EA201590396A1 - Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения - Google Patents

Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения

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EA201590396A1
EA201590396A1 EA201590396A EA201590396A EA201590396A1 EA 201590396 A1 EA201590396 A1 EA 201590396A1 EA 201590396 A EA201590396 A EA 201590396A EA 201590396 A EA201590396 A EA 201590396A EA 201590396 A1 EA201590396 A1 EA 201590396A1
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Prior art keywords
composition containing
sterehemistry
dynucleotides
cyclic purine
preparation
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EA201590396A
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English (en)
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мл. Томас В. Дубенский
Дэвид Б. Канне
Мередит Лай Лин Леон
Эдвард Эмили Лемменс
Лора Хикс Гликмен
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Адуро Биотек, Инк.
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Publication of EA201590396A1 publication Critical patent/EA201590396A1/ru

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    • C07H19/16—Purine radicals
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

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Abstract

Задачей настоящего изобретения является получение новых и высокоактивных иммуностимуляторов, представляющих собой циклические динуклеотиды (ЦДН), которые активируют ДК через недавно обнаруженный цитоплазматический рецептор, известный как STING (стимулятор генов интерферонов). В частности, ЦДН согласно настоящему изобретению предложены в форме композиции, содержащей один или более циклических пуриновых динуклеотидов, которые индуцируют STING-зависимую активацию TBK1, при этом циклические пуриновые динуклеотиды, присутствующие в указанной композиции, представляют собой, по существу, чистые Rp,Rp или Rp,Sp-стереоизмеры и, в частности, по существу, чистые Rp,Rp или Rp,Sp-диастереомеры тиофосфатных ЦДН.
EA201590396A 2012-12-13 2013-12-13 Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения EA201590396A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261737006P 2012-12-13 2012-12-13
US201361790514P 2013-03-15 2013-03-15
PCT/US2013/075189 WO2014093936A1 (en) 2012-12-13 2013-12-13 Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use

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JP (2) JP6333843B2 (ru)
KR (1) KR20150095668A (ru)
CN (2) CN105008381B (ru)
AU (2) AU2013358892B2 (ru)
BR (1) BR112015013440B1 (ru)
CA (1) CA2886456A1 (ru)
DK (1) DK2931738T3 (ru)
EA (1) EA201590396A1 (ru)
ES (1) ES2718910T3 (ru)
HK (1) HK1212707A1 (ru)
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MX (1) MX361680B (ru)
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