IL294451A - immune conjugates - Google Patents

immune conjugates

Info

Publication number
IL294451A
IL294451A IL294451A IL29445122A IL294451A IL 294451 A IL294451 A IL 294451A IL 294451 A IL294451 A IL 294451A IL 29445122 A IL29445122 A IL 29445122A IL 294451 A IL294451 A IL 294451A
Authority
IL
Israel
Prior art keywords
amino acid
seq
domain
mutant
polypeptide
Prior art date
Application number
IL294451A
Other languages
English (en)
Hebrew (he)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL294451A publication Critical patent/IL294451A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5418IL-7
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
IL294451A 2020-04-15 2021-04-13 immune conjugates IL294451A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20169510 2020-04-15
PCT/EP2021/059473 WO2021209402A2 (en) 2020-04-15 2021-04-13 Immunoconjugates

Publications (1)

Publication Number Publication Date
IL294451A true IL294451A (en) 2022-09-01

Family

ID=70289616

Family Applications (1)

Application Number Title Priority Date Filing Date
IL294451A IL294451A (en) 2020-04-15 2021-04-13 immune conjugates

Country Status (17)

Country Link
US (1) US20230192795A1 (es)
EP (1) EP4135848A2 (es)
JP (1) JP2023521238A (es)
KR (1) KR20230004494A (es)
CN (1) CN115485028A (es)
AR (1) AR121856A1 (es)
AU (1) AU2021256936A1 (es)
BR (1) BR112022020629A2 (es)
CA (1) CA3168460A1 (es)
CL (1) CL2022002751A1 (es)
CO (1) CO2022014884A2 (es)
CR (1) CR20220512A (es)
IL (1) IL294451A (es)
MX (1) MX2022012541A (es)
PE (1) PE20230111A1 (es)
TW (1) TW202200609A (es)
WO (1) WO2021209402A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240041379A (ko) * 2021-07-09 2024-03-29 브라이트 피크 테라퓨틱스 아게 Il-2에 접합된 체크포인트 억제제 및 이의 용도
WO2023062048A1 (en) * 2021-10-14 2023-04-20 F. Hoffmann-La Roche Ag Alternative pd1-il7v immunoconjugates for the treatment of cancer
AU2022362681A1 (en) * 2021-10-14 2024-04-04 F. Hoffmann-La Roche Ag New interleukin-7 immunoconjugates

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Also Published As

Publication number Publication date
KR20230004494A (ko) 2023-01-06
CN115485028A (zh) 2022-12-16
WO2021209402A2 (en) 2021-10-21
CR20220512A (es) 2022-11-07
US20230192795A1 (en) 2023-06-22
CA3168460A1 (en) 2021-10-21
TW202200609A (zh) 2022-01-01
AR121856A1 (es) 2022-07-20
BR112022020629A2 (pt) 2022-11-29
CO2022014884A2 (es) 2022-11-08
WO2021209402A3 (en) 2021-12-02
CL2022002751A1 (es) 2023-05-19
JP2023521238A (ja) 2023-05-23
AU2021256936A1 (en) 2022-07-21
PE20230111A1 (es) 2023-01-27
EP4135848A2 (en) 2023-02-22
MX2022012541A (es) 2022-11-07

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