CH561739A5 - 4-Hydroxy-2-butenoic acid lactone steroid derivs - cardiotonic, anti-inflammatory, hypocholesterolaemic, mineralocorticoid agents - Google Patents

4-Hydroxy-2-butenoic acid lactone steroid derivs - cardiotonic, anti-inflammatory, hypocholesterolaemic, mineralocorticoid agents

Info

Publication number
CH561739A5
CH561739A5 CH730567A CH730567A CH561739A5 CH 561739 A5 CH561739 A5 CH 561739A5 CH 730567 A CH730567 A CH 730567A CH 730567 A CH730567 A CH 730567A CH 561739 A5 CH561739 A5 CH 561739A5
Authority
CH
Switzerland
Prior art keywords
hydroxy
butenoic acid
acid lactone
oxo
bromo
Prior art date
Application number
CH730567A
Other languages
German (de)
English (en)
Original Assignee
Ayerst Mckenna & Harrison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ayerst Mckenna & Harrison filed Critical Ayerst Mckenna & Harrison
Publication of CH561739A5 publication Critical patent/CH561739A5/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
CH730567A 1966-05-24 1967-05-24 4-Hydroxy-2-butenoic acid lactone steroid derivs - cardiotonic, anti-inflammatory, hypocholesterolaemic, mineralocorticoid agents CH561739A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US552389A US3398138A (en) 1966-05-24 1966-05-24 Novel cardenolides and derivatives
US62935867A 1967-04-10 1967-04-10

Publications (1)

Publication Number Publication Date
CH561739A5 true CH561739A5 (en) 1975-05-15

Family

ID=27070024

Family Applications (1)

Application Number Title Priority Date Filing Date
CH730567A CH561739A5 (en) 1966-05-24 1967-05-24 4-Hydroxy-2-butenoic acid lactone steroid derivs - cardiotonic, anti-inflammatory, hypocholesterolaemic, mineralocorticoid agents

Country Status (6)

Country Link
US (2) US3398138A (fr)
CH (1) CH561739A5 (fr)
DE (1) DE1618065C3 (fr)
FR (1) FR7151M (fr)
GB (1) GB1190403A (fr)
NL (1) NL6707219A (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859272A (en) * 1968-07-23 1975-01-07 Hoechst Ag 19-alkylene-14- ' -hydroxy-cardenolide derivatives and process for preparing them
BE786645A (fr) * 1971-07-22 1973-01-24 Hoechst Ag Heterosides de 14,15 beta -epoxy-cardenolides et de 14,15 beta -epoxy bufadienolides et medicaments qui en renferment
US3783149A (en) * 1971-10-27 1974-01-01 Boehringer Sohn Ingelheim {60 -l talomethylosides of certain genins of the cardenolide and bufadienolide series
US3855207A (en) * 1972-01-24 1974-12-17 Searle & Co 9alpha,11alpha-epoxy spirolactones, spirolactols and lactol ethers corresponding
DE2336445C2 (de) * 1973-07-18 1982-06-03 Knoll Ag, 6700 Ludwigshafen Neue Cardenolide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
CN1046736C (zh) * 1993-10-27 1999-11-24 默里尔药物公司 用作甾族化合物ｃ17－20裂解酶抑制剂的δ16不饱和ｃ17杂环甾族化合物
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6503896B1 (en) 1997-12-24 2003-01-07 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6548491B2 (en) * 1997-12-24 2003-04-15 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
EP3492242B1 (fr) * 2017-07-21 2022-05-11 CL Schutzrechtsverwaltungs GmbH Appareil de fabrication additive d'objets tridimensionnels

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2968596A (en) * 1955-06-07 1961-01-17 Upjohn Co Process for the production of digitoxigenin and intermediates
CH421093A (de) * 1962-04-11 1966-09-30 Sandoz Ag Verfahren zur Herstellung von neuen Steroiden
DE1467928A1 (de) * 1962-08-10 1969-04-30 Hoffmann La Roche Verfahren zur Gewinnung herzaktiver Monoglykoside

Also Published As

Publication number Publication date
GB1190403A (en) 1970-05-06
DE1618065A1 (de) 1971-03-25
DE1618065C3 (de) 1979-02-22
DE1618065B2 (de) 1977-06-08
US3431258A (en) 1969-03-04
FR7151M (fr) 1969-08-04
NL6707219A (fr) 1967-11-27
US3398138A (en) 1968-08-20

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Legal Events

Date Code Title Description
PL Patent ceased