedstuff is 0.5～1%, and described flavoring agent can be one or more in careless enzyme agent, fruit flavouring agent, vegetalitas citric acid.
In described feedstuff, can also add antioxidation promoter, the percentage by weight of described antioxidation promoter in described feedstuff is 5%～7%, and described antioxidation promoter comprises lipotropy dihydropyridine ester or hydrophilic cysteamine or its mixing.
The present invention also provides the application of above-mentioned Chinese medicine composition in the food of preparation treatment pig hyperpyrexia syndrome.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
By Cortex Phellodendri 75g, Rhizoma Polygoni Cuspidati 45g, Radix Paeoniae Alba 20g, Cortex Dictamni 20g, Herba Asari 15g, Herba Menthae 10g, Herba Potentillae Discoloris 20g, Fructus Anisi Stellati 15g, Folium Et Cacumen Murrayae 20g, Rhizoma Saururi (Herba Saururi) 30g, Radix Sophorae Tonkinensis 30g, Pseudobulbus Cremastrae Seu Pleiones 15g, Rhizoma Polygonati 35g, Herba Senecionis Scandentis 20g, Fructus Ligustri Lucidi 35g, Ramulus et Folium Bauhiniae Faberi 20g, Radix Codonopsis 55g, Rhizoma Atractylodis Macrocephalae 35g, Caulis Spatholobi 25g and Herba Dendrobii 35g mix, be ground into 100 object powder, adding 2300g determining alcohol is 80% ethanol, heating and refluxing extraction 2 hours, obtain extracting solution, extracting liquid filtering, obtain the first filtrate and filtering residue, it is 80% ethanol that the filtering residue of acquisition is added to 600g determining alcohol, heating and refluxing extraction 2 hours, extracting liquid filtering, obtain the second filtrate, the first filtrate and the second filtrate are merged, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer, guarantee that inlet temperature is at 180 ℃, 70 ℃ of leaving air temps, through super-dry, obtain described Chinese medicine composition 1.
Toxicity test
Select SD rat, give the Chinese medicine composition decoct 1 of the embodiment of the present invention 1 preparation of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: Chinese medicinal composition preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each is organized main organs histopathological examination and shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicinal composition preparation of the present invention, in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, rat is had no significant effect, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicinal composition preparation clinical practice of the present invention higher.
Embodiment 2 Chinese medicine compositions 2
By Cortex Phellodendri 80g, Rhizoma Polygoni Cuspidati 47g, Radix Paeoniae Alba 18g, Cortex Dictamni 23g, Herba Asari 12g, Herba Menthae 6g, Herba Potentillae Discoloris 22g, Fructus Anisi Stellati 13g, Folium Et Cacumen Murrayae 23g, Rhizoma Saururi (Herba Saururi) 32g, Radix Sophorae Tonkinensis 35g, Pseudobulbus Cremastrae Seu Pleiones 12g, Rhizoma Polygonati 40g, Herba Senecionis Scandentis 18g, Fructus Ligustri Lucidi 38g, Ramulus et Folium Bauhiniae Faberi 18g, Radix Codonopsis 60g, Rhizoma Atractylodis Macrocephalae 40g, Caulis Spatholobi 22g and Herba Dendrobii 39g mix, be ground into 100 object powder, adding 2300g determining alcohol is 80% ethanol, heating and refluxing extraction 2 hours, obtain extracting solution, extracting liquid filtering, obtain the first filtrate and filtering residue, it is 80% ethanol that the filtering residue of acquisition is added to 600g determining alcohol, heating and refluxing extraction 2 hours, extracting liquid filtering, obtain the second filtrate, the first filtrate and the second filtrate are merged, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer, guarantee that inlet temperature is at 180 ℃, 70 ℃ of leaving air temps, through super-dry, obtain described Chinese medicine composition 2.
Embodiment 3 feedstuffs 1
In the starch 100g as feed adhesive, add 20g water to start modified, refining temperature is 63 ℃, after stirring, pours in spraying machine; Semen Tritici aestivi 500g as feed vector is ground into 100 object powder, pours in spraying machine, mix homogeneously with the starch after modulation; stir 3 minutes, continue to be warming up to 90 ℃, complete expanded; in product after expanded; the Chinese medicine composition additive 50g that adds embodiment 1 preparation, stirs, and puts into granulator and granulates; dry, obtain described feedstuff 1.
Embodiment 4 feedstuffs 2
In the starch 100g as feed adhesive, add 20g water to start modified, refining temperature is 63 ℃, after stirring, pours in spraying machine; Semen Tritici aestivi 500g as feed vector is ground into 100 object powder, pours in spraying machine, mix homogeneously with the starch after modulation; stir 3 minutes, continue to be warming up to 90 ℃, complete expanded; in product after expanded; the Chinese medicine composition additive 40g that adds embodiment 2 preparations, stirs, and puts into granulator and granulates; dry, obtain described feedstuff 2.
Embodiment 5 clinical experiments
Laboratory animal
Experiment is Xingan County village farmer breed with pig, 350 of the interior ternary growth barren sows of 37 ages in days of being introduced by other places, raising condition is all identical, JIUYUE in 2010 morbidity on the 26th, increase to 58 to a JIUYUE 28 days morbidity number, dead 3, within 28th, pay a home visit, adopting immediately pathological material of disease diagnostic analysis laboratory checks, censorship on October 2 is that so-called " hyperpyrexia disease " is high-pathogenicity blue ear disease secondary swine fever, circovirus disease, septic streptococcicosis, clostridieum welchii disease, contagious pleuropneumonia, to October 2, pig is divided into two groups, 206 of experimental grouies, 112 of blank groups.
Test method
Test group adopts the feedstuff of embodiment 3 preparations, feeds continuously 5 days.Matched group is without Chinese medicinal composition preparation.
Result
Test group: take after the feedstuff of the embodiment of the present invention 3 preparations, the appetite of the 3rd day sick pig is recovered substantially, spirit takes a turn for the better, and breathes and relaxes, and fecaluria turns for the better by and large, normal 39.4 ℃ of body temperature, mortality rate is reducing; Medication the 4th day, skin tip gradually fades, and does not occur death; Observe medication the 5th day, the rehabilitation of full group's test group.Amount to 206 pigs, dead 8, mortality rate 3.88%, survival rate 96.12%, illustrates and uses Chinese medicine composition of the present invention to have certain curative effect to the pig hyperpyrexia syndrome of current appearance.
Blank group: observe 5 days, amount to 112, dead 30, mortality rate 26.79%, survival rate 73.21%, illustrate primary disease be a kind of high heat, skin blue, propagate height lethal infectious disease rapidly.
Model case 1
The white hybridized pigs morbidity of 17 of journey raising, 10 is female 7 male, body weight 60 ~ 80 kg.Main suit: have suddenly 7 ill, 41.5 ~ 42 ℃ of body temperature, do not eat or drink, sleeping ground is lazy moving, is a cup too low.Swine fever, pig erysipelas etc. be routine immunization; With antibiotics, astragalus polysaccharides and antipyretic etc., do not feel any better.Disease is seen: 41 ~ 41.5 ℃ of body temperature, be peony in one's ear, and skin rubefaction, back is cerebrol sample, and eye conjunctiva height is congested, and that argol is is spherical, surface is with mucosa, and urine amount is less, color depth is yellow, be dense mucus shape, have shy stink, Mental fatigue, sleeping ground body is motionless.Treatment: the Chinese medicine composition that gavages the embodiment of the present invention 1 preparation is dissolved in water, forms 0.5g (crude drug)/ml, each 150ml, every day 2 times, through 3 days, then has no morbidity.
Model case 2
On August 19th, 2009,31 white hybridized pigs of Lee's raising, body weight 40 ~ 80kg, 15 of boars, 16 of sows, heating, body temperature are 41.5 ~ 42 ℃ suddenly, and spirit is depressed, sleepingly motionless, and appetite is absolutely useless, conjunctival congestion flushing, urine yellow skin.Injected the vaccines such as swine fever.Treatment: gavage the Chinese medicine composition decoct of the embodiment of the present invention 1 preparation, form 0.5g (crude drug)/ml, each 150ml, every day 2 times, is used in conjunction 3 days, recovery from illness.
Model case 3
On March 25th, 2010, the growing and fattening pigs morbidity that 47 average 60Kg of Jiang Yuqin family are heavy, poultry master has been used in conjunction dipyrone, antibiotic etc injection has no improvement for two days, before morning March 27, sees a doctor.Clinical symptoms: spirit is depressed, and dyspnea, is shown in eyelet and anus, vaginal orifice cyanosis, and skin rubefaction is reluctant to stand sleepingly, and during walking, gait is waved, anorexia, drinks water on a small quantity, and 40.3 ~ 41.8 ℃ of body temperature, are hard and dry, oliguria yellowish urine, eyelid swelled, cough, snivel.Gather disease Sanguis sus domestica sample, send laboratory to do antibacterial and viral serological diagnosis, antibacterial culturing is not found pathogenic bacterium, but pathogeny of hog cholera test positive.Treatment: gavage the Chinese medicine composition decoct of the embodiment of the present invention 2 preparations, form 0.5g (crude drug)/ml, each 150ml, every day 2 times, is used in conjunction 7 days, recovery from illness.
Model case 4
On July 16th, 2010, the growing and fattening pigs morbidity of wearing 1 about 40Kg of farrowing sow of positive China man.Disease is seen skin rubefaction, dyspnea, and cough once in a while, snivel, does not eat, drowsiness, is reluctant to stand, and is hard and dry, and nose has the petechia like mosquito bite, 40.7 ~ 42 ℃ of body temperature.Treatment: gavage the Chinese medicine composition decoct of the embodiment of the present invention 2 preparations, form 0.5g (crude drug)/ml, each 150ml, every day 2 times, is used in conjunction 5 days, recovery from illness.
All above-mentioned veterinary drugs are implemented this intellectual property, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. a Chinese medicine composition that is used for the treatment of pig hyperpyrexia syndrome, is characterized in that: described Chinese medicine composition is only by Cortex Phellodendri, Rhizoma Polygoni Cuspidati, the Radix Paeoniae Alba, Cortex Dictamni, Herba Asari, Herba Menthae, Herba Potentillae Discoloris, Fructus Anisi Stellati, Folium Et Cacumen Murrayae, Rhizoma Saururi (Herba Saururi), Radix Sophorae Tonkinensis, Pseudobulbus Cremastrae Seu Pleiones, Rhizoma Polygonati, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Ramulus et Folium Bauhiniae Faberi, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi and Herba Dendrobii;
In described Chinese medicine composition, the ratio of weight and number of various components is: Cortex Phellodendri 70～80 weight portions, Rhizoma Polygoni Cuspidati 40～50 weight portions, the Radix Paeoniae Alba 15～25 weight portions, Cortex Dictamni 15～25 weight portions, Herba Asari 10～20 weight portions, Herba Menthae 5～15 weight portions, Herba Potentillae Discoloris 15～25 weight portions, Fructus Anisi Stellati 10～20 weight portions, Folium Et Cacumen Murrayae 15～25 weight portions, Rhizoma Saururi (Herba Saururi) 25～35 weight portions, Radix Sophorae Tonkinensis 25～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 10～20 weight portions, Rhizoma Polygonati 30～40 weight portions, Herba Senecionis Scandentis 15～25 weight portions, Fructus Ligustri Lucidi 30～40 weight portions, Ramulus et Folium Bauhiniae Faberi 15～25 weight portions, Radix Codonopsis 50～60 weight portions, the Rhizoma Atractylodis Macrocephalae 30～40 weight portions, Caulis Spatholobi 20～30 weight portions and Herba Dendrobii 30～40 weight portions.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: in described Chinese medicine composition, the ratio of weight and number of various components is: Cortex Phellodendri 75～80 weight portions, Rhizoma Polygoni Cuspidati 45～50 weight portions, the Radix Paeoniae Alba 20～25 weight portions, Cortex Dictamni 20～25 weight portions, Herba Asari 15～20 weight portions, Herba Menthae 10～15 weight portions, Herba Potentillae Discoloris 20～25 weight portions, Fructus Anisi Stellati 15～20 weight portions, Folium Et Cacumen Murrayae 20～25 weight portions, Rhizoma Saururi (Herba Saururi) 30～35 weight portions, Radix Sophorae Tonkinensis 30～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 15～20 weight portions, Rhizoma Polygonati 35～40 weight portions, Herba Senecionis Scandentis 20～25 weight portions, Fructus Ligustri Lucidi 35～40 weight portions, Ramulus et Folium Bauhiniae Faberi 20～25 weight portions, Radix Codonopsis 55～60 weight portions, the Rhizoma Atractylodis Macrocephalae 35～40 weight portions, Caulis Spatholobi 25～30 weight portions and Herba Dendrobii 35～40 weight portions.
3. the preparation method of Chinese medicine composition claimed in claim 1, is characterized in that, comprising:
The first step, each component in described Chinese medicine composition is mixed in proportion, be ground into 100 order～200 object powder, add the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 70～80%, heating and refluxing extraction 1～3 hour, obtain extracting solution, extracting liquid filtering, obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds the ethanol that the determining alcohol with respect to 1～3 times of its quality is 70～80%, heating and refluxing extraction 1～3 hour, extracting liquid filtering, obtains the second filtrate;
The 3rd step, merges the first filtrate and the second filtrate, and concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer, guarantee that inlet temperature is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, through super-dry, obtain described Chinese medicine composition.
4. a feedstuff, is characterized in that: only by feed vector, make as additive as feed adhesive and the Chinese medicine composition claimed in claim 1 of starch;
Described feed vector is for being broken into one or more mixing in 100 order ~ 200 object Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.
5. feedstuff as claimed in claim 4, is characterized in that: in described feedstuff, the percentage by weight of each component is, feed vector 50%～80%, the additive 3%～5% of described Chinese medicine composition, described starch 10%～20%.
6. the preparation method of feedstuff as claimed in claim 4, is characterized in that, comprising:
The first step, prepares described Chinese medicine composition additive according to the method for preparing Chinese medicine composition claimed in claim 3, is ground into 200 order～400 object powder standby;
Second step, adds water with respect to feed adhesive 10～20 weight portions of 100 weight portions to start the starch as feed adhesive modified, and refining temperature is 60 ~ 66 ℃, after stirring, pours in spraying machine;
The 3rd step, is ground into 100 order ~ 200 object powder by described feed vector, pours in spraying machine, mixs homogeneously with the feed adhesive after modulation, stirs 1 ~ 3 minute, continues to be warming up to 80 ℃ ~ 90 ℃, completes expanded;
The 4th step, in the product after the 3rd step is expanded, adds described Chinese medicine composition additive, stirs, and puts into granulator and granulates, dry, obtains described feedstuff.
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| CN104855690A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Compound feed for grown pigs and preparation method of compound feed |
| CN106472833A (en) * | 2016-09-28 | 2017-03-08 | 佛山市高明通威饲料有限公司 | A kind of big swine feed and preparation method |
| CN107149045A (en) * | 2017-06-20 | 2017-09-12 | 宁国市仙之居家庭农场 | A kind of Chinese medicine pig feed including sealwort and the stem of noble dendrobium and preparation method thereof |
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| 中草药在防治猪病上的应用;张保平等;《中国动物保健》;20070415(第04期);第48-49页 * |
| 张保平等.中草药在防治猪病上的应用.《中国动物保健》.2007,(第04期), * |
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