CL2021000028A1 - Anticuerpo multiespecifico (divisional de solicitud 937-2020). - Google Patents
Anticuerpo multiespecifico (divisional de solicitud 937-2020).Info
- Publication number
- CL2021000028A1 CL2021000028A1 CL2021000028A CL2021000028A CL2021000028A1 CL 2021000028 A1 CL2021000028 A1 CL 2021000028A1 CL 2021000028 A CL2021000028 A CL 2021000028A CL 2021000028 A CL2021000028 A CL 2021000028A CL 2021000028 A1 CL2021000028 A1 CL 2021000028A1
- Authority
- CL
- Chile
- Prior art keywords
- multispecific antibody
- divisional application
- nucleic acid
- vector
- binding domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La presente invención tiene relación con un anticuerpo multiespecífico que comprende al menos un dominio de unión CD137 y al menos un dominio de unión a PDL1, y composiciones farmacéuticas y métodos de uso de las mismas. La presente invención tiene relación además con un ácido nucleico que codifica dicho anticuerpo multiespecífico, un vector que comprende dicho ácido nucleico, una célula huésped que comprende dicho ácido nucleico o dicho vector, y un método para producir dicho anticuerpo multiespecífico.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17195779.8A EP3470426A1 (en) | 2017-10-10 | 2017-10-10 | Multispecific antibody |
EP18150465 | 2018-01-05 | ||
EP18167093 | 2018-04-12 | ||
EP18180814 | 2018-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021000028A1 true CL2021000028A1 (es) | 2021-05-28 |
Family
ID=63799025
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020000937A CL2020000937A1 (es) | 2017-10-10 | 2020-04-07 | Anticuerpo multiespecífico. |
CL2021000028A CL2021000028A1 (es) | 2017-10-10 | 2021-01-06 | Anticuerpo multiespecifico (divisional de solicitud 937-2020). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020000937A CL2020000937A1 (es) | 2017-10-10 | 2020-04-07 | Anticuerpo multiespecífico. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20230192897A1 (es) |
EP (1) | EP3694873A1 (es) |
JP (1) | JP7442443B2 (es) |
KR (1) | KR20200063155A (es) |
CN (1) | CN111194323A (es) |
AU (1) | AU2018348429A1 (es) |
BR (1) | BR112020006999A2 (es) |
CA (1) | CA3075969A1 (es) |
CL (2) | CL2020000937A1 (es) |
CO (1) | CO2020003882A2 (es) |
IL (1) | IL273576A (es) |
MA (1) | MA50352A (es) |
MX (1) | MX2020003562A (es) |
SG (1) | SG11202002982YA (es) |
WO (1) | WO2019072868A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018224094A1 (en) | 2017-02-24 | 2019-09-19 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
KR20200063153A (ko) * | 2017-10-10 | 2020-06-04 | 누맙 세러퓨틱스 아게 | Cd137을 표적화하는 항체 및 이의 사용 방법 |
CA3082321A1 (en) * | 2017-11-13 | 2019-05-16 | Crescendo Biologics Limited | Single domain antibodies that bind to cd137 |
WO2021013142A1 (zh) * | 2019-07-22 | 2021-01-28 | 江苏恒瑞医药股份有限公司 | 抗4-1bb抗体、其抗原结合片段及双特异性抗体 |
EP4041772A4 (en) | 2019-10-11 | 2024-04-24 | Nanjing Leads Biolabs Co Ltd | 4-1BB-BINDING ANTIBODIES AND USES THEREOF |
EP3816185A1 (en) * | 2019-11-04 | 2021-05-05 | Numab Therapeutics AG | Multispecific antibody directed against pd-l1 and a tumor-associated antigen |
CN114195900B (zh) * | 2020-09-17 | 2024-02-23 | 普米斯生物技术(珠海)有限公司 | 一种抗4-1bb/pd-l1双特异性抗体及其用途 |
EP3988568A1 (en) | 2020-10-21 | 2022-04-27 | Numab Therapeutics AG | Combination treatment |
WO2022136693A1 (en) | 2020-12-23 | 2022-06-30 | Numab Therapeutics AG | Antibody variable domains and antibodies having decreased immunogenicity |
WO2023001987A2 (en) | 2021-07-22 | 2023-01-26 | University Of Dundee | Therapeutic muteins |
EP4273162A1 (en) | 2022-05-06 | 2023-11-08 | Numab Therapeutics AG | Antibody variable domains and antibodies having decreased immunogenicity |
WO2023214047A1 (en) | 2022-05-06 | 2023-11-09 | Numab Therapeutics AG | Antibody variable domains and antibodies having decreased immunogenicity |
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JPS60500673A (ja) | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
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US6267964B1 (en) | 1989-08-01 | 2001-07-31 | Affibody Technology Sweden Ab | Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives |
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KR20200063153A (ko) * | 2017-10-10 | 2020-06-04 | 누맙 세러퓨틱스 아게 | Cd137을 표적화하는 항체 및 이의 사용 방법 |
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-
2018
- 2018-10-09 CA CA3075969A patent/CA3075969A1/en active Pending
- 2018-10-09 MX MX2020003562A patent/MX2020003562A/es unknown
- 2018-10-09 CN CN201880065327.3A patent/CN111194323A/zh active Pending
- 2018-10-09 EP EP18783483.3A patent/EP3694873A1/en active Pending
- 2018-10-09 AU AU2018348429A patent/AU2018348429A1/en active Pending
- 2018-10-09 KR KR1020207010048A patent/KR20200063155A/ko not_active Application Discontinuation
- 2018-10-09 SG SG11202002982YA patent/SG11202002982YA/en unknown
- 2018-10-09 WO PCT/EP2018/077509 patent/WO2019072868A1/en unknown
- 2018-10-09 JP JP2020519761A patent/JP7442443B2/ja active Active
- 2018-10-09 BR BR112020006999-0A patent/BR112020006999A2/pt unknown
- 2018-10-09 MA MA050352A patent/MA50352A/fr unknown
- 2018-10-09 US US16/754,604 patent/US20230192897A1/en active Pending
-
2020
- 2020-03-24 IL IL273576A patent/IL273576A/en unknown
- 2020-03-30 CO CONC2020/0003882A patent/CO2020003882A2/es unknown
- 2020-04-07 CL CL2020000937A patent/CL2020000937A1/es unknown
-
2021
- 2021-01-06 CL CL2021000028A patent/CL2021000028A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL273576A (en) | 2020-05-31 |
SG11202002982YA (en) | 2020-04-29 |
AU2018348429A1 (en) | 2020-03-12 |
JP2021501744A (ja) | 2021-01-21 |
CA3075969A1 (en) | 2019-04-18 |
WO2019072868A1 (en) | 2019-04-18 |
JP7442443B2 (ja) | 2024-03-04 |
MA50352A (fr) | 2020-08-19 |
KR20200063155A (ko) | 2020-06-04 |
MX2020003562A (es) | 2020-10-01 |
EP3694873A1 (en) | 2020-08-19 |
BR112020006999A2 (pt) | 2020-10-06 |
CL2020000937A1 (es) | 2020-09-25 |
US20230192897A1 (en) | 2023-06-22 |
CO2020003882A2 (es) | 2020-05-29 |
CN111194323A (zh) | 2020-05-22 |
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