IL294451A - immune conjugates - Google Patents
immune conjugatesInfo
- Publication number
- IL294451A IL294451A IL294451A IL29445122A IL294451A IL 294451 A IL294451 A IL 294451A IL 294451 A IL294451 A IL 294451A IL 29445122 A IL29445122 A IL 29445122A IL 294451 A IL294451 A IL 294451A
- Authority
- IL
- Israel
- Prior art keywords
- amino acid
- seq
- domain
- mutant
- polypeptide
- Prior art date
Links
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20169510 | 2020-04-15 | ||
PCT/EP2021/059473 WO2021209402A2 (en) | 2020-04-15 | 2021-04-13 | Immunoconjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
IL294451A true IL294451A (en) | 2022-09-01 |
Family
ID=70289616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL294451A IL294451A (en) | 2020-04-15 | 2021-04-13 | immune conjugates |
Country Status (17)
Country | Link |
---|---|
US (1) | US20230192795A1 (es) |
EP (1) | EP4135848A2 (es) |
JP (1) | JP2023521238A (es) |
KR (1) | KR20230004494A (es) |
CN (1) | CN115485028A (es) |
AR (1) | AR121856A1 (es) |
AU (1) | AU2021256936A1 (es) |
BR (1) | BR112022020629A2 (es) |
CA (1) | CA3168460A1 (es) |
CL (1) | CL2022002751A1 (es) |
CO (1) | CO2022014884A2 (es) |
CR (1) | CR20220512A (es) |
IL (1) | IL294451A (es) |
MX (1) | MX2022012541A (es) |
PE (1) | PE20230111A1 (es) |
TW (1) | TW202200609A (es) |
WO (1) | WO2021209402A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20240041379A (ko) * | 2021-07-09 | 2024-03-29 | 브라이트 피크 테라퓨틱스 아게 | Il-2에 접합된 체크포인트 억제제 및 이의 용도 |
WO2023062048A1 (en) * | 2021-10-14 | 2023-04-20 | F. Hoffmann-La Roche Ag | Alternative pd1-il7v immunoconjugates for the treatment of cancer |
AU2022362681A1 (en) * | 2021-10-14 | 2024-04-04 | F. Hoffmann-La Roche Ag | New interleukin-7 immunoconjugates |
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-
2021
- 2021-04-13 WO PCT/EP2021/059473 patent/WO2021209402A2/en active Application Filing
- 2021-04-13 CN CN202180027849.6A patent/CN115485028A/zh active Pending
- 2021-04-13 CA CA3168460A patent/CA3168460A1/en active Pending
- 2021-04-13 KR KR1020227035960A patent/KR20230004494A/ko unknown
- 2021-04-13 US US17/996,338 patent/US20230192795A1/en active Pending
- 2021-04-13 JP JP2022562714A patent/JP2023521238A/ja active Pending
- 2021-04-13 MX MX2022012541A patent/MX2022012541A/es unknown
- 2021-04-13 PE PE2022002198A patent/PE20230111A1/es unknown
- 2021-04-13 IL IL294451A patent/IL294451A/en unknown
- 2021-04-13 AU AU2021256936A patent/AU2021256936A1/en active Pending
- 2021-04-13 CR CR20220512A patent/CR20220512A/es unknown
- 2021-04-13 EP EP21717456.4A patent/EP4135848A2/en active Pending
- 2021-04-13 BR BR112022020629A patent/BR112022020629A2/pt unknown
- 2021-04-14 TW TW110113346A patent/TW202200609A/zh unknown
- 2021-04-15 AR ARP210101004A patent/AR121856A1/es unknown
-
2022
- 2022-10-06 CL CL2022002751A patent/CL2022002751A1/es unknown
- 2022-10-19 CO CONC2022/0014884A patent/CO2022014884A2/es unknown
Also Published As
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---|---|
KR20230004494A (ko) | 2023-01-06 |
CN115485028A (zh) | 2022-12-16 |
WO2021209402A2 (en) | 2021-10-21 |
CR20220512A (es) | 2022-11-07 |
US20230192795A1 (en) | 2023-06-22 |
CA3168460A1 (en) | 2021-10-21 |
TW202200609A (zh) | 2022-01-01 |
AR121856A1 (es) | 2022-07-20 |
BR112022020629A2 (pt) | 2022-11-29 |
CO2022014884A2 (es) | 2022-11-08 |
WO2021209402A3 (en) | 2021-12-02 |
CL2022002751A1 (es) | 2023-05-19 |
JP2023521238A (ja) | 2023-05-23 |
AU2021256936A1 (en) | 2022-07-21 |
PE20230111A1 (es) | 2023-01-27 |
EP4135848A2 (en) | 2023-02-22 |
MX2022012541A (es) | 2022-11-07 |
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