CL2022002751A1 - Inmunoconjugados - Google Patents
InmunoconjugadosInfo
- Publication number
- CL2022002751A1 CL2022002751A1 CL2022002751A CL2022002751A CL2022002751A1 CL 2022002751 A1 CL2022002751 A1 CL 2022002751A1 CL 2022002751 A CL2022002751 A CL 2022002751A CL 2022002751 A CL2022002751 A CL 2022002751A CL 2022002751 A1 CL2022002751 A1 CL 2022002751A1
- Authority
- CL
- Chile
- Prior art keywords
- immunoconjugates
- polypeptides
- mutant interleukin
- polynucleotide molecules
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
La presente invención se refiere en general a polipéptidos de interleucina-7 mutante, inmunoconjugados, particularmente inmunoconjugados que comprenden un polipéptido de interleucina-7 mutante y un anticuerpo que se fija a PD-1. Además, la invención se refiere a moléculas de polinucleótidos que codifican los polipéptidos de interleucina-7 mutante o los inmunoconjugados, y vectores y células huésped que comprenden dichas moléculas de polinucleótidos. La invención se refiere además a métodos para producir los polipéptidos de interleucina-7 mutante, inmunoconjugados, composiciones farmacéuticas que los comprenden, y usos de estos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20169510 | 2020-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022002751A1 true CL2022002751A1 (es) | 2023-05-19 |
Family
ID=70289616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022002751A CL2022002751A1 (es) | 2020-04-15 | 2022-10-06 | Inmunoconjugados |
Country Status (17)
Country | Link |
---|---|
US (1) | US20230192795A1 (es) |
EP (1) | EP4135848A2 (es) |
JP (1) | JP2023521238A (es) |
KR (1) | KR20230004494A (es) |
CN (1) | CN115485028A (es) |
AR (1) | AR121856A1 (es) |
AU (1) | AU2021256936A1 (es) |
BR (1) | BR112022020629A2 (es) |
CA (1) | CA3168460A1 (es) |
CL (1) | CL2022002751A1 (es) |
CO (1) | CO2022014884A2 (es) |
CR (1) | CR20220512A (es) |
IL (1) | IL294451A (es) |
MX (1) | MX2022012541A (es) |
PE (1) | PE20230111A1 (es) |
TW (1) | TW202200609A (es) |
WO (1) | WO2021209402A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230250181A1 (en) * | 2021-07-09 | 2023-08-10 | Bright Peak Therapeutics Ag | Modified checkpoint inhibitors and uses thereof |
AU2022362681A1 (en) * | 2021-10-14 | 2024-04-04 | F. Hoffmann-La Roche Ag | New interleukin-7 immunoconjugates |
WO2023062048A1 (en) * | 2021-10-14 | 2023-04-20 | F. Hoffmann-La Roche Ag | Alternative pd1-il7v immunoconjugates for the treatment of cancer |
Family Cites Families (65)
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US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
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ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
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JP2022532249A (ja) * | 2019-05-16 | 2022-07-13 | アーチ オンコロジー,インコーポレイテッド | インターロイキンタンパク質の類似体と組み合わせて癌を処置するための治療用組成物及び方法 |
-
2021
- 2021-04-13 KR KR1020227035960A patent/KR20230004494A/ko unknown
- 2021-04-13 EP EP21717456.4A patent/EP4135848A2/en active Pending
- 2021-04-13 CA CA3168460A patent/CA3168460A1/en active Pending
- 2021-04-13 US US17/996,338 patent/US20230192795A1/en active Pending
- 2021-04-13 JP JP2022562714A patent/JP2023521238A/ja active Pending
- 2021-04-13 IL IL294451A patent/IL294451A/en unknown
- 2021-04-13 BR BR112022020629A patent/BR112022020629A2/pt unknown
- 2021-04-13 MX MX2022012541A patent/MX2022012541A/es unknown
- 2021-04-13 AU AU2021256936A patent/AU2021256936A1/en active Pending
- 2021-04-13 CR CR20220512A patent/CR20220512A/es unknown
- 2021-04-13 WO PCT/EP2021/059473 patent/WO2021209402A2/en active Application Filing
- 2021-04-13 CN CN202180027849.6A patent/CN115485028A/zh active Pending
- 2021-04-13 PE PE2022002198A patent/PE20230111A1/es unknown
- 2021-04-14 TW TW110113346A patent/TW202200609A/zh unknown
- 2021-04-15 AR ARP210101004A patent/AR121856A1/es unknown
-
2022
- 2022-10-06 CL CL2022002751A patent/CL2022002751A1/es unknown
- 2022-10-19 CO CONC2022/0014884A patent/CO2022014884A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021209402A3 (en) | 2021-12-02 |
CN115485028A (zh) | 2022-12-16 |
KR20230004494A (ko) | 2023-01-06 |
AU2021256936A1 (en) | 2022-07-21 |
US20230192795A1 (en) | 2023-06-22 |
CR20220512A (es) | 2022-11-07 |
BR112022020629A2 (pt) | 2022-11-29 |
CA3168460A1 (en) | 2021-10-21 |
WO2021209402A2 (en) | 2021-10-21 |
IL294451A (en) | 2022-09-01 |
TW202200609A (zh) | 2022-01-01 |
CO2022014884A2 (es) | 2022-11-08 |
PE20230111A1 (es) | 2023-01-27 |
JP2023521238A (ja) | 2023-05-23 |
MX2022012541A (es) | 2022-11-07 |
AR121856A1 (es) | 2022-07-20 |
EP4135848A2 (en) | 2023-02-22 |
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