CL2022000125A1 - Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos. (divisional de solicitud 202002253) - Google Patents
Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos. (divisional de solicitud 202002253)Info
- Publication number
- CL2022000125A1 CL2022000125A1 CL2022000125A CL2022000125A CL2022000125A1 CL 2022000125 A1 CL2022000125 A1 CL 2022000125A1 CL 2022000125 A CL2022000125 A CL 2022000125A CL 2022000125 A CL2022000125 A CL 2022000125A CL 2022000125 A1 CL2022000125 A1 CL 2022000125A1
- Authority
- CL
- Chile
- Prior art keywords
- methyl
- fluoro
- hydrogen
- deuterium
- cyclopropyl
- Prior art date
Links
- XELRMPRLCPFTBH-UHFFFAOYSA-N quinazoline-2,4-diamine Chemical class C1=CC=CC2=NC(N)=NC(N)=C21 XELRMPRLCPFTBH-UHFFFAOYSA-N 0.000 title 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 4
- 229910052805 deuterium Inorganic materials 0.000 abstract 4
- 150000001408 amides Chemical class 0.000 abstract 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- -1 hydroxy, amino Chemical group 0.000 abstract 3
- 150000002825 nitriles Chemical class 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003246 quinazolines Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Esta solicitud se refiere a derivados de quinazolina de fórmula (I), composiciones farmacéuticas que comprenden los compuestos de fórmula (I), y al uso de los compuestos de fórmual (I) en el tratamiento o la prevención de un infección vírica, de una enfermedad inducida por virus, de un cáncer o de una alergia. En la fórmula (I), R1 es alquilo C3-8, opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor, hidroxilo, amino, nitrilo, éster, amida, alquilo C1-3 o alcoxi C1-3, el carbono de R1 unido a la amina en la posición 4 de la quinazolina se encuentra en la configuración (R), R2 es hidrógeno, deuterio, flúor, cloro, metilo, metoxi, ciclopropilo, trifluorometilo o amida carboxílica, en donde cada uno de metilo, metoxi y ciclopropilo está opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor y nitrilo, R3 es hidrógeno o deuterio, R4 es hidrógeno, deuterio, flúor, metilo, éster carboxílico, amida carboxílica, nitrilo, ciclopropilo, heterociclo C4-7 o un grupo heteroarilo de 5 miembros, en donde cada uno de metilo, ciclopropilo, heterociclo C4-7 y grupo heteroarilo de 5 miembros está opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor, hidroxilo o metilo, R5 es hidrógeno, deuterio, flúor, cloro, metilo o metoxi, a condición de que al menos uno de R2, R3, R4 y R5 no sea hidrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18159583 | 2018-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2022000125A1 true CL2022000125A1 (es) | 2022-10-07 |
Family
ID=61557126
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020002253A CL2020002253A1 (es) | 2018-03-01 | 2020-08-31 | Derivados de 2,4 - diaminoquinazolina y usos médicos de los mismos. |
| CL2021001753A CL2021001753A1 (es) | 2018-03-01 | 2021-06-30 | Compuestos derivados de 2,4-diaminoquinazolina; composición farmacéutica; y su uso para el tratamiento de una infección vírica, cáncer, entre otras (divisional de solicitud 202002253). |
| CL2022000125A CL2022000125A1 (es) | 2018-03-01 | 2022-01-18 | Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos. (divisional de solicitud 202002253) |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020002253A CL2020002253A1 (es) | 2018-03-01 | 2020-08-31 | Derivados de 2,4 - diaminoquinazolina y usos médicos de los mismos. |
| CL2021001753A CL2021001753A1 (es) | 2018-03-01 | 2021-06-30 | Compuestos derivados de 2,4-diaminoquinazolina; composición farmacéutica; y su uso para el tratamiento de una infección vírica, cáncer, entre otras (divisional de solicitud 202002253). |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US11597704B2 (es) |
| EP (2) | EP4059924A1 (es) |
| JP (1) | JP2021514981A (es) |
| KR (1) | KR20200128394A (es) |
| CN (1) | CN111868040A (es) |
| AR (1) | AR114420A1 (es) |
| AU (1) | AU2019226342B2 (es) |
| BR (1) | BR112020017702A2 (es) |
| CA (1) | CA3091076A1 (es) |
| CL (3) | CL2020002253A1 (es) |
| DK (1) | DK3759083T3 (es) |
| EA (1) | EA202092052A1 (es) |
| ES (1) | ES2923579T3 (es) |
| HR (1) | HRP20220781T1 (es) |
| HU (1) | HUE059149T2 (es) |
| IL (2) | IL276952B2 (es) |
| JO (1) | JOP20200208A1 (es) |
| LT (1) | LT3759083T (es) |
| MA (1) | MA52411B1 (es) |
| MD (1) | MD3759083T2 (es) |
| MX (2) | MX2020009071A (es) |
| PH (1) | PH12020551345A1 (es) |
| PL (1) | PL3759083T3 (es) |
| PT (1) | PT3759083T (es) |
| RS (1) | RS63401B1 (es) |
| SG (1) | SG11202008293YA (es) |
| SI (1) | SI3759083T1 (es) |
| TW (1) | TW201945003A (es) |
| UA (1) | UA127590C2 (es) |
| WO (1) | WO2019166532A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017027350A2 (en) | 2015-08-07 | 2017-02-16 | Arrowhead Pharmaceuticals, Inc. | Rnai therapy for hepatitis b virus infection |
| JOP20170161A1 (ar) | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
| WO2020150113A1 (en) * | 2019-01-14 | 2020-07-23 | Innate Tumor Immunity, Inc. | Substituted quinazolines as nlrp3 modulators, for use in the treatment of cancer |
| WO2020255039A1 (en) * | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives |
| CA3147836A1 (en) * | 2019-08-19 | 2021-02-25 | Shanghai Zhimeng Biopharma, Inc. | 2-aminopyrimidine compounds and pharmaceutical compositions and uses thereof |
| CN114555565B (zh) * | 2019-12-13 | 2024-03-05 | 四川科伦博泰生物医药股份有限公司 | 含氮并环化合物、其制备方法及用途 |
| AU2020416484A1 (en) * | 2020-01-02 | 2022-08-25 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal form of pyridopyrimidine derivative and preparation method thereof |
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